KEGG ENZYME: 1.12.1.3

ENZYME: 1.12.1.3

Entry

EC 1.12.1.3                 Enzyme

Name

hydrogen dehydrogenase (NADP+);
NADP+-linked hydrogenase;
NADP+-reducing hydrogenase;
hydrogenase (ambiguous);
hydrogenase I (ambiguous)

Class

Oxidoreductases;
Acting on hydrogen as donor;
With NAD+ or NADP+ as acceptor

Sysname

hydrogen:NADP+ oxidoreductase

Reaction(IUBMB)

H2 + NADP+ = H+ + NADPH [RN:R07181]

Reaction(KEGG)

R07181

Substrate

H2 [CPD:C00282];
NADP+ [CPD:C00006]

Product

H+ [CPD:C00080];
NADPH [CPD:C00005]

Comment

The protein from the bacterium Desulfovibrio fructosovorans is an iron-sulfur protein that exclusively functions as a hydrogen dehydrogenase [1], while the enzyme from the archaeon Pyrococcus furiosus is a nickel, iron, iron-sulfur protein, that is part of a heterotetrameric complex where the alpha and delta subunits function as a hydrogenase while the beta and gamma subunits function as sulfur reductase (EC 1.12.98.4, sulfhydrogenase). Different from EC 1.12.1.5, hydrogen dehydrogenase [NAD(P)+].

History

EC 1.12.1.3 created 2002, modified 2013

Orthology

K17992

NADP-reducing hydrogenase subunit HndB

K17993

sulfhydrogenase subunit alpha

K17994

sulfhydrogenase subunit delta

K18330

NADP-reducing hydrogenase subunit HndA

K18331

NADP-reducing hydrogenase subunit HndC

K18332

NADP-reducing hydrogenase subunit HndD

Genes

BHO:

D560_2878

BHM:

D558_2856

OCA:

OCAR_5286

OCG:	OCA5_c26870

OCO:	OCA4_c26860

RRF:

F11_01565

GPI:	GPICK_09395

GEB:	GM18_1856 GM18_1857 GM18_1858 GM18_1859

GEO:	Geob_0218(bamH-1) Geob_0234(bamH-2)

PCA:	Pcar_1602(hndA-3) Pcar_1603(hndB-3) Pcar_1604(hndC-3) Pcar_1605(hndD-3) Pcar_1633(hndD-2) Pcar_1634(hndC-2) Pcar_1635(hndB-2) Pcar_1636(hndA-2) Pcar_1844(hndC-1) Pcar_1845(hndB-1) Pcar_1846(hndA-1) Pcar_2708(hndC-5)

PACE:

A6070_04705 A6070_07085 A6070_07090 A6070_07095 A6070_07100 A6070_07285 A6070_07950 A6070_07955 A6070_07960 A6070_07965 A6070_09010

PEF:	A7E78_02215 A7E78_02220 A7E78_02225 A7E78_02230 A7E78_06775 A7E78_06780

PPD:	Ppro_3516 Ppro_3517 Ppro_3518

DMA:	DMR_02450 DMR_02460 DMR_02470(nuoF) DMR_02480

DCB:	C3Y92_00825 C3Y92_00830 C3Y92_00835 C3Y92_00840

DAL:

Dalk_2271

DAT:	HRM2_16520

DTO:	TOL2_C03720(bamH1) TOL2_C28870 TOL2_C28900 TOL2_C41380(bamH2) TOL2_C43510(bamH3)

DOV:	DSCO28_20310 DSCO28_66020

DALK:

DSCA_31590 DSCA_31610

DML:	Dmul_28600(nuoF3) Dmul_34230(morB)

DLI:	dnl_05790 dnl_18600 dnl_18610(nuoF) dnl_49300

DMM:	dnm_042000(nuoF1) dnm_042010 dnm_042020

DEK:	DSLASN_10770 DSLASN_26630 DSLASN_26640 DSLASN_26650 DSLASN_26660

SAT:	SYN_00152 SYN_01370

DTI:	Desti_1918 Desti_2752 Desti_2753

SFU:

Sfum_0844

DAX:	FDQ92_01160(nuoF)

DBR:	Deba_0481 Deba_0785 Deba_1519 Deba_1520 Deba_2120

THET:

F1847_07590

TNR:	Thena_1510

TACI:

TDSAC_1040

OTE:

Oter_1545

SLOM:

PXH66_06815

OBA:	ASA1KI_43220

MKC:

kam1_1223

VBS:	EGM51_01930(nuoF) EGM51_01935

TTF:	THTE_2881 THTE_3843

KST:	KSMBR1_0596(nuoF_1) KSMBR1_1330(nuoF_2)

BROC:

IPI25_00220(nuoE) IPI25_07695(nuoF)

PBU:	L21SP3_00034(hndD_1) L21SP3_00309(hndD_2) L21SP3_00310(hndC_3)

PBP:	STSP1_00009(hndD_1) STSP1_00010(hndC_1) STSP1_01250(hndD_2)

PBAS:

SMSP2_01580(hndB) SMSP2_01581(hndC_2) SMSP2_01582(hndD_2) SMSP2_01657(hndD_3)

ALUS:

STSP2_01432(hndB) STSP2_01433(hndC) STSP2_01434(hndD)

VBL:	L21SP4_00378 L21SP4_00379 L21SP4_00380 L21SP4_01302(hndD_2)

TAER:

GT409_10650 GT409_10655 GT409_10660 GT409_14290

VAI:	BU251_02010 BU251_02015 BU251_02020

TBE:	Trebr_0332 Trebr_0333

TPI:	TREPR_3595

TPED:

