Entry
Name
phospholipid-hydroperoxide glutathione peroxidase;
peroxidation-inhibiting protein;
PHGPX;
peroxidation-inhibiting protein:peroxidase,glutathione (phospholipid hydroperoxide-reducing);
phospholipid hydroperoxide glutathione peroxidase;
hydroperoxide glutathione peroxidase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
BRITE hierarchy
Sysname
glutathione:lipid-hydroperoxide oxidoreductase
Reaction(IUBMB)
2 glutathione + a hydroperoxy-fatty-acyl-[lipid] = glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O [RN:
R03167 ]
Reaction(KEGG)
Substrate
glutathione [CPD:
C00051 ];
hydroperoxy-fatty-acyl-[lipid]
Product
glutathione disulfide [CPD:
C00127 ];
hydroxy-fatty-acyl-[lipid];
H2O [CPD:
C00001 ]
Comment
A protein containing a selenocysteine residue. The products of action of EC
1.13.11.12 lipoxygenase on phospholipids can act as acceptors; H2O2 can also act, but much more slowly (cf. EC
1.11.1.9 glutathione peroxidase).
History
EC 1.11.1.12 created 1989, modified 2015
Pathway
ec00590 Arachidonic acid metabolism
Orthology
K05361 phospholipid-hydroperoxide glutathione peroxidase
Genes
MYB : 102247160 102257806(GPX4)
MLF : 102424448(GPX4) 106697200
AJM : 119044582 119044584(GPX4) 119047584
PDIC : 114503559(GPX4) 114515394
SARA : 101549194 101556647(GPX4)
XLA : 100036920(gpx4.L) 734888(gpx4.S)
DRE : 352928(gpx4a) 352929(gpx4b)
CCAR : 109071199 109095832
CGIB : 127938347 127943422 127951669
PTET : 122328086(gpx4a) 122335633(gpx4b)
LROH : 127154036(gpx4a) 127178548(gpx4b)
OMC : 131522086 131530650(gpx4a)
PPRM : 120471296(gpx4b) 120486531(gpx4a)
RKG : 130075349(gpx4b) 130089248(gpx4a)
MAMB : 125251077(gpx4b) 125252116(gpx4a)
CIDE : 127519981 127522684
CERY : 137003417(gpx4b) 137027722(gpx4a)
MASI : 127438863 127443054
TROS : 130548448(gpx4a) 130555007(gpx4b)
TDW : 130418275(gpx4b) 130430621(gpx4a)
IFU : 128613432(gpx4a) 128624279(gpx4b)
SMEO : 124390796(gpx4a) 124403356(gpx4b)
TVC : 132845451(gpx4b) 132852631(gpx4a) 132852639 132852660
TRN : 134302451(gpx4b) 134331354(gpx4a)
AMEX : 103026361(gpx4b) 103047294(gpx4a)
CMAO : 118797289(gpx4b) 118818681(gpx4a)
CHAR : 105889685(gpx4a) 122131805
SPIL : 134068608 134102740
TFS : 130529177(gpx4a) 130539092
TNG : GSTEN00024700G001 GSTEN00028551G001
TBEN : 117488934 117496016(gpx4a)
CGOB : 115006643 115023020
PGEO : 117445429(gpx4a) 117462837
GACU : 117532617 117555205(gpx4a)
EMAC : 134865874 134869266(gpx4a)
ELY : 117254152(gpx4a) 117272200
EFO : 125895672(gpx4a) 125902182
PLEP : 121939387(gpx4a) 121951193
SLUC : 116037299 116063394(gpx4a)
ECRA : 117950202(gpx4a) 117953870
ESP : 116696111(gpx4) 116699145
PFLV : 114561982(gpx4) 114565634
PPUG : 119209805 119216983
CLUM : 117730040(gpx4a) 117746743
PSWI : 130193447(gpx4a) 130198386
CANA : 137779359 137795521(gpx4a)
CVE : 137866484(gpx4a) 137892401
MSAM : 119884432 119900945(gpx4a) 119902192
SCHU : 122878234(gpx4a) 122886314
CUD : 121512726(gpx4a) 121520718
SPUL : 138607030(gpx4a) 138611338
LMIX : 132972047(gpx4a) 132979002
ALAT : 119011833 119029309(gpx4a)
ASTR : 137599206(gpx4a) 137611999
MZE : 101475014 101481366(gpx4)
OAU : 116319194 116327902(gpx4a)
OLA : 101160642 101160762 111946273
OML : 112147668 112150257(gpx4a)
