KEGG   ENZYME: 1.11.2.2
Entry
EC 1.11.2.2                 Enzyme                                 
Name
myeloperoxidase;
MPO;
verdoperoxidase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxygenases
Sysname
chloride:hydrogen-peroxide oxidoreductase (hypochlorite-forming)
Reaction(IUBMB)
Cl- + H2O2 + H+ = HClO + H2O [RN:R09564]
Reaction(KEGG)
R09564;
(other) R11906
Substrate
Cl- [CPD:C00698];
H2O2 [CPD:C00027];
H+ [CPD:C00080]
Product
HClO [CPD:C19697];
H2O [CPD:C00001]
Comment
Contains calcium and covalently bound heme (proximal ligand histidine). It is present in phagosomes of neutrophils and monocytes, where the hypochlorite produced is strongly bactericidal. It differs from EC 1.11.1.10 chloride peroxidase in its preference for formation of hypochlorite over the chlorination of organic substrates under physiological conditions (pH 5-8). Hypochlorite in turn forms a number of antimicrobial products (Cl2, chloramines, hydroxyl radical, singlet oxygen). MPO also oxidizes bromide, iodide and thiocyanate. In the absence of halides, it oxidizes phenols and has a moderate peroxygenase activity toward styrene.
History
EC 1.11.2.2 created 2011
Pathway
ec00983  Drug metabolism - other enzymes
Orthology
K10789  myeloperoxidase
Genes
HSA4353(MPO)
PTR748680(MPO)
PPS100992079(MPO)
GGO101135280(MPO)
PON100461693(MPO)
NLE100606582(MPO)
MCC714246(MPO)
MCF102130410(MPO)
MTHB126939378
CSAB103242854(MPO)
CATY105583311(MPO)
PANU101011165(MPO)
TGE112609921(MPO)
RRO104669826(MPO)
RBB108521655(MPO)
TFN117067295(MPO)
PTEH111537628(MPO)
CJC100408045(MPO)
SBQ101046117(MPO)
CSYR103266720(MPO)
MMUR105870807(MPO)
LCAT123620433(MPO)
OGA100962386(MPO)
MMU17523(Mpo)
MCAL110305648(Mpo)
MPAH110331385(Mpo)
RNO303413(Mpo)
MCOC116077242(Mpo)
MUN110566146(Mpo)
CGE100752227(Mpo) 100757792
MAUA101830171(Mpo)
PLEU114699237 114699257
MORG121456890(Mpo)
MFOT126510373
AAMP119813072(Mpo)
NGI103741805(Mpo)
HGL101707361(Mpo)
CPOC100725291(Mpo)
CCAN109674413 109702951
DORD105983334(Mpo)
DSP122119242(Mpo)
NCAR124980398
OCU100340692(MPO)
OPI101519625(MPO)
TUP102501858(MPO)
CFA609986(MPO)
CLUD112655186(MPO)
VVP112918144(MPO)
VLG121473582(MPO)
AML100472895(MPO)
UMR103667463(MPO)
UAH113268870(MPO)
UAR123777005(MPO)
ELK111151617
LLV125088054
MPUF101693526(MPO)
ORO101380182(MPO)
EJU114213918(MPO)
ZCA113907839(MPO)
MLX118025032(MPO)
NSU110592908(MPO)
FCA100142673(MPO)
PYU121044726
PBG122485326(MPO)
LRUF124512901
PTG102973033(MPO)
PPAD109247205(MPO)
AJU106989943(MPO)
HHV120241939(MPO)
BTA511206(MPO)
BOM102286491(MPO)
BIU109573426(MPO)
BBUB102404921(MPO)
CHX102185772(MPO)
OAS101123053(MPO)
ODA120866469(MPO)
CCAD122449725(MPO)
SSC100517120(MPO)
CFR102510136(MPO)
CBAI105065870(MPO)
CDK105097806(MPO)
VPC102544839(MPO)
BACU103004965(MPO)
LVE103083642(MPO)
OOR101290133(MPO)
DLE111163673(MPO)
PCAD102982078(MPO)
PSIU116745756(MPO)
ECB100070920(MPO)
EPZ103546343(MPO)
EAI106822013(MPO)
MYB102240978(MPO)
MYD102756726(MPO)
MMYO118671763(MPO)
MLF102433380(MPO)
MNA107535307(MPO)
PKL118728102(MPO)
HAI109379730(MPO)
DRO112316355(MPO)
SHON119003703(MPO)
AJM119062632(MPO)
PDIC114503163(MPO)
PHAS123817428(MPO)
MMF118634389(MPO)
RFQ117013909(MPO)
PALE102883356(MPO)
PGIG120621150(MPO)
PVP105302124(MPO)
RAY107499177(MPO)
MJV108397175(MPO)
TOD119231003(MPO)
SARA101554218(MPO)
LAV100662013(MPO)
TMU101340378
DNM101415126(MPO)
MDO100012330(MPO) 100022606
GAS123246127(MPO) 123246781
SHR100918289
PCW110212135
OAA100078069(MPO)
GGA417466(LPO) 417467(MPO)
PCOC116228224(LPO)
MGP100547955(LPO)
NMEL110407540(EPX) 110407753
APLA101801315 101805061
ACYG106041022 106041024(MPO)
AFUL116497396 116497447
TGU116809130
LSR110475906
PMOA120513449
OTC121346857(EPX) 121346871
PRUF121362958 121362959(EPX)
GFR102037835(MPO)
FAB101820562(MPO)
CCW104695782
CBRC103618347 103618349
ETL114063781
ZAB102063561 102067212
ACHL103802301 103802303 103808840
FPG101914513(EPX) 101914689(MPO)
FCH102052043 102052208
CLV102084173 102084361
EGZ104131757 104131758(MPO)
NNI104012465(LPO)
PLET104628114 104628115
