KEGG   ENZYME: 1.12.98.1Help
Entry
EC 1.12.98.1                Enzyme                                 

Name
coenzyme F420 hydrogenase;
8-hydroxy-5-deazaflavin-reducing hydrogenase;
F420-reducing hydrogenase;
coenzyme F420-dependent hydrogenase
Class
Oxidoreductases;
Acting on hydrogen as donor;
With other, known, physiological acceptors
BRITE hierarchy
Sysname
hydrogen:coenzyme F420 oxidoreductase
Reaction(IUBMB)
H2 + oxidized coenzyme F420 = reduced coenzyme F420 [RN:R03025]
Reaction(KEGG)
Substrate
H2 [CPD:C00282];
oxidized coenzyme F420 [CPD:C00876]
Product
reduced coenzyme F420 [CPD:C01080]
Comment
An iron-sulfur flavoprotein (FAD) containing nickel. The enzyme from some sources contains selenocysteine. The enzyme also reduces the riboflavin analogue of F420, flavins and methylviologen, but to a lesser extent. The hydrogen acceptor coenzyme F420 is a deazaflavin derivative.
History
EC 1.12.98.1 created 1989 as EC 1.12.99.1, transferred 2002 to EC 1.12.98.1
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00440  coenzyme F420 hydrogenase subunit alpha
K00441  coenzyme F420 hydrogenase subunit beta
K00443  coenzyme F420 hydrogenase subunit gamma
Genes
TPS: THAPSDRAFT_14482
PBM: CL52_07485
MICC: AUP74_01017
MAGA: Mag101_14625
TMB: Thimo_3072
HHA: Hhal_1640
HHC: M911_14490
EBS: ECTOBSL9_0693
PDQ: CL55_00013230
RAC: RA876_15740
RGE: RGE_14160
DRT: Dret_0422
DSF: UWK_00468
DOL: Dole_1150
DBR: Deba_0887
RPA: RPA1501
RPB: RPB_4023
RPC: RPC_1245
RPD: RPD_3777
RPE: RPE_1300
RPT: Rpal_1688
RVA: Rvan_2125
JAN: Jann_0300
RDE: RD1_3988
DSH: Dshi_3268
SSAN: NX02_24175
BLAS: BSY18_1802
RRU: Rru_A0937
RRF: F11_04830
RCE: RC1_0144(frhB)
RPM: RSPPHO_01934(frhB)
BPB: bpr_I2415
PTH: PTH_1492(FrhB)
AWO: Awo_c13400(frhB)
CTHM: CFE_1724
CHY: CHY_1362
MCHE: BB28_08225
ROP: ROP_54820
SALU: DC74_399
SALL: SAZ_02480
STRE: GZL_08882
ACH: Achl_2944
MPH: MLP_48650
NML: Namu_4481
RXY: Rxyl_0964
DET: DET0214
DMD: dcmb_217
TTR: Tter_1334
MMP: MMP0083 MMP0817(frcB) MMP0818(frcG) MMP0820(frcA) MMP1382(fruA) MMP1384(fruG) MMP1385(fruB)
MAC: MA_0975(frhA) MA_0977(frhG) MA_0978(frhB) MA_4220 MA_4520
MBU: Mbur_2261
MTP: Mthe_0174
MCJ: MCON_2320(frhB)
MHI: Mhar_2358
MBG: BN140_1378(frhA) BN140_1380(frhG) BN140_1381(frhB) BN140_1566
MPD: MCP_2174(frhB-1) MCP_2409(frhA-1) MCP_2411(frhG-1) MCP_2412(frhB-2) MCP_2452(frhA-2) MCP_2453(frhG-2) MCP_2454(frhB-3)
MEZ: Mtc_0999(frhB-1) Mtc_1000(frhG-1) Mtc_1001(frhA-1) Mtc_1195(frhB-3) Mtc_2127(frhA-2) Mtc_2129(frhG-2) Mtc_2130(frhB-2)
