KEGG   ENZYME: 1.12.98.1
Entry
EC 1.12.98.1                Enzyme                                 
Name
coenzyme F420 hydrogenase;
8-hydroxy-5-deazaflavin-reducing hydrogenase;
F420-reducing hydrogenase;
coenzyme F420-dependent hydrogenase
Class
Oxidoreductases;
Acting on hydrogen as donor;
With other, known, physiological acceptors
Sysname
hydrogen:coenzyme F420 oxidoreductase
Reaction(IUBMB)
H2 + oxidized coenzyme F420 = reduced coenzyme F420 [RN:R03025]
Reaction(KEGG)
R03025
Substrate
H2 [CPD:C00282];
oxidized coenzyme F420 [CPD:C00876]
Product
reduced coenzyme F420 [CPD:C01080]
Comment
An iron-sulfur flavoprotein (FAD) containing nickel. The enzyme from some sources contains selenocysteine. The enzyme also reduces the riboflavin analogue of F420, flavins and methyl viologen, but to a lesser extent. The hydrogen acceptor coenzyme F420 is a deazaflavin derivative.
History
EC 1.12.98.1 created 1989 as EC 1.12.99.1, transferred 2002 to EC 1.12.98.1
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00440  coenzyme F420 hydrogenase subunit alpha
K00441  coenzyme F420 hydrogenase subunit beta
K00443  coenzyme F420 hydrogenase subunit gamma
Genes
TPSTHAPSDRAFT_14482
ECRECIAI1_2115
BNGEH206_14015
AEDE3U36_04400
PFLPFL_4653
PPRCPFLCHA0_c47280
PPROPPC_4757
PSAPST_2497
PSZPSTAB_2397 PSTAB_2411
PSRPSTAA_2604
PSCA458_13260
PSHPsest_1834
PSTUUIB01_08725
PCHLLLJ08_08175
PBMCL52_07485
PSEDDM292_06365
PTKEXN22_14375
MAQMaqu_2619
SHLShal_1492
PPHEPP2015_422
MICCAUP74_01017
MAGAMag101_14625
TMBThimo_3072
THIPN838_25660 N838_32285
HHAHhal_1640
HHKHH1059_07720
HHCM911_11680 M911_14490
EBSECTOBSL9_0693
SSALSPISAL_07630
BURKDM992_25460
PDQCL55_00013230
RACRA876_15740
ACIPCBP36_17455
ACISCBP35_01460
LIHL63ED372_00671
RGERGE_14160
RBNRBXJA2T_16747
METRBSY238_1534 BSY238_421
MEUACJ67_08100
SNIVSFSGTM_02320
EBAebA1514
TAKTharo_0195
BEBAEM42_08485
CURECUREO_1379
CGEOCGEO_1581
APAIAPAC_0709
DFLDFE_1763
DSDGD606_11715
DAFDesaf_1867
DSXGD604_12470
DRTDret_0422
DSFUWK_00468
DOLDole_1150
DMLDmul_28810
DALDalk_2982 Dalk_4964
DATHRM2_13650 HRM2_33500
DOVDSCO28_47620
DWDDSCW_39800
DLIdnl_31830(frhB)
DMMdnm_016200
DEKDSLASN_40720
DTIDesti_1358
DBRDeba_0887
MLNA9174_30235
MAMOA6B35_10450
MESPC1M53_28665
MHUAMCHK_0584
MJREB229_30835
MERDEB233_27040
AAKAA2016_4908
RPODE0E05_01115
RPARPA1501
RPBRPB_4023
RPCRPC_1245
