KEGG   ENZYME: 1.11.2.1Help
Entry
EC 1.11.2.1                 Enzyme                                 

Name
unspecific peroxygenase;
aromatic peroxygenase;
mushroom peroxygenase;
haloperoxidase-peroxygenase;
Agrocybe aegerita peroxidase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxygenases
BRITE hierarchy
Sysname
substrate:hydrogen-peroxide oxidoreductase (RH-hydroxylating or -epoxidising)
Reaction(IUBMB)
RH + H2O2 = ROH + H2O [RN:R09507]
Reaction(KEGG)
Substrate
RH [CPD:C01371];
H2O2 [CPD:C00027]
Product
ROH [CPD:C01335];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (P-450). Enzymes of this type include glycoproteins secreted by agaric basidiomycetes. They catalyse the insertion of an oxygen atom from H2O2 into a wide variety of substrates, including aromatic rings such as naphthalene, toluene, phenanthrene, pyrene and p-nitrophenol, recalcitrant heterocycles such as pyridine, dibenzofuran, various ethers (resulting in O-dealkylation) and alkanes such as propane, hexane and cyclohexane. Reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, O- and N-dealkylation, bromination and one-electron oxidations. They have little or no activity toward chloride. Mechanistically, the catalytic cycle of unspecific (mono)-peroxygenases combines elements of the "shunt" pathway of cytochrome P-450s (a side activity that utilizes a peroxide in place of dioxygen and NAD[P]H) and the classic heme peroxidase cycle.
History
EC 1.11.2.1 created 2011
Orthology
K21820  unspecific peroxygenase
Genes
ADL: AURDEDRAFT_110995(HTP11) AURDEDRAFT_139536(HTP6) AURDEDRAFT_145147(HTP8) AURDEDRAFT_63312(HTP13) AURDEDRAFT_63331(HTP12) AURDEDRAFT_67260(HTP1) AURDEDRAFT_68894(HTP5) AURDEDRAFT_72695(HTP9) AURDEDRAFT_74851(HTP4)
LBC: LACBIDRAFT_295571
CCI: CC1G_08427 CC1G_08975 CC1G_08981 CC1G_10475
ABP: AGABI1DRAFT111702(AGABI1DRAFT_111702) AGABI1DRAFT111721(AGABI1DRAFT_111721) AGABI1DRAFT111729(AGABI1DRAFT_111729) AGABI1DRAFT111731(AGABI1DRAFT_111731) AGABI1DRAFT111734(AGABI1DRAFT_111734) AGABI1DRAFT111735(AGABI1DRAFT_111735) AGABI1DRAFT111738(AGABI1DRAFT_111738) AGABI1DRAFT113735(AGABI1DRAFT_113735) AGABI1DRAFT114754(AGABI1DRAFT_114754) AGABI1DRAFT115045(AGABI1DRAFT_115045) AGABI1DRAFT115049(AGABI1DRAFT_115049) AGABI1DRAFT115479(AGABI1DRAFT_115479) AGABI1DRAFT118546(AGABI1DRAFT_118546) AGABI1DRAFT118596(AGABI1DRAFT_118596) AGABI1DRAFT121696(AGABI1DRAFT_121696) AGABI1DRAFT121894(AGABI1DRAFT_121894) AGABI1DRAFT122208(AGABI1DRAFT_122208) AGABI1DRAFT134005(AGABI1DRAFT_134005) AGABI1DRAFT30296(AGABI1DRAFT_30296) AGABI1DRAFT76879(AGABI1DRAFT_76879) AGABI1DRAFT76887(AGABI1DRAFT_76887) AGABI1DRAFT78772(AGABI1DRAFT_78772) AGABI1DRAFT88344(AGABI1DRAFT_88344)
ABV: AGABI2DRAFT134420(AGABI2DRAFT_134420) AGABI2DRAFT139842(AGABI2DRAFT_139842) AGABI2DRAFT179594(AGABI2DRAFT_179594) AGABI2DRAFT183665(AGABI2DRAFT_183665) AGABI2DRAFT183721(AGABI2DRAFT_183721) AGABI2DRAFT183842(AGABI2DRAFT_183842) AGABI2DRAFT186833(AGABI2DRAFT_186833) AGABI2DRAFT188448(AGABI2DRAFT_188448) AGABI2DRAFT188774(AGABI2DRAFT_188774) AGABI2DRAFT190943(AGABI2DRAFT_190943) AGABI2DRAFT190967(AGABI2DRAFT_190967) AGABI2DRAFT190973(AGABI2DRAFT_190973) AGABI2DRAFT190977(AGABI2DRAFT_190977) AGABI2DRAFT190980(AGABI2DRAFT_190980) AGABI2DRAFT190985(AGABI2DRAFT_190985) AGABI2DRAFT193563(AGABI2DRAFT_193563) AGABI2DRAFT195432(AGABI2DRAFT_195432) AGABI2DRAFT195436(AGABI2DRAFT_195436) AGABI2DRAFT207786(AGABI2DRAFT_207786) AGABI2DRAFT226793(AGABI2DRAFT_226793) AGABI2DRAFT64972(AGABI2DRAFT_64972) AGABI2DRAFT65123(AGABI2DRAFT_65123)
Taxonomy
Reference
1  [PMID:15294788]
  Authors
Ullrich R, Nuske J, Scheibner K, Spantzel J, Hofrichter M
  Title
Novel haloperoxidase from the agaric basidiomycete Agrocybe aegerita oxidizes aryl alcohols and aldehydes.
