KEGG   ENZYME: 1.11.1.8Help
Entry
EC 1.11.1.8                 Enzyme                                 

Name
iodide peroxidase;
thyroid peroxidase;
iodotyrosine deiodase;
iodinase;
iodoperoxidase (heme type);
iodide peroxidase-tyrosine iodinase;
iodotyrosine deiodinase;
monoiodotyrosine deiodinase;
thyroperoxidase;
tyrosine iodinase;
TPO
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
BRITE hierarchy
Sysname
iodide:hydrogen-peroxide oxidoreductase
Reaction(IUBMB)
(1) 2 iodide + H2O2 + 2 H+ = diiodine + 2 H2O [RN:R02810];
(2) [thyroglobulin]-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O;
(3) [thyroglobulin]-3-iodo-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O;
(4) 2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-L-thyroxine + [thyroglobulin]-aminoacrylate + 2 H2O [RN:R08523];
(5) [thyroglobulin]-3-iodo-L-tyrosine + [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + 2 H2O [RN:R08522]
Reaction(KEGG)
Substrate
iodide [CPD:C00708];
H2O2 [CPD:C00027];
H+ [CPD:C00080];
[thyroglobulin]-L-tyrosine [CPD:C16733];
[thyroglobulin]-3-iodo-L-tyrosine [CPD:C16732];
[thyroglobulin]-3,5-diiodo-L-tyrosine [CPD:C16731]
Product
diiodine [CPD:C01382];
H2O [CPD:C00001];
[thyroglobulin]-3-iodo-L-tyrosine [CPD:C16732];
[thyroglobulin]-3,5-diiodo-L-tyrosine [CPD:C16731];
[thyroglobulin]-L-thyroxine [CPD:C16729];
[thyroglobulin]-aminoacrylate [CPD:C16734];
[thyroglobulin]-3,5,3'-triiodo-L-thyronine [CPD:C16730]
Comment
Thyroid peroxidase catalyses the biosynthesis of the thyroid hormones L-thyroxine and triiodo-L-thyronine. It catalyses both the iodination of tyrosine residues in thyroglobulin (forming mono- and di-iodinated forms) and their coupling to form either L-thyroxine or triiodo-L-thyronine.
History
EC 1.11.1.8 created 1961, modified 2012
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
Orthology
K00431  thyroid peroxidase
Genes
HSA: 7173(TPO)
PTR: 112208205(TPO)
PPS: 100996140(TPO)
GGO: 101154382(TPO)
PON: 100456793(TPO)
NLE: 100600125(TPO)
MCC: 721610(TPO)
MCF: 102125126(TPO)
CSAB: 103220948(TPO)
RRO: 104680243(TPO)
RBB: 108520786(TPO)
CJC: 100386952(TPO)
SBQ: 101037216(TPO)
MMU: 22018(Tpo)
RNO: 54314(Tpo)
CGE: 100774668(Tpo)
NGI: 103747657(Tpo)
HGL: 101704548(Tpo)
CCAN: 109698840(Tpo)
OCU: 100358662(TPO)
TUP: 102498362(TPO)
CFA: 403521(TPO)
AML: 100482359(TPO)
UMR: 103659385(TPO)
ORO: 101386003(TPO)
FCA: 101098706(TPO)
PTG: 102968585(TPO)
AJU: 106970832(TPO)
BTA: 525013(TPO)
BOM: 102270919(TPO)
PHD: 102328542(TPO)
CHX: 102182976(TPO)
OAS: 101116464 105606468(TPO)
SSC: 445522(TPO)
CFR: 102509347(TPO)
CDK: 105105788(TPO)
BACU: 103019738(TPO)
LVE: 103068590(TPO)
OOR: 101277595(TPO)
ECB: 100072955(TPO)
EPZ: 103558875(TPO)
EAI: 106831426(TPO)
MYB: 102261673(TPO)
MYD: 102752073(TPO)
HAI: 109384713(TPO)
RSS: 109458409(TPO)
PALE: 102894645(TPO)
LAV: 100654315(TPO)
TMU: 101356790
MDO: 100032350(TPO)
SHR: 100914346(TPO) 100922174
OAA: 100080616(TPO)
GGA: 776120(TPO)
MGP: 100547103(TPO)
CJO: 107312163(TPO)
APLA: 101799650(TPO)
ACYG: 106030804(TPO)
TGU: 100218312(TPO)
GFR: 102035753(TPO)
FAB: 101810932(TPO)
PHI: 102101957(TPO)
PMAJ: 107202328(TPO)
CCAE: 111926044(TPO)
CCW: 104685517(TPO)
FPG: 101922364(TPO)
FCH: 102045733(TPO)
CLV: 102095211(TPO)
EGZ: 104122160(TPO)
AAM: 106492987(TPO)
ASN: 102375780(TPO)
AMJ: 106736998(TPO)
PSS: 102447524(TPO)
CMY: 102940210(TPO)
CPIC: 101932866(TPO)
ACS: 100562991(tpo)
PVT: 110073409(TPO)
PBI: 103055216(TPO)
GJA: 107108843 107120374(TPO)
XLA: 100049788(tpo.S)
XTR: 100036738(tpo)
NPR: 108789262(TPO)
DRE: 100331172(epx) 569363(tpo)
SRX: 107707791(tpo)
SANH: 107678715(tpo) 107701038
SGH: 107594129
IPU: 108269580(tpo) 108274988
AMEX: 103026466 103032699(tpo)
LCO: 104928854 104934649(tpo)
MZE: 101470734(tpo) 101472649
OLA: 101167362 105356959(tpo)
NFU: 107388669 107392598(tpo)
KMR: 108230067 108241739(tpo)
CSEM: 103379991(tpo) 103380299
SDU: 111226032(tpo)
BPEC: 110155374(tpo) 110169467
MALB: 109965011(tpo) 109972931
SASA: 106584777 106611389(tpo)
OTW: 112256946(tpo)
ELS: 105028745(tpo) 105029701
SFM: 108942507(tpo)
LCM: 102362813(TPO)
CMK: 103175078 103185975(tpo)
 » show all
Taxonomy
Reference
1  [PMID:13718859]
  Authors
CUNNINGHAM BA, KIRKWOOD S.