RPDRPD_3777
RPERPE_1300
RPTRpal_1688
RPXRpdx1_4020
RBKE0H22_24335
RVARvan_2125
METGHT051_12535
BSBBresu_1932
BRLBZG35_10160
JANJann_0300
RDERD1_3988
RLIRLO149_c004490
RPONG3256_14000
DSHDshi_3268 Dshi_4135
YPACCEW88_22385
RIDRIdsm_02181
ROMEI983_11210
THAACFI11_15475
ROTFIV09_12385
THWBMG03_14215
TECAKL02_013570
LVSLOKVESSMR4R_00309
GEHHYN69_07605
TAWEI545_14340
HMLHmaOT1_00150
MONG8E03_15935
FAQG5B39_00075
HBCAEM38_14705
NGFFRF71_14365
SPHPLH20_09100
SSANNX02_24175
SCHYGVO57_06980
CIJWG74_05475
BLASBSY18_1802
BFWB5J99_18565
SANDH3309_11940
POQKZX46_15340
ADOA6F68_00892
CMANA9D14_18715
ERKCD351_00550
PNSA9D12_02835
SRFLHU95_08290
RRURru_A0937
RRFF11_04830
RCERC1_0144(frhB)
RPMRSPPHO_01934(frhB)
HTQFRZ44_21620 FRZ44_28090
HADHFRZ61_19490 FRZ61_46560
ELIOKO353_07150
APMHIMB5_00009010
VHLBME96_16060
PRDF7984_17650
PGMPGRAT_08430
PAEFR50345_19830
PAEQR50912_24675
PRIPRIO_1788
PSONJI735_17225
CPRFK7H06_00440 K7H06_00445
CAMLH6X83_03935
BPBbpr_I2415
PTHPTH_1492(FrhB)
DKUDesku_1352
FWADCMF_01990
DGIDesgi_0750
AWOAwo_c13400(frhB)
CTHMCFE_1724
CHYCHY_1362
PFTJBW_00662 JBW_00687
FROAALO17_22500
MCHEBB28_08225
ROPROP_54820
ROAPd630_LPD01993
RKOJWS14_29705
SALUDC74_399
SALLSAZ_02480
STREGZL_08882
SNRSNOUR_40375
SRIMCP984_36735
STRIC7M71_016960
MFOLDXT68_02715
MSFIT882_02440
SALDFVA74_02080
LTREVS81_09935
ACHAchl_2944
MICKB1A86_00002585
BRVCFK39_09540
PSEIGCE65_02420
ORZFNH13_03090
GEZFE251_13185
MPHMLP_48650
NSNEXE58_03555
NMLNamu_4481
PLABC6361_20945
PLATC6W10_22815
PRYPrubr_38160
DVCDvina_20345
ARDAXF14_02990
ACTZCWT12_02570
FLHEJ997_04785
BLMBLLJ_0375
BADLBADO_1646
BGXESN35_02040
ABAIIMCC26256_11151
RXYRxyl_0964
RRDRradSPS_0875
RUBGBA63_07080
AYMYM304_10050
ATQGH723_05255
AQZKSP35_10660
IAMHC251_03195
ERZER308_10375 ER308_12355
EUZDVS28_a4262
HAOPCC7418_1410 PCC7418_1874
CYTcce_3352
MPROBJP34_09040
NOSNos7107_3400
NOECLI64_13380
RIVRiv7116_0483
FISFIS3754_16890
DETDET0214
DEBDehaBAV1_0139
DMDdcmb_217
DMYX793_00995
DUCUCH007_02440
PSUBPelsub_P2257
TTRTter_1334
AHELQ31a_57140
BVOPan97_07220
VBCC5Q97_10110
SBUSpiBuddy_0395
CTMCabther_B0079
BDOEL88_10345
PGOLK6V26_09400
ZPRZPR_0559
PLITK8354_18420
TAMTheam_1117 Theam_1118 Theam_1119
DTEDester_0449 Dester_0450 Dester_0451
MINFMESINF_0685 MESINF_2236
TIDThein_1778
MJAMJ_0031 MJ_0032 MJ_0725 MJ_0726 MJ_0727 MJ_1349