TPE_0917 TPE_2309

TPK:	JO40_11355

TRZ:	GWP43_12150

TRC:	DYE49_00610 DYE49_00615 DYE49_00620

TRP:	ABH09_11120 ABH09_11130

BPAA:

K7I13_10510 K7I13_10520

SSM:	Spirs_0474 Spirs_3688 Spirs_3689

STA:	STHERM_c06260 STHERM_c13740 STHERM_c13750 STHERM_c13760

STQ:	Spith_1507 Spith_1508 Spith_1509

SFC:	Spiaf_1750 Spiaf_2407 Spiaf_2409

SPER:

EW093_05445 EW093_05450

SLR:	L21SP2_0274 L21SP2_0275

OCK:	EXM22_15350 EXM22_15355(nuoF) EXM22_15360

ECUL:

PVA46_04200

ENEM:

PVA44_05530

EET:	PVA45_05775

SBU:	SpiBuddy_2313 SpiBuddy_2314

SGP:	SpiGrapes_2477 SpiGrapes_2478

SASS:

MUG09_08965 MUG09_12690 MUG09_12700

SCC:	Spico_0354

TAZ:	TREAZ_3248 TREAZ_3249

SCD:	Spica_2775

BHC:	JFL75_09000 JFL75_09005

TPX:	Turpa_2746

BHY:	BHWA1_02502(hymC) BHWA1_02503(nuoF)

BHD:	BHYOB78_03730 BHYOB78_03735

BRM:

Bmur_2160

BIP:	Bint_0726(hymC) Bint_0727(nuoF)

BHP:	BHAMNSH16_10855 BHAMNSH16_10860

TAQU:

KDW03_01340 KDW03_01350

GEX:	GETHOR_22120

GEP:	Q9293_03605 Q9293_13405 Q9293_13410(nuoE)

GET:	QOZ81_000696 QOZ81_002489

MSIL:

METEAL_03840 METEAL_13880 METEAL_13890 METEAL_24020

MSEA:

METESE_03910 METESE_12970 METESE_17730

EMI:	Emin_0532 Emin_0533

EPO:	Epro_0734(hydA) Epro_0735(hydB) Epro_0736

BTH:	BT_0123 BT_0124 BT_0125

BTHO:

Btheta7330_03239(hndC) Btheta7330_03240(hndD) Btheta7330_03241(hndA)

BXY:	BXY_41360 BXY_41370 BXY_41380

BOA:	Bovatus_04980(hndA) Bovatus_04981(hndD) Bovatus_04982(hndC)

BCEL:

BcellWH2_04988(hndC) BcellWH2_04989(hndD) BcellWH2_04990(hndA)

BCAC:

CGC64_09630 CGC64_09635 CGC64_09640

BHF:	C3V43_03950 C3V43_03955 C3V43_03960

BIS:	DXK01_013735 DXK01_013740 DXK01_013745(nuoE)

BFE:	K6V30_13375(nuoE) K6V30_13380 K6V30_13385

BNO:	K8P02_07460 K8P02_07465 K8P02_07470

BFC:	BacF7301_14380(nuoE) BacF7301_14385 BacF7301_14390

BSAL:

K6V25_15505(nuoF) K6V25_15510 K6V25_15515(nuoE)

BVU:

BVU_0396

PBT:	ING2E5B_2397 ING2E5B_2398(hndC) ING2E5B_2399(hndD) ING2E5B_2400

PMUC:

ING2E5A_0853(hndB) ING2E5A_0854(hndC) ING2E5A_0855(hndD) ING2E5A_0856(hndA)

PET:	PEIBARAKI_6525 PEIBARAKI_6526 PEIBARAKI_6527 PEIBARAKI_6528

PSAC:

PSM36_3019 PSM36_3020(hndD) PSM36_3021(hndC) PSM36_3022

PROJ:

KDN43_02040(nuoE) KDN43_02045 KDN43_02050(nuoF) KDN43_02055 KDN43_02090

PDI:	BDI_1042 BDI_1043 BDI_1044 BDI_1045

PARC:

CI960_08930 CI960_08935 CI960_08940 CI960_08945

PMER:

INE87_00694(hndA) INE87_00695(hndD) INE87_00696(hndC) INE87_00697(hndB)

PGOL:

K6V26_09170 K6V26_09175 K6V26_09180 K6V26_09185

PJO:	LK449_07260 LK449_07265 LK449_07270 LK449_07275

PFAI:

NXY11_08570 NXY11_08575 NXY11_08580 NXY11_08585

OSP:	Odosp_0184 Odosp_0185 Odosp_0186 Odosp_0187

BUY:	D8S85_07440 D8S85_07445 D8S85_07450 D8S85_07455

BVIR:

I6J59_09400 I6J59_09405 I6J59_09410 I6J59_09415

BFH:	F1611_03285 F1611_03290 F1611_03295 F1611_03300

RBC:	BN938_1638 BN938_2212 BN938_2258

TTZ:	FHG85_08335 FHG85_08495 FHG85_09610(nuoE) FHG85_09615 FHG85_09620 FHG85_09625 FHG85_09660

BLQ:	L21SP5_00769(hndB) L21SP5_00770(hndC_2) L21SP5_00771(hndD_1) L21SP5_00772(hndA_2) L21SP5_00830(hndD_2)

BACC:

BRDCF_p1395(nuoE2) BRDCF_p1396(nuoG) BRDCF_p1397(nuoF2) BRDCF_p1398 BRDCF_p1719

DORI:

FH5T_02925 FH5T_03065 FH5T_03070 FH5T_03075 FH5T_03080

DRC:	G0Q07_16470 G0Q07_16595 G0Q07_16600 G0Q07_16605 G0Q07_16610

MCOS:

GM418_18965 GM418_18970 GM418_18975 GM418_18980 GM418_20635

ANF:	AQPE_3191 AQPE_3192 AQPE_3193 AQPE_3194 AQPE_5015

HLAM:

K4L44_02470 K4L44_02475 K4L44_02480 K4L44_02485

HXY:	K5X82_16770 K5X82_16775 K5X82_16780 K5X82_16785

ASX:	CDL62_11530 CDL62_11585 CDL62_11590 CDL62_11595 CDL62_11600

MBAS:

ALGA_2626 ALGA_2627 ALGA_2628 ALGA_2629 ALGA_3125

FLS:	GLV81_05450

LUT:	Lupro_00310

IAL:	IALB_0531(hydA)

MRO:

MROS_2482

CACI:

CLOAM1181 CLOAM1183(hymB) CLOAM1184

CPO:	COPRO5265_0177 COPRO5265_0179 COPRO5265_0180 COPRO5265_0181

CEX:	CSE_11940 CSE_11960 CSE_11970

CNI:	Calni_1549

CABY:

Cabys_3677 Cabys_3678

DTH:	DICTH_0768

DTU:

Dtur_0918

TYE:	THEYE_A1727

TOB:	V4D31_06035

TAUT:

V4D30_01355

DTP:	JZK55_05510 JZK55_11800 JZK55_21900 JZK55_21910 JZK55_21920

NLI:	G3M70_15045

ALAM:

RT761_02739(hndD_2)

TVX:	QBE54_04025 QBE54_04045

PAEQ:

R50912_06580 R50912_06585

PAEA:

R70723_15795 R70723_15800

PAEE:

R70331_15235 R70331_15240

PBAC:

HUB98_24435

PTJ:	JRJ22_12795(nuoF) JRJ22_12800

LRN:	CMV25_02440 CMV25_02445

EGV:	EGCR1_07010 EGCR1_07015

EAV:	EH197_17435(nuoF) EH197_17440

ERAF:

J9537_09250(nuoF) J9537_09255

EMS:	P3T75_07410

CBK:

CLL_A2000

CBT:	CLH_1604 CLH_1644

CBE:

Cbei_1773

CBZ:

Cbs_1773

CBEI:

LF65_01916 LF65_03652

CLJ:	CLJU_c07040

CCB:	Clocel_2588

CLS:	CXIVA_00910 CXIVA_06850 CXIVA_14930 CXIVA_16350 CXIVA_21460(NuoF) CXIVA_23660 CXIVA_23670(NuoF) CXIVA_23680 CXIVA_23700(NuoE)

CLB:	Clo1100_0751 Clo1100_2676 Clo1100_2677 Clo1100_2678 Clo1100_2680

CSR:	Cspa_c24540 Cspa_c33070(hndD1) Cspa_c35380 Cspa_c47550(nuoF)

CPAT:

CLPA_c34400(hndC)

CPAE:

CPAST_c34400(hndC)

CSB:	CLSA_c23760(hndD)

CAH:	CAETHG_2795

CSQ:

CSCA_4946

CACE:

CACET_c32700 CACET_c32710 CACET_c32730 CACET_c32740 CACET_c35720(nuoG) CACET_c35740

CCK:	Ccar_16070

CTAE:

BGI42_08165

CFM:	BJL90_01765 BJL90_01780 BJL90_01785

CDRK:

B9W14_20080

CIA:	BEN51_01050 BEN51_03310

CDY:	F3K33_08790

CFER:

D4Z93_04800

CLOS:

DMR38_03370

CCAA:

KQH81_00505

CNN:

CNEO_2610

CGEL:

psyc5s11_20550 psyc5s11_26420

CINT:

HZF06_14260

CTHD:

CDO33_16050 CDO33_16055 CDO33_16060 CDO33_16070

CALE:

FDN13_01610 FDN13_01615(nuoF) FDN13_01620 FDN13_10460 FDN13_12880 FDN13_12885

CALD:

PWK10_05325 PWK10_05335 PWK10_13980

CRS:	FQB35_03905 FQB35_03910(nuoF) FQB35_03915 FQB35_11220 FQB35_14710

CPRF:

K7H06_03105 K7H06_03110(nuoF) K7H06_03115 K7H06_03125 K7H06_03130(nuoF) K7H06_03135 K7H06_11915 K7H06_17800

CRAS:

KVH43_01525 KVH43_01530(nuoF) KVH43_01535 KVH43_05375

OCW:	OW730_18890

PROQ:

P6M73_16520

CTH:	Cthe_0338 Cthe_0340 Cthe_0341 Cthe_0342

CTX:	Clo1313_1881 Clo1313_1882 Clo1313_1883 Clo1313_1885

CCL:	Clocl_1309 Clocl_1311 Clocl_1312 Clocl_1313

HSC:	HVS_11610(hndB1) HVS_12575(hndD2) HVS_12580(hndC2) HVS_12585(hndB2) HVS_12595(hndA2)

CCE:	Ccel_2232 Ccel_2233 Ccel_2234 Ccel_2236 Ccel_2467

RHER:

EHE19_005425(nuoE) EHE19_005435 EHE19_005440(nuoF) EHE19_005445

RPAY:

P0092_04420 P0092_15145 P0092_15150(nuoF) P0092_15155 P0092_15165(nuoE)

CSS:	Cst_c09400(nuoE) Cst_c09420 Cst_c09430(nuoF2) Cst_c09440

CSD:	Clst_0900(fhbA) Clst_0902(fdx1) Clst_0903(fhbB) Clst_0904(fhbC)

FPLA:

A4U99_00370 A4U99_03555 A4U99_03560 A4U99_03565

EHA:	Ethha_2293

RAL:	Rumal_2964 Rumal_2965

RCH:	RUM_16060 RUM_16080 RUM_16090 RUM_16100

OVA:

OBV_29610

SMAN:

C12CBH8_13120 C12CBH8_13130 C12CBH8_13140 C12CBH8_13160

ACOL:

K5I23_04445 K5I23_04450

LASA:

L9O85_09690 L9O85_09700

PETR:

QKW49_00175 QKW49_00180(nuoF) QKW49_00185 QKW49_16100 QKW49_20025

PALM:

RBG61_01760(nuoF) RBG61_01765

RUK:	A4V00_14230 A4V00_14235 A4V00_14240

ESR:	ES1_19890 ES1_19910 ES1_19930

ESU:	EUS_11280 EUS_11300 EUS_11320

CCEL:

CCDG5_0742 CCDG5_0743(hndC) CCDG5_0744(hndD)

CAPR:

EQM14_01110

CFEM:

HCR03_13575

AMUR:

ADH66_14095 ADH66_14100 ADH66_14105

AGAT:

RWV98_11875

STH:

STH3209

SWO:	Swol_0784 Swol_1017 Swol_1701 Swol_2436

SLP:	Slip_0124 Slip_0125 Slip_0543 Slip_2098

SALQ:

SYNTR_0507 SYNTR_1606 SYNTR_1607

SGY:	Sgly_2185 Sgly_2914

DED:	DHBDCA_p1588(hymB) DHBDCA_p1589 DHBDCA_p1590(hymA) DHBDCA_p1640 DHBDCA_p874(hymC)

DEC:	DCF50_p1598(hymB) DCF50_p1599 DCF50_p1600(hymA) DCF50_p1649 DCF50_p933(hymC)

DRS:	DEHRE_08805 DEHRE_11740 DEHRE_11745 DEHRE_11750 DEHRE_11890 DEHRE_12025

DCA:	Desca_1017 Desca_1224 Desca_1225 Desca_1997 Desca_1998

PTH:	PTH_1377 PTH_1378(NuoF) PTH_2010

DRM:	Dred_0463 Dred_1651 Dred_1652

DRU:	Desru_0515 Desru_0516 Desru_2397 Desru_2398 Desru_3431

DFG:	B0537_03245 B0537_07840 B0537_07845

DAE:	Dtox_0172 Dtox_0173 Dtox_0174 Dtox_0176 Dtox_3504 Dtox_3829 Dtox_3830

DKU:	Desku_0995 Desku_1528 Desku_2307 Desku_2308 Desku_2309 Desku_2311 Desku_2934

DAU:	Daud_0109 Daud_0152 Daud_1338 Daud_1548 Daud_1923

TFR:	BR63_13425 BR63_13430(nuoF) BR63_13435 BR63_13440(nuoE) BR63_18510 BR63_18515 BR63_18520

FWA:	DCMF_01595 DCMF_07650 DCMF_07660 DCMF_07665 DCMF_20805

TJR:	TherJR_0743 TherJR_2550 TherJR_2551 TherJR_2552

DGI:	Desgi_1115 Desgi_1983 Desgi_2137

HMO:	HM1_1029(nuoG)

HCV:	FTV88_2333 FTV88_2334 FTV88_2507 FTV88_2509

ELM:	ELI_0845 ELI_0846 ELI_0847

EMT:	CPZ25_017165 CPZ25_017170 CPZ25_017175

ELIM:

B2M23_11915 B2M23_11925 B2M23_11930 B2M23_11935

AWO:	Awo_c26970(hydA1) Awo_c26980(hydB) Awo_c26990(hydD)

AWI:	CHL1_000834 CHL1_000835(nuoF) CHL1_000836

ALKA:

J0B03_01890 J0B03_02965 J0B03_03015

ACAE:

HYG86_02045(nuoF) HYG86_02050 HYG86_03675 HYG86_07620

ALAC:

JYE50_07305 JYE50_07315

AHC:	JYE49_07300 JYE49_07310

CTHM:

CFE_2039 CFE_2040 CFE_2217

IBU:	IB211_00393 IB211_00394 IB211_00395

PROM:

QO263_02380

BPRM:

CL3_28570

BPRS:

CK3_02010

CBAF:

JS518_02080 JS518_02090

CCT:	CC1_10620 CC1_10630 CC1_10640

CCOM:

I6K69_07370

BPRO:

PMF13cell1_04623(hndD_2)

BLAR:

LC508_04225

BHV:	BLHYD_15530 BLHYD_15540(hndD_1)

CPY:	Cphy_2056 Cphy_3801 Cphy_3803 Cphy_3804 Cphy_3805

LACY:

A4V08_01515 A4V08_10155 A4V08_10160 A4V08_10165

CSCI:

HDCHBGLK_00083(hndD_1) HDCHBGLK_00084(hndC_1) HDCHBGLK_00085(hndB) HDCHBGLK_00087(hndA) HDCHBGLK_00500(hndD_2)

CHYL:

CE91St63_25470 CE91St63_25480 CE91St63_25490 CE91St63_29810

CSH:	Closa_3390 Closa_3392 Closa_3393 Closa_3394

CSO:

CLS_02870

LXA:	OW255_17365 OW255_17370(nuoF) OW255_17375

BPRL:

CL2_24320

ARF:	AR1Y2_2834

ACAC:

EYQ97_04130

HSD:	SD1D_2323 SD1D_2324(hndC) SD1D_2325(hndD)

