KEGG   ENZYME: 1.11.2.6
Entry
EC 1.11.2.6                 Enzyme                                 
Name
L-tyrosine peroxygenase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxygenases
Sysname
L-tyrosine:hydrogen-peroxide oxidoreductase (L-dopa-forming)
Reaction(IUBMB)
L-tyrosine + H2O2 = L-dopa + H2O [RN:R12611]
Reaction(KEGG)
R12611
Substrate
L-tyrosine [CPD:C00082];
H2O2 [CPD:C00027]
Product
L-dopa [CPD:C00355];
H2O [CPD:C00001]
Comment
The enzyme from the bacterium Streptomyces lincolnensis participates in the biosynthesis of the antibiotic lincomycin A, while that from Streptomyces refuineus is involved in anthramycin biosynthesis. The enzyme, which contains a heme b cofactor, is rapidly inactivated in the presence of hydrogen peroxide, but the presence of L-tyrosine protects it. cf. EC 1.11.2.5, 3-methyl-L-tyrosine peroxygenase.
History
EC 1.11.2.6 created 2020
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K24287  L-tyrosine peroxygenase
Genes
THIPN838_30010
NBRO3I_021195
NOZDMB37_35910
NAHF5544_09850
SHYSHJG_8632
SHOSHJGH_8392
SPHWNFX46_21415
SLSSLINC_0235
SNZDC008_26540
SRKFGW37_26110
SFUGCNQ36_06410
SMOBJ7W19_03340
SPRACP972_04310
SANUK7396_13290
SDDD9753_04025
STUBMMF93_32200
SLAIP8A22_34785
KABB7C62_33400
SACGFDZ84_04225
AMDAMED_5527
AMNRAM_28170
AMMAMES_5460
AMZB737_5460
AOIAORI_5444
AABA4R43_02250
AMYYYIM_25150
AORISD37_10250
KALKALB_5794
LEDBBK82_27955
AIHAiant_51630
PSUUPsuf_065210
DFUDfulv_34100
 » show all
Reference
1  [PMID:9531633]
  Authors
Neusser D, Schmidt H, Spizek J, Novotna J, Peschke U, Kaschabeck S, Tichy P, Piepersberg W
  Title
The genes lmbB1 and lmbB2 of Streptomyces lincolnensis encode enzymes involved in the conversion of L-tyrosine to propylproline during the biosynthesis of the antibiotic lincomycin A.
  Journal
Arch Microbiol 169:322-32 (1998)
DOI:10.1007/s002030050578
Reference
2  [PMID:21919439]
  Authors
Connor KL, Colabroy KL, Gerratana B
  Title
A heme peroxidase with a functional role as an L-tyrosine hydroxylase in the biosynthesis of anthramycin.
  Journal
Biochemistry 50:8926-36 (2011)
DOI:10.1021/bi201148a
Other DBs
ExplorEnz - The Enzyme Database: 1.11.2.6
IUBMB Enzyme Nomenclature: 1.11.2.6
ExPASy - ENZYME nomenclature database: 1.11.2.6
BRENDA, the Enzyme Database: 1.11.2.6

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