MFEMefer_0177 Mefer_1239 Mefer_1240 Mefer_1242
MVUMetvu_0629 Metvu_0630 Metvu_0631 Metvu_0895 Metvu_1282 Metvu_1284 Metvu_1285
MFSMFS40622_0230 MFS40622_0947 MFS40622_0948 MFS40622_0950 MFS40622_1445 MFS40622_1446 MFS40622_1447
MIFMetin_0065 Metin_0512 Metin_0513 Metin_0515 Metin_0869
MJHJH146_0253 JH146_1152 JH146_1153 JH146_1154 JH146_1534 JH146_1536 JH146_1537
MESGMLAUSG7_0242 MLAUSG7_0243 MLAUSG7_0244 MLAUSG7_0824 MLAUSG7_1219(frhB) MLAUSG7_1220(frhG) MLAUSG7_1222(frhA)
MESAMLASG1_0368 MLASG1_0555(frhA) MLASG1_0557(frhG) MLASG1_0558(frhB) MLASG1_1431 MLASG1_1432 MLASG1_1433
MIGMetig_0358 Metig_0359 Metig_0360 Metig_1038 Metig_1200 Metig_1202 Metig_1203 Metig_1792 Metig_1793 Metig_1795
MMPMMP0083 MMP0817(frcB) MMP0818(frcG) MMP0820(frcA) MMP1382(fruA) MMP1384(fruG) MMP1385(fruB)
MMQMmarC5_0193 MmarC5_0194 MmarC5_0196 MmarC5_0646 MmarC5_0647 MmarC5_0649 MmarC5_1595
MMXMmarC6_0585 MmarC6_0866 MmarC6_1288 MmarC6_1289 MmarC6_1291
MMZMmarC7_0627 MmarC7_0629 MmarC7_0630 MmarC7_1081
MMDGYY_00425 GYY_04745 GYY_04750 GYY_04760 GYY_07740 GYY_07750 GYY_07755
MMAKMMKA1_00860 MMKA1_09020(frhB) MMKA1_09030(frhG) MMKA1_09050(frhA) MMKA1_16060(fruA) MMKA1_16080(frhG) MMKA1_16090(frhB)
MMAOMMOS7_01110 MMOS7_08800(frhB) MMOS7_08810(frhG) MMOS7_08830(frhA) MMOS7_14870(fruA) MMOS7_14890(frhG) MMOS7_14900(frhB)
MMADMMJJ_01770(frcA) MMJJ_01790(frcG) MMJJ_01800(frcB) MMJJ_10110 MMJJ_14540(fruB) MMJJ_14550(fruG) MMJJ_14570(fruA)
MAEMaeo_1042 Maeo_1043 Maeo_1045 Maeo_1303
MVNMevan_0073 Mevan_0075 Mevan_0076 Mevan_0692 Mevan_0694 Mevan_0695 Mevan_1095
MVOMvol_0587 Mvol_0589 Mvol_0590 Mvol_0988 Mvol_0989 Mvol_0991 Mvol_1429
MOKMetok_0177 Metok_0178 Metok_0180 Metok_0606 Metok_0896 Metok_0898 Metok_0899
METFCFE53_05470(frhA) CFE53_05480(frhG) CFE53_05485(frhB) CFE53_06285
MTHMTH_1297 MTH_1298 MTH_1300 MTH_193 MTH_341
MMGMTBMA_c06440 MTBMA_c16830(frhB) MTBMA_c16840(frhG) MTBMA_c16860(frhA)
METCMTCT_0158 MTCT_1177 MTCT_1178 MTCT_1180
MWOMWSIV6_0607(frhB1) MWSIV6_0735(frhB3) MWSIV6_1686(frhB5) MWSIV6_1687(frhG) MWSIV6_1689(frhA)
METEtca_00175 tca_00310 tca_01251 tca_01252(ndhK) tca_01254
METZMETMT2_0657 METMT2_1291 METMT2_1292 METMT2_1294
METKFVF72_01325 FVF72_05075(frhA) FVF72_05085(frhG) FVF72_05090(frhB)
MTHMFZP57_02890 FZP57_03505 FZP57_08255(frhB) FZP57_08260(frhG) FZP57_08270(frhA)
