KEGG   ENZYME: 1.11.1.18Help
Entry
EC 1.11.1.18                Enzyme                                 

Name
bromide peroxidase;
bromoperoxidase;
haloperoxidase (ambiguous);
eosinophil peroxidase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
BRITE hierarchy
Sysname
bromide:hydrogen-peroxide oxidoreductase
Reaction(IUBMB)
RH + HBr + H2O2 = RBr + 2 H2O [RN:R09505]
Reaction(KEGG)
Substrate
RH [CPD:C01371];
HBr [CPD:C13645];
H2O2 [CPD:C00027]
Product
RBr [CPD:C00720];
H2O [CPD:C00001]
Comment
Bromoperoxidases of red and brown marine algae (Rhodophyta and Phaeophyta) contain vanadate. They catalyse the bromination of a range of organic molecules such as sesquiterpenes, forming stable C-Br bonds. Bromoperoxidases also oxidize iodides.
History
EC 1.11.1.18 created 2010
Orthology
K20206  bromide peroxidase
Reference
1
  Authors
De Boer, E., Tromp, M.G.M., Plat, H., Krenn, G.E. and Wever, R
  Title
Vanadium(v) as an essential element for haloperoxidase activity in marine brown-algae - purification and characterization of a vanadium(V)-containing bromoperoxidase from Laminaria saccharina.
  Journal
Biochim Biophys Acta 872:104-115 (1986)
Reference
2  [PMID:2400770]
  Authors
Tromp MG, Olafsson G, Krenn BE, Wever R
  Title
Some structural aspects of vanadium bromoperoxidase from Ascophyllum nodosum.
  Journal
Biochim Biophys Acta 1040:192-8 (1990)
DOI:10.1016/0167-4838(90)90075-Q
Reference
3  [PMID:10843856]
  Authors
Isupov MN, Dalby AR, Brindley AA, Izumi Y, Tanabe T, Murshudov GN, Littlechild JA
  Title
Crystal structure of dodecameric vanadium-dependent bromoperoxidase from the red  algae Corallina officinalis.
  Journal
J Mol Biol 299:1035-49 (2000)
DOI:10.1006/jmbi.2000.3806
  Sequence
Reference
4  [PMID:15548002]
  Authors
Carter-Franklin JN, Butler A
  Title
Vanadium bromoperoxidase-catalyzed biosynthesis of halogenated marine natural products.
  Journal
J Am Chem Soc 126:15060-6 (2004)
DOI:10.1021/ja047925p
Reference
5  [PMID:15133166]
  Authors
Ohshiro T, Littlechild J, Garcia-Rodriguez E, Isupov MN, Iida Y, Kobayashi T, Izumi Y
  Title
Modification of halogen specificity of a vanadium-dependent bromoperoxidase.
  Journal
Protein Sci 13:1566-71 (2004)
DOI:10.1110/ps.03496004
Other DBs
ExplorEnz - The Enzyme Database: 1.11.1.18
IUBMB Enzyme Nomenclature: 1.11.1.18
ExPASy - ENZYME nomenclature database: 1.11.1.18
BRENDA, the Enzyme Database: 1.11.1.18

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