ENZYME: 1.11.1.20 Help
Entry
Name
prostamide/prostaglandin F2alpha synthase;
prostamide/PGF synthase;
prostamide F synthase;
prostamide/prostaglandin F synthase;
tPGF synthase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
BRITE hierarchy
Sysname
thioredoxin:(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate oxidoreductase
Reaction(IUBMB)
thioredoxin + (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate = thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate [RN:
R09506 ]
Reaction(KEGG)
Substrate
thioredoxin [CPD:
C00342 ];
(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate [CPD:
C00427 ]
Product
thioredoxin disulfide [CPD:
C00343 ];
(5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate [CPD:
C00639 ]
Comment
The enzyme contains a thioredoxin-type disulfide as a catalytic group. Prostamide H2 and prostaglandin H2 are the best substrates; the latter is converted to prostaglandin F2alpha. The enzyme also reduces tert-butyl hydroperoxide, cumene hydroperoxide and H2O2, but not prostaglandin D2 or prostaglandin E2.
History
EC 1.11.1.20 created 2011
Pathway
ec00590 Arachidonic acid metabolism
Orthology
K15717 prostamide/prostaglandin F2alpha synthase
Genes
RBB : 108526093 108536020(FAM213B)
ANU : 117702120 117708991(Prxl2b)
MORG : 121443586 121448621
SANH : 107654427 107702003
MASI : 127426433 127428031
TNG : GSTEN00002808G001 GSTEN00027565G001
ARUT : 117425520 117969679
LPIC : 129279834 129280092 129280094
HASI : 137268343 137272481
CANU : 128185479 128187392
OED : 125664582 125676318 130052268
SHX : MS3_00007277(PRXL2B)
AQU : 100632965 100633093 100640356
» show all
Taxonomy
Reference
Authors
Moriuchi H, Koda N, Okuda-Ashitaka E, Daiyasu H, Ogasawara K, Toh H, Ito S, Woodward DF, Watanabe K
Title
Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily.
Journal
Sequence
Reference
Authors
Yoshikawa K, Takei S, Hasegawa-Ishii S, Chiba Y, Furukawa A, Kawamura N, Hosokawa M, Woodward DF, Watanabe K, Shimada A
Title
Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 1.11.1.20