KEGG   ENZYME: 1.11.1.8
Entry
EC 1.11.1.8                 Enzyme                                 
Name
iodide peroxidase;
thyroid peroxidase;
iodoperoxidase (heme type);
iodide peroxidase-tyrosine iodinase;
thyroperoxidase;
tyrosine iodinase;
TPO;
iodinase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
Sysname
iodide:hydrogen-peroxide oxidoreductase
Reaction(IUBMB)
(1) 2 iodide + H2O2 + 2 H+ = diiodine + 2 H2O [RN:R02810];
(2) [thyroglobulin]-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O;
(3) [thyroglobulin]-3-iodo-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O;
(4) 2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-L-thyroxine + [thyroglobulin]-aminoacrylate + 2 H2O [RN:R08523];
(5) [thyroglobulin]-3-iodo-L-tyrosine + [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + 2 H2O [RN:R08522]
Reaction(KEGG)
Substrate
iodide [CPD:C00708];
H2O2 [CPD:C00027];
H+ [CPD:C00080];
[thyroglobulin]-L-tyrosine [CPD:C16733];
[thyroglobulin]-3-iodo-L-tyrosine [CPD:C16732];
[thyroglobulin]-3,5-diiodo-L-tyrosine [CPD:C16731]
Product
diiodine [CPD:C01382];
H2O [CPD:C00001];
[thyroglobulin]-3-iodo-L-tyrosine [CPD:C16732];
[thyroglobulin]-3,5-diiodo-L-tyrosine [CPD:C16731];
[thyroglobulin]-L-thyroxine [CPD:C16729];
[thyroglobulin]-aminoacrylate [CPD:C16734];
[thyroglobulin]-3,5,3'-triiodo-L-thyronine [CPD:C16730]
Comment
Thyroid peroxidase catalyses the biosynthesis of the thyroid hormones L-thyroxine and triiodo-L-thyronine. It catalyses both the iodination of tyrosine residues in thyroglobulin (forming mono- and di-iodinated forms) and their coupling to form either L-thyroxine or triiodo-L-thyronine.
History
EC 1.11.1.8 created 1961, modified 2012
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
Orthology
K00431  thyroid peroxidase
Genes
HSA7173(TPO)
PTR112208205(TPO)
PPS100996140(TPO)
GGO101154382(TPO)
PON100456793(TPO)
NLE100600125(TPO) 115834294
MCC721610(TPO)
MCF102125126(TPO)
MTHB126933457
CSAB103220948(TPO)
CATY105587598(TPO)
PANU101002980(TPO)
TGE112604644(TPO)
RRO104680243(TPO)
RBB108520786(TPO)
TFN117062801(TPO)
PTEH111526756(TPO)
CJC100386952(TPO)
SBQ101037216(TPO)
CSYR103263957(TPO)
MMUR105870505(TPO)
LCAT123636559(TPO)
OGA100950962(TPO)
MMU22018(Tpo)
MCAL110307221(Tpo)
MPAH110324682(Tpo)
RNO54314(Tpo)
MCOC116080994(Tpo)
MUN110552563 110561242
CGE100774668(Tpo)
MAUA101838356(Tpo)
PLEU114683239(Tpo)
MORG121432305(Tpo)
MFOT126491107
AAMP119807272(Tpo)
NGI103747657(Tpo)
HGL101704548(Tpo)
CPOC100723704(Tpo)
CCAN109698840(Tpo)
DORD105995174(Tpo)
DSP122100091(Tpo)
NCAR124962925
OCU100358662(TPO)
OPI101529357(TPO)
TUP102498362(TPO)
CFA403521(TPO)
CLUD112664926(TPO)
VVP112927779(TPO)
VLG121491902(TPO)
AML100482359(TPO)
UMR103659385(TPO)
UAH113269244(TPO)
