KEGG   ENZYME: 1.12.7.2
Entry
EC 1.12.7.2                 Enzyme                                 
Name
ferredoxin hydrogenase;
H2 oxidizing hydrogenase;
H2 producing hydrogenase [ambiguous];
bidirectional hydrogenase;
hydrogen-lyase [ambiguous];
hydrogenase (ferredoxin);
hydrogenase I;
hydrogenase II;
hydrogenlyase [ambiguous];
uptake hydrogenase [ambiguous]
Class
Oxidoreductases;
Acting on hydrogen as donor;
With an iron-sulfur protein as acceptor
Sysname
hydrogen:ferredoxin oxidoreductase
Reaction(IUBMB)
H2 + 2 oxidized ferredoxin = 2 reduced ferredoxin + 2 H+ [RN:R00019]
Reaction(KEGG)
R00019
Substrate
H2 [CPD:C00282];
oxidized ferredoxin [CPD:C00139]
Product
reduced ferredoxin [CPD:C00138];
H+ [CPD:C00080]
Comment
Contains iron-sulfur clusters. The enzymes from some sources contains nickel. Can use molecular hydrogen for the reduction of a variety of substances.
History
EC 1.12.7.2 created 1961 as EC 1.98.1.1, transferred 1965 to EC 1.12.1.1, transferred 1972 to EC 1.12.7.1, transferred 1978 to EC 1.18.3.1, transferred 1984 to EC 1.18.99.1, transferred 2002 to EC 1.12.7.2
Orthology
K00532  ferredoxin hydrogenase
K00533  ferredoxin hydrogenase large subunit
K00534  ferredoxin hydrogenase small subunit
K06441  ferredoxin hydrogenase gamma subunit
K18016  membrane-bound hydrogenase subunit alpha
K18017  membrane-bound hydrogenase subunit beta
K18023  membrane-bound hydrogenase subunit mbhJ
Genes
CAMAF384_12650
SLIGGTU79_09600(nuoB)
SONSO_3920(hydA) SO_3921(hydB)
SHEShewmr4_3250 Shewmr4_3251
SHNShewana3_0710 Shewana3_0711
SHLShal_1408 Shal_1409
SCAATUM17387_33930(hydA) TUM17387_33940(hydB)
SXMMKD32_03735(hydB) MKD32_03740(hydA)
FBLFbal_2054 Fbal_2055
LHKLHK_02328(hydC)
CHIZHQ393_09295
CFONHZU75_11905
SUTKFG381_03575
SWSI6J16_02785 I6J16_10810 I6J16_10815
BBAYA4V04_04850
SUASaut_2037
CRXCRECT_1405 CRECT_1406
SDLSdel_1194
PACOAACT_1247
SUNSUN_0264
SLHYH65_09710
SINUIMZ28_06720
NAMNAMH_1060
NAPC3L23_05405
CMEDFE773_04180 FE773_06940
CPAFC6V80_06065
PCAPcar_2502(hndD-1)
PPDPpro_0594 Ppro_2783 Ppro_2791 Ppro_3524 Ppro_3525
DVEDESUT3_02240
DVUDVU_1769(hydA) DVU_1770(hydB) DVU_1771(hydC)
DVLDvul_0967 Dvul_1384 Dvul_1385 Dvul_1386
DVMDvMF_3192
DVGDeval_1527 Deval_1528 Deval_1529 Deval_2122
DDSDdes_1502 Ddes_1503 Ddes_1882
DFIAXF13_01430 AXF13_01435 AXF13_11600
DPGDESPIGER_1380 DESPIGER_1381 DESPIGER_2247
DEFCNY67_02785 CNY67_09530 CNY67_09535
DTRRSDT_0231(cooL)
DFLDFE_1213 DFE_1214
DSDGD606_03045 GD606_03050 GD606_05420 GD606_05425
DMADMR_12950 DMR_12960
DCBC3Y92_14580 C3Y92_14585
DDEDde_0082 Dde_2280 Dde_2281
DMSE8L03_18925 E8L03_18930
DSADesal_1332 Desal_1333
DHYDESAM_22768(hydB) DESAM_22769(hydA)
DASDaes_0301 Daes_0302 Daes_0598 Daes_0599
DPIBN4_20197(cooL)
PPRFDPRO_0997(hndD) DPRO_0999(hydA) DPRO_1000(hydB)
PSELGM415_17540
PSEFPSDVSF_31440(hydA_2)
DSXGD604_04685 GD604_04690
PBIZLWC08_02130(nuoB) LWC08_02370(nuoB) LWC08_11100 LWC08_11105
DOAAXF15_03285 AXF15_03290
DPSDP0159
DATHRM2_26580(hydA2)
DWDDSCW_39420(hydC)
DALKDSCA_39340(hydC)
DEKDSLASN_44700(hydA_1) DSLASN_44710(hydB_1) DSLASN_44720(hydA_2) DSLASN_44730(hydB_2)
DTIDesti_5160 Desti_5161
