KEGG   ENZYME: 1.12.1.2
Entry
EC 1.12.1.2                 Enzyme                                 
Name
hydrogen dehydrogenase;
H2:NAD+ oxidoreductase;
NAD+-linked hydrogenase;
bidirectional hydrogenase;
hydrogenase
Class
Oxidoreductases;
Acting on hydrogen as donor;
With NAD+ or NADP+ as acceptor
Sysname
hydrogen:NAD+ oxidoreductase
Reaction(IUBMB)
H2 + NAD+ = H+ + NADH [RN:R00700]
Reaction(KEGG)
R00700
Substrate
H2 [CPD:C00282];
NAD+ [CPD:C00003]
Product
H+ [CPD:C00080];
NADH [CPD:C00004]
Comment
An iron-sulfur flavoprotein (FMN or FAD). Some forms of this enzyme contain nickel.
History
EC 1.12.1.2 created 1972, modified 2002
Orthology
K00436  NAD-reducing hydrogenase large subunit
K18005  [NiFe] hydrogenase diaphorase moiety large subunit
K18006  [NiFe] hydrogenase diaphorase moiety small subunit
K18007  NAD-reducing hydrogenase small subunit
Genes
PPRPBPRB0250(WS0479)
GHOAL542_16860 AL542_16865 AL542_16870 AL542_16875
PINPing_1215 Ping_1216 Ping_1217
MCAMCA0114 MCA2724 MCA2725 MCA2726
METUGNH96_02900 GNH96_04195 GNH96_04200 GNH96_04205
MMTMetme_0247 Metme_0248 Metme_0249 Metme_0250
MDNJT25_003635 JT25_003640 JT25_003645 JT25_003650
MDHAYM39_16540 AYM39_16545 AYM39_16550 AYM39_16555
MKOMKLM6_3400 MKLM6_3401 MKLM6_3402 MKLM6_3403
METLU737_06830 U737_06835 U737_06840 U737_06845
MPADKEF85_00650 KEF85_00655 KEF85_00660 KEF85_00665
MELLIVG45_16785 IVG45_16790 IVG45_16795 IVG45_16800
MAHMEALZ_1304(hoxH) MEALZ_1305(hoxY) MEALZ_1306 MEALZ_1307(hoxF)
MBUREQU24_08675 EQU24_08680 EQU24_08685 EQU24_08690
MPSYCEK71_01410 CEK71_01420 CEK71_01425 CEK71_01430
MMOBF6R98_18325 F6R98_18330 F6R98_18335 F6R98_21070
MEINmethR_P2292 methR_P2293 methR_P2294 methR_P2351
MOZMoryE10_07920 MoryE10_07930 MoryE10_07940 MoryE10_07950
MISZMishRS11D_03740 MishRS11D_03750 MishRS11D_03760 MishRS11D_05140
MESLKKZ03_21165 KKZ03_21170 KKZ03_21175 KKZ03_21180
CYQQ91_0786 Q91_0787 Q91_0788 Q91_0789
CZACYCME_1794(hoxX) CYCME_1795(hoxY) CYCME_1796(hoxU) CYCME_1797(hoxF)
CYYCPC19_08685 CPC19_08690 CPC19_08695 CPC19_08700
TIGTHII_1521 THII_1522 THII_1523 THII_1524
THISHZT40_20925 HZT40_20930 HZT40_20935
TUNJ9260_16470 J9260_16475 J9260_16480 J9260_16485
TANIJ8380_12325 J8380_12330 J8380_12335 J8380_12340
ALVAlvin_1867 Alvin_1868
ATEPAtep_21050 Atep_21060
TVIThivi_1129 Thivi_1131
TMBThimo_2353 Thimo_2354
MPURMARPU_05130 MARPU_05140
TSYTHSYN_09520 THSYN_09530 THSYN_22655 THSYN_22660 THSYN_22665 THSYN_22670
TTPE6P07_08990 E6P07_08995
THIPN838_32675 N838_32680 N838_32685 N838_32690
CJAPGWK36_10075 GWK36_10080