LUA:	D4A81_12960

EHL:	EHLA_0358 EHLA_2242

ANR:	Ana3638_06225 Ana3638_06230(nuoF) Ana3638_06235

ACEL:

acsn021_01000 acsn021_01010 acsn021_01020 acsn021_01040

ACHT:

bsdcttw_47950 bsdcttw_47960 bsdcttw_47970

EEL:	EUBELI_00201

RTO:

RTO_15320

CBOL:

CGC65_22485 CGC65_22490 CGC65_22495 CGC65_22580

CASP:

NQ535_07105 NQ535_07135 NQ535_07140(nuoF) NQ535_07145

ECLF:

QMP25_09335 QMP25_38670 QMP25_38675(nuoF) QMP25_38680

AHB:	bsdtb5_26960 bsdtb5_26970

CBIL:

EUBC25_21330 EUBC25_21340 EUBC25_21350

HHJ:	NQ487_13200 NQ487_25765 NQ487_25770(nuoF) NQ487_25775 NQ487_26355

LBW:	C3V36_13275 C3V36_13280 C3V36_13285

LBX:	lbkm_2368 lbkm_3446 lbkm_3447 lbkm_3448

CLE:	Clole_2394 Clole_2395 Clole_2396 Clole_2397

CEW:	EKH84_14585 EKH84_14590 EKH84_14595

CBAR:

PATL70BA_1019(hndD) PATL70BA_1020(hndC) PATL70BA_1021 PATL70BA_2848(hndD)

VGU:	HYG85_00670 HYG85_10350 HYG85_10355 HYG85_10360 HYG85_15080 HYG85_15085 HYG85_15090

VPY:	HZI73_02030 HZI73_02035 HZI73_02040 HZI73_06730 HZI73_11280 HZI73_22865 HZI73_22870 HZI73_22875 HZI73_22880

MDV:	C5Q96_03535 C5Q96_03540

MNL:	QU661_05090 QU661_05095(nuoF)

ETM:	CE91St48_32250

EMJ:	V1225_14350 V1225_14375

AMT:	Amet_0638 Amet_0639 Amet_0640 Amet_4100 Amet_4101 Amet_4109

GFE:	Gferi_09405 Gferi_20695 Gferi_20705 Gferi_20765 Gferi_20770 Gferi_22870 Gferi_22875

CSPO:

QNI18_01045 QNI18_01055 QNI18_03795

PBIF:

KXZ80_11255

PSOR:

RSJ16_04570 RSJ16_12970

ROC:	HF520_03830

RIL:

CRIB_1054

RHOM:

FRIFI_1132 FRIFI_1310

PHX:	KGNDJEFE_00571(hndD)

TEM:	JW646_04820

TGC:	L0P85_03540

TMY:	TEMA_38980(rsxB_6)

TPET:

TPHSE_09090(rsxB_2)

TEB:	T8CH_1954(hndD) T8CH_2293(hndD) T8CH_3077(hndD)

THYR:

P4S50_01025 P4S50_05740

IBR:	NQ514_03810

EAC:	EAL2_808p02660 EAL2_c04310(hymC)

CMIU:

B1H56_03765 B1H56_04375 B1H56_04380 B1H56_04385

TTE:	TTE0892 TTE0893(NuoF) TTE0894(NuoG)

TEX:	Teth514_2138 Teth514_2139 Teth514_2140

THX:	Thet_0795 Thet_0796 Thet_0797

TPD:	Teth39_1456 Teth39_1457 Teth39_1458

TIT:	Thit_0828 Thit_0829 Thit_0830

TMT:	Tmath_0867 Tmath_0868 Tmath_0869

TBO:	Thebr_1491 Thebr_1492 Thebr_1493

TWI:	Thewi_0978 Thewi_0979 Thewi_0980

TKI:	TKV_c19580(hydA1)

THEZ:

OEI98_000982 OEI98_000983(nuoF) OEI98_000984

ADG:	Adeg_0290 Adeg_0332 Adeg_1781 Adeg_1783

TPZ:	Tph_c18450

GEK:	kuro4_25690

TTM:	Tthe_1116 Tthe_1118 Tthe_1119 Tthe_1120

TTO:	Thethe_01060 Thethe_01062 Thethe_01063 Thethe_01064

TXY:	Thexy_1580 Thexy_1581 Thexy_1582 Thexy_1584

TSH:	Tsac_2126 Tsac_2127 Tsac_2128 Tsac_2130

THED:

SAMN05660242_2934 SAMN05660242_2935 SAMN05660242_2936

AAUT:

ACETAC_10975

MAS:	Mahau_1250 Mahau_1252 Mahau_1253 Mahau_1254 Mahau_1381 Mahau_1382

MTA:	Moth_1717 Moth_1718

MTHO:

MOTHE_c17260(hndD1) MOTHE_c17270(hndC1)

MTHZ:

MOTHA_c18090(hndD1) MOTHA_c18100(hndC1)

MHUI:

MHLNE_17410(hndD_2)

TEP:	TepRe1_1888 TepRe1_1889 TepRe1_1890

TAE:	TepiRe1_2033(hndD) TepiRe1_2034(hndC) TepiRe1_2035

BACG:

D2962_10795(nuoE) D2962_10805 D2962_10815

TOC:	Toce_0693 Toce_0695 Toce_0696 Toce_0697

NTH:	Nther_0098 Nther_0099 Nther_0703

NCD:	ACONDI_00300(hndD) ACONDI_02921(hndB_2)

HOR:	Hore_06320 Hore_06330

HAS:	Halsa_1862 Halsa_1863 Halsa_1864 Halsa_1866

HPK:	Hprae_1627 Hprae_1628 Hprae_1629 Hprae_1631

HALS:

