KEGG   ENZYME: 1.13.11.12Help
Entry
EC 1.13.11.12               Enzyme                                 

Name
linoleate 13S-lipoxygenase;
13-lipoxidase;
carotene oxidase;
13-lipoperoxidase;
fat oxidase;
13-lipoxydase;
lionoleate:O2 13-oxidoreductase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
linoleate:oxygen 13-oxidoreductase
Reaction(IUBMB)
(1) linoleate + O2 = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate [RN:R03626];
(2) alpha-linolenate + O2 = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate [RN:R07869]
Reaction(KEGG)
R03626 R07869;
(other) R07864
Show
Substrate
linoleate [CPD:C01595];
O2 [CPD:C00007];
alpha-linolenate [CPD:C06427]
Product
(9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate;
(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate
Comment
Contains nonheme iron. A common plant lipoxygenase that oxidizes linoleate and alpha-linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C-13 position with (S)-configuration. This enzyme produces precursors for several important compounds, including the plant hormone jasmonic acid. EC 1.13.11.58, linoleate 9S-lipoxygenase, catalyses a similar reaction at the second available position of these fatty acids.
History
EC 1.13.11.12 created 1961 as EC 1.99.2.1, transferred 1965 to EC 1.13.1.13, transferred 1972 to EC 1.13.11.12, modified 2011, modified 2012
Pathway
ec00591  Linoleic acid metabolism
ec00592  alpha-Linolenic acid metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00454  lipoxygenase
Genes
ATH: AT1G17420(LOX3) AT1G67560(LOX6) AT1G72520(LOX4) AT3G45140(LOX2)
ALY: ARALYDRAFT_471947 ARALYDRAFT_475859 ARALYDRAFT_476385 ARALYDRAFT_484907
CRB: 17885306 17886469 17895615 17896557 17898539
CSAT: 104701360 104701936 104710269 104712857 104740437 104750555 104751101 104756072 104772992 104772994 104775852 104780363 104780364 104787768 104788700 104790766 104790767
EUS: EUTSA_v10000639mg EUTSA_v10006732mg EUTSA_v10018089mg EUTSA_v10018091mg EUTSA_v10022540mg
BRP: 103830390 103830993 103830995 103830997 103831021 103835956 103842751 103852169 103852410 103852787
BNA: 106353334 106353868 106358574 106361173 106377834 106377835 106377836 106380862 106381296 106383072 106383749 106387621 106392120 106396874 106403712 106406325 106406326 106406355 106410653 106410673 106430278 106446190 111207131 111211798
BOE: 106300136 106300336 106300607 106311934 106312730 106320988 106321032 106321232 106321402 106321533 106322048 106327154 106327768
THJ: 104807897 104807899 104808056 104808057 104812216 104814043
CPAP: 110816034 110817847 110818329 110821650 110822645 110822659
LJA: Lj0g3v0005049.1(Lj0g3v0005049.1) Lj0g3v0090849.1(Lj0g3v0090849.1) Lj0g3v0092489.1(Lj0g3v0092489.1) Lj0g3v0209939.1(Lj0g3v0209939.1) Lj3g3v2576900.1(Lj3g3v2576900.1) Lj3g3v3281570.1(Lj3g3v3281570.1) Lj4g3v0451290.1(Lj4g3v0451290.1) Lj4g3v2528130.1(Lj4g3v2528130.1) Lj6g3v1038780.1(Lj6g3v1038780.1) Lj6g3v2019810.1(Lj6g3v2019810.1)
DOSA: Os02t0194700-01(Os02g0194700) Os03t0179900-01(Os03g0179900) Os04t0447100-01(Os04g0447100) Os05t0304600-01(Os05g0304600) Os08t0508800-01(Os08g0508800) Os08t0509100-01(Os08g0509100) Os12t0559200-01(Os12g0559200) Os12t0559934-00(Os12g0559934)
ATS: 109731694(LOC109731694) 109734703(LOC109734703) 109740157(LOC109740157) 109745563(LOC109745563) 109753441(LOC109753441) 109763690(LOC109763690) 109766344(LOC109766344) 109782110(LOC109782110) 109782804(LOC109782804)
ZMA: 100037806(lox9) 100037807(lox7) 100037808(ts1) 100037809(lox10) 100037810(lox11) 100037829(LOX12) 103642039
MNG: MNEG_2334
 » show all
Taxonomy
Reference
1  [PMID:5461103]
  Authors
Christopher J, Pistorius E, Axelrod B
  Title
Isolation of an isozyme of soybean lipoxygenase.
  Journal
Biochim Biophys Acta 198:12-9 (1970)
DOI:10.1016/0005-2744(70)90028-8
Reference
2  [PMID:18907700]
  Authors
THEORELL H, HOLMAN RT, AKESON A
  Title
Crystalline lipoxidase.
  Journal
Acta Chem Scand 1:571-6 (1947)
Reference
3  [PMID:5447012]
  Authors
Zimmerman DC, Vick BA.
  Title
Specificity of flaxseed lipoxidase.
  Journal
Lipids 5:392-7 (1970)
DOI:10.1007/BF02532104
Reference
4  [PMID:8702864]
  Authors
Royo J, Vancanneyt G, Perez AG, Sanz C, Stormann K, Rosahl S, Sanchez-Serrano JJ
  Title
Characterization of three potato lipoxygenases with distinct enzymatic activities and different organ-specific and wound-regulated expression patterns.
  Journal
J Biol Chem 271:21012-9 (1996)
DOI:10.1074/jbc.271.35.21012
  Sequence
Reference
5  [PMID:12452441]
  Authors
Bachmann A, Hause B, Maucher H, Garbe E, Voros K, Weichert H, Wasternack C, Feussner I
  Title
Jasmonate-induced lipid peroxidation in barley leaves initiated by distinct 13-LOX forms of chloroplasts.
  Journal
Biol Chem 383:1645-57 (2002)
DOI:10.1515/BC.2002.185
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.12
IUBMB Enzyme Nomenclature: 1.13.11.12
ExPASy - ENZYME nomenclature database: 1.13.11.12
BRENDA, the Enzyme Database: 1.13.11.12
CAS: 9029-60-1

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