KEGG   ENZYME: 1.11.1.11
Entry
EC 1.11.1.11                Enzyme                                 
Name
L-ascorbate peroxidase;
L-ascorbic acid peroxidase;
L-ascorbic acid-specific peroxidase;
ascorbate peroxidase;
ascorbic acid peroxidase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
Sysname
L-ascorbate:hydrogen-peroxide oxidoreductase
Reaction(IUBMB)
2 L-ascorbate + H2O2 + 2 H+ = L-ascorbate + L-dehydroascorbate + 2 H2O (overall reaction) [RN:R00644];
(1a) 2 L-ascorbate + H2O2 + 2 H+ = 2 monodehydroascorbate + 2 H2O [RN:R09540];
(1b) 2 monodehydroascorbate = L-ascorbate + L-dehydroascorbate (spontaneous) [RN:R03186]
Reaction(KEGG)
Substrate
L-ascorbate [CPD:C00072];
H2O2 [CPD:C00027];
H+ [CPD:C00080];
monodehydroascorbate [CPD:C01041]
Product
L-ascorbate [CPD:C00072];
L-dehydroascorbate [CPD:C05422];
H2O [CPD:C00001];
monodehydroascorbate [CPD:C01041]
Comment
A heme protein. Oxidizes ascorbate and low molecular weight aromatic substrates. The monodehydroascorbate radical produced is either directly reduced back to ascorbate by EC 1.6.5.4 [monodehydroascorbate reductase (NADH)] or undergoes non-enzymic disproportionation to ascorbate and dehydroascorbate.
History
EC 1.11.1.11 created 1983, modified 2010, modified 2011
Pathway
ec00053  Ascorbate and aldarate metabolism
ec00480  Glutathione metabolism
ec01100  Metabolic pathways
Orthology
K00434  L-ascorbate peroxidase
Genes
SHON118997631
AJM119035166
CGLO123266757
HMG100213023
ATHAT1G07890(APX1) AT1G77490(TAPX) AT3G09640(APX2) AT4G08390(SAPX) AT4G09010(TL29) AT4G32320(APX6) AT4G35000(APX3) AT4G35970(APX5)
ALY9303117 9303168 9305354 9308432 9310603 9318697 9322135 9322136 9325208 9328486
CRB17878438 17879152 17880619 17884052 17884559 17890815 17893627 17893747 17896270 17899405
CSAT104702532 104707160 104707215 104713416 104716524 104716637 104716949 104719794 104720283 104721287 104729589 104729717 104730042 104736879 104736925 104739373 104745137 104747469 104747470 104751645 104754395 104754965 104764660 104765991 104766972 104766975 104792024 104792033
EUSEUTSA_v10008402mg EUTSA_v10018581mg EUTSA_v10021381mg EUTSA_v10022797mg EUTSA_v10023023mg EUTSA_v10025686mg EUTSA_v10025911mg EUTSA_v10025942mg EUTSA_v10028739mg EUTSA_v10028759mg
BRP103832195 103836413 103838791 103843426 103848043 103858501 103860476 103862119 103862385 103871533 103871729
BNA106346376 106346377 106347996 106354606 106362267 106386647 106389449 106401842 106407140 106415142 106419633 106420215 106422138 106423276 106427935 106428784 106433208 106435662 106435671 106438471 106439834 106446154 106446926 111199406 111207743
BOE106294764 106300129 106303893 106306187 106307224 106308404 106312994 106324757 106324893 106328411 106328985
RSZ108812703 108814310 108814761 108814785 108820821 108822828 108824179 108837581 108844696 108848897 108851335 108851337 108856542 108856708
THJ104800618 104803658 104804273 104804329 104813110 104813151 104813669 104815756 104816316 104826354
CPAP110806432 110808580 110813572 110816636 110822345 110825509
CIT102607382 102610460 102618981 102622081 102622372 102623082 102629716 102630188
CICCICLE_v10001194mg CICLE_v10001685mg CICLE_v10008868mg CICLE_v10012554mg CICLE_v10026205mg CICLE_v10028990mg CICLE_v10030198mg
PVY116124157 116126833 116129839 116129862 116131607 116138091 116144782 116144787 116145613
MINC123194353 123198607 123200457 123201325 123203234 123205515 123206824 123207163 123209556 123212144 123214773 123224991 123228152 123229226 123229694
TCC18587790 18590832(APX) 18592115 18592363 18597892 18607557 18610739