PCRI104024842
ACUN113487144 113487180(MPO)
TALA104366892 104366894
PADL103916612 103916613
AFOR103896569 103896570
ACHC115347511 115347673
HALD104314380 104314381
CCRI104165474 104167995
CSTI104553514
EHS104506248 104506249
CMAC104478087 104482911
MUI104536751 104539284
FGA104083379 104083380
GSTE104253887 104256813
LDI104352898 104352899
MNB103768197 103768198
OHA104334726(EPX)
NNT104407111
DPUB104300255(MPO)
PGUU104466180 104466182(LPO)
ACAR104531742 104531743
AVIT104268383
CVF104289864 104289865
AAM106496096 106496104(MPO)
AROW112964994 112965020(MPO)
NPD112956708(MPO) 112956744
TGT104572398
DNE112987317 112987346
SCAM104146231(MPO) 104146262
ASN102372031 102379880
AMJ102559230(LPO)
CPOO109317469 109317472
GGN109288980 109289040
PSS102454048 102463089
CMY102933916 102934149 102941880
CPIC101935994 101946833 101947097
TST117867690(MPO) 117867693 117867698
CABI116818731(MPO) 116818741 116818742
MRV120387502 120387503 120387580
ACS100567371 107983822
PVT110084498 110084515
SUND121916987
PBI103062626 103062866(LPO)
PMUR107288571(MPO)
CTIG120309089 120309240(MPO)
TSR106549249(MPO) 106553876(LPO)
PGUT117667550
VKO123036688 123036689
PMUA114585840
ZVI118097261
GJA107112485
STOW125445776 125446010
XLA373710(mpo.S) 394386(mpo.L) 398084(epx.L)
XTR100490938(mpo) 100496213(epx)
NPR108785838 108785844 108797850
RTEM120927532 120927666 120927668 120927671
BBUF120993645 120993647 120993648 120994701 120994817
BGAR122931700 122931701 122931839 122931840 122932447 122932595 122940269
SRX107713297
SANH107688477
SGH107569391
CCAR109052003 109052065
SASA100380666(perm)
OTW112231092
OMY110509901
SALP111964113
SFM108930109 108932527
PSPA121303039(mpx)
LCM102347787 102348047(MPO)
RTP109913294 109913296 109926715 109937198 109937200
BCOO119072211 119073474 119084658
FOC113214016 113217140
TPAL117644798
PTRU123513466
BGT106065603
HRF124118159 124122769 124127939 124136579 124136580 124136585 124141281 124141282 124141286 124141287 124141289 124141290
HRJ124253595 124256926 124262128
CRG105319077 105333777 105347615 117683867
PMAX117340028 117342135
MMER123537740 123537814 123538598 123539213 123541376 123546341
OSN115216508
XEN124440570
NGRNAEGRDRAFT_70645
 » show all
Reference
1
  Authors
Agner, K.
  Title
Myeloperoxidase.
  Journal
Adv Enzymol 3:137-148 (1943)
Reference
2  [PMID:176150]
  Authors
Harrison JE, Schultz J
  Title
Studies on the chlorinating activity of myeloperoxidase.
  Journal
J Biol Chem 251:1371-4 (1976)
Reference
3  [PMID:9922160]
  Authors
Furtmuller PG, Burner U, Obinger C
  Title
Reaction of myeloperoxidase compound I with chloride, bromide, iodide, and thiocyanate.
  Journal
Biochemistry 37:17923-30 (1998)
DOI:10.1021/bi9818772
Reference
4  [PMID:10652281]
  Authors
Tuynman A, Spelberg JL, Kooter IM, Schoemaker HE, Wever R
  Title
Enantioselective epoxidation and carbon-carbon bond cleavage catalyzed by Coprinus cinereus peroxidase and myeloperoxidase.
  Journal
J Biol Chem 275:3025-30 (2000)
DOI:10.1074/jbc.275.5.3025
Reference
5  [PMID:15689384]
  Authors
Klebanoff SJ
  Title
Myeloperoxidase: friend and foe.
  Journal
J Leukoc Biol 77:598-625 (2005)
DOI:10.1189/jlb.1204697
Reference
6  [PMID:10766826]
  Authors
Fiedler TJ, Davey CA, Fenna RE
  Title
X-ray crystal structure and characterization of halide-binding sites of human myeloperoxidase at 1.8 A resolution.
  Journal
J Biol Chem 275:11964-71 (2000)
DOI:10.1074/jbc.275.16.11964
  Sequence
[hsa:4353]
Reference
7  [PMID:11593004]
  Authors
Gaut JP, Yeh GC, Tran HD, Byun J, Henderson JP, Richter GM, Brennan ML, Lusis AJ, Belaaouaj A, Hotchkiss RS, Heinecke JW
  Title
Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis.
  Journal
Proc Natl Acad Sci U S A 98:11961-6 (2001)
DOI:10.1073/pnas.211190298
Other DBs
ExplorEnz - The Enzyme Database: 1.11.2.2
IUBMB Enzyme Nomenclature: 1.11.2.2
ExPASy - ENZYME nomenclature database: 1.11.2.2
BRENDA, the Enzyme Database: 1.11.2.2

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