KEGG ENZYME: 1.10.5.1

ENZYME: 1.10.5.1

Entry

EC 1.10.5.1                 Enzyme

Name

ribosyldihydronicotinamide dehydrogenase (quinone);
NRH:quinone oxidoreductase 2;
NQO2;
NAD(P)H:quinone oxidoreductase-2 (misleading);
QR2;
quinone reductase 2;
N-ribosyldihydronicotinamide dehydrogenase (quinone);
NAD(P)H:quinone oxidoreductase2 (misleading)

Class

Oxidoreductases;
Acting on diphenols and related substances as donors;
With a quinone or related compound as acceptor

Sysname

1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase

Reaction(IUBMB)

1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a quinol [RN:R07361]

Reaction(KEGG)

R07361

Substrate

1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide [CPD:C15497];
quinone [CPD:C15602]

Product

1-(beta-D-ribofuranosyl)nicotinamide [CPD:C03150];
quinol [CPD:C15603]

Comment

A flavoprotein. Unlike EC 1.6.5.2, NAD(P)H dehydrogenase (quinone), this quinone reductase cannot use NADH or NADPH; instead it uses N-ribosyl- and N-alkyldihydronicotinamides. Polycyclic aromatic hydrocarbons, such as benz[a]anthracene, and the estrogens 17beta-estradiol and diethylstilbestrol are potent inhibitors, but dicoumarol is only a very weak inhibitor [2]. This enzyme can catalyse both 2-electron and 4-electron reductions, but one-electron acceptors, such as potassium ferricyanide, cannot be reduced [3].

History

EC 1.10.5.1 created 2005 as EC 1.10.99.2, transferred 2015 to EC 1.10.5.1

Orthology

K08071

ribosyldihydronicotinamide dehydrogenase (quinone)

Genes

HSA:	4835(NQO2)

PTR:	462395(NQO2)

PPS:	100992910(NQO2)

GGO:	101132190(NQO2)

PON:	100174417(NQO2)

PPYG:

129038558(NQO2)

NLE:	100597917(NQO2)

HMH:	116459925(NQO2)

SSYN:

129472976(NQO2)

MCC:	707675(NQO2)

MCF:	102119230(NQO2)

MTHB:

126952542

MNI:	105487313(NQO2)

CSAB:

103222288(NQO2)

CATY:

105596425(NQO2)

PANU:

101010086(NQO2)

TGE:	112623429(NQO2)

MLEU:

105542850(NQO2)

RRO:	104661230(NQO2)

RBB:	108514231(NQO2)

TFN:	117086619(NQO2)

PTEH:

111548564(NQO2)

CANG:

105507094(NQO2)

CJC:	100387941(NQO2)

SBQ:	101047567(NQO2)

CIMI:

108281785(NQO2)

ANAN:

105708677(NQO2)

CSYR:

103272006(NQO2)

MMUR:

105873485(NQO2)

LCAT:

123638175(NQO2)

PCOQ:

105816069(NQO2)

OGA:	100948509(NQO2)

MMU:	18105(Nqo2)

MCAL:

110307948(Nqo2)

MPAH:

110333764(Nqo2)

RNO:	291084(Nqo2)

MCOC:

116082571(Nqo2)

ANU:	117713712(Nqo2)

MUN:	110561377(Nqo2)

CGE:	100760827(Nqo2)

MAUA:

101835294(Nqo2)

PROB:

127229358(Nqo2)

PLEU:

114701293(Nqo2)

MORG:

121433920(Nqo2)

MFOT:

126501522

AAMP:

119816686(Nqo2)

NGI:

103741921

HGL:	101696975(Nqo2)

CPOC:

100715791(Nqo2)

CCAN:

109695454(Nqo2)

DORD:

105985892(Nqo2)

DSP:	122108437(Nqo2)

PLOP:

125353065(Nqo2)

NCAR:

124988824

MMMA:

107160991(Nqo2)

OCU:	100301550(NQO2)

OPI:	101518423(NQO2)

TUP:	102501485(NQO2)

GVR:	103581773(NQO2)

CFA:	606932(NQO2)

CLUD:

112659348(NQO2)

VVP:	112907396(NQO2)

VLG:	121500053(NQO2)

NPO:	129508180(NQO2)

AML:	100470883(NQO2)

UMR:	103664966(NQO2)

UAH:	113264395(NQO2)

UAR:	123801499(NQO2)

ELK:

111156722

LLV:

125103138

MPUF:

101684988(NQO2)