THIMKFB96_13895 KFB96_13905 KFB96_21000 KFB96_21005 KFB96_21010 KFB96_21015
TBOGLT988_09435 LT988_09445 LT988_16210 LT988_16215 LT988_16220 LT988_16225
HCHHCH_00105 HCH_00106 HCH_00107 HCH_00108(nuoF)
HAHEENC22_00505 ENC22_00510 ENC22_00515 ENC22_00520
HSRHSBAA_33610
KAKKalk_19725 Kalk_19730 Kalk_19735 Kalk_19740
TAUTola_1506 Tola_1507
SEDSAAY24_09240 AAY24_09245 AAY24_09250 AAY24_09255
VFFVITFI_CDS1490 VITFI_CDS1491 VITFI_CDS1492 VITFI_CDS1493
CHRMFYK34_05850 FYK34_05855 FYK34_05860 FYK34_05865
CHIZHQ393_06285 HQ393_06290 HQ393_06295 HQ393_06300
REHPHG088(hoxF) PHG089(hoxU) PHG090(hoxY) PHG091(hoxH)
RMERmet_1522(hoxF) Rmet_1523(hoxU) Rmet_1524(hoxY) Rmet_1525(hoxH)
BUIAX768_20315 AX768_20320 AX768_20325 AX768_20330
BXEBxe_C0528 Bxe_C0529 Bxe_C0530 Bxe_C0531
BXBDR64_7916(hoxH) DR64_7917(hoxY) DR64_7918(hoxU) DR64_7919(hoxF)
RFRRfer_3855 Rfer_3856 Rfer_3857 Rfer_3858
RHGEXZ61_06120 EXZ61_06125 EXZ61_06130 EXZ61_06135
CBXCenrod_0973 Cenrod_0974 Cenrod_0975 Cenrod_0976
HPSEHPF_01495(hoxF) HPF_01500(hoxU) HPF_01505(hoxY) HPF_01510(hoxH)
HTNKI616_01590 KI616_01595 KI616_01600 KI616_01605
CBAASRAA_1133(hoxF) SRAA_1134(hoxU) SRAA_1135(hoxY) SRAA_1136(hoxH)
CBABSMCB_1158(hoxF) SMCB_1159(hoxU) SMCB_1160(hoxY) SMCB_1161(hoxH)
LCHLcho_1459 Lcho_1460 Lcho_1461 Lcho_1462
AONDEH84_12670 DEH84_12675 DEH84_12680 DEH84_12685
IDCLRM40_10405 LRM40_10410 LRM40_10415 LRM40_10420
NIINit79A3_1351 Nit79A3_1352 Nit79A3_2064 Nit79A3_2065
NCOAAW31_04325 AAW31_04330 AAW31_04335 AAW31_16025
NMUNmul_A1670 Nmul_A1671 Nmul_A1672 Nmul_A1673
NLCEBAPG3_014445 EBAPG3_014450 EBAPG3_014455 EBAPG3_014460
SHDSUTH_02049 SUTH_02050 SUTH_02051 SUTH_02052
METRBSY238_1847(hoxH) BSY238_1848(hoxY) BSY238_1849 BSY238_1850(hoxF)
DOEDENOEST_2269(hoxF) DENOEST_2270(hoxU) DENOEST_2271(hoxY) DENOEST_2272(hoxH)
SLTSlit_1608 Slit_1609 Slit_1610 Slit_1611
GCAGalf_1581 Galf_1582 Galf_1583 Galf_1584
FKUFGKAn22_11130 FGKAn22_11140 FGKAn22_11150 FGKAn22_11160
SEMEMIZ01_1345 MIZ01_1346 MIZ01_1347 MIZ01_1348
SDRSCD_n01600 SCD_n01601 SCD_n01602 SCD_n01603
SULFCAP31_11350 CAP31_11355 CAP31_11360 CAP31_11365
SLACSKTS_26850 SKTS_26860 SKTS_26870 SKTS_26880
DSUDsui_3027 Dsui_3028 Dsui_3029 Dsui_3030
ARESIWH25_15900 IWH25_15905 IWH25_15910 IWH25_15915
AIQAzoinq_01560 Azoinq_01565 Azoinq_01570 Azoinq_01575
NIVJY500_10480 JY500_10485 JY500_10490 JY500_10495 JY500_10500 JY500_10505
APETToN1_38210 ToN1_38220 ToN1_38230 ToN1_38240
RBHB4966_04825 B4966_04830 B4966_04835 B4966_04840
DARDaro_0979 Daro_0980 Daro_0981 Daro_0982
