KEGG   ENZYME: 1.12.7.2
Entry
EC 1.12.7.2                 Enzyme                                 

Name
ferredoxin hydrogenase;
H2 oxidizing hydrogenase;
H2 producing hydrogenase [ambiguous];
bidirectional hydrogenase;
hydrogen-lyase [ambiguous];
hydrogenase (ferredoxin);
hydrogenase I;
hydrogenase II;
hydrogenlyase [ambiguous];
uptake hydrogenase [ambiguous]
Class
Oxidoreductases;
Acting on hydrogen as donor;
With an iron-sulfur protein as acceptor
Sysname
hydrogen:ferredoxin oxidoreductase
Reaction(IUBMB)
H2 + 2 oxidized ferredoxin = 2 reduced ferredoxin + 2 H+ [RN:R00019]
Reaction(KEGG)
R00019
Substrate
H2 [CPD:C00282];
oxidized ferredoxin [CPD:C00139]
Product
reduced ferredoxin [CPD:C00138];
H+ [CPD:C00080]
Comment
Contains iron-sulfur clusters. The enzymes from some sources contains nickel. Can use molecular hydrogen for the reduction of a variety of substances.
History
EC 1.12.7.2 created 1961 as EC 1.98.1.1, transferred 1965 to EC 1.12.1.1, transferred 1972 to EC 1.12.7.1, transferred 1978 to EC 1.18.3.1, transferred 1984 to EC 1.18.99.1, transferred 2002 to EC 1.12.7.2
Orthology
K00532  ferredoxin hydrogenase
K00533  ferredoxin hydrogenase large subunit
K00534  ferredoxin hydrogenase small subunit
K06441  ferredoxin hydrogenase gamma subunit
K18016  membrane-bound hydrogenase subunit alpha
K18017  membrane-bound hydrogenase subunit beta
K18023  membrane-bound hydrogenase subunit mbhJ
Genes
CAMA: F384_12650
SON: SO_3920(hydA) SO_3921(hydB)
SHE: Shewmr4_3250 Shewmr4_3251
SHN: Shewana3_0710 Shewana3_0711
SHL: Shal_1408 Shal_1409
FBL: Fbal_2054 Fbal_2055
LHK: LHK_02328(hydC)
CHIZ: HQ393_09295
CFON: HZU75_11905
SUTK: FG381_03575
SUA: Saut_2037
PACO: AACT_1247
SDL: Sdel_1194
SUN: SUN_0264
NAM: NAMH_1060
GEM: GM21_1074
PCA: Pcar_2502(hndD-1)
DVU: DVU1769(hydA) DVU1770(hydB) DVU1771(hydC)
DVM: DvMF_3192
DHY: DESAM_22768(hydB) DESAM_22769(hydA)
DTR: RSDT_0231(cooL)
DPI: BN4_20197(cooL)
PPRF: DPRO_0997(hndD) DPRO_0999(hydA) DPRO_1000(hydB)
DPS: DP0159
DAT: HRM2_26580(hydA2)
DWD: DSCW_39420(hydC)
DALK: DSCA_39340(hydC)
RPA: RPA0134(hydC)
RPC: RPC_4504
RPE: RPE_3860
RPT: Rpal_0137
BVR: BVIR_2957
BLAG: BLTE_01200(hydC)
RHC: RGUI_3846
AZL: AZL_b04730(nuoB)
ALI: AZOLI_p20532(cooL1) AZOLI_p40581(cooL2)
CAC: CA_C0028(hydA)
CAE: SMB_G0028(nuoG)
CAY: CEA_G0028(hydA)
CPE: CPE2346
CPF: CPF_2655(hydA)
CPR: CPR_2341(hydA)
CTC: CTC_02417
CBK: CLL_A0052
CBN: CbC4_1525
CBT: CLH_0034
CKL: CKL_2257
CKR: CKR_1986
CPAS: Clopa_0056
CBV: U729_1141
CTYK: CTK_C05160(hydA)
ASF: SFBM_0914
CPY: Cphy_0090
SWO: Swol_1925
SLP: Slip_1534
SAY: TPY_3749
CTHM: CFE_0167(cooL)
TKI: TKV_c01250(ech1C)
CHY: CHY_1830(cooL)
SRI: SELR_07900(hydA) SELR_07910(hydB)
HAU: Haur_3385
ATM: ANT_22050
EMI: Emin_1130
EPO: Epro_0038(nuoC) Epro_0039(echE)
BLQ: L21SP5_01257(hycE)
BANA: BARAN1_0180(MbhJ) BARAN1_0181(MbhK) BARAN1_0182(MbhL)
MFV: Mfer_0626
PHO: PH1434(PH1434) PH1435(PH1435) PH1437(PH1437)
TGA: TGAM_0036(mbhL) TGAM_0037(mbhK) TGAM_0038(mbhJ)
MPD: MCP_2637
MEZ: Mtc_0486
RCI: RCIX483
SMR: Smar_1063
BARC: AOA65_1904(mbhK) AOA65_1922(mbhL) AOA65_1923(mbhJ)
 » show all
Reference
1
  Authors
Shug, A.L., Wilson, P.W., Green, D.E. and Mahler, H.R.
  Title
The role of molybdenum and flavin in hydrogenase.
  Journal
J Am Chem Soc 76:3355-3356 (1954)
Reference
2
  Authors
Tagawa, K. and Arnon, D.I.
  Title
Ferredoxin as electron carriers in photosynthesis and in the bioogical production and consumption of hydrogen gas.
  Journal
Nature (Lond) 195:537-543 (1962)
Reference
3
  Authors
Valentine, R.C., Mortenson, L.E. and Carnahan, J.E.
  Title
The hydrogenase system of Clostridium pasteurianum.
  Journal
J Biol Chem 238:1141-1144 (1963)
Reference
4  [PMID:164247]
  Authors
Zumft WG, Mortenson LE.
  Title
The nitrogen-fixing complex of bacteria.
  Journal
Biochim Biophys Acta 416:1-52 (1975)
DOI:10.1016/0304-4173(75)90012-9
Reference
5  [PMID:2173950]
  Authors
Adams MW.
  Title
The structure and mechanism of iron-hydrogenases.
  Journal
Biochim Biophys Acta 1020:115-45 (1990)
DOI:10.1016/0005-2728(90)90044-5
Reference
6  [PMID:9836629]
  Authors
Peters JW, Lanzilotta WN, Lemon BJ, Seefeldt LC.
  Title
X-ray crystal structure of the Fe-only hydrogenase (CpI) from Clostridium pasteurianum to 1.8 angstrom resolution.
  Journal
Science 282:1853-8 (1998)
DOI:10.1126/science.282.5395.1853
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.12.7.2
IUBMB Enzyme Nomenclature: 1.12.7.2
ExPASy - ENZYME nomenclature database: 1.12.7.2
UM-BBD (Biocatalysis/Biodegradation Database): 1.12.7.2
BRENDA, the Enzyme Database: 1.12.7.2
CAS: 9027-05-8

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