  Title
Enzyme systems concerned with the synthesis of monoiodotyrosine. III. Ion requirements of the soluble system.
  Journal
J Biol Chem 236:485-9 (1961)
Reference
2  [PMID:13964156]
  Authors
HOSOYA T, KONDO Y, UI N.
  Title
Peroxidase activity in thyroid gland and partial purification of the enzyme.
  Journal
J Biochem 52:180-9 (1962)
Reference
3  [PMID:12325367]
  Authors
Coval ML, Taurog A.
  Title
Purification and iodinating activity of hog thyroid peroxidase.
  Journal
J Biol Chem 242:5510-23 (1967)
Reference
4  [PMID:7021557]
  Authors
Gavaret JM, Cahnmann HJ, Nunez J
  Title
Thyroid hormone synthesis in thyroglobulin. The mechanism of the coupling reaction.
  Journal
J Biol Chem 256:9167-73 (1981)
Reference
5  [PMID:7142155]
  Authors
Ohtaki S, Nakagawa H, Nakamura M, Yamazaki I
  Title
One- and two-electron oxidations of tyrosine, monoiodotyrosine, and diiodotyrosine catalyzed by hog thyroid peroxidase.
  Journal
J Biol Chem 257:13398-403 (1982)
Reference
6  [PMID:6706930]
  Authors
Magnusson RP, Taurog A, Dorris ML
  Title
Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase.
  Journal
J Biol Chem 259:197-205 (1984)
Reference
7  [PMID:2996435]
  Authors
Virion A, Courtin F, Deme D, Michot JL, Kaniewski J, Pommier J
  Title
Spectral characteristics and catalytic properties of thyroid peroxidase-H2O2 compounds in the iodination and coupling reactions.
  Journal
Arch Biochem Biophys 242:41-7 (1985)
DOI:10.1016/0003-9861(85)90477-1
Reference
8  [PMID:1497352]
  Authors
Rawitch AB, Pollock G, Yang SX, Taurog A
  Title
Thyroid peroxidase glycosylation: the location and nature of the N-linked oligosaccharide units in porcine thyroid peroxidase.
  Journal
Arch Biochem Biophys 297:321-7 (1992)
DOI:10.1016/0003-9861(92)90679-Q
  Sequence
[ssc:445522]
Reference
9  [PMID:8448141]
  Authors
Sun W, Dunford HB
  Title
Kinetics and mechanism of the peroxidase-catalyzed iodination of tyrosine.
  Journal
Biochemistry 32:1324-31 (1993)
Reference
10 [PMID:8651700]
  Authors
Taurog A, Dorris ML, Doerge DR
  Title
Mechanism of simultaneous iodination and coupling catalyzed by thyroid peroxidase.
  Journal
Arch Biochem Biophys 330:24-32 (1996)
DOI:10.1006/abbi.1996.0222
Reference
11 [PMID:16098474]
  Authors
Ruf J, Carayon P
  Title
Structural and functional aspects of thyroid peroxidase.
  Journal
Arch Biochem Biophys 445:269-77 (2006)
DOI:10.1016/j.abb.2005.06.023
Other DBs
ExplorEnz - The Enzyme Database: 1.11.1.8
IUBMB Enzyme Nomenclature: 1.11.1.8
ExPASy - ENZYME nomenclature database: 1.11.1.8
BRENDA, the Enzyme Database: 1.11.1.8
CAS: 9031-28-1

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