KEGG ENZYME: 1.11.1.20

ENZYME: 1.11.1.20

Entry

EC 1.11.1.20                Enzyme

Name

prostamide/prostaglandin F2alpha synthase;
prostamide/PGF synthase;
prostamide F synthase;
prostamide/prostaglandin F synthase;
tPGF synthase

Class

Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases

Sysname

thioredoxin:(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate oxidoreductase

Reaction(IUBMB)

thioredoxin + (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate = thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate [RN:R09506]

Reaction(KEGG)

R09506

Substrate

thioredoxin [CPD:C00342];
(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate [CPD:C00427]

Product

thioredoxin disulfide [CPD:C00343];
(5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate [CPD:C00639]

Comment

The enzyme contains a thioredoxin-type disulfide as a catalytic group. Prostamide H2 and prostaglandin H2 are the best substrates; the latter is converted to prostaglandin F2alpha. The enzyme also reduces tert-butyl hydroperoxide, cumene hydroperoxide and H2O2, but not prostaglandin D2 or prostaglandin E2.

History

EC 1.11.1.20 created 2011

Pathway

ec00590

Arachidonic acid metabolism

ec01100

Metabolic pathways

Orthology

K15717

prostamide/prostaglandin F2alpha synthase

Genes

HSA:	127281(PRXL2B)

PTR:	744202(FAM213B)

PPS:	100989393(PRXL2B)

GGO:	101134253(PRXL2B)

PON:	100190803(FAM213B)

NLE:	100586906(PRXL2B)

HMH:	116812814(PRXL2B)

MCC:	695160(PRXL2B)

MCF:	102136927(PRXL2B)

MTHB:

126961352

MNI:	105496693(FAM213B)

CSAB:

103225752(FAM213B)

CATY:

105594459(FAM213B)

PANU:

101025665(PRXL2B)

TGE:	112635916(FAM213B)

MLEU:

105544670(FAM213B)

RRO:	104664581(PRXL2B)

RBB:	108526093 108536020(FAM213B)

TFN:	117093419(PRXL2B)

PTEH:

111544585(PRXL2B)

CANG:

105503939(FAM213B)

CJC:	100403434(PRXL2B)

SBQ:	101029200(FAM213B)

CIMI:

108313855(PRXL2B)

CSYR:

103255709(FAM213B)

OGA:	100946213(FAM213B)

MMU:	66469(Prxl2b)

MCAL:

110292660(Prxl2b)

MPAH:

110323558(Fam213b)

RNO:	362676(Prxl2b)

MCOC:

116097123(Prxl2b)

ANU:	117702120 117708991(Prxl2b)

MUN:	110560454(Prxl2b)

CGE:	100755514(Prxl2b)

MAUA:

101839932(Prxl2b)

PROB:

127213418(Prxl2b)

PLEU:

114708266(Prxl2b)

MORG:

121443586 121448621

MFOT:

126508201

AAMP:

119817565(Prxl2b)

NGI:	103749778(Fam213b)

HGL:	101722975(Fam213b)

CPOC:

100733270(Fam213b)

CCAN:

109691456(Fam213b)

DSP:	122127368(Prxl2b)

PLOP:

125354210(Prxl2b)

NCAR:

124994031

TUP:	102487629(FAM213B)

CFA:	489616(PRXL2B)

CLUD:

112646968(PRXL2B)

VVP:	112924718(PRXL2B)

VLG:	121500282(PRXL2B)

NPO:	129497738(PRXL2B)

AML:	100476330(PRXL2B)

UMR:	103678433(PRXL2B)

UAH:	113270607(PRXL2B)

UAR:	123796070(PRXL2B)

ELK:

111154768

LLV:

125098949

MPUF:

101684965(FAM213B)

MNP:	132000683(PRXL2B)

ORO:	101379247(FAM213B)

EJU:	114213396(PRXL2B)

ZCA:	113939340(PRXL2B)

MLX:	118020359(PRXL2B)

NSU:	110579934(PRXL2B)

LWW:	102746463(PRXL2B)

FCA:	101090122(PRXL2B)

PYU:	121019479(PRXL2B)

PCOO:

112848612(PRXL2B)

PBG:	122479830(PRXL2B)

LRUF:

124516138

PTG:	102951174(FAM213B)

PPAD:

109273971(FAM213B)

PUC:

125913765

AJU:	106984648(PRXL2B)

HHV:	120242519(PRXL2B)

BTA:	617001(PRXL2B)

BOM:	102268856(FAM213B)

BIU:	109570724(FAM213B)

BBUB:

102407584(PRXL2B)

BBIS:

104995916(FAM213B)

CHX:	102184926(FAM213B)

OAS:	101120767(PRXL2B)

BTAX:

128061576(PRXL2B)

ODA:	120880656(PRXL2B)

CCAD:

122452364(PRXL2B)

MBEZ:

129551073(PRXL2B)