  Journal
Appl Environ Microbiol 70:4575-81 (2004)
DOI:10.1128/AEM.70.8.4575-4581.2004
  Sequence
Reference
2  [PMID:16253244]
  Authors
Ullrich R, Hofrichter M
  Title
The haloperoxidase of the agaric fungus Agrocybe aegerita hydroxylates toluene and naphthalene.
  Journal
FEBS Lett 579:6247-50 (2005)
DOI:10.1016/j.febslet.2005.10.014
  Sequence
Reference
3  [PMID:17601809]
  Authors
Anh DH, Ullrich R, Benndorf D, Svatos A, Muck A, Hofrichter M
  Title
The coprophilous mushroom Coprinus radians secretes a haloperoxidase that catalyzes aromatic peroxygenation.
  Journal
Appl Environ Microbiol 73:5477-85 (2007)
DOI:10.1128/AEM.00026-07
Reference
4  [PMID:19022254]
  Authors
Ullrich R, Dolge C, Kluge M, Hofrichter M
  Title
Pyridine as novel substrate for regioselective oxygenation with aromatic peroxygenase from Agrocybe aegerita.
  Journal
FEBS Lett 582:4100-6 (2008)
DOI:10.1016/j.febslet.2008.11.006
  Sequence
Reference
5  [PMID:19039585]
  Authors
Aranda E, Kinne M, Kluge M, Ullrich R, Hofrichter M
  Title
Conversion of dibenzothiophene by the mushrooms Agrocybe aegerita and Coprinellus radians and their extracellular peroxygenases.
  Journal
Appl Microbiol Biotechnol 82:1057-66 (2009)
DOI:10.1007/s00253-008-1778-6
Reference
6  [PMID:19394224]
  Authors
Kinne M, Poraj-Kobielska M, Aranda E, Ullrich R, Hammel KE, Scheibner K, Hofrichter M
  Title
Regioselective preparation of 5-hydroxypropranolol and 4'-hydroxydiclofenac with  a fungal peroxygenase.
  Journal
Bioorg Med Chem Lett 19:3085-7 (2009)
DOI:10.1016/j.bmcl.2009.04.015
  Sequence
Reference
7  [PMID:18815784]
  Authors
Kluge M, Ullrich R, Dolge C, Scheibner K, Hofrichter M
  Title
Hydroxylation of naphthalene by aromatic peroxygenase from Agrocybe aegerita proceeds via oxygen transfer from H2O2 and intermediary epoxidation.
  Journal
Appl Microbiol Biotechnol 81:1071-6 (2009)
DOI:10.1007/s00253-008-1704-y
  Sequence
Reference
8  [PMID:19713216]
  Authors
Kinne M, Poraj-Kobielska M, Ralph SA, Ullrich R, Hofrichter M, Hammel KE
  Title
Oxidative cleavage of diverse ethers by an extracellular fungal peroxygenase.
  Journal
J Biol Chem 284:29343-9 (2009)
DOI:10.1074/jbc.M109.040857
Reference
9  [PMID:19434406]
  Authors
Pecyna MJ, Ullrich R, Bittner B, Clemens A, Scheibner K, Schubert R, Hofrichter M
  Title
Molecular characterization of aromatic peroxygenase from Agrocybe aegerita.
  Journal
Appl Microbiol Biotechnol 84:885-97 (2009)
DOI:10.1007/s00253-009-2000-1
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.11.2.1
IUBMB Enzyme Nomenclature: 1.11.2.1
ExPASy - ENZYME nomenclature database: 1.11.2.1
BRENDA, the Enzyme Database: 1.11.2.1

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