KEGG   ENZYME: 1.12.98.3
Entry
EC 1.12.98.3                Enzyme                                 
Name
Methanosarcina-phenazine hydrogenase;
methanophenazine hydrogenase;
methylviologen-reducing hydrogenase
Class
Oxidoreductases;
Acting on hydrogen as donor;
With other, known, physiological acceptors
Sysname
hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase
Reaction(IUBMB)
H2 + 2-(2,3-dihydropentaprenyloxy)phenazine = 2-dihydropentaprenyloxyphenazine [RN:R09095]
Reaction(KEGG)
R09095
Substrate
H2 [CPD:C00282];
2-(2,3-dihydropentaprenyloxy)phenazine [CPD:C11903]
Product
2-dihydropentaprenyloxyphenazine
Comment
Contains nickel, iron-sulfur clusters and cytochrome b. The enzyme from some sources contains selenocysteine.
History
EC 1.12.98.3 created 2002
Orthology
K14068  methanophenazine hydrogenase, large subunit
K14069  methanophenazine hydrogenase, cytochrome b subunit
K14070  methanophenazine hydrogenase
Genes
AVEArcve_0139 Arcve_1314
ASTAsulf_02249
FPLFerp_0834 Ferp_1615
GACGACE_0715 GACE_1725
GAHGAH_00910 GAH_02042
MBAMbar_A1839 Mbar_A1840 Mbar_A1841 Mbar_A1845 Mbar_A1846 Mbar_A1847
MBYMSBRM_2559 MSBRM_2560 MSBRM_2561 MSBRM_2565 MSBRM_2566 MSBRM_2567
MBWMSBRW_2889 MSBRW_2890 MSBRW_2891 MSBRW_2894 MSBRW_2895 MSBRW_2896
MBARMSBR2_2533 MSBR2_2534 MSBR2_2535 MSBR2_2539 MSBR2_2540 MSBR2_2541
MBAKMSBR3_2555 MSBR3_2556 MSBR3_2557 MSBR3_2562 MSBR3_2563 MSBR3_2564
MACMA_1141(vhtG) MA_1142(vhtA) MA_1143(vhtC) MA_1146(vhtG) MA_1147(vhtA) MA_1148(vhtC)
MMAMM_2169(vhtG) MM_2170(vhtA) MM_2171(vhtC) MM_2175 MM_2176 MM_2177 MM_2312(vhoC) MM_2313(vhoA) MM_2314(vhoG)
MMAZMmTuc01_2221 MmTuc01_2222 MmTuc01_2223 MmTuc01_2227 MmTuc01_2228 MmTuc01_2229 MmTuc01_2361
MMJMSMAS_2387 MSMAS_2388 MSMAS_2389 MSMAS_2512 MSMAS_2513 MSMAS_2514 MSMAS_2518 MSMAS_2519 MSMAS_2520
MMACMSMAC_1925 MSMAC_1926 MSMAC_1927 MSMAC_1931 MSMAC_1932 MSMAC_1933 MSMAC_2057 MSMAC_2058 MSMAC_2059
MVCMSVAZ_2597 MSVAZ_2598 MSVAZ_2599 MSVAZ_2603 MSVAZ_2604 MSVAZ_2605
MEKMSKOL_2601 MSKOL_2602 MSKOL_2603 MSKOL_2607 MSKOL_2608 MSKOL_2609
MLSMSLAZ_0687 MSLAZ_0689 MSLAZ_0690 MSLAZ_0691 MSLAZ_1004 MSLAZ_1005 MSLAZ_1006
METMMSMTP_2424 MSMTP_2425 MSMTP_2426 MSMTP_2429 MSMTP_2430 MSMTP_2431
MEFMSWH1_2363 MSWH1_2364 MSWH1_2365 MSWH1_2368 MSWH1_2369 MSWH1_2370
MEQMSWHS_2735 MSWHS_2736 MSWHS_2737 MSWHS_2740 MSWHS_2741 MSWHS_2742
MSJMSSAC_3200 MSSAC_3201 MSSAC_3202 MSSAC_3205 MSSAC_3206 MSSAC_3207
MSZMSSIH_1030 MSSIH_1031 MSSIH_1032 MSSIH_1035 MSSIH_1036 MSSIH_1037
MSWMSSIT_1077 MSSIT_1078 MSSIT_1079 MSSIT_1082 MSSIT_1083 MSSIT_1084
MTHRMSTHT_1112 MSTHT_1113 MSTHT_1114 MSTHT_1117 MSTHT_1118 MSTHT_1119
MTHEMSTHC_2184 MSTHC_2185 MSTHC_2186 MSTHC_2189 MSTHC_2190 MSTHC_2191
MHORMSHOH_3149 MSHOH_3150 MSHOH_3151 MSHOH_3154 MSHOH_3155 MSHOH_3156
MFZAOB57_010820 AOB57_010825 AOB57_010830 AOB57_010845 AOB57_010850 AOB57_010855
MMETMCMEM_1333 MCMEM_1334
MELOJ7W08_05350 J7W08_05355
MZHMzhil_0914 Mzhil_0915
MPDMCP_2934(vhtG) MCP_2935(vhtA) MCP_2936(vhtC)
MEZMtc_0470(vhtG) Mtc_0471(vhtA) Mtc_0472(vhtC)
RCIRCIX880(vhtG) RCIX882(vhtA) RCIX885(vhtC)
MEAMMU439_03135 MU439_03140 MU439_03145
 » show all
Reference
1  [PMID:9555882]
  Authors
Abken HJ, Tietze M, Brodersen J, Baumer S, Beifuss U, Deppenmeier U.
  Title
Isolation and characterization of methanophenazine and function of phenazines in membrane-bound electron transport of Methanosarcina mazei Go1.
  Journal
J Bacteriol 180:2027-32 (1998)
DOI:10.1128/JB.180.8.2027-2032.1998
Reference
2  [PMID:10471795]
  Authors
Deppenmeier U, Lienard T, Gottschalk G.
  Title
Novel reactions involved in energy conservation by methanogenic archaea.
  Journal
FEBS Lett 457:291-7 (1999)
DOI:10.1016/S0014-5793(99)01026-1
Reference
3  [PMID:10941105]
  Authors
Beifuss U, Tietze M, Baumer S, Deppenmeier U.
  Title
Methanophenazine: Structure, Total Synthesis, and Function of a New Cofactor from Methanogenic Archaea This work was supported by the Deutsche Forschungsgemeinschaft (Sonderforschungsbereich 416; grants De 488/6-1 and De 488/4-2) and the Fonds der Chemischen Industrie. We are grateful to Drs. J. Paust and H. Jaedicke (BASF AG, Ludwigshafen) and Dr. R. K. Muller (Hoffmann-La Roche Ltd., Basel) for generously providing chemicals.
  Journal
Angew Chem Int Ed Engl 39:2470-2472 (2000)
DOI:10.1002/1521-3773(20000717)39:14<2470::AID-ANIE2470>3.0.CO;2-R
Other DBs
ExplorEnz - The Enzyme Database: 1.12.98.3
IUBMB Enzyme Nomenclature: 1.12.98.3
ExPASy - ENZYME nomenclature database: 1.12.98.3
BRENDA, the Enzyme Database: 1.12.98.3
CAS: 9027-05-8

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