D7D81_01595 D7D81_01605 D7D81_17425

IFN:	GM661_14115 GM661_14135 GM661_17630 GM661_17640

AAR:	Acear_0268 Acear_0269 Acear_0270 Acear_0271 Acear_0532 Acear_0982 Acear_1883 Acear_1884 Acear_2301 Acear_2302

HHL:	Halha_0376 Halha_0377 Halha_2285 Halha_2286 Halha_2287 Halha_2289

AFT:	BBF96_04540 BBF96_04550 BBF96_07410 BBF96_07415 BBF96_09125 BBF96_09130 BBF96_09135

KME:	H0A61_01405(hndC_2) H0A61_01871(hndA_4) H0A61_01873(hndB_1) H0A61_01874(hndC_4) H0A61_01875(hndD_3) H0A61_01878(hndA_5) H0A61_01879(hndB_2) H0A61_01881(hndD_4)

HPRF:

HLPR_07960 HLPR_14960

MPEC:

B9O19_02155 B9O19_02156

FMA:

FMG_1155

PMIC:

NW74_03325 NW74_07160

PHAR:

NCTC13077_00350(nqo1)

GBX:	SANA_15110 SANA_22130 SANA_22140

SPOA:

EQM13_17995 EQM13_18000 EQM13_18005

KPAR:

JL105_09265 JL105_10660

CAZO:

G3A45_06540 G3A45_06545 G3A45_11645 G3A45_11650(nuoF) G3A45_11655 G3A45_11715 G3A45_11730

SEDZ:

JYG23_10935(nuoE) JYG23_10940 JYG23_10945(nuoF) JYG23_10950

SEDM:

RBQ61_03360 RBQ61_03370 RBQ61_10420

VRG:	OKW85_02505

MED:

MELS_0888

MEG:	DKB62_05660 DKB62_05665 DKB62_11300

MMAX:

LCQ47_05555

SSG:	Selsp_1525

SRI:	SELR_26360

MHG:

MHY_20970

MFUN:

GXM21_01745 GXM21_01755

SGBI:

P3F81_01335 P3F81_01345 P3F81_02580 P3F81_02600 P3F81_12770

PUF:

UFO1_1386

PFT:	JBW_04037 JBW_04038 JBW_04039

MANA:

MAMMFC1_00410 MAMMFC1_00827(hndD_2) MAMMFC1_00828(hndC_3) MAMMFC1_00830(hndD_3) MAMMFC1_00831(hndC_4) MAMMFC1_00940(hndD_4)

STED:

SPTER_13820(hndD_1) SPTER_13950(sfrA) SPTER_14070(hndB) SPTER_14080(hndC_2) SPTER_14090(hndD_3)

SSPH:

SPSPH_007560(hndD_1) SPSPH_009200(hndA_2) SPSPH_009220(hndD_2) SPSPH_014020(hndD_3) SPSPH_014350(hndB) SPSPH_014370(hndD_4)

SOVA:

SOV_13460(hndD_1) SOV_14580(hndB) SOV_14600(hndD_2) SOV_46430(hndD_4) SOV_46450(hndA_4)

SSID:

SPSIL_016340(hndD_1) SPSIL_018690(hndD_2) SPSIL_019650(hndB) SPSIL_019670(hndD_3) SPSIL_040710(hndD_4)

SACV:

SPACI_001180(hndB_1) SPACI_016200(hndD_1) SPACI_019180(hndD_2) SPACI_019420(hndB_2) SPACI_019440(hndD_3) SPACI_055740(hndD_4)

AFN:	Acfer_1955

AIN:	Acin_2259(nuoG)

PFAC:

PFJ30894_00902(hndB) PFJ30894_00903(hndC) PFJ30894_00904(hndD_1)

BULL:

JOS54_06760

EBM:	SG0102_13030

LCG:	L3BBH23_06690

SMOE:

RGT18_07110

AHQ:	NMU03_11435 NMU03_11445

ERB:	A4V01_20385

CIU:	G4D55_17605

TUR:	AT726_09495 AT726_09500 AT726_09505

TSG:	HLK68_09355 HLK68_09360(nuoF) HLK68_09365

TBB:	J0J69_12740 J0J69_12745(nuoF) J0J69_12750

TFC:	T23_05470 T23_05490

TUK:	VXM77_08890 VXM77_08900

ERM:	EYR00_09750 EYR00_09785 EYR00_09790 EYR00_09795

TSF:	NQ543_04425 NQ543_04430 NQ543_04435

LPIL:

LIP_0871

FCZ:	IMF26_08180 IMF26_08190

CSC:	Csac_1860 Csac_1862 Csac_1863 Csac_1864

ATE:	Athe_1295 Athe_1297 Athe_1298 Athe_1299

COB:	COB47_1258 COB47_1259 COB47_1260 COB47_1262

CHD:	Calhy_1427 Calhy_1428 Calhy_1429 Calhy_1431

COW:	Calow_1086 Calow_1088 Calow_1089 Calow_1090

CKI:	Calkr_1280 Calkr_1282 Calkr_1283 Calkr_1284

CLC:	Calla_0683 Calla_0685 Calla_0686 Calla_0687

CKN:	Calkro_1402 Calkro_1403 Calkro_1404 Calkro_1406

CCHA:

ELD05_06980 ELD05_06985(nuoF) ELD05_06990 ELD05_07000(nuoE)

CDIA:

CaldiYA01_12070 CaldiYA01_12080 CaldiYA01_12090 CaldiYA01_12110

CNAG:

OTJ99_001433 OTJ99_001434(nuoF) OTJ99_001435 OTJ99_001437(nuoE)

CMOR:

OTK00_001330 OTK00_001331(nuoF) OTK00_001332 OTK00_001334(nuoE)

CDAN:

SOJ16_001252(nuoE) SOJ16_001254 SOJ16_001255(nuoF) SOJ16_001256

MANR:

MPAN_008040 MPAN_013430 MPAN_013450

XCL:	G4Z02_04365 G4Z02_06970

MBJ:	KQ51_00322(hndB_1) KQ51_00323(hndC_1) KQ51_00324 KQ51_00791(hndD_1) KQ51_01818(hndB_2) KQ51_01835(nuoG)

TBM:	BK010_06995 BK010_07000 BK010_07005

TBZ:	BK011_07465 BK011_07470 BK011_07475

OLS:	Olsu_0826 Olsu_1006

TIO:	INP52_07055

CGO:	Corgl_0838

CAER:

CSV91_04530

SHI:	Shel_16530

EYY:	EGYY_04050 EGYY_15690

AEQ:

AEQU_2224

AHAT:

ADCFC_00730

ERZ:	ER308_18500

PDX:

Psed_3296

PHH:	AFB00_26060

ATM:	ANT_17790 ANT_17800 ANT_17820

ABAT:

CFX1CAM_1213 CFX1CAM_1215 CFX1CAM_1216

PSUB:

Pelsub_P1914 Pelsub_P1915 Pelsub_P1917

LEK:	hrd7_26600

ABAO:

BEQ56_02675

TTR:

Tter_1539

TAI:	Taci_0147 Taci_0148 Taci_0149 Taci_0150

CPOR:

BED41_00310 BED41_00320 BED41_05425

ACO:	Amico_1557

AMIZ:

RBH88_01835

TLI:	Tlie_1466 Tlie_1619

AMO:	Anamo_0024 Anamo_1679

ARAM:

KAR29_00200 KAR29_00205 KAR29_00210(nuoF) KAR29_00215 KAR29_00255

TMA:	TM0011 TM0201

TMM:	Tmari_0008 Tmari_0199

TMI:	THEMA_03725 THEMA_04745

TMW:	THMA_0007 THMA_0208

TMQ:	THMB_0007 THMB_0208

TMX:	THMC_0007 THMC_0208

TPT:

Tpet_0912

TNP:	Tnap_0642 Tnap_0831

TRQ:	TRQ2_0747 TRQ2_0934

TNA:

CTN_0687

THQ:	T2812B_03795 T2812B_04725

THZ:	CELL2_04735

THR:	TRQ7_03890 TRQ7_04910

TLE:	Tlet_1350 Tlet_1518 Tlet_1521

TTA:	Theth_0092 Theth_1566 Theth_1569

PHY:	AJ81_00105 AJ81_08385 AJ81_08400

TME:	Tmel_1168 Tmel_1171 Tmel_1601

TAF:	THA_1554 THA_1558 THA_1808

THP:	BG95_06645 BG95_06660 BG95_08710

THER:

Y592_06725 Y592_06740 Y592_08815

TFE:	JYK00_00830 JYK00_08075

FNO:	Fnod_0236 Fnod_0991 Fnod_0994

FPE:	Ferpe_0291 Ferpe_0292 Ferpe_1116 Ferpe_1120

FIA:	NA23_01740 NA23_05520(nuoF) NA23_05535

FRR:	IB67_06645 IB67_06650 IB67_08860 IB67_08880

OCY:	OSSY52_17030 OSSY52_21290(hymB) OSSY52_21300 OSSY52_21310

PMO:	Pmob_0724 Pmob_0725 Pmob_0726 Pmob_1149

MPZ:	Marpi_1895 Marpi_1896 Marpi_1897

MARN:

LN42_10050 LN42_10055

MAEO:

JRV97_02895 JRV97_10880

DTN:	DTL3_0214 DTL3_0799(hndD3)

OCS:	OF820_03175 OF820_03180 OF820_12015

KOL:	Kole_0172 Kole_0181 Kole_0184

KPF:	IX53_02690 IX53_02705 IX53_02780

MPG:	Theba_0461 Theba_0464

MINF:

MESINF_2168 MESINF_2171

ASAC:

ATHSA_0551 ATHSA_0552 ATHSA_0845 ATHSA_1936

FVA:	FV113G1_03860(nuoF) FV113G1_03870(nuoG) FV113G1_24290 FV113G1_26580

FUL:	C4N20_00705 C4N20_04455 C4N20_04460 C4N20_10420

FMO:	C4N19_00165 C4N19_03610 C4N19_03615

FGO:	C4N16_04400

FNF:	BSQ88_02970 BSQ88_02975

FHO:	H9Q81_04735

IPO:	Ilyop_0625 Ilyop_0626 Ilyop_0627 Ilyop_0628 Ilyop_0635 Ilyop_0689 Ilyop_0690 Ilyop_2431

CSOM:

MKD34_03080 MKD34_03085 MKD34_03090 MKD34_10650 MKD34_12420

LEO:	AMK43_00690 AMK43_00695 AMK43_00700

STR:	Sterm_0623 Sterm_0624 Sterm_0625 Sterm_3599 Sterm_3600 Sterm_3601

HABY:

HLVA_12340 HLVA_12350 HLVA_12360 HLVA_12370

BANA:

BARAN1_0488 BARAN1_0490(HoxF) BARAN1_0495

BIH:	BIP78_1096 BIP78_1098 BIP78_1103

MOX:

DAMO_0854

FBN:	HY931_01555

PFU:	PF0893 PF0894 PF1331 PF1332

PFI:	PFC_03675 PFC_03680 PFC_05870 PFC_05875

PHO:	PH1292(PH1292) PH1294(PH1294)