GRA105767858 105769825 105769872 105772729 105773104 105773990 105781150 105785908 105787462 105792368 105792370 105792371 105795404
GHI107898310 107900057 107901425 107906191 107908653 107909465 107916997 107922467 107924317 107927982 107936563 107938996 107942909 107952958 107959060 107961677 107962527 107962799 107962802 107962803 121212696 121218230 121229506 121230344
GAB108453402 108453752 108463433 108467585 108467715 108470238 108475956 108484207 108484599 108486104 108488538 108489681
DZI111281977 111285965 111296490 111297878 111300438 111302517 111303578 111308750 111312285 111312419 111315649 111317254 111317709
EGR104415274 104418937 104421699 104422782 104432832 104435850 104437032 104439814 104447987 104450927
GMX100170727 100170737 100784258 100792735 100795192 100799504 100802238 100806101 100813526 112998405 553156(APX1) 606508(APX2)
GSJ114373310 114374032 114374988 114375739 114379910 114380179 114385361 114394932 114410407 114411121 114414979 114415422 114419669
PVUPHAVU_002G104700g PHAVU_002G107000g PHAVU_008G176700g PHAVU_009G093000g PHAVU_009G1265000 PHAVU_011G035000g PHAVU_011G071300g
VRA106756337 106756347 106759908 106762832 106776684 106776989 106778813
VAR108319177 108321266 108321268 108330815 108331841 108336305 108340597 108340692
VUN114162470 114164188 114169494 114169897 114173407 114193534
CCAJ109798454 109798834 109800264 109800265 109800266 109800688 109808156 109817680 109819079
APRC113846832 113859214 113864980 113866037 113866932 113868726
MTRMTR_3g088160 MTR_3g107060 MTR_4g061140 MTR_4g073410 MTR_5g008440 MTR_5g022510 MTR_5g064610
CAM101496561 101497640 101497868(peroxidase) 101506692 101507560 101511999(peroxidase)
LJALj1g3v0250130.2(Lj1g3v0250130.2) Lj1g3v0839140.1(Lj1g3v0839140.1) Lj1g3v0839140.2(Lj1g3v0839140.2) Lj1g3v1901620.1(Lj1g3v1901620.1) Lj3g3v3465510.1(Lj3g3v3465510.1)
ADU107457615 107459152 107460700 107461634 107463271 107476561 107476911 107487471
AIP107606045 107609049 107611695 107612004 107628775 107629166 107641638
AHF112703206 112706052 112707898 112708373 112736565 112737011 112747725 112764605 112765009 112771587 112772858 112786625 112789081 112800332
LANG109325078 109328226 109328584 109332963 109339736 109343738 109344314 109348741 109351626 109353210 109355353 109355503 109363606
FVE101294792 101295782 101296044 101298335 101302838 101306607 101311062 101312209
RCN112167733 112172770 112172888 112173456 112175756 112175757 112175820 112183427 112183428 112193157
PPER109950245 18768608 18769065 18772001 18774632 18788446 18788761 18789330
PMUM103319568 103319703 103319803 103324634 103334818 103337744 103340411 103340413
PAVI110744516 110750580 110751953 110752748 110753793 110758673 110758720 110763755
PDUL117613978 117614320 117624608 117629757 117630724 117636035 117636036 117637594
MDM103407746 103410608 103412451 103413542 103413735 103415927 103415928 103428850 103436352 103441493 103447832 103456150 103456198
PXB103929005 103929006 103934327 103939335 103939660 103943785 103946703 103948906 103953464 103953465 103962147 103965570 103965571 103965607 103965616 103967787
ZJU107404477 107405610 107405611 107411282 107411283 107420732 107421087 107421180 107424432 107427498 107432898
MNT112092028 21385400 21387990 21394468 21396537 21407196 21407716 21409300 21409302 21409303
CSV101203032 101206941 101210336 101216396 101216755 101220337 101221563
CMO103485146 103488313 103490293 103497220 103501901 103503691 103504072
BHJ120072693 120075834 120076694 120078025 120083781 120085546 120087817