MNP:	132017565(NQO2)

MLK:	131834460(NQO2)

NVS:	122912350(NQO2)

EJU:	114223916(NQO2)

ZCA:	113927119(NQO2)

MLX:	118027396(NQO2)

NSU:	110586634(NQO2)

LWW:	102727208(NQO2)

FCA:	101085630(NQO2)

PYU:	121020426(NQO2)

PCOO:

112853680(NQO2)

PBG:	122489294(NQO2)

PVIV:

125166310(NQO2)

LRUF:

124529369

PTG:	102964944(NQO2)

PPAD:

109249469(NQO2)

PUC:

125908449

AJU:

106976161

HHV:	120241451(NQO2)

BTA:	508566(NQO2)

BOM:	102280064(NQO2)

BIU:	109577276(NQO2)

BBUB:

102389366(NQO2)

BBIS:

104982109(NQO2)

CHX:	102174178(NQO2)

OAS:	101122988(NQO2) 114118753

BTAX:

128055998(NQO2)

ODA:	120869996(NQO2)

CCAD:

122429864(NQO2)

MBEZ:

129543549(NQO2)

SSC:	100739771(NQO2)

CFR:	102516140(NQO2)

CBAI:

105079770(NQO2)

CDK:	105087260(NQO2)

VPC:	102527353(NQO2)

BACU:

102998501(NQO2)

BMUS:

118903886(NQO2)

LVE:	103080201(NQO2)

OOR:	101275294(NQO2)

DLE:	111181306(NQO2)

PCAD:

102986827(NQO2)

PSIU:

116762852(NQO2)

NASI:

112395532(NQO2)

ECB:	100057868(NQO2)

EPZ:	103548130(NQO2)

EAI:	106847885(NQO2)

MYB:	102244529(NQO2)

MYD:	102767115(NQO2)

MMYO:

118677072(NQO2)

MLF:	102425403(NQO2)

MDT:	132230662(NQO2)

PKL:	118724467(NQO2)

EFUS:

103302886(NQO2)

MNA:	107542940(NQO2)

DRO:	112297552(NQO2) 112313165

AJM:

119042330

PDIC:

114496747(NQO2)

PHAS:

123820765(NQO2)

MMF:	118626549(NQO2)

PPAM:

129085547(NQO2)

RFQ:	117027727(NQO2)

PALE:

102885731(NQO2)

PGIG:

120607713(NQO2)

PVP:	105296779(NQO2)

RAY:	107521728(NQO2)

MJV:	108409763(NQO2)

TOD:	119251908(NQO2)

SETR:

125996089

LAV:	100666204(NQO2)

TMU:

101353523

ETF:	101659703 101660020

DNM:	101416911(NQO2)

MDO:	100028625(NQO2) 100028661

GAS:	123231865(NQO2)

SHR:	100914437 100934580

AFZ:	127544233 127544234

PCW:

110201160

TVP:	118839992(NQO2) 118857422

OAA:	100079677(NQO2)

GGA:	420886(NQO2)

PCOC:

116226410(NQO2)

MGP:	100543456(NQO2)

CJO:	107309575(NQO2)

TPAI:

128087729(NQO2)

LMUT:

125690556(NQO2)

NMEL:

110393000(NQO2)

APLA:

101801396(NQO2)

ACYG:

106043848(NQO2)

CATA:

118251014(NQO2)

AFUL:

116486849(NQO2)

TGU:	100190610(NQO2) 100220924(NQO2)

LSR:	110478235 110478241

SCAN:

103817683(NQO2)

PMOA:

120497252(NQO2)

OTC:	121340416 121340461

PRUF:

121354851 121357757(NQO2)

GFR:	102038242 102038415

FAB:	101805969 101806163

OMA:	130250430 130250431

PHI:	102112623(NQO2)

PMAJ:

107199553(NQO2)

CCAE:

111923829 111923830

CCW:	104696786 120409664(NQO2)

CBRC:

103618648(NQO2)

ETL:	114062376(NQO2) 114072345 114072735

ZAB:	102066463(NQO2)

ZLE:	135443200 135444143

SVG:	106850788(NQO2)

MMEA:

130578077 130578078 130588075

HRT:	120760315 120760327

SATI:

136365111 136365389

FPG:	101913611(NQO2)

FCH:	102058647(NQO2)

CCRI:

104169264

NNT:	104402266(NQO1)

SHAB:

115615088(NQO2)

ACUN:

113476989(NQO2)

TALA:

104356076(NQO2)

ACHC:

115353042(NQO2)

HALD:

104320735

HLE:	104835340(NQO2)

AGEN:

126048675

GCL:

127012917

CSTI:

104549998

LDI:

104340821

MNB:

103775737

DPUB:

104303201(NQO2)

AVIT:

104268405

BRHI:

104489606(NQO2)

EGZ:	104122836(NQO2)

NNI:	104021841(NQO2)

PCRI:

104037714(NQO2)

PCAO:

104042369

PADL:

103919012(NQO2)

AFOR:

103898823(NQO2)

FGA:

104071342

GSTE:

104251561

CLV:	102093500(NQO2)

MUI:

104537376

PGUU:

104459889(NQO2)

PLET:

104620211(NQO2)

EHS:

104503999

CMAC:

104482864

CUCA:

104066621(NQO2)

TEO:

104370731

BREG:

104633864

OHA:

104333498

ACAR:

104531559

CPEA:

104391588(NQO2)

CVF:	104286636(NQO2)

RTD:	128906250(NQO2)

AAM:	106481991(NQO2)

AROW:

112968061(NQO2)

NPD:	112947640(NQO2)

TGT:	104573391(NQO2)

DNE:	112992014(NQO2)

SCAM:

104146122(NQO2)

ASN:	102368685(NQO2)

AMJ:	102572705(NQO2)

CPOO:

109315071(NQO2)

GGN:	109301057(NQO2)

CMY:	122461324(NQO2)

CCAY:

125632090(NQO2)

DCC:	119851334(NQO2)

CABI:

116835502(NQO2)

ACS:	100556008(nqo2)

ASAO:

132774552(NQO2)

PVT:	110077079(NQO2)

SUND:

121929357(NQO2)

PBI:	103061661(NQO2)

PMUR:

107287232(NQO2) 107289998 107300078

CTIG:

120307630(NQO2)

PGUT:

117672431(NQO2)

APRI:

131194872(NQO2)

PTEX:

113445742(NQO2)

NSS:	113417993(NQO2)

VKO:	123020618(NQO2)

HCG:	128324804(NQO2)

GJA:	107112824(NQO2)

EMC:	129333761(NQO2)

NPR:	108793407(NQO2)

RTEM:

120940659(NQO2)

BBUF:

121001071(NQO2)

BGAR:

122938929(NQO2)

MUO:	115460285(NQO2)

GSH:	117354850(NQO2)

SASA:

106586559

LCM:

102360651

HRJ:	124279219 124279221 124279222

MCAF:

127738320

LAK:

106178845

ATEN:

116308879

KNG:	KNAG_0C04760(KNAG0C04760) KNAG_0E00950(KNAG0E00950) KNAG_0H01480(KNAG0H01480)

FFC:	NCS54_01224800

FKR:	NCS57_01212300

CHIG:

CH63R_10732

CPI:

Cpin_4986

» show all

Reference

1 [PMID:14465018]

Authors

LIAO S, DULANEY JT, WILLIAMS-ASHMAN HG.

Title

Purification and properties of a flavoprotein catalyzing the oxidation of reduced ribosyl nicotinamide.

Journal

J Biol Chem 237:2981-7 (1962)

Reference

2 [PMID:9050836]

Authors

Zhao Q, Yang XL, Holtzclaw WD, Talalay P

Title

Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase)

Journal

Proc Natl Acad Sci U S A 94:1669-74 (1997)
DOI:10.1073/pnas.94.5.1669

Sequence

[hsa:4835]

Reference

3 [PMID:9367528]

Authors

Wu K, Knox R, Sun XZ, Joseph P, Jaiswal AK, Zhang D, Deng PS, Chen S

Title

Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase.

Journal

Arch Biochem Biophys 347:221-8 (1997)
DOI:10.1006/abbi.1997.0344

Sequence

[hsa:4835]

Reference

4 [PMID:8182056]

Authors

Jaiswal AK

Title

Human NAD(P)H:quinone oxidoreductase2. Gene structure, activity, and tissue-specific expression.

Journal

J Biol Chem 269:14502-8 (1994)

Sequence

[hsa:4835]

Other DBs

ExplorEnz - The Enzyme Database:

1.10.5.1

IUBMB Enzyme Nomenclature:

1.10.5.1

ExPASy - ENZYME nomenclature database:

1.10.5.1

BRENDA, the Enzyme Database:

1.10.5.1

CAS:	667919-86-0

DBGET integrated database retrieval system