UAR123786594(TPO)
ELK111154148
LLV125108840
MPUF101677724(TPO)
ORO101386003(TPO)
EJU114206012(TPO)
ZCA113937469(TPO)
MLX118007270 118007322
NSU110587338(TPO)
FCA101098706(TPO)
PYU121044026(TPO)
PBG122467124(TPO)
LRUF124525761
PTG102968585(TPO)
PPAD109258749(TPO)
AJU106970832(TPO)
HHV120247915(TPO)
BTA525013(TPO)
BOM102270919(TPO)
BBUB102407971(TPO)
CHX102182976(TPO)
OAS105606468(TPO)
ODA120864488(TPO)
CCAD122432081(TPO)
SSC445522(TPO)
CFR102509347(TPO)
CBAI105075311(TPO)
CDK105105788(TPO)
VPC102531846(TPO)
BACU103019738(TPO)
LVE103068590(TPO)
OOR101277595(TPO)
DLE111167991(TPO)
PCAD102992243(TPO)
PSIU116764397(TPO)
ECB100072955(TPO)
EPZ103558875(TPO)
EAI106831426(TPO)
MYB102261673(TPO)
MYD102752073(TPO)
MMYO118669324(TPO)
MNA107526670(TPO)
PKL118714838(TPO)
HAI109384713(TPO)
DRO112298003(TPO)
SHON118988799(TPO)
AJM119053969(TPO)
PDIC114498752(TPO)
PHAS123822481(TPO)
MMF118630987(TPO)
RFQ117032670(TPO)
PALE102894645(TPO)
PGIG120596537(TPO)
PVP105306937(TPO)
RAY107516248(TPO)
MJV108410043(TPO)
TOD119258688(TPO)
SARA101544834(TPO)
LAV100654315(TPO)
TMU101356790
DNM101411611(TPO)
MDO100032350(TPO)
GAS123233464(TPO)
SHR100914346(TPO)
PCW110193820(TPO)
OAA100080616(TPO)
GGA776120(TPO)
PCOC116240489(TPO)
MGP100547103(TPO)
CJO107312163(TPO)
NMEL110396710(TPO)
APLA101799650(TPO)
ACYG106030804(TPO)
AFUL116487946(TPO)
TGU100218312(TPO)
LSR110482186(TPO)
SCAN103822861(TPO)
PMOA120505263(TPO)
OTC121344293(TPO)
PRUF121359149(TPO)
GFR102035753(TPO)
FAB101810932(TPO)
PHI102101957(TPO)
PMAJ107202328(TPO)
CCAE111926044(TPO)
CCW104685517(TPO)
CBRC103622838(TPO)
ETL114069616(TPO)
ZAB102067657(TPO)
ACHL103798919(TPO)
FPG101922364(TPO)
FCH102045733(TPO)
CLV102095211(TPO)
EGZ104122160(TPO)
NNI104013841(TPO)
PLET104625294
PCRI104032438
ACUN113477604(TPO)
TALA104359736(TPO)
PADL103921358(TPO)
AFOR103895897(TPO)
ACHC115351124(TPO)
HALD104315049(TPO)
CCRI104164426(TPO)
EHS104504514(TPO)
MUI104533545(TPO)
FGA104079472(TPO)
GSTE104252217(TPO)
LDI104351831(TPO)
MNB103777585(TPO)
OHA104329380(TPO)
DPUB104305690(TPO)
PGUU104469372(TPO)
ACAR104529229(TPO)
AVIT104270482(TPO)
CVF104289037(TPO)
AAM106492987(TPO)
AROW112973093(TPO)
NPD112945458(TPO)
TGT104580334(TPO)
DNE112992818(TPO)
SCAM104143498(TPO)
ASN102375780(TPO)
AMJ106736998(TPO)
CPOO109312104(TPO)
GGN109300041(TPO)
PSS102447524(TPO)
CMY102940210(TPO)
CPIC101932866(TPO)
TST117874041(TPO)
CABI116817604(TPO)
MRV120401415(TPO)
ACS100562991(tpo)
PVT110073409(TPO)
SUND121925349(TPO)
PBI103055216(TPO)
PMUR107288276(TPO)
CTIG120310082(TPO)
TSR106551315(TPO)
PGUT117674498(TPO)
VKO123017669(TPO)
PMUA114593754(TPO) 114600521
ZVI118078350 118082781(TPO)
GJA107108843 107120374(TPO)
STOW125426778 125439527(TPO)
XLA100049788(tpo.S)
XTR100036738(tpo)
