KEGG ENZYME: 1.11.2.2

ENZYME: 1.11.2.2

Entry

EC 1.11.2.2                 Enzyme

Name

myeloperoxidase;
MPO;
verdoperoxidase

Class

Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxygenases

Sysname

chloride:hydrogen-peroxide oxidoreductase (hypochlorite-forming)

Reaction(IUBMB)

Cl- + H2O2 + H+ = HClO + H2O [RN:R09564]

Reaction(KEGG)

R09564;
(other) R11906

Substrate

Cl- [CPD:C00698];
H2O2 [CPD:C00027];
H+ [CPD:C00080]

Product

HClO [CPD:C19697];
H2O [CPD:C00001]

Comment

Contains calcium and covalently bound heme (proximal ligand histidine). It is present in phagosomes of neutrophils and monocytes, where the hypochlorite produced is strongly bactericidal. It differs from EC 1.11.1.10 chloride peroxidase in its preference for formation of hypochlorite over the chlorination of organic substrates under physiological conditions (pH 5-8). Hypochlorite in turn forms a number of antimicrobial products (Cl2, chloramines, hydroxyl radical, singlet oxygen). MPO also oxidizes bromide, iodide and thiocyanate. In the absence of halides, it oxidizes phenols and has a moderate peroxygenase activity toward styrene.

History

EC 1.11.2.2 created 2011

Pathway

ec00983

Drug metabolism - other enzymes

Orthology

K10789

myeloperoxidase

Genes

HSA:

4353(MPO)

PTR:	748680(MPO)

PPS:	100992079(MPO)

GGO:	101135280(MPO)

PON:	100461693(MPO)

NLE:	100606582(MPO)

MCC:	714246(MPO)

MCF:	102130410(MPO)

MTHB:

126939378

CSAB:

103242854(MPO)

CATY:

105583311(MPO)

PANU:

101011165(MPO)

TGE:	112609921(MPO)

RRO:	104669826(MPO)

RBB:	108521655(MPO)

TFN:	117067295(MPO)

PTEH:

111537628(MPO)

CJC:	100408045(MPO)

SBQ:	101046117(MPO)

CSYR:

103266720(MPO)

MMUR:

105870807(MPO)

LCAT:

123620433(MPO)

OGA:	100962386(MPO)

MMU:	17523(Mpo)

MCAL:

110305648(Mpo)

MPAH:

110331385(Mpo)

RNO:	303413(Mpo)

MCOC:

116077242(Mpo)

MUN:	110566146(Mpo)

CGE:	100752227(Mpo) 100757792

MAUA:

101830171(Mpo)

PLEU:

114699237 114699257

MORG:

121456890(Mpo)

MFOT:

126510373

AAMP:

119813072(Mpo)

NGI:	103741805(Mpo)

HGL:	101707361(Mpo)

CPOC:

100725291(Mpo)

CCAN:

109674413 109702951

DORD:

105983334(Mpo)

DSP:	122119242(Mpo)

NCAR:

124980398

OCU:	100340692(MPO)

OPI:	101519625(MPO)

TUP:	102501858(MPO)

CFA:	609986(MPO)

CLUD:

112655186(MPO)

VVP:	112918144(MPO)

VLG:	121473582(MPO)

AML:	100472895(MPO)

UMR:	103667463(MPO)

UAH:	113268870(MPO)

UAR:	123777005(MPO)

ELK:

111151617

LLV:

125088054

MPUF:

101693526(MPO)

ORO:	101380182(MPO)

EJU:	114213918(MPO)

ZCA:	113907839(MPO)

MLX:	118025032(MPO)

NSU:	110592908(MPO)

FCA:	100142673(MPO)

PYU:

121044726

PBG:	122485326(MPO)

LRUF:

124512901

PTG:	102973033(MPO)

PPAD:

109247205(MPO)

AJU:	106989943(MPO)

HHV:	120241939(MPO)

BTA:	511206(MPO)

BOM:	102286491(MPO)

BIU:	109573426(MPO)

BBUB:

102404921(MPO)

CHX:	102185772(MPO)