SSC:	100134955(FAM213B)

CFR:	102509927(PRXL2B)

CBAI:

105071041(FAM213B)

CDK:	105106649(PRXL2B)

VPC:	102545592(PRXL2B)

BACU:

103000861(FAM213B)

LVE:	103071802(FAM213B)

OOR:	101284921(PRXL2B)

DLE:	111187128(PRXL2B)

PCAD:

102995093(PRXL2B)

PSIU:

116759306(PRXL2B)

ECB:	100054405(FAM213B)

EPZ:	103545047(FAM213B)

EAI:	106844791(PRXL2B)

HAI:	109391141(FAM213B)

RFQ:	117026966(PRXL2B)

PALE:

102887804(FAM213B)

PGIG:

120614127(PRXL2B)

PVP:	105310241(FAM213B)

RAY:	107510670(FAM213B)

SARA:

101536925(FAM213B)

LAV:	100674527(FAM213B)

TMU:

101348540

ETF:	101649403(PRXL2B)

MDO:	100027973(FAM213B)

GAS:	123255792(PRXL2B)

SHR:	100932106(PRXL2B)

AFZ:

127555974

PCW:	110200413(FAM213B)

ASN:	102371358(FAM213B)

AMJ:	102569997(FAM213B)

CPOO:

109314495(FAM213B)

GGN:	109293540(FAM213B)

PSS:	102455880(FAM213B)

CMY:	102948080(PRXL2B)

CCAY:

125624198(PRXL2B)

DCC:	119845035(PRXL2B)

CPIC:

101934510(PRXL2B)

TST:	117867831(PRXL2B)

CABI:

116815392(PRXL2B)

MRV:	120387816(PRXL2B)

PVT:	110088238(FAM213B)

PMUA:

114602569(PRXL2B)

PRAF:

128419677(PRXL2B)

ZVI:	118087844(PRXL2B)

HCG:	128327400(PRXL2B)

GJA:	107110400(FAM213B)

STOW:

125445430(PRXL2B)

EMC:	129344800(PRXL2B)

XLA:	447017(prxl2b.L)

XTR:	549974(prxl2b)

NPR:	108783702(FAM213B)

RTEM:

120915711(PRXL2B)

BBUF:

120999182(PRXL2B)

BGAR:

122926843(PRXL2B)

DRE:	406605(prxl2b)

SRX:	107712975 107756615

SANH:

107654427 107702003

SGH:	107582414 107592888

CCAR:

109098633

CAUA:

113055415(prxl2b)

CGIB:

128022057

PTET:

122353627(prxl2b)

OMC:	131548906(prxl2b)

PPRM:

120480845(prxl2b)

MAMB:

125256639(prxl2b)

CIDE:

127522339

MASI:

127426433 127428031

TROS:

130571152(prxl2b)

MANU:

129427928(prxl2b)

IPU:	108254989(prxl2b)

IFU:	128625148(prxl2b)

PHYP:

113537949(prxl2b)

SMEO:

124402060(prxl2b)

TFD:	113657185(prxl2b)

AMEX:

103027709(fam213b)

CMAO:

118799386(prxl2b)

CHAR:

105909872(prxl2b)

TRU:	101064795(prxl2b)

TFS:	130524003(prxl2b)

TNG:	GSTEN00002808G001 GSTEN00027565G001

LCO:	104919355(prxl2b)

NCC:	104955273(fam213b)

CGOB:

115008443(prxl2b)

ELY:	117256418(prxl2b)

EFO:	125896486(prxl2b)

PLEP:

121953555(prxl2b)

SLUC:

116051307(prxl2b)

ECRA:

117943159(prxl2b)

ESP:	116688070(prxl2b)

PFLV:

114553644(prxl2b)

GAT:	120835746(prxl2b)

PPUG:

119194034(prxl2b)

AFB:	129105924(prxl2b)

CLUM:

117730909(prxl2b)

MSAM:

119885718(prxl2b)

SCHU:

122863053(prxl2b)

CUD:	121504156(prxl2b)

ALAT:

119021145(prxl2b)

MZE:	101467269(fam213b)

ONL:	100710550(prxl2b)

OAU:	116316511(prxl2b)

OLA:	101173382(fam213b)

OML:	112145312(prxl2b)

XMA:	102226891(fam213b)

XCO:	114135769(prxl2b)

XHE:	116710674(prxl2b)

PRET:

103464468(fam213b)

PFOR:

103136509(fam213b)

PLAI:

106956446(fam213b)

PMEI:

106926086(fam213b)

GAF:	122834478(prxl2b)

CVG:	107087519(fam213b)

CTUL:

119772771(prxl2b)

GMU:	124856148(prxl2b)

NFU:	107385267(fam213b)

KMR:	108231542(prxl2b)

ALIM:

106513842(fam213b)

NWH:	119411824(prxl2b)

AOCE:

111588019(fam213b)