NPR108789262(TPO)
RTEM120936386(TPO)
BBUF120999023(TPO)
BGAR122935226(TPO)
DRE100331172(epx) 569363(tpo)
SRX107707791(tpo) 107732259
SANH107676453 107678715(tpo) 107701038
SGH107594129
CCAR109084952 109099142
CAUA113042938 113085118(tpo)
PPRM120471728(epx) 120473217 120473261
MAMB125247940(epx) 125269309(tpo)
IPU108269580(tpo) 108274988(epx)
PHYP113529680 113538844(tpo)
SMEO124389670(tpo) 124392946(epx)
TFD113653966(epx) 113659460(tpo)
AMEX103026466 103032699(tpo)
EEE113572650(tpo) 113583564
TRU101062981 101079869 115247027
TNGGSTEN00010284G001 GSTEN00012455G001
LCO104928854 104934649(tpo)
NCC104944637
CGOB115009405 115027547(tpo)
ELY117261785(epx) 117267275
EFO125886852(epx) 125901384(tpo)
PLEP121950093(epx) 121953636(tpo)
SLUC116038497(epx) 116042521(tpo)
ECRA117935626(tpo) 117949679(epx)
ESP116669921(tpo) 116694341
PFLV114547036(tpo) 114560272
GAT120808678(epx) 120832611(tpo)
PPUG119195992(epx) 119227498(tpo)
MSAM119893789(epx) 119910842(tpo)
CUD121514495(epx) 121526598
ALAT119005006(tpo) 119024167(epx)
MZE101470734(tpo) 101472649
ONL100692514 100700906(tpo)
OAU116326276(epx) 120434955(tpo)
OLA101167362 105356959(tpo)
OML112143527(tpo) 112152280(epx)
XMA102230399 102232241
XCO114134369 114151183
XHE116709035 116709593 116732146
PRET103460527 103466494
PFOR103141318 103154181(tpo)
PLAI106953134(tpo) 106964663
PMEI106923933(tpo) 106933097
GAF122835368(epx) 122845674(tpo)
CVG107100628
CTUL119787434(epx) 119797839(tpo)
GMU124858077(epx) 124884924(tpo)
NFU107388669 107392598(tpo)
KMR108230067(epx) 108241739(tpo)
ALIM106521174 106521219(tpo)
NWH119416466(epx) 119427722(tpo)
AOCE111562581(tpo) 111584102
MCEP125014719(epx) 125023792(tpo)
CSEM103379991(tpo) 103380299
POV109624077 109627948(tpo)
SSEN122776537(epx) 122783162(tpo)
HHIP117756338 117762621(epx)
HSP118109462(epx) 118116664(tpo)
LCF108886978(epx) 108897943
SDU111226032(tpo) 111229744
SLAL111666321 111666895 111670224(tpo)
XGL120792877(epx) 120795322(tpo)
HCQ109507502 109530238
BPEC110155374(tpo) 110169467
MALB109965011(tpo) 109972931
BSPL114848308(tpo) 114857330(epx)
SASA106584777 106611389(tpo)
STRU115161765 115192923
OTW112256946(tpo)
OMY110504252(tpo) 110522697(epx)
OGO124037374(epx) 124046982(tpo)
ONE115121024
SALP112069494(tpo) 112070266
SNH120022964 120022991 120051654(epx)
CCLU121540756(epx) 121544226(tpo)
ELS105028745(tpo) 105029701
SFM108942507(tpo)
PKI111848005 111857914(tpo)
AANG118215539(epx) 118234749(tpo)
LOC102695049(tpo)
PSPA121294970(epx) 121317659(tpo)
ARUT117411246(tpo) 117432329(epx)
LCM102362813(TPO)
CMK103175078 103185975(tpo)
RTP109918711 109928222
CIN100183311 100183818 445593
SCLV120346294
PFLAPflav_004530
 » show all
Reference
1  [PMID:13718859]
  Authors
CUNNINGHAM BA, KIRKWOOD S.