CSAI : 133451920 133458162(gpx4a)
XMA : 102218769 102219707(gpx4)
XCO : 114147031 114150819(gpx4)
XHE : 116722172 116725535(gpx4)
PRET : 103463715(gpx4) 103479268
PFOR : 103151222 103151223 103155162(gpx4)
PLAI : 106949670(gpx4) 106961711
PMEI : 106917758(gpx4) 106918624 106926317
GAF : 122838806(gpx4a) 122840802
PPRL : 129361645 129371536(gpx4a)
CVG : 107091856 107095297(gpx4)
CTUL : 119773700 119790048(gpx4a)
GMU : 124869953 124873595(gpx4a)
NFU : 107384121 107393348(gpx4)
KMR : 108230562(gpx4a) 108239424
NWH : 119407986(gpx4a) 119414633
AOCE : 111563473 111571007
EJA : 138198621(gpx4a) 138202810
BFRE : 138618847(gpx4a) 138625275
MCEP : 125009873(gpx4a) 125011311
CSEM : 103376758(gpx4) 103395914
SSEN : 122780472(gpx4a) 122781861(gpx4b)
HHIP : 117760019(gpx4a) 117778055
HSP : 118118007 124854676(gpx4a)
PPLT : 128448346(gpx4a) 128455032
SMAU : 118311442 118318584(gpx4a)
SLAL : 111653742(gpx4) 111658891
XGL : 120790974(gpx4a) 120799459
SSCV : 125972914(gpx4a) 125985250
SBIA : 133503717(gpx4a) 133511306
PEE : 133406844(gpx4a) 133411661
PTAO : 133480984(gpx4a) 133489082
BPEC : 110157283 110174007(gpx4)
MALB : 109966994(gpx4) 109969232
BSPL : 114845018 114853090(gpx4a)
SJO : 128361533(gpx4a) 128368581
SSCO : 133984601(gpx4a) 133990330
SASA : 100194734(gpx4b) 106573579
STRU : 115157354 115158193
OTW : 112250826 112252227(gpx4a) 112260797
OKE : 118373929(gpx4a) 118389079
SALP : 111952959 111957159 111975698
CCLU : 121535669 121576785(gpx4a)
PKI : 111836622(gpx4) 111860199
AANG : 118224614(gpx4a) 118230010(gpx4b)
AROT : 135251323(gpx4b) 135253006(gpx4a)
CCOG : 133126770 133129392
ARUT : 117428936 117966230
BBEL : 109478343 109484469
LPIC : 129270906 129270920
RZE : 108377947 108381437 108381438
CQU : CpipJ_CPIJ006047 CpipJ_CPIJ010637
AGIF : 122849604 122855894
VCAN : 122417172 122417219 122417221 122417335 122417342 122417361
SOY : 115874706 115877136 115880649 115880650
AGRG : 126741086 126742075 126742196 126750027
ATD : 109596245 109596246 109596247
CSET : 123306794 123307673 123308152 123309141 123322658
AGB : 108907641 108907642 108907643
LDC : 111504102 111512566 111512567
APLN : 108732800 108737053 108737061 108737077 112906260
PPYR : 116180501 116180502
DPL : KGM_202360 KGM_212277
SLIU : 111357572 111357612
CFEL : 113364132 113364133
BTAB : 109035151 109036432
SGRE : 126272591 126352401 126352417
DPX : DAPPUDRAFT_220769 DAPPUDRAFT_233749 DAPPUDRAFT_310801
PCLA : 123746973 138349823
LSM : 121114086 121114097 121131904
RSAN : 119374760 119404627
VJA : 111259647 111267629 111267630
CSCU : 111620010 111620011 111620045
PCAN : 112554193 112573590
SMM : Smp_058690 Smp_058700 Smp_124360
PDAM : 113682059 113683366
EHX : EMIHUDRAFT_61670 EMIHUDRAFT_67177
» show all
Taxonomy
Reference
Authors
Ursini F, Maiorino M, Gregolin C.
Title
The selenoenzyme phospholipid hydroperoxide glutathione peroxidase.
Journal
Reference
Authors
Schnurr K, Belkner J, Ursini F, Schewe T, Kuhn H
Title
The selenoenzyme phospholipid hydroperoxide glutathione peroxidase controls the activity of the 15-lipoxygenase with complex substrates and preserves the specificity of the oxygenation products.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 1.11.1.12