MCHA111004683 111005573 111006019 111007684 111011899 111015531 111025487
CMAX111468480 111469373 111476489 111478732 111481050 111484522 111486242 111487023 111489480 111492742 111496267 111499924
CMOS111435312 111442901 111445585 111445914 111448698 111451461 111452295 111453891 111454238 111455146 111458967 111464664
CPEP111776845 111782837 111787438 111788220 111792489 111794479 111796536 111799327 111804443 111808383 111811124 111811568
RCU8259449 8260651 8261021 8263921 8277776 8281693 8283829
JCU105630648(APX) 105637635 105638985 105642164 105647126
HBR110633839 110634700 110636716 110641765 110649030 110652554 110652862 110657885 110663897
MESC110603739 110606172 110606901 110606939 110606978 110613836 110618929 110621319 110626416 110627151
POP18099176 18100237 7453643 7460959 7463149 7467602 7468886 7471595 7491126 7494249
PEU105107245 105110717 105114120 105114652 105127784 105136153 105138704 105140948 105141227 105142465
PALZ118029249 118029860 118034724 118040460 118045884 118048545 118050275 118050465 118056899 118058813
JRE108981203 108982181 108989652 108992224 108993393 109006594 109017737 109019580 109020260
QSU111986906 111986907 112016529 112020834 112028339 112034268 112035433 112037058
QLO115953030 115960304 115968592 115973879 115973880 115974948 115988749 115994468
TWL119979903 119989178 119993665 119996455 119997328 120002798 120009115 120013531 120015397
VVI100233013 100233048(APX) 100246866 100247405 100254009 104879121 104882489
VRI117906785 117907543 117911064 117912265 117913691 117916461 117919656
SLY101257790 101258987 101262528(APX7) 101263901 101264261 101264282 101264583 778223(APX1) 778224(APX2) 778341(APX6)
SPEN107005028 107007774 107008867 107009391 107017865 107023536 107023623 107023881 107029071 107029646 107029648
SOT102578720 102579602 102585566 102586145(APX) 102586473(APx) 102591426 102595667 102597356(APX) 102597359 102597684
SSTN125845069 125849001 125849502 125852379 125867429 125871593 125872555 125874359 125874399 125878176
CANN107838875 107840564 107842932 107859857 107859858 107867450 107868078 107873001 107873422 107873435
NTA107759348 107759703 107763284 107765289(APX) 107774730 107775122 107776943 107779974 107782353 107782355 107783195 107783197 107787273 107791412 107792162 107795195 107809385 107819788 107821470
NSY104216288 104221831 104232845 104233186 104234451 104243324 104243325 104244992 104249444 104249656
NTO104093447 104101322 104105876 104105877 104110367 104112174 104112377 104115045 104119562
NAU109208242 109208522 109208525 109208571 109209066 109215800 109229383 109238727 109242045
INI109156366 109163296 109163297 109165070 109169557 109170049 109177383 109177732 109192924
ITR115995685 116000189 116002721 116006215 116017364 116024878 116024879 116032398
SIND105155173 105155321 105159461 105164521 105169784 105170682 105174346 105177323
OEU111369609 111372265 111374886 111387515 111393231 111399815 111401391 111403155 111410119
EGT105949203 105957766 105959157 105966872 105974328 105977246
SSPL121742289 121745414 121748480 121750417 121752419 121764629 121779838 121782989 121785033 121786877 121792767 121795610 121801014
HAN110871293 110898546 110911573 110911973 110918963 110926092 110939906 110941205 110941291
ECAD122590766 122602698 122607164 122607341 122609751 122610025 122611228
LSV111882573 111883147 111884264 111888025 111895628 111897078 111897079 111897082 111897699 111899201 111902014 111909485 111910758 111915410 111915448 111915449 122197874