DEYHYN24_11065 HYN24_11070 HYN24_11075 HYN24_11080
QAUKI612_15500 KI612_15505 KI612_15510 KI612_15515
FLEKI610_05085 KI610_05090 KI610_05095 KI610_05100
AZOazo1412(hoxF) azo1413(hoxU) azo1414(hoxY) azo1415(hoxH)
AOAdqs_1536 dqs_1537 dqs_1538 dqs_1539
AZAAZKH_3040(hoxH) AZKH_3041(hoxY) AZKH_3042(hoxU) AZKH_3043(hoxF)
AZIAzCIB_2977 AzCIB_2978 AzCIB_2979 AzCIB_2980
ACOMCEW83_06155 CEW83_06160 CEW83_06165 CEW83_06170
AZDCDA09_16135 CDA09_16140 CDA09_16145 CDA09_16150
AZRCJ010_08800 CJ010_08805 CJ010_08810 CJ010_08815
TMZTmz1t_2247 Tmz1t_2248 Tmz1t_2249 Tmz1t_2250
THUAC731_001620 AC731_001625 AC731_001630 AC731_001635
TCLTchl_2689 Tchl_2690 Tchl_2691 Tchl_2692
THKCCZ27_21350 CCZ27_21355 CCZ27_21360 CCZ27_21365
TAKTharo_1984 Tharo_1985 Tharo_1986 Tharo_1987
AZQG3580_08690 G3580_08695 G3580_08700 G3580_08705
ZPAC3497_04480 C3497_04485 C3497_04490 C3497_04495
FMYHO273_03090 HO273_03095 HO273_03100 HO273_03105
APPCAP2UW1_0998 CAP2UW1_0999 CAP2UW1_1000 CAP2UW1_1001
DDZDSYM_11760 DSYM_11770 DSYM_11780 DSYM_11790
SBALHUE88_04290 HUE88_04295
HEBRAEBR_2775 AEBR_2776
AANAAANAER_2709 AANAER_2710
GSUGSU2718(hoxL) GSU2719(hoxS)
GSKKN400_2661(hoxL) KN400_2662(hoxS)
GMEGmet_1112(hoxS) Gmet_1113(hoxL)
GPIGPICK_12405 GPICK_12410
GEFFO488_14290 FO488_16710
GLOGlov_2791 Glov_2792
DPSDP2211 DP2212
DAKDaAHT2_1418 DaAHT2_1419
DPRDespr_2069 Despr_2070
DOGHP555_12195 HP555_12200
DMLDmul_00910 Dmul_00920
DWDDSCW_32880 DSCW_63760 DSCW_63770
DTIDesti_0341 Desti_0342
SFUSfum_2715 Sfum_2716
MSLMsil_2748 Msil_2749 Msil_2750 Msil_2751
BVRBVIR_497
BLAGBLTE_23460
MBRYB1812_19405 B1812_19410 B1812_19415 B1812_19420
MHEYH2LOC_018240 H2LOC_018245 H2LOC_018250 H2LOC_018255
PLEOOHA_1_03385(hoxH) OHA_1_03386(hoxY) OHA_1_03387(hoxU) OHA_1_03388(hoxF)
HDIHDIA_0428(hoxH) HDIA_0429(hoxY) HDIA_0430(hoxU) HDIA_0431(hoxF)
LAPACP90_05750 ACP90_05755 ACP90_05760 ACP90_05765
LABRCHH27_14885 CHH27_14890 CHH27_14895 CHH27_14900
LABPFJ695_08510 FJ695_08515 FJ695_08520 FJ695_08525
LABTFIU93_11385(hoxF) FIU93_11390(hoxU) FIU93_11395(hoxY) FIU93_11400(hoxH)
LAGGB0E33_17305 B0E33_17310 B0E33_17315 B0E33_17320
TGLHFZ77_16965 HFZ77_16970 HFZ77_16975 HFZ77_16980
RCPRCAP_rcc00761(hoxH)
LCKHN018_25875 HN018_25880 HN018_25885 HN018_25890
RPMRSPPHO_00581 RSPPHO_00582(fdhA)
MAGamb3393 amb3394 amb3395 amb3396
MAGXXM1_4287(hoxH) XM1_4288(hoxY) XM1_4289(hoxU) XM1_4290(hoxF)
MAGNWV31_00500 WV31_00505 WV31_00510 WV31_00515
MAESGa0123461_0575 Ga0123461_0576 Ga0123461_0577 Ga0123461_0578
MFNGa0123462_1687 Ga0123462_1688 Ga0123462_1689 Ga0123462_1690