RPARPA0134(hydC)
RPCRPC_4504
RPERPE_3860
RPTRpal_0137
RPXRpdx1_0128
BVRBVIR_2957
BLAGBLTE_01200(hydC)
RHCRGUI_3846
RAPRHOA_1102(hndD)
AZLAZL_b04730(nuoB)
ALIAZOLI_p20532(cooL1) AZOLI_p40581(cooL2)
AOZHUE56_08720(nuoB)
RRFF11_01620 F11_07345
BACIB1NLA3E_11400
CACCA_C0028(hydA)
CAESMB_G0028(nuoG)
CAYCEA_G0028(hydA)
CPECPE2346
CPFCPF_2655(hydA)
CPRCPR_2341(hydA)
CTCCTC_02417
CNONT01CX_2259
CBKCLL_A0052
CBNCbC4_1525
CBTCLH_0034
CKLCKL_2257
CKRCKR_1986
CCBClocel_4097
CPASClopa_0056
CPATCLPA_c00280
CPAECPAST_c00280
CSBCLSA_c00340
CLTCM240_0483
CBVU729_1141
CBUTATN24_01590
CTYKCTK_C05160(hydA)
CTAEBGI42_00165
CCHVBTM20_00205
CIABEN51_00210
CSEPCP523_07965
CDYF3K33_11495
CGASJ1C67_05910
CCAAKQH81_17245
CMAHC1I91_09460
CRWCROST_002350 CROST_028220(ndhI_1)
CFBCLFE_000670 CLFE_026720(ndhI_2)
CAUNCLAUR_002770(ndhI_1) CLAUR_027730
CNNCNEO_0042
ASFSFBM_0914
ASMMOUSESFB_0852
ASOSFBmNL_00989
ASBRATSFB_0771
SARJHH195_03980 HH195_07660 HH195_10480
PBIFKXZ80_05610
CPYCphy_0090
ACELacsn021_01060
EELEUBELI_01405
EREEUBREC_2390
SWOSwol_1925
SLPSlip_1534
DCADesca_0343
TFRBR63_06595(nuoB)
TJRTherJR_2965
SAYTPY_3749
SAPSulac_3444
CTHMCFE_0167(cooL)
TKITKV_c01250(ech1C)
CHYCHY_1830(cooL)
TNRThena_0637 Thena_1518 Thena_1519
NTHNther_0884
HORHore_02090
SRISELR_07900(hydA) SELR_07910(hydB)
CIUG4D55_11710
LCGL3BBH23_12750
HAUHaur_3385
ATMANT_22050
LEKhrd7_20260
PBFCFX0092_A0260
VAIBU251_04515
ORPMOP44_23855(nuoB)
EMIEmin_1130
EPOEpro_0038(nuoC) Epro_0039(echE)
ACOAmico_1264 Amico_1265 Amico_1266
TLITlie_1201 Tlie_1202 Tlie_1203
AMOAnamo_1448 Anamo_1449 Anamo_1450
PPIOCE91St28_20420 CE91St28_20430
BLQL21SP5_01257(hycE)
DTEDester_0139 Dester_0140
KOLKole_0568 Kole_0570
KPFIX53_06775 IX53_06785
CPOCOPRO5265_0922 COPRO5265_0933
TYETHEYE_A0988 THEYE_A1725 THEYE_A1726
TIDThein_0497 Thein_0498
BANABARAN1_0180(MbhJ) BARAN1_0181(MbhK) BARAN1_0182(MbhL)
BIHBIP78_0245 BIP78_0246 BIP78_0247
MFVMfer_0626
PFUPF1432 PF1433 PF1434
PFIPFC_06385 PFC_06390 PFC_06395
PHOPH1434(PH1434) PH1435(PH1435) PH1437(PH1437)
PABPAB1890 PAB1891 PAB1892
PYNPNA2_0024 PNA2_0025 PNA2_0026
PYAPYCH_11320 PYCH_11330 PYCH_11340
PYSPy04_1314 Py04_1315 Py04_1316
PYCTQ32_09910 TQ32_09915 TQ32_09920
TKOTK2089 TK2090 TK2091
TONTON_1024 TON_1591 TON_1592 TON_1593
TGATGAM_0036(mbhL) TGAM_0037(mbhK) TGAM_0038(mbhJ)
TSITSIB_1284 TSIB_1285 TSIB_1286 TSIB_1298 TSIB_1299 TSIB_1300
TBATERMP_01146 TERMP_01473 TERMP_01474 TERMP_01475 TERMP_01487 TERMP_01488 TERMP_01489
THEGQS_07460 GQS_07465 GQS_07470 GQS_07530 GQS_07535 GQS_07540
THATAM4_1143 TAM4_1158 TAM4_1377
THMCL1_1131 CL1_1132 CL1_1133
TLTOCC_08599 OCC_08604 OCC_08609 OCC_08669 OCC_08674 OCC_08679
THSTES1_1204 TES1_1453 TES1_1454 TES1_1455 TES1_1467 TES1_1468 TES1_1469
TNUBD01_1882 BD01_1883 BD01_1884
TEUTEU_02000 TEU_02005 TEU_02010
TGYX802_04245 X802_04250 X802_04255
THVADU37_CDS05850 ADU37_CDS05860 ADU37_CDS05870 ADU37_CDS05990 ADU37_CDS06000 ADU37_CDS06010
TCHCHITON_1644 CHITON_1645 CHITON_1646
TPEPA0127_05340 A0127_05345 A0127_05350
TPIEA7C91_04180 A7C91_04185
TGGA3K92_08545 A3K92_08550 A3K92_08555
TCEA3L02_07790 A3L02_07795 A3L02_07800
