KEGG   ENZYME: 1.12.98.2
Entry
EC 1.12.98.2                Enzyme                                 
Name
5,10-methenyltetrahydromethanopterin hydrogenase;
H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase;
nonmetal hydrogenase;
N5,N10-methenyltetrahydromethanopterin hydrogenase;
hydrogen:N5,N10-methenyltetrahydromethanopterin oxidoreductase
Class
Oxidoreductases;
Acting on hydrogen as donor;
With other, known, physiological acceptors
Sysname
hydrogen:5,10-methenyltetrahydromethanopterin oxidoreductase
Reaction(IUBMB)
H2 + 5,10-methenyltetrahydromethanopterin = H+ + 5,10-methylenetetrahydromethanopterin [RN:R04455]
Reaction(KEGG)
R04455
Substrate
H2 [CPD:C00282];
5,10-methenyltetrahydromethanopterin [CPD:C04330]
Product
H+ [CPD:C00080];
5,10-methylenetetrahydromethanopterin [CPD:C04377]
Comment
Does not catalyse the reduction of artificial dyes. Does not by itself catalyse a H2/H+ exchange reaction. Does not contain nickel or iron-sulfur clusters.
History
EC 1.12.98.2 created 1999 as EC 1.12.99.4, transferred 2002 to EC 1.12.98.2, modified 2004
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K13942  5,10-methenyltetrahydromethanopterin hydrogenase
Genes
MJAMJ_0784
MFEMefer_0990
MVUMetvu_0027
MFSMFS40622_1391
MIFMetin_0843
MJHJH146_1110
MESGMLAUSG7_0273(hmd)
MESAMLASG1_1401(hmd)
MIGMetig_1130
MMPMMP0127(hmd)
MMQMmarC5_1551
MMXMmarC6_0825
MMZMmarC7_1126
MMDGYY_00645
MMAKMMKA1_01320(hmd)
MMAOMMOS7_01580(hmd)
MMADMMJJ_09590
MAEMaeo_1025
MVNMevan_1132
MVOMvol_1349
MOKMetok_0558
METFCFE53_06010
MTHMTH_1142
MMGMTBMA_c15260(hmd)
METCMTCT_1035
MWOMWSIV6_1534(hmd)
METEtca_01099
METZMETMT2_1150
METKFVF72_05875(hmd)
MTHMFZP57_07345(hmd)
METJFZP68_03330(hmd)
MTEEMTTB_02800
MRUmru_0526(hmd)
MSIMsm_0572
MEBAbm4_0007(hmd)
MMILsm9_0397(hmd1) sm9_1140(hmd2)
MEYETL18_01650 TL18_01655
MOLYLM1_0193
METTCIT01_01065(hmd)
MEMEHYG87_04865
MFVMfer_0722
MKAMK0013(hmd)
MLAMlab_1744
MPIMpet_2002
MFOMetfor_0867
 » show all
Reference
1
  Authors
Zirngibl, C., Hedderich, R. and Thauer, R.K.
  Title
N5,N10-Methylenetetrahydromethanopterin dehydrogenase from Methanobacterium thermoautotrophicum has hydrogenase activity.
  Journal
FEBS Lett 261:112-116 (1990)
Reference
2  [PMID:7628605]
  Authors
Klein AR, Fernandez VM, Thauer RK
  Title
H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase: mechanism of H2 formation analyzed using hydrogen isotopes.
  Journal
FEBS Lett 368:203-6 (1995)
DOI:10.1016/0014-5793(95)00642-M
Other DBs
ExplorEnz - The Enzyme Database: 1.12.98.2
IUBMB Enzyme Nomenclature: 1.12.98.2
ExPASy - ENZYME nomenclature database: 1.12.98.2
BRENDA, the Enzyme Database: 1.12.98.2
CAS: 100357-01-5

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