METJFZP68_02500(frhA) FZP68_02510(frhG) FZP68_02515(frhB) FZP68_07920 FZP68_08535
MTEEMTTB_01410 MTTB_01430 MTTB_01440 MTTB_08530 MTTB_13330
MSTMsp_0668 Msp_1302(frhA) Msp_1304(frhG) Msp_1305(frhB)
METBAW729_02095 AW729_09105 AW729_09110 AW729_09120
MRUmru_2061(frhB1) mru_2062(frhG) mru_2064(frhA) mru_2081(frhB2)
MSIMsm_0135 Msm_1121 Msm_1122 Msm_1124
MEBAbm4_0826(frhB2) Abm4_1630(frhB1) Abm4_1632(frhG) Abm4_1634(frhA)
MMILsm9_0191(frhA) sm9_0193(frhG) sm9_0194(frhB1) sm9_1453(frhB2)
MEYETL18_02075 TL18_09865 TL18_09870 TL18_09880
MOLYLM1_1805 YLM1_1807 YLM1_1808
MAROMarbSA_01980 MarbSA_10380 MarbSA_10390 MarbSA_10410
MELMetbo_0218 Metbo_0220 Metbo_0221 Metbo_0574 Metbo_0863
MEWMSWAN_1791 MSWAN_2262 MSWAN_2263 MSWAN_2265
METHMBMB1_1414 MBMB1_1908(frhB) MBMB1_1909(frhG) MBMB1_1911(frhA)
MFCBRM9_0650(frhB2) BRM9_2249(frhB) BRM9_2250(frhG) BRM9_2252(frhA)
MFIDSM1535_0622 DSM1535_1181(frhB) DSM1535_1182(frhG) DSM1535_1184(frhA)
MCUBMCBB_1652(frhB1) MCBB_2184(frhB3) MCBB_2185(frhG) MCBB_2187(frhA3)
MSUBBK009_06075 BK009_08715 BK009_08720 BK009_08730
METNBK008_01615 BK008_04365 BK008_04370 BK008_04380
METTCIT01_04660(frhB) CIT01_04665(frhG) CIT01_04675(frhA) CIT01_09700
METOCIT02_07975(frhA) CIT02_07985(frhG) CIT02_07990(frhB) CIT02_10915
MEMEHYG87_00830 HYG87_05695(frhB) HYG87_05700(frhG) HYG87_05710(frhA) HYG87_10100 HYG87_10910
MFVMfer_1032 Mfer_1034 Mfer_1035 Mfer_1105
MKAMK0537 MK0538 MK0539 MK0929 MK0930 MK0931 MK1202(hyaB)
APOArcpr_1589
AVEArcve_1117
PYAPYCH_10960 PYCH_10970 PYCH_10980
PYCTQ32_09745 TQ32_09750 TQ32_09755
TONTON_1559 TON_1560 TON_1561
TGATGAM_0066(frhB) TGAM_0067(frhG) TGAM_0068(frhA)
THEGQS_02345 GQS_02350 GQS_02355
THMCL1_1149 CL1_1150 CL1_1151
THSTES1_1498 TES1_1499 TES1_1500 TES1_1501
TNUBD01_1900 BD01_1901 BD01_1902
TEUTEU_01935 TEU_01940 TEU_01945
TGYX802_04305 X802_04310 X802_04315
TPIEA7C91_04330 A7C91_04335 A7C91_04340
TPAFA3L08_06600 A3L08_06605 A3L08_06610
TICFH039_06095 FH039_06100
THEMFPV09_03250 FPV09_03255 FPV09_03260
MBAMbar_A0449 Mbar_A0450 Mbar_A0452 Mbar_A0662 Mbar_A0881 Mbar_A2287 Mbar_A2289 Mbar_A2290
MBYMSBRM_0112 MSBRM_1453 MSBRM_1454 MSBRM_1455 MSBRM_3017 MSBRM_3018 MSBRM_3020 MSBRM_3227
MBWMSBRW_0117 MSBRW_0341 MSBRW_0550 MSBRW_0552 MSBRW_0553 MSBRW_2454 MSBRW_2455 MSBRW_2457
MBARMSBR2_0948 MSBR2_0949 MSBR2_0950 MSBR2_2268 MSBR2_2975 MSBR2_2978 MSBR2_3187
