KEGG   ENZYME: 1.11.2.6
Entry
EC 1.11.2.6                 Enzyme                                 

Name
L-tyrosine peroxygenase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxygenases
Sysname
L-tyrosine:hydrogen-peroxide oxidoreductase (L-dopa-forming)
Reaction(IUBMB)
L-tyrosine + H2O2 = L-dopa + H2O [RN:R12611]
Reaction(KEGG)
R12611
Substrate
L-tyrosine [CPD:C00082];
H2O2 [CPD:C00027]
Product
L-dopa [CPD:C00355];
H2O [CPD:C00001]
Comment
The enzyme from the bacterium Streptomyces lincolnensis participates in the biosynthesis of the antibiotic lincomycin A, while that from Streptomyces refuineus is involved in anthramycin biosynthesis. The enzyme, which contains a heme b cofactor, is rapidly inactivated in the presence of hydrogen peroxide, but the presence of L-tyrosine protects it. cf. EC 1.11.2.5, 3-methyl-L-tyrosine peroxygenase.
History
EC 1.11.2.6 created 2020
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K24287  L-tyrosine peroxygenase
Genes
THIP: N838_30010
NBR: O3I_021195
NOZ: DMB37_35910
NAH: F5544_09850
SHY: SHJG_8632
SHO: SHJGH_8392
SLS: SLINC_0235
SNZ: DC008_26540
SRK: FGW37_26110
SFUG: CNQ36_06410
AMD: AMED_5527
AMN: RAM_28170
AMM: AMES_5460
AMZ: B737_5460
AOI: AORI_5444
AMYY: YIM_25150
AORI: SD37_10250
KAL: KALB_5794
 » show all
Reference
1  [PMID:9531633]
  Authors
Neusser D, Schmidt H, Spizek J, Novotna J, Peschke U, Kaschabeck S, Tichy P, Piepersberg W
  Title
The genes lmbB1 and lmbB2 of Streptomyces lincolnensis encode enzymes involved in the conversion of L-tyrosine to propylproline during the biosynthesis of the antibiotic lincomycin A.
  Journal
Arch Microbiol 169:322-32 (1998)
DOI:10.1007/s002030050578
Reference
2  [PMID:21919439]
  Authors
Connor KL, Colabroy KL, Gerratana B
  Title
A heme peroxidase with a functional role as an L-tyrosine hydroxylase in the biosynthesis of anthramycin.
  Journal
Biochemistry 50:8926-36 (2011)
DOI:10.1021/bi201148a
Other DBs
ExplorEnz - The Enzyme Database: 1.11.2.6
IUBMB Enzyme Nomenclature: 1.11.2.6
ExPASy - ENZYME nomenclature database: 1.11.2.6
BRENDA, the Enzyme Database: 1.11.2.6

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