HTLHPTL_1420(hoxF) HPTL_1421(hoxU) HPTL_1422(hoxY) HPTL_1423(hoxH)
MCOOMCOO_35620 MCOO_35630 MCOO_35640 MCOO_35650
MGAUMGALJ_01620 MGALJ_01630 MGALJ_01640 MGALJ_01650
MMAMK3U93_06395 K3U93_06400 K3U93_06405 K3U93_06410
MVAMvan_4113 Mvan_4114 Mvan_4115 Mvan_4116
MRHMycrhN_0019 MycrhN_0020 MycrhN_0021 MycrhN_0022
MDRMDOR_09760 MDOR_09770 MDOR_09780 MDOR_09790
MMORMMOR_48320 MMOR_48330 MMOR_48340 MMOR_48350
MGADMGAD_22340 MGAD_22350 MGAD_22360 MGAD_22380(nuoF_1)
MHEVMHEL_07680 MHEL_07690 MHEL_07700 MHEL_07710
MAUBMAUB_05680 MAUB_05690 MAUB_05700 MAUB_05710
MPOFMPOR_21560 MPOR_21570 MPOR_21580 MPOR_21590
CDPCD241_0616
CDHCDB402_0590
CDTCDHC01_0615
CDECDHC02_0622
CDRCDHC03_0600
CDZCD31A_0680
CDBCDBH8_0638
CDSCDC7B_0631
CDDCDCE8392_0625
CDVCDVA01_0563
CDIPERS451417_00613(hoxH)
CCHOCCHOA_09905
XYLET495_13970
AUSIPK37_03790 IPK37_03795 IPK37_06285 IPK37_06290 IPK37_06295 IPK37_06300
RAINRai3103_04820
MCUHMPREF0573_10777
SYNsll1224(hoxY) sll1226(hoxH)
SYZMYO_115290(hoxH) MYO_115320(hoxY)
SYYSYNGTS_1516(hoxH) SYNGTS_1519(hoxY)
SYTSYNGTI_1516(hoxH) SYNGTI_1519(hoxY)
SYSSYNPCCN_1515(hoxH) SYNPCCN_1518(hoxY)
SYQSYNPCCP_1515(hoxH) SYNPCCP_1518(hoxY)
SYJD082_26240(hoxH) D082_26260(hoxY)
SYOC7I86_07865 C7I86_07880
SYCsyc1554_d(hoxY) syc1555_d(hoxH)
SYUM744_03425 M744_03430
SYFSynpcc7942_2555 Synpcc7942_2556
SYPSYNPCC7002_A0198(hoxY) SYNPCC7002_A0200(hoxH)
SYVAWQ23_01170 AWQ23_01180
SYLAWQ21_01010 AWQ21_01020
SYNCCB0101_04265 CB0101_04270
CGCCyagr_3405 Cyagr_3406
CYICBM981_1702(hoxH) CBM981_1703(mvhG)
AMRAM1_D0183 AM1_D0187(hoxH)
LSCKIK02_12040 KIK02_12050
LSKJ5X98_11265 J5X98_11280
PSERABRG53_3999(hoxH) ABRG53_4000(hoxY)
GEEGM3708_1653 GM3708_1655
MARMAE_14210(hoxH) MAE_57940(hoxY)
MPKVL20_1799 VL20_893
MIQB5D77_17565 B5D77_18430
MVZmyaer102_30120(hoxY) myaer102_48120(hoxH)
CANCyan10605_3472 Cyan10605_3475
HAOPCC7418_3034 PCC7418_3035
CYTcce_2315(hoxH) cce_2316(hoxY)
CYPPCC8801_0095 PCC8801_0096
CYHCyan8802_0092 Cyan8802_0093
CYCPCC7424_4160 PCC7424_4163
CYJCyan7822_3465 Cyan7822_3467
CYNCyan7425_4043 Cyan7425_4046
ARPNIES39_L04020(hoxH) NIES39_L04030(hoxY)
PAGHNIES204_36890(hoxY) NIES204_36900(hoxH)
OXYHCG48_12735 HCG48_12745
LFSHFV01_05495 HFV01_05500
MICMic7113_3066 Mic7113_3067
GEIGEI7407_1930 GEI7407_1931
OACOscil6304_5912 Oscil6304_5913
ONIOsc7112_1440 Osc7112_1441
PHORJWS08_06405 JWS08_06410
ANAalr0764(hoxY) alr0766(hoxH)
NOSNos7107_2359 Nos7107_2361
NOPNos7524_1730 Nos7524_1733
NONNOS3756_41980 NOS3756_42000
NOECLI64_10570 CLI64_10580
NSHGXM_09291 GXM_09296
NEDHUN01_33345 HUN01_33360
AVAAva_4659 Ava_4661