MBAKMSBR3_2970 MSBR3_2971 MSBR3_2973 MSBR3_3176
MACMA_0975(frhA) MA_0977(frhG) MA_0978(frhB) MA_4220 MA_4520
MMAMM_0969 MM_1225 MM_3042 MM_3043 MM_3045
MMAZMmTuc01_1000 MmTuc01_1266 MmTuc01_3122 MmTuc01_3124
MMJMSMAS_0087 MSMAS_0334 MSMAS_1645 MSMAS_1647 MSMAS_1648
MMACMSMAC_0093 MSMAC_0352 MSMAC_2996 MSMAC_2998 MSMAC_2999
MVCMSVAZ_1818 MSVAZ_1820 MSVAZ_3107 MSVAZ_3108 MSVAZ_3110 MSVAZ_3226 MSVAZ_3399
MEKMSKOL_1795 MSKOL_1796 MSKOL_1798 MSKOL_3070 MSKOL_3071 MSKOL_3073 MSKOL_3194 MSKOL_3359
MLSMSLAZ_0135 MSLAZ_2767 MSLAZ_3014
METMMSMTP_0120 MSMTP_0393 MSMTP_0724
MEFMSWH1_0115 MSWH1_2850
MEQMSWHS_0117 MSWHS_2152
MSJMSSAC_0973 MSSAC_0974 MSSAC_0976 MSSAC_3863 MSSAC_4279
MSZMSSIH_0875 MSSIH_0876 MSSIH_0878 MSSIH_3110 MSSIH_3394 MSSIH_3784
MSWMSSIT_0909 MSSIT_0910 MSSIT_0912 MSSIT_3464 MSSIT_3753 MSSIT_3861
MTHRMSTHT_1416 MSTHT_1418 MSTHT_1566
MTHEMSTHC_1723 MSTHC_1871 MSTHC_1873 MSTHC_1874
MHORMSHOH_0103 MSHOH_0435 MSHOH_2436 MSHOH_2438 MSHOH_2439
MFZAOB57_006170(frhB) AOB57_006175(frhG) AOB57_006185(frhA) AOB57_006920
MBUMbur_2261
MMETMCMEM_0409 MCMEM_1996
MELOJ7W08_08875
MMHMmah_1792 Mmah_1967
MHAZBHR79_03800 BHR79_04710
MEVMetev_1040
MZHMzhil_0337
MPYMpsy_1310 Mpsy_1371
MZIHWN40_01910 HWN40_02110 HWN40_05515
MHZMetho_0305 Metho_1361
MTPMthe_0174 Mthe_0959
MCJMCON_2320(frhB)
MHIMhar_2015 Mhar_2358
MHUMhun_0783 Mhun_2329 Mhun_2330 Mhun_2332
MRTJKHC33_09700 KHC33_15955(frhA) KHC33_15965(frhG) KHC33_15970(frhB)
MLAMlab_0012 Mlab_0013 Mlab_0015
MEMMemar_0331 Memar_0955 Memar_2174 Memar_2176 Memar_2177
MBGBN140_1378(frhA) BN140_1380(frhG) BN140_1381(frhB) BN140_1566
MEMAMMAB1_1762 MMAB1_1765(frhG) MMAB1_1766(frhB) MMAB1_2005
MCHKMchiMG62_04480 MchiMG62_24880(frhA) MchiMG62_24900(frhG) MchiMG62_24910(frhB)
MPIMpet_0590 Mpet_0592 Mpet_0593 Mpet_1260
MBNMboo_0476 Mboo_0477 Mboo_0479 Mboo_1693 Mboo_2023
MFOMetfor_1221 Metfor_2713 Metfor_2715 Metfor_2716
MPLMpal_0084 Mpal_0086 Mpal_0087 Mpal_2707
MPDMCP_2174(frhB-1) MCP_2409(frhA-1) MCP_2411(frhG-1) MCP_2412(frhB-2) MCP_2452(frhA-2) MCP_2453(frhG-2) MCP_2454(frhB-3)
MEZMtc_0999(frhB-1) Mtc_1000(frhG-1) Mtc_1001(frhA-1) Mtc_1195(frhB-3) Mtc_2127(frhA-2) Mtc_2129(frhG-2) Mtc_2130(frhB-2)
RCIRCIX1471(frhB-3) RCIX2136(frhB-2) RCIX2137(frhG-2) RCIX2138(frhA-2) RCIX2388(frhA-1) RCIX2390(frhG-1) RCIX2391(frhB-1) RCIX2759(frhB-4)
HJEHacjB3_10145
HALREFA46_002130