CCAV112508077 112511125 112512067 112514070 112517937 112521260 112524471 112527989
DCR108192373 108205033 108205636 108205654 108205727 108214806 108215779 108217695 108219534 108221051
CSIN114265311 114279703 114284060 114284953 114285269 114287938 114289093 114291220 114297777 114298111 114302892 114311391 114323159
BVG104891011 104891829 104895166 104895169 104895170 104895172 104895312 104895313 104903122 104903932 104904642 104908745 104908898
SOE110778432 110779417 110786989 110788379 110790239 110790627 110790631 110797270 110802362 110802381 110804485 110805721
CQI110694728 110694729 110694783 110695745 110698631 110701606 110701628 110701631 110701632 110705037 110706627 110709676 110709763 110711843 110718539 110721056 110724440 110724531 110724607 110733589 110739342
NNU104587545 104592451 104594740 104603616 104605785 104612906
MING122057883 122063806 122071585 122075921 122077285 122085172 122087413 122090469
TSS122648216 122648778 122652897 122653276 122658417 122663885 122666184 122668032 122669521
PSOM113282817 113288942 113290889 113297564 113301834 113309651 113321825 113330609 113346337 113356406 113357184 113361130
NCOL116245954 116248806 116254643 116255429 116255882 116260421 116266339 116266532
OSA4329643 4332474 4335202 4335896 4336886 4344397 4346078 4346247 4351663 4351664 9269342
DOSAOs02t0553200-01(Os02g0553200) Os03t0285700-01(Os03g0285700) Os04t0223300-00(Os04g0223300) Os04t0434800-01(Os04g0434800) Os04t0602100-01(Os04g0602100) Os07t0694700-01(Os07g0694700) Os08t0522400-01(Os08g0522400) Os08t0549100-01(Os08g0549100) Os12t0178100-01(Os12g0178100) Os12t0178200-01(Os12g0178200)
OBR102702265 102702954 102703203 102709920 102713566 102713598 102714726 102719916
BDI100825789 100826086 100828614 100831503 100836915 100836984 100838031 100838967 100839539
ATS109739529 109747802 109748346 109749043 109749624 109757934 109771362 109785628 109786189
TDC119285357 119290733 119300763 119308144 119318682 119325534 119328631 119336473 119348043 119353103 119355195 119356316 119358815 119362135 119362185 119364322 119365484
TAES123043447 123043501 123045501 123046551 123048498 123051366 123053349 123054409 123085536 123092501 123097814 123102836 123111065 123120058 123130688 123140069 123146328 123151359 123152520 123156422 123164630 123165359 123176406 123184518 123187311 123189249 123189250 123190287 542880
TUA125508522 125515615 125519646 125530284 125535467 125538321 125539586 125552029
SBI110436335 8058035 8064261 8067730 8076303 8077530 8080310 8081349 8081447
ZMA100193740 100193965 100194161 100272974 100282326 100283135 100285887 103634173 103634427 103639279 542476
SITA101753441 101754668 101760004 101761338 101769679 101775209 101776821 101780973 101786781
SVS117837486 117842945 117859935 117860239 117862975 117863384 117865913 117865975
PVIR120640175 120640948 120641028 120641670 120652750 120662269 120663742 120678459 120678528 120681934 120682240 120682370 120683430 120687989 120696865 120712855 120713778
PHAI112873832 112880254 112884946 112890455 112896534 112896981 112899800 112899872 112901091
PDA103701344 103702852 103706176 103706644 103708739 103709007 103716649 103719946 103720470
EGU105033983 105034165 105038429 105044047 105044666 105045793 105046775 105051809 105053549 105055090
MUS103968393 103969335 103971212 103984165(APX) 103985795 103989062 103989729 103990393 103991735 103992108
DCT110094846 110097560 110101121 110101780 110102819 110107707
PEQ110019994 110022020 110024096 110027172 110031920 110034160 110035128
AOF109823240 109825876 109830309 109845098 109848456 109850069 109851292
