KEGG   ENZYME: 1.10.5.1Help
Entry
EC 1.10.5.1                 Enzyme                                 

Name
ribosyldihydronicotinamide dehydrogenase (quinone);
NRH:quinone oxidoreductase 2;
NQO2;
NAD(P)H:quinone oxidoreductase-2 (misleading);
QR2;
quinone reductase 2;
N-ribosyldihydronicotinamide dehydrogenase (quinone);
NAD(P)H:quinone oxidoreductase2 (misleading)
Class
Oxidoreductases;
Acting on diphenols and related substances as donors;
With a quinone or related compound as acceptor
BRITE hierarchy
Sysname
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase
Reaction(IUBMB)
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a quinol [RN:R07361]
Reaction(KEGG)
Substrate
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide [CPD:C15497];
quinone [CPD:C15602]
Product
1-(beta-D-ribofuranosyl)nicotinamide [CPD:C03150];
quinol [CPD:C15603]
Comment
A flavoprotein. Unlike EC 1.6.5.2, NAD(P)H dehydrogenase (quinone), this quinone reductase cannot use NADH or NADPH; instead it uses N-ribosyl- and N-alkyldihydronicotinamides. Polycyclic aromatic hydrocarbons, such as benz[a]anthracene, and the estrogens 17beta-estradiol and diethylstilbestrol are potent inhibitors, but dicoumarol is only a very weak inhibitor [2]. This enzyme can catalyse both 2-electron and 4-electron reductions, but one-electron acceptors, such as potassium ferricyanide, cannot be reduced [3].
History
EC 1.10.5.1 created 2005 as EC 1.10.99.2, transfered 2015 to EC 1.10.5.1
Orthology
K08071  ribosyldihydronicotinamide dehydrogenase (quinone)
Genes
HSA: 4835(NQO2)
PTR: 462395(NQO2)
PPS: 100992910(NQO2)
GGO: 101132190(NQO2)
PON: 100174417(NQO2)
NLE: 100597917(NQO2)
MCC: 707675(NQO2)
MCF: 102119230(NQO2)
CSAB: 103222288(NQO2)
RRO: 104661230(NQO2)
RBB: 108514231(NQO2)
CJC: 100387941(NQO2)
SBQ: 101047567(NQO2)
MMU: 18105(Nqo2)
RNO: 291084(Nqo2)
CGE: 100760827(Nqo2)
NGI: 103741921
HGL: 101696975(Nqo2)
CCAN: 109695454(Nqo2)
OCU: 100301550(NQO2)
TUP: 102501485(NQO2)
CFA: 606932(NQO2)
AML: 100470883(NQO2)
UMR: 103664966(NQO2)
ORO: 101367483(NQO2)
FCA: 101085630(NQO2)
PTG: 102964944(NQO2)
AJU: 106976161(NQO2)
BTA: 508566(NQO2)
BOM: 102280064(NQO2)
BIU: 109577276(NQO2)
PHD: 102339147(NQO2)
CHX: 102174178(NQO2)
OAS: 101122988(NQO2)
SSC: 100739771(NQO2)
CFR: 102516140(NQO2)
CDK: 105087260(NQO2)
BACU: 102998501(NQO2)
LVE: 103080201(NQO2)
OOR: 101275294(NQO2)
ECB: 100057868(NQO2)
EPZ: 103548130(NQO2)
EAI: 106847885(NQO2)
MYB: 102244529(NQO2)
MYD: 102767115(NQO2)
RSS: 109458597(NQO2)
PALE: 102885731(NQO2)
LAV: 100666204(NQO2)
TMU: 101353523
MDO: 100028625(NQO2) 100028661
OAA: 100079677(NQO2)
GGA: 420886(NQO2)
MGP: 100543456(NQO2)
CJO: 107309575(NQO2)
APLA: 101801396(NQO2)
ACYG: 106043848(NQO2)
TGU: 100190610(NQO2) 100220924
PHI: 102110055 102112623(NQO2)
PMAJ: 107199553(NQO2)
CCW: 104696786(NQO2)
FPG: 101913611(NQO2)
FCH: 102058647(NQO2)
CLV: 102093500(NQO2)
EGZ: 104122836(NQO2)
AAM: 106481991(NQO2)
ASN: 102368685(NQO2)
AMJ: 102572705(NQO2)
PSS: 106733053(NQO2)
ACS: 100556008(nqo2)
PVT: 110077079(NQO2)
PBI: 103061661(NQO2)
GJA: 107112824(NQO2)
NPR: 108793407(NQO2)
PRET: 103459390
SASA: 106586559
LCM: 102360651
CMK: 103176305(nqo2)
LAK: 106178845
 » show all
Taxonomy
Reference
1  [PMID:14465018]
  Authors
LIAO S, DULANEY JT, WILLIAMS-ASHMAN HG.
  Title
Purification and properties of a flavoprotein catalyzing the oxidation of reduced ribosyl nicotinamide.
  Journal
J Biol Chem 237:2981-7 (1962)
Reference
2  [PMID:9050836]
  Authors
Zhao Q, Yang XL, Holtzclaw WD, Talalay P.
  Title
Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase)
  Journal
Proc Natl Acad Sci U S A 94:1669-74 (1997)
DOI:10.1073/pnas.94.5.1669
  Sequence
[hsa:4835]
Reference
3  [PMID:9367528]
  Authors
Wu K, Knox R, Sun XZ, Joseph P, Jaiswal AK, Zhang D, Deng PS, Chen S.
  Title
Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase.
  Journal
Arch Biochem Biophys 347:221-8 (1997)
DOI:10.1006/abbi.1997.0344
  Sequence
[hsa:4835]
Reference
4  [PMID:8182056]
  Authors
Jaiswal AK.
  Title
Human NAD(P)H:quinone oxidoreductase2. Gene structure, activity, and tissue-specific expression.
  Journal
J Biol Chem 269:14502-8 (1994)
  Sequence
[hsa:4835]
Other DBs
ExplorEnz - The Enzyme Database: 1.10.5.1
IUBMB Enzyme Nomenclature: 1.10.5.1
ExPASy - ENZYME nomenclature database: 1.10.5.1
BRENDA, the Enzyme Database: 1.10.5.1
CAS: 667919-86-0

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