MCEP:

125006154(prxl2b)

CSEM:

103385682(fam213b)

POV:	109638523(fam213b)

SSEN:

122768689(prxl2b)

HHIP:

117761412(prxl2b)

HSP:	118102623(prxl2b)

LCF:	108899895(prxl2b)

SDU:	111223974(fam213b)

SLAL:

111657924(fam213b)

XGL:	120783443(prxl2b)

HCQ:	109529232(fam213b)

SSCV:

125977705

BPEC:

110166956(fam213b)

BSPL:

114855743(prxl2b)

SASA:

106582827(fam213b)

STRU:

115150906(prxl2b)

OTW:	112254326(prxl2b)

OMY:	110527842(prxl2b)

OGO:	124031526(prxl2b)

ONE:	115136777(prxl2b)

OKI:	109890910(prxl2b)

OKE:	118400048(prxl2b)

SALP:

111969820(fam213b)

SNH:	120064947(prxl2b)

CCLU:

121578739(prxl2b)

ELS:	105017396(prxl2b)

SFM:	108918216(prxl2b)

AANG:

118211691(prxl2b)

LOC:	102682812(fam213b)

PSPA:

121328415(prxl2b)

ARUT:

117425520 117969679

PSEX:

120531112(prxl2b)

LCM:	102361632(FAM213B)

RTP:

109939063

LERI:

129711758(prxl2b)

BFO:

118429862

BBEL:

109472697

CIN:

100184332

SCLV:

120328807

SPU:

591310

LPIC:

129279834 129280092 129280094

APLC:

110985701

AJC:

117113253

BCOO:

119070364

DSM:

124409848

NPT:

124218231

NFB:

124179436

NLO:

107224332

NVG:

124302121

BMOR:

101742192

BMAN:

114249548

MSEX:

115456332

DPL:	KGM_201654

BANY:

112049805

MJU:

123878105

NIQ:

126778576

VCD:

124540816

MCIX:

123667413

PMAC:

106709420

PPOT:

106108897

PXU:

106125689

PRAP:

111000037

PBX:

123720484

PNAP:

125052236

ZCE:

119836031

CCRC:

123703832

LSIN:

126976577

HAW:

110382629

HZE:

124642916

TNL:

113507591

SLIU:

111358085

OFU:

114352771

PXY:	105383581 105388714

PGW:

126378190

CFEL:

113367431

HVI:

124359949

IEL:

124163889

FCD:

110852137

DPX:	DAPPUDRAFT_231765

DMK:

116931219

DPZ:

124340562

PVM:

113809215

PJA:

122249212

PCHN:

125030920

PMOO:

119583720

HAME:

121861186

PCLA:

123761958

CQD:

128695354

PTRU:

123510753

ESN:

127006528

HAZT:

108664354

EAF:

111699676

PPOI:

119106348

DSV:

119445319

RSAN:

119390926

RMP:

119167968

UDV:

129228637

SDM:

118196814

LPOL:

106470009

LGI:	LOTGIDRAFT_235844

PCAN:

112557854

BGT:

106052380

HRF:

124117723

HRJ:

124257496

CRG:	105330608 105339209

CVN:	111132317 111132326

CANU:

128185479 128187392

OED:	125664582 125676318

MYI:

110460228

PMAX:

117345148

MCAF:

127719276

MMER:

123526940

DPOL:

127831292

LAK:	106156095 106175694

SMM:	Smp_194940

EGL:

EGR_01663

NVE:

5504619

EPA:

110247772

ATEN:

116296525

ADF:

107339164

AMIL:

114960027

PDAM:

113664245

SPIS:

111332461

DGT:

114517949

HMG:

100204118

HSY:

130641489

AQU:	100632965 100633093 100640356

PPP:	112283185 112290260

FFU:	CLAFUR5_14586

» show all

Reference

1 [PMID:18006499]

Authors

Moriuchi H, Koda N, Okuda-Ashitaka E, Daiyasu H, Ogasawara K, Toh H, Ito S, Woodward DF, Watanabe K

Title

Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily.

Journal

J Biol Chem 283:792-801 (2008)
DOI:10.1074/jbc.M705638200

Sequence

[ssc:100134955]

Reference

2 [PMID:20950588]

Authors

Yoshikawa K, Takei S, Hasegawa-Ishii S, Chiba Y, Furukawa A, Kawamura N, Hosokawa M, Woodward DF, Watanabe K, Shimada A

Title

Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system.

Journal

Brain Res 1367:22-32 (2011)
DOI:10.1016/j.brainres.2010.10.019

Sequence

[mmu:66469]

Other DBs

ExplorEnz - The Enzyme Database:

1.11.1.20

IUBMB Enzyme Nomenclature:

1.11.1.20

ExPASy - ENZYME nomenclature database:

1.11.1.20

BRENDA, the Enzyme Database:

1.11.1.20

DBGET integrated database retrieval system