KEGG   ENZYME: 1.12.98.2Help
Entry
EC 1.12.98.2                Enzyme                                 

Name
5,10-methenyltetrahydromethanopterin hydrogenase;
H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase;
nonmetal hydrogenase;
N5,N10-methenyltetrahydromethanopterin hydrogenase;
hydrogen:N5,N10-methenyltetrahydromethanopterin oxidoreductase
Class
Oxidoreductases;
Acting on hydrogen as donor;
With other, known, physiological acceptors
BRITE hierarchy
Sysname
hydrogen:5,10-methenyltetrahydromethanopterin oxidoreductase
Reaction(IUBMB)
H2 + 5,10-methenyltetrahydromethanopterin = H+ + 5,10-methylenetetrahydromethanopterin [RN:R04455]
Reaction(KEGG)
Substrate
H2 [CPD:C00282];
5,10-methenyltetrahydromethanopterin [CPD:C04330]
Product
H+ [CPD:C00080];
5,10-methylenetetrahydromethanopterin [CPD:C04377]
Comment
Does not catalyse the reduction of artificial dyes. Does not by itself catalyse a H2/H+ exchange reaction. Does not contain nickel or iron-sulfur clusters.
History
EC 1.12.98.2 created 1999 as EC 1.12.99.4, transferred 2002 to EC 1.12.98.2, modified 2004
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K13942  5,10-methenyltetrahydromethanopterin hydrogenase
Genes
MJA: MJ_0784
MFE: Mefer_0990
MVU: Metvu_0027
MFS: MFS40622_1391
MIF: Metin_0843
MJH: JH146_1110
MIG: Metig_1130
MMP: MMP0127(hmd)
MMQ: MmarC5_1551
MMX: MmarC6_0825
MMD: GYY_00645
MAE: Maeo_1025
MVO: Mvol_1349
MTH: MTH_1142
MMG: MTBMA_c15260(hmd)
METC: MTCT_1035
MWO: MWSIV6_1534(hmd)
METE: tca_01099
MSI: Msm_0572
MRU: mru_0526(hmd)
MEB: Abm4_0007(hmd)
MMIL: sm9_0397(hmd1) sm9_1140(hmd2)
MOL: YLM1_0193
METT: CIT01_01065(hmd)
MFV: Mfer_0722
MKA: MK0013(hmd)
MLA: Mlab_1744
MPI: Mpet_2002
 » show all
Taxonomy
Reference
1
  Authors
Zirngibl, C., Hedderich, R. and Thauer, R.K.
  Title
N5,N10-Methylenetetrahydromethanopterin dehydrogenase from Methanobacterium thermoautotrophicum has hydrogenase activity.
  Journal
FEBS Lett 261:112-116 (1990)
Reference
2  [PMID:7628605]
  Authors
Klein AR, Fernandez VM, Thauer RK.
  Title
H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase: mechanism of H2 formation analyzed using hydrogen isotopes.
  Journal
FEBS Lett 368:203-6 (1995)
DOI:10.1016/0014-5793(95)00642-M
Other DBs
ExplorEnz - The Enzyme Database: 1.12.98.2
IUBMB Enzyme Nomenclature: 1.12.98.2
ExPASy - ENZYME nomenclature database: 1.12.98.2
BRENDA, the Enzyme Database: 1.12.98.2
CAS: 100357-01-5

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