TBSA3L01_08715 A3L01_08720 A3L01_08725 A3L01_08785 A3L01_08790 A3L01_08795
THHCDI07_08695 CDI07_08700 CDI07_08705 CDI07_08765 CDI07_08770 CDI07_08775
TSLA3L11_02185 A3L11_02190 A3L11_02195 A3L11_02255 A3L11_02260 A3L11_02265
TTDA3L14_11280 A3L14_11285 A3L14_11290 A3L14_11350 A3L14_11355 A3L14_11360
TPRFA3L09_01690 A3L09_01695 A3L09_01700
TRLA3L10_08195 A3L10_08200 A3L10_08205 A3L10_08265 A3L10_08270 A3L10_08275
TPAFA3L08_01780 A3L08_01785 A3L08_01790
THYA3L12_04505 A3L12_04510 A3L12_04515
TICFH039_00320(nuoB) FH039_00325 FH039_00330 FH039_00390 FH039_00395 FH039_00400
TCQTIRI35C_2081(mbhJ) TIRI35C_2082(mbhK) TIRI35C_2083(mbhL) TIRI35C_2095(mbhJ) TIRI35C_2096 TIRI35C_2097(mbhL)
THEMFPV09_08550 FPV09_08555 FPV09_08560 FPV09_08620 FPV09_08625 FPV09_08630
THEIK1720_09530 K1720_09535 K1720_09540 K1720_09600 K1720_09605 K1720_09610
PPACPAP_01140 PAP_01145 PAP_01150 PAP_01210 PAP_01215 PAP_01220
MHUMhun_2588 Mhun_2589 Mhun_2590
MRTJKHC33_03665 KHC33_03670 KHC33_03675
MLAMlab_0957 Mlab_0958 Mlab_0959
MPIMpet_1573 Mpet_1574 Mpet_1575
MFOMetfor_0144
MPDMCP_2637
MEZMtc_0486
RCIRCIX483
HUTHuta_2227 Huta_2228
HTIHTIA_2018 HTIA_2019
HALAHrd1104_02775 Hrd1104_02780
HARCHARCEL1_02940
MEAMMU439_05905 MU439_05910 MU439_05915
ABIAboo_0673 Aboo_0674 Aboo_0675
ACFAciM339_1163 AciM339_1164 AciM339_1165
SMRSmar_1063
DKADKAM_0419 DKAM_1023
DFDDesfe_0340 Desfe_1141
DMUDesmu_0053 Desmu_0818
TAGTagg_0051 Tagg_0624 Tagg_0625
IAGIgag_1912 Igag_1913 Igag_1914
THGTCELL_1276 TCELL_1277
TCBTCARB_0877
BARCAOA65_1904(mbhK) AOA65_1922(mbhL) AOA65_1923(mbhJ)
 » show all
Reference
1
  Authors
Shug, A.L., Wilson, P.W., Green, D.E. and Mahler, H.R.
  Title
The role of molybdenum and flavin in hydrogenase.
  Journal
J Am Chem Soc 76:3355-3356 (1954)
Reference
2
  Authors
Tagawa, K. and Arnon, D.I.
  Title
Ferredoxin as electron carriers in photosynthesis and in the bioogical production and consumption of hydrogen gas.
  Journal
Nature (Lond) 195:537-543 (1962)
Reference
3
  Authors
Valentine, R.C., Mortenson, L.E. and Carnahan, J.E.
  Title
The hydrogenase system of Clostridium pasteurianum.
  Journal
J Biol Chem 238:1141-1144 (1963)
Reference
4  [PMID:164247]
  Authors
Zumft WG, Mortenson LE.
  Title
The nitrogen-fixing complex of bacteria.
  Journal
Biochim Biophys Acta 416:1-52 (1975)
DOI:10.1016/0304-4173(75)90012-9
Reference
5  [PMID:2173950]
  Authors
Adams MW.
  Title
The structure and mechanism of iron-hydrogenases.
  Journal
Biochim Biophys Acta 1020:115-45 (1990)
DOI:10.1016/0005-2728(90)90044-5
Reference
6  [PMID:9836629]
  Authors
Peters JW, Lanzilotta WN, Lemon BJ, Seefeldt LC
  Title
X-ray crystal structure of the Fe-only hydrogenase (CpI) from Clostridium pasteurianum to 1.8 angstrom resolution.
  Journal
Science 282:1853-8 (1998)
DOI:10.1126/science.282.5395.1853
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.12.7.2
IUBMB Enzyme Nomenclature: 1.12.7.2
ExPASy - ENZYME nomenclature database: 1.12.7.2
UM-BBD (Biocatalysis/Biodegradation Database): 1.12.7.2
BRENDA, the Enzyme Database: 1.12.7.2
CAS: 9027-05-8

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