RCI: RCIX1471(frhB-3) RCIX2136(frhB-2) RCIX2137(frhG-2) RCIX2138(frhA-2) RCIX2388(frhA-1) RCIX2390(frhG-1) RCIX2391(frhB-1) RCIX2759(frhB-4)
MWO: MWSIV6_0607(frhB1) MWSIV6_0735(frhB3) MWSIV6_1686(frhB5) MWSIV6_1687(frhG) MWSIV6_1689(frhA)
MST: Msp_1302(frhA) Msp_1304(frhG) Msp_1305(frhB)
MRU: mru_2061(frhB1) mru_2062(frhG) mru_2064(frhA) mru_2081(frhB2)
MEB: Abm4_0826(frhB2) Abm4_1630(frhB1) Abm4_1632(frhG) Abm4_1634(frhA)
MMIL: sm9_0191(frhA) sm9_0193(frhG) sm9_0194(frhB1) sm9_1453(frhB2)
METH: MBMB1_1414 MBMB1_1908(frhB) MBMB1_1909(frhG) MBMB1_1911(frhA)
MFC: BRM9_0650(frhB2) BRM9_2249(frhB) BRM9_2250(frhG) BRM9_2252(frhA)
MCUB: MCBB_1652(frhB1) MCBB_2184(frhB3) MCBB_2185(frhG) MCBB_2187(frhA3)
NPH: NP_4006A
HME: HFX_6483
NAT: NJ7G_0302
SALI: L593_06175
TGA: TGAM_0066(frhB) TGAM_0067(frhG) TGAM_0068(frhA)
BARC: AOA65_2033(frhB)
LOKI: Lokiarch_07380(frhB_1) Lokiarch_09930(frhB_3) Lokiarch_10850(frhB_4) Lokiarch_12690(fpoF_1) Lokiarch_17890(fpoF_2) Lokiarch_19690(frhB_5) Lokiarch_21140(frhB_6) Lokiarch_51590(frhB_9)
 » show all
Taxonomy
Reference
1  [PMID:6786341]
  Authors
Adams MW, Mortenson LE, Chen JS.
  Title
Hydrogenase.
  Journal
Biochim Biophys Acta 594:105-76 (1980)
Reference
2  [PMID:6211447]
  Authors
Yamazaki S.
  Title
A selenium-containing hydrogenase from Methanococcus vannielii. Identification of the selenium moiety as a selenocysteine residue.
  Journal
J Biol Chem 257:7926-9 (1982)
Reference
3  [PMID:3663585]
  Authors
Fox JA, Livingston DJ, Orme-Johnson WH, Walsh CT.
  Title
8-Hydroxy-5-deazaflavin-reducing hydrogenase from Methanobacterium thermoautotrophicum: 1. Purification and characterization.
  Journal
Biochemistry 26:4219-27 (1987)
  Sequence
Reference
4  [PMID:3121317]
  Authors
Muth E, Morschel E, Klein A.
  Title
Purification and characterization of an 8-hydroxy-5-deazaflavin-reducing hydrogenase from the archaebacterium Methanococcus voltae.
  Journal
Eur J Biochem 169:571-7 (1987)
DOI:10.1111/j.1432-1033.1987.tb13647.x
Reference
5  [PMID:2738024]
  Authors
Baron SF, Ferry JG.
  Title
Purification and properties of the membrane-associated coenzyme F420-reducing hydrogenase from Methanobacterium formicicum.
  Journal
J Bacteriol 171:3846-53 (1989)
DOI:10.1128/JB.171.7.3846-3853.1989
Other DBs
ExplorEnz - The Enzyme Database: 1.12.98.1
IUBMB Enzyme Nomenclature: 1.12.98.1
ExPASy - ENZYME nomenclature database: 1.12.98.1
BRENDA, the Enzyme Database: 1.12.98.1
CAS: 9027-05-8

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