  Title
Enzyme systems concerned with the synthesis of monoiodotyrosine. III. Ion requirements of the soluble system.
  Journal
J Biol Chem 236:485-9 (1961)
Reference
2  [PMID:13964156]
  Authors
HOSOYA T, KONDO Y, UI N.
  Title
Peroxidase activity in thyroid gland and partial purification of the enzyme.
  Journal
J Biochem 52:180-9 (1962)
DOI:10.1093/oxfordjournals.jbchem.a127594
Reference
3  [PMID:12325367]
  Authors
Coval ML, Taurog A.
  Title
Purification and iodinating activity of hog thyroid peroxidase.
  Journal
J Biol Chem 242:5510-23 (1967)
Reference
4  [PMID:7021557]
  Authors
Gavaret JM, Cahnmann HJ, Nunez J
  Title
Thyroid hormone synthesis in thyroglobulin. The mechanism of the coupling reaction.
  Journal
J Biol Chem 256:9167-73 (1981)
Reference
5  [PMID:7142155]
  Authors
Ohtaki S, Nakagawa H, Nakamura M, Yamazaki I
  Title
One- and two-electron oxidations of tyrosine, monoiodotyrosine, and diiodotyrosine catalyzed by hog thyroid peroxidase.
  Journal
J Biol Chem 257:13398-403 (1982)
Reference
6  [PMID:6706930]
  Authors
Magnusson RP, Taurog A, Dorris ML
  Title
Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase.
  Journal
J Biol Chem 259:197-205 (1984)
Reference
7  [PMID:2996435]
  Authors
Virion A, Courtin F, Deme D, Michot JL, Kaniewski J, Pommier J
  Title
Spectral characteristics and catalytic properties of thyroid peroxidase-H2O2 compounds in the iodination and coupling reactions.
  Journal
Arch Biochem Biophys 242:41-7 (1985)
DOI:10.1016/0003-9861(85)90477-1
Reference
8  [PMID:1497352]
  Authors
Rawitch AB, Pollock G, Yang SX, Taurog A
  Title
Thyroid peroxidase glycosylation: the location and nature of the N-linked oligosaccharide units in porcine thyroid peroxidase.
  Journal
Arch Biochem Biophys 297:321-7 (1992)
DOI:10.1016/0003-9861(92)90679-Q
  Sequence
[ssc:445522]
Reference
9  [PMID:8448141]
  Authors
Sun W, Dunford HB
  Title
Kinetics and mechanism of the peroxidase-catalyzed iodination of tyrosine.
  Journal
Biochemistry 32:1324-31 (1993)
DOI:10.1021/bi00056a018
Reference
10 [PMID:8651700]
  Authors
Taurog A, Dorris ML, Doerge DR
  Title
Mechanism of simultaneous iodination and coupling catalyzed by thyroid peroxidase.
  Journal
Arch Biochem Biophys 330:24-32 (1996)
DOI:10.1006/abbi.1996.0222
Reference
11 [PMID:16098474]
  Authors
Ruf J, Carayon P
  Title
Structural and functional aspects of thyroid peroxidase.
  Journal
Arch Biochem Biophys 445:269-77 (2006)
DOI:10.1016/j.abb.2005.06.023
Other DBs
ExplorEnz - The Enzyme Database: 1.11.1.8
IUBMB Enzyme Nomenclature: 1.11.1.8
ExPASy - ENZYME nomenclature database: 1.11.1.8
BRENDA, the Enzyme Database: 1.11.1.8
CAS: 9031-28-1

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