PAB:	PAB0640(hydD-2) PAB0641(hydA-2) PAB1786 PAB1787

PYN:	PNA2_1551 PNA2_1553 PNA2_1665 PNA2_1666

PYA:	PYCH_00040 PYCH_00050 PYCH_08370 PYCH_08380

PYS:	Py04_0892 Py04_0893 Py04_1129 Py04_1130

PYC:	TQ32_02785 TQ32_02790 TQ32_03115 TQ32_03120

TKO:	TK2069 TK2070

TON:	TON_0052 TON_0053 TON_0534 TON_0535

TSI:	TSIB_0284 TSIB_0285 TSIB_1522 TSIB_1523

TBA:	TERMP_00069 TERMP_00070 TERMP_00536 TERMP_00537

THE:	GQS_02470 GQS_02475 GQS_04985 GQS_04990

THA:	TAM4_296 TAM4_701 TAM4_99

THM:	CL1_0143 CL1_0144 CL1_0643 CL1_0644

TLT:	OCC_03062 OCC_03067 OCC_12216 OCC_12221

THS:	TES1_0166 TES1_0167

TNU:	BD01_0437 BD01_0438 BD01_2067 BD01_2068

TEU:	TEU_09725 TEU_09730

TGY:	X802_03245 X802_03250 X802_07560 X802_07565

THV:	ADU37_CDS02170 ADU37_CDS02180 ADU37_CDS16280 ADU37_CDS16290

TCH:	CHITON_0949 CHITON_0950 CHITON_1019 CHITON_1020

TPEP:

A0127_05275 A0127_05280 A0127_07135 A0127_07140

TPIE:

A7C91_06185 A7C91_06190 A7C91_08725 A7C91_08730

TGG:	A3K92_08480 A3K92_08485

TCE:	A3L02_00965 A3L02_00970 A3L02_02385 A3L02_02390

TBS:	A3L01_00920 A3L01_00925 A3L01_03415 A3L01_03420

THH:	CDI07_00920 CDI07_00925 CDI07_03355 CDI07_03360

TSL:	A3L11_04675 A3L11_04680 A3L11_07375 A3L11_07380

TTD:	A3L14_02375 A3L14_02380 A3L14_05100 A3L14_05105

TPRF:

A3L09_05685 A3L09_05690 A3L09_05740 A3L09_05745

TRL:	A3L10_03150 A3L10_03155 A3L10_05635 A3L10_05640

TPAF:

A3L08_06480 A3L08_06485

THY:	A3L12_05480 A3L12_05485

TIC:	FH039_02775 FH039_02780 FH039_05970 FH039_05975

TCQ:	TIRI35C_0406(shyA) TIRI35C_0407(shyD) TIRI35C_0918(hydA) TIRI35C_0919(hydD)

THEM:

FPV09_03375 FPV09_03380 FPV09_06575 FPV09_06580

THEI:

K1720_00335 K1720_00340 K1720_04545 K1720_04550

PPAC:

PAP_01490 PAP_01495 PAP_03250 PAP_03255

MCJ:	MCON_3103(nuoF)

HUT:

Huta_2099

HTI:

HTIA_1871

HARC:

HARCEL1_01230

KCR:	Kcr_0321 Kcr_0322

BARB:

AOA66_1503(shyD) AOA66_1504(hydA)

» show all

Reference

1 [PMID:9703971]

Authors

de Luca G, de Philip P, Rousset M, Belaich JP, Dermoun Z

Title

The NADP-reducing hydrogenase of Desulfovibrio fructosovorans: evidence for a native complex with hydrogen-dependent methyl-viologen-reducing activity.

Journal

Biochem Biophys Res Commun 248:591-6 (1998)
DOI:10.1006/bbrc.1998.9022

Sequence

[ag:AAA87054 AAA87055 AAA87056 AAA87057]

Reference

2 [PMID:2538471]

Authors

Bryant FO, Adams MW

Title

Characterization of hydrogenase from the hyperthermophilic archaebacterium, Pyrococcus furiosus.

Journal

J Biol Chem 264:5070-9 (1989)
DOI:10.1016/S0021-9258(18)83701-2

Sequence

[pfu:PF0894 PF0893]

Reference

3 [PMID:8389482]

Authors

Ma K, Schicho RN, Kelly RM, Adams MW

Title

Hydrogenase of the hyperthermophile Pyrococcus furiosus is an elemental sulfur reductase or sulfhydrogenase: evidence for a sulfur-reducing hydrogenase ancestor.

Journal

Proc Natl Acad Sci U S A 90:5341-4 (1993)
DOI:10.1073/pnas.90.11.5341

Reference

Authors

Ma K, Zhou ZH, Adams MW.

Title

Hydrogen production from pyruvate by enzymes purified from the hyperthermophilic archaeon, Pyrococcus furiosus: A key role for NADPH.

Journal

FEMS Microbiol Lett 122:245-250 (1994)

Reference

5 [PMID:18156274]

Authors

van Haaster DJ, Silva PJ, Hagedoorn PL, Jongejan JA, Hagen WR

Title

Reinvestigation of the steady-state kinetics and physiological function of the soluble NiFe-hydrogenase I of Pyrococcus furiosus.

Journal

J Bacteriol 190:1584-7 (2008)
DOI:10.1128/JB.01562-07

Other DBs

ExplorEnz - The Enzyme Database:

1.12.1.3

IUBMB Enzyme Nomenclature:

1.12.1.3

ExPASy - ENZYME nomenclature database:

1.12.1.3

BRENDA, the Enzyme Database:

1.12.1.3

CAS:

9027-05-8

DBGET integrated database retrieval system