HARAAArcS_2106(frhB)
HAADMW046_02360
HALJG9465_00900
NPHNP_4006A
NSALHWV07_06345
HUTHuta_0177 Huta_1326
HALAHrd1104_09220
HRRHZS55_06925
HPELHZS54_07460
HARCHARCEL1_09110 HARCEL1_13195
HMEHFX_6483
HBOHbor_39930
SRUBC2R22_17210
HALGHUG10_08905
HALUHUG12_07175
HTUHtur_0242 Htur_3038
HDABB347_12790
HJTDVR14_08720 DVR14_12970
HSALJMJ58_08005
HLOJ0X27_10355 J0X27_13720
HAKZJ0X25_07650
HXAHalxa_0685 Halxa_1303 Halxa_1972
NATNJ7G_0302
NPENatpe_0727 Natpe_3732
NVRFEJ81_18045
NPLFGF80_16735
NAYHYG81_11250
NOUNatoc_0114 Natoc_4170
SALIL593_06175
HLRHALLA_05305
NAJB1756_07615
NASGCU68_05190
FFOFFONT_0644
CSUCSUB_C1525
BARCAOA65_2033(frhB)
LOKILokiarch_07380(frhB_1) Lokiarch_09930(frhB_3) Lokiarch_10850(frhB_4) Lokiarch_12690(fpoF_1) Lokiarch_19690(frhB_5) Lokiarch_21140(frhB_6) Lokiarch_51590(frhB_9)
 » show all
Reference
1  [PMID:6786341]
  Authors
Adams MW, Mortenson LE, Chen JS.
  Title
Hydrogenase.
  Journal
Biochim Biophys Acta 594:105-76 (1980)
DOI:10.1016/0304-4173(80)90007-5
Reference
2  [PMID:6211447]
  Authors
Yamazaki S.
  Title
A selenium-containing hydrogenase from Methanococcus vannielii. Identification of the selenium moiety as a selenocysteine residue.
  Journal
J Biol Chem 257:7926-9 (1982)
Reference
3  [PMID:3663585]
  Authors
Fox JA, Livingston DJ, Orme-Johnson WH, Walsh CT.
  Title
8-Hydroxy-5-deazaflavin-reducing hydrogenase from Methanobacterium thermoautotrophicum: 1. Purification and characterization.
  Journal
Biochemistry 26:4219-27 (1987)
DOI:10.1021/bi00388a007
  Sequence
Reference
4  [PMID:3121317]
  Authors
Muth E, Morschel E, Klein A.
  Title
Purification and characterization of an 8-hydroxy-5-deazaflavin-reducing hydrogenase from the archaebacterium Methanococcus voltae.
  Journal
Eur J Biochem 169:571-7 (1987)
DOI:10.1111/j.1432-1033.1987.tb13647.x
Reference
5  [PMID:2738024]
  Authors
Baron SF, Ferry JG.
  Title
Purification and properties of the membrane-associated coenzyme F420-reducing hydrogenase from Methanobacterium formicicum.
  Journal
J Bacteriol 171:3846-53 (1989)
DOI:10.1128/JB.171.7.3846-3853.1989
Other DBs
ExplorEnz - The Enzyme Database: 1.12.98.1
IUBMB Enzyme Nomenclature: 1.12.98.1
ExPASy - ENZYME nomenclature database: 1.12.98.1
BRENDA, the Enzyme Database: 1.12.98.1
CAS: 9027-05-8

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