OAS:	101123053(MPO)

ODA:	120866469(MPO)

CCAD:

122449725(MPO)

SSC:	100517120(MPO)

CFR:	102510136(MPO)

CBAI:

105065870(MPO)

CDK:	105097806(MPO)

VPC:	102544839(MPO)

BACU:

103004965(MPO)

LVE:	103083642(MPO)

OOR:	101290133(MPO)

DLE:	111163673(MPO)

PCAD:

102982078(MPO)

PSIU:

116745756(MPO)

ECB:	100070920(MPO)

EPZ:	103546343(MPO)

EAI:	106822013(MPO)

MYB:	102240978(MPO)

MYD:	102756726(MPO)

MMYO:

118671763(MPO)

MLF:	102433380(MPO)

MNA:	107535307(MPO)

PKL:	118728102(MPO)

HAI:	109379730(MPO)

DRO:	112316355(MPO)

SHON:

119003703(MPO)

AJM:	119062632(MPO)

PDIC:

114503163(MPO)

PHAS:

123817428(MPO)

MMF:	118634389(MPO)

RFQ:	117013909(MPO)

PALE:

102883356(MPO)

PGIG:

120621150(MPO)

PVP:	105302124(MPO)

RAY:	107499177(MPO)

MJV:	108397175(MPO)

TOD:	119231003(MPO)

SARA:

101554218(MPO)

LAV:	100662013(MPO)

TMU:

101340378

DNM:	101415126(MPO)

MDO:	100012330(MPO) 100022606

GAS:	123246127(MPO) 123246781

SHR:

100918289

PCW:

110212135

OAA:	100078069(MPO)

GGA:	417466(LPO) 417467(MPO)

PCOC:

116228224(LPO)

MGP:	100547955(LPO)

NMEL:

110407540(EPX) 110407753

APLA:

101801315 101805061

ACYG:

106041022 106041024(MPO)

AFUL:

116497396 116497447

TGU:

116809130

LSR:

110475906

PMOA:

120513449

OTC:	121346857(EPX) 121346871

PRUF:

121362958 121362959(EPX)

GFR:	102037835(MPO)

FAB:	101820562(MPO)

CCW:

104695782

CBRC:

103618347 103618349

ETL:

114063781

ZAB:	102063561 102067212

ACHL:

103802301 103802303 103808840

FPG:	101914513(EPX) 101914689(MPO)

FCH:	102052043 102052208

CLV:	102084173 102084361

EGZ:	104131757 104131758(MPO)

NNI:	104012465(LPO)

PLET:

104628114 104628115

PCRI:

104024842

ACUN:

113487144 113487180(MPO)

TALA:

104366892 104366894

PADL:

103916612 103916613

AFOR:

103896569 103896570

ACHC:

115347511 115347673

HALD:

104314380 104314381

CCRI:

104165474 104167995

CSTI:

104553514

EHS:	104506248 104506249

CMAC:

104478087 104482911

MUI:	104536751 104539284

FGA:	104083379 104083380

GSTE:

104253887 104256813

LDI:	104352898 104352899

MNB:	103768197 103768198

OHA:	104334726(EPX)

NNT:

104407111

DPUB:

104300255(MPO)

PGUU:

104466180 104466182(LPO)

ACAR:

104531742 104531743

AVIT:

104268383

CVF:	104289864 104289865

AAM:	106496096 106496104(MPO)

AROW:

112964994 112965020(MPO)

NPD:	112956708(MPO) 112956744

TGT:

104572398

DNE:	112987317 112987346

SCAM:

104146231(MPO) 104146262

ASN:	102372031 102379880

AMJ:	102559230(LPO)

CPOO:

109317469 109317472

GGN:	109288980 109289040

PSS:	102454048 102463089

CMY:	102933916 102934149 102941880

CPIC:

101935994 101946833 101947097

TST:	117867690(MPO) 117867693 117867698

CABI:

116818731(MPO) 116818741 116818742

MRV:	120387502 120387503 120387580

ACS:	100567371 107983822

PVT:	110084498 110084515

SUND:

121916987

PBI:	103062626 103062866(LPO)

PMUR:

107288571(MPO)

CTIG:

120309089 120309240(MPO)

TSR:	106549249(MPO) 106553876(LPO)

PGUT:

117667550

VKO:	123036688 123036689

PMUA:

114585840

ZVI:

118097261

GJA:

107112485

STOW:

125445776 125446010

XLA:	373710(mpo.S) 394386(mpo.L) 398084(epx.L)

XTR:	100490938(mpo) 100496213(epx)

NPR:	108785838 108785844 108797850

RTEM:

120927532 120927666 120927668 120927671

BBUF:

120993645 120993647 120993648 120994701 120994817

BGAR:

122931700 122931701 122931839 122931840 122932447 122932595 122940269

SRX:

107713297

SANH:

107688477

SGH:

107569391

CCAR:

109052003 109052065

SASA:

100380666(perm)

OTW:

112231092

OMY:

110509901

SALP:

111964113

SFM:	108930109 108932527

PSPA:

121303039(mpx)

LCM:	102347787 102348047(MPO)

RTP:	109913294 109913296 109926715 109937198 109937200

BCOO:

119072211 119073474 119084658

FOC:	113214016 113217140

TPAL:

117644798

PTRU:

123513466

BGT:

106065603

HRF:	124118159 124122769 124127939 124136579 124136580 124136585 124141281 124141282 124141286 124141287 124141289 124141290

HRJ:	124253595 124256926 124262128

CRG:	105319077 105333777 105347615 117683867

PMAX:

117340028 117342135

MMER:

123537740 123537814 123538598 123539213 123541376 123546341

OSN:

115216508

XEN:

124440570

NGR:	NAEGRDRAFT_70645

» show all

Reference

Authors

Agner, K.

Title

Myeloperoxidase.

Journal

Adv Enzymol 3:137-148 (1943)

Reference

2 [PMID:176150]

Authors

Harrison JE, Schultz J

Title

Studies on the chlorinating activity of myeloperoxidase.

Journal

J Biol Chem 251:1371-4 (1976)

Reference

3 [PMID:9922160]

Authors

Furtmuller PG, Burner U, Obinger C

Title

Reaction of myeloperoxidase compound I with chloride, bromide, iodide, and thiocyanate.

Journal

Biochemistry 37:17923-30 (1998)
DOI:10.1021/bi9818772

Reference

4 [PMID:10652281]

Authors

Tuynman A, Spelberg JL, Kooter IM, Schoemaker HE, Wever R

Title

Enantioselective epoxidation and carbon-carbon bond cleavage catalyzed by Coprinus cinereus peroxidase and myeloperoxidase.

Journal

J Biol Chem 275:3025-30 (2000)
DOI:10.1074/jbc.275.5.3025

Reference

5 [PMID:15689384]

Authors

Klebanoff SJ

Title

Myeloperoxidase: friend and foe.

Journal

J Leukoc Biol 77:598-625 (2005)
DOI:10.1189/jlb.1204697

Reference

6 [PMID:10766826]

Authors

Fiedler TJ, Davey CA, Fenna RE

Title

X-ray crystal structure and characterization of halide-binding sites of human myeloperoxidase at 1.8 A resolution.

Journal

J Biol Chem 275:11964-71 (2000)
DOI:10.1074/jbc.275.16.11964

Sequence

[hsa:4353]

Reference

7 [PMID:11593004]

Authors

Gaut JP, Yeh GC, Tran HD, Byun J, Henderson JP, Richter GM, Brennan ML, Lusis AJ, Belaaouaj A, Hotchkiss RS, Heinecke JW

Title

Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis.

Journal

Proc Natl Acad Sci U S A 98:11961-6 (2001)
DOI:10.1073/pnas.211190298

Other DBs

ExplorEnz - The Enzyme Database:

1.11.2.2

IUBMB Enzyme Nomenclature:

1.11.2.2

ExPASy - ENZYME nomenclature database:

1.11.2.2

BRENDA, the Enzyme Database:

1.11.2.2

DBGET integrated database retrieval system