NAZAazo_4256
ANBANA_C11895 ANA_C11897(hoxY)
ACYAnacy_4251 Anacy_4253
AWAAA650_20930
ANNEH233_26655 EH233_26665
RSINB6N60_02900 B6N60_02902
FISFIS3754_15960 FIS3754_37110
NSPBMF81_04255(hoxH) BMF81_04256(hoxY)
DOUBMF77_04008(hoxY) BMF77_04010(hoxH)
DFSHGD76_18045 HGD76_18055
CCURIAR63_16620 IAR63_16630
AFLOHEQ12_10780 HEQ12_10790
TOQHCG51_25730 HCG51_25735
NCNBZZ01_04265 BZZ01_04275
CTHEChro_1832 Chro_1833
PLPPle7327_2684 Ple7327_2685
STANSTA3757_00070 STA3757_00080
RRSRoseRS_3539 RoseRS_3540
RCARcas_1367 Rcas_1368
CAUCaur_1187 Caur_1188
CHLChy400_1300 Chy400_1301
CAGCagg_2476 Cagg_2477
ATMANT_09660(hoxH) ANT_09670(hoxY) ANT_12540(hoxY) ANT_12550(hoxH)
PSUBPelsub_P1691 Pelsub_P1919 Pelsub_P1920
CAPCLDAP_28460(hoxH) CLDAP_28470(hoxY)
PBFCFX0092_A0141(hoxY) CFX0092_A0142(hoxH)
ULIETAA1_62340(hoxH) ETAA1_62350(hoxY)
TSPHKIH39_06275 KIH39_06280 KIH39_06285 KIH39_06290
PBORBSF38_02026(hoxH_1) BSF38_03469(hoxY) BSF38_03470
AGVOJF2_55700(hoxY) OJF2_55710(hoxH)
PBASSMSP2_00049(hoxF)
VBLL21SP4_01307(hoxF)
TAERGT409_14275
ABASACPOL_5874 ACPOL_5875
SUSAcid_5015 Acid_5016
PFERIRI77_00830 IRI77_00835
IPOIlyop_1220 Ilyop_1221
ACOAmico_1553 Amico_1554
TLITlie_1615 Tlie_1616
AMOAnamo_1675 Anamo_1676
TTZFHG85_09665
BLQL21SP5_00831(hoxF)
DORIFH5T_02920
DRCG0Q07_16465
MCOSGM418_20640
ASXCDL62_11525
MBASALGA_3124
FLSGLV81_05460 GLV81_05465
LUTLupro_04090 Lupro_04095 Lupro_04100
SHYRLA303_06855 LA303_06860 LA303_06865 LA303_06870
IALIALB_0256
MROMROS_2487 MROS_2488
DINSelin_1985 Selin_2008
CNICalni_1551 Calni_1552
DTHDICTH_1782 DICTH_1783
DTUDtur_0077 Dtur_0078
BANABARAN1_0492(hoxH) BARAN1_0493(hoxY)
BIHBIP78_1100 BIP78_1101
HUTHuta_2101 Huta_2102
HTIHTIA_1873(hoxH)
HALAHrd1104_12735 Hrd1104_12740
HDSHSR122_2945(frhG2) HSR122_2946(frhA2)
HARCHARCEL1_01240 HARCEL1_01245
 » show all
Reference
1  [PMID:13968752]
  Authors
BONE DH, BERNSTEIN S, VISHNIAC W.
  Title
Purification and some properties of different forms of hydrogen dehydrogenase.
  Journal
Biochim Biophys Acta 67:581-8 (1963)
DOI:10.1016/0006-3002(63)91868-7
Reference
2  [PMID:186126]
  Authors
Schneider K, Schlegel HG
  Title
Purification and properties of soluble hydrogenase from Alcaligenes eutrophus H 16.
  Journal
Biochim Biophys Acta 452:66-80 (1976)
DOI:10.1016/0005-2744(76)90058-9
Other DBs
ExplorEnz - The Enzyme Database: 1.12.1.2
IUBMB Enzyme Nomenclature: 1.12.1.2
ExPASy - ENZYME nomenclature database: 1.12.1.2
BRENDA, the Enzyme Database: 1.12.1.2
CAS: 9027-05-8

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