ATR18423687 18431875 18436903 18443982 18446589
SMOSELMODRAFT_108251 SELMODRAFT_119039 SELMODRAFT_126894 SELMODRAFT_131845 SELMODRAFT_133248 SELMODRAFT_139337 SELMODRAFT_144791 SELMODRAFT_156990 SELMODRAFT_157825 SELMODRAFT_169019 SELMODRAFT_270176 SELMODRAFT_271672 SELMODRAFT_74674 SELMODRAFT_85469 SELMODRAFT_92054 SELMODRAFT_94117
PPP112273052 112273380 112273502 112273527 112276544 112285230 112294750
CRECHLRE_02g087700v5 CHLRE_05g233900v5 CHLRE_06g285150v5
VCNVOLCADRAFT_105827 VOLCADRAFT_62034(apx2) VOLCADRAFT_82395(apx1)
MNGMNEG_1131 MNEG_3533
CSLCOCSUDRAFT_19106 COCSUDRAFT_20424 COCSUDRAFT_26227 COCSUDRAFT_49139 COCSUDRAFT_58469
CVRCHLNCDRAFT_19036 CHLNCDRAFT_28686 CHLNCDRAFT_48220
APROF751_5812 F751_6473
OLUOSTLU_32890 OSTLU_6186 OSTLU_93205
OTAOT_ostta01g03640 OT_ostta08g00190 OT_ostta09g00500
BPGBathy04g00180 Bathy10g03910
MISMICPUN_109237 MICPUN_51963 MICPUN_70664
MPPMICPUCDRAFT_48214 MICPUCDRAFT_56164 MICPUCDRAFT_8305
CMECYME_CMM158C
GSLGasu_32860 Gasu_33520
CCPCHC_T00008640001 CHC_T00010024001
PPEIPpBr36_04871
GLZGLAREA_10389
MPRMPER_08989
MBRMONBRDRAFT_13407 MONBRDRAFT_18816
SREPTSG_00062
SMINv1.2.006460.t2(symbB.v1.2.006460.t2) v1.2.015684.t1(symbB.v1.2.015684.t1) v1.2.018236.t1(symbB.v1.2.018236.t1) v1.2.018679.t1(symbB.v1.2.018679.t1) v1.2.024207.t2(symbB.v1.2.024207.t2) v1.2.024207.t3(symbB.v1.2.024207.t3) v1.2.028328.t1(symbB.v1.2.028328.t1) v1.2.032093.t1(symbB.v1.2.032093.t1)
PTIPHATRDRAFT_13174 PHATRDRAFT_46616 PHATRDRAFT_47395
FCYFRACYDRAFT_173923(APX1) FRACYDRAFT_287495(APX3)
TPSTHAPSDRAFT_262753(ApxS) THAPSDRAFT_262809 THAPSDRAFT_38724
GTTGUITHDRAFT_153788 GUITHDRAFT_65752
TCR503745.30 506193.60
LMALMJF_34_0070(APX)
LIFLINJ_34_0070(APX)
LDOLDBPK_340070
LMILMXM_33_0070
LBZLBRM_20_0150(APX)
LPANLPMP_200320(APX)
 » show all
Reference
1  [PMID:6772104]
  Authors
Shigeoka S, Nakano Y, Kitaoka S.
  Title
Purification and some properties of L-ascorbic-acid-specific peroxidase in Euglena gracilis Z.
  Journal
Arch Biochem Biophys 201:121-7 (1980)
DOI:10.1016/0003-9861(80)90495-6
Reference
2  [PMID:6768357]
  Authors
Shigeoka S, Nakano Y, Kitaoka S.
  Title
Metabolism of hydrogen peroxide in Euglena gracilis Z by L-ascorbic acid peroxidase.
  Journal
Biochem J 186:377-80 (1980)
DOI:10.1042/bj1860377
Reference
3
  Authors
Nakano, Y and Asada, K.
  Title
Purification of ascorbate peroxidase in spinach chloroplasts; its inactivation in ascorbate-depleted medium and reactivation by monodehydroascorbate radical.
  Journal
Plant Cell Physiol 28:131-140 (1987)
Reference
4  [PMID:7703247]
  Authors
Patterson WR, Poulos TL
  Title
Crystal structure of recombinant pea cytosolic ascorbate peroxidase.
  Journal
Biochemistry 34:4331-41 (1995)
DOI:10.1021/bi00013a023
Reference
5  [PMID:15236572]
  Authors
Sharp KH, Moody PC, Brown KA, Raven EL
  Title
Crystal structure of the ascorbate peroxidase-salicylhydroxamic acid complex.
  Journal
Biochemistry 43:8644-51 (2004)
DOI:10.1021/bi049343q
  Sequence
[gmx:553156]
Reference
6  [PMID:16784232]
  Authors
Macdonald IK, Badyal SK, Ghamsari L, Moody PC, Raven EL
  Title
Interaction of ascorbate peroxidase with substrates: a mechanistic and structural analysis.
  Journal
Biochemistry 45:7808-17 (2006)
DOI:10.1021/bi0606849
  Sequence
[gmx:553156]
Other DBs
ExplorEnz - The Enzyme Database: 1.11.1.11
IUBMB Enzyme Nomenclature: 1.11.1.11
ExPASy - ENZYME nomenclature database: 1.11.1.11
BRENDA, the Enzyme Database: 1.11.1.11
CAS: 72906-87-7

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