KEGG   ENZYME: 1.11.2.5
Entry
EC 1.11.2.5                 Enzyme                                 

Name
3-methyl-L-tyrosine peroxygenase;
SfmD;
SacD;
3-methyltyrosine peroxidase;
3-methyl-L-tyrosine peroxidase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxygenases
Sysname
3-methyl-L-tyrosine:hydrogen-peroxide oxidoreductase (3-hydroxy-5-methyl-L-tyrosine-forming)
Reaction(IUBMB)
3-methyl-L-tyrosine + H2O2 = 3-hydroxy-5-methyl-L-tyrosine + H2O [RN:R10721]
Reaction(KEGG)
R10721
Substrate
3-methyl-L-tyrosine [CPD:C20800];
H2O2 [CPD:C00027]
Product
3-hydroxy-5-methyl-L-tyrosine [CPD:C20801];
H2O [CPD:C00001]
Comment
The heme-containing peroxygenase from the bacterium Streptomyces lavendulae is involved in biosynthesis of saframycin A, a potent antitumor antibiotic that belongs to the tetrahydroisoquinoline family.
History
EC 1.11.2.5 created 2014
Orthology
K20208  3-methyl-L-tyrosine peroxygenase
Reference
1  [PMID:22187429]
  Authors
Tang MC, Fu CY, Tang GL
  Title
Characterization of SfmD as a Heme peroxidase that catalyzes the regioselective hydroxylation of 3-methyltyrosine to 3-hydroxy-5-methyltyrosine in saframycin A biosynthesis.
  Journal
J Biol Chem 287:5112-21 (2012)
DOI:10.1074/jbc.M111.306316
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.11.2.5
IUBMB Enzyme Nomenclature: 1.11.2.5
ExPASy - ENZYME nomenclature database: 1.11.2.5
BRENDA, the Enzyme Database: 1.11.2.5

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