KEGG ENZYME: 1.13.11.12

ENZYME: 1.13.11.12

Entry

EC 1.13.11.12               Enzyme

Name

linoleate 13S-lipoxygenase;
13-lipoxidase;
carotene oxidase;
13-lipoperoxidase;
fat oxidase;
13-lipoxydase;
lionoleate:O2 13-oxidoreductase

Class

Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen

Sysname

linoleate:oxygen 13-oxidoreductase

Reaction(IUBMB)

(1) linoleate + O2 = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate [RN:R03626];
(2) alpha-linolenate + O2 = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate [RN:R07869]

Reaction(KEGG)

R03626 R07869;
(other) R07864

Substrate

linoleate [CPD:C01595];
O2 [CPD:C00007];
alpha-linolenate [CPD:C06427]

Product

(9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate;
(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate

Comment

Contains nonheme iron. A common plant lipoxygenase that oxidizes linoleate and alpha-linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C-13 position with (S)-configuration. This enzyme produces precursors for several important compounds, including the plant hormone jasmonic acid. EC 1.13.11.58, linoleate 9S-lipoxygenase, catalyses a similar reaction at the second available position of these fatty acids.

History

EC 1.13.11.12 created 1961 as EC 1.99.2.1, transferred 1965 to EC 1.13.1.13, transferred 1972 to EC 1.13.11.12, modified 2011, modified 2012

Pathway

ec00591

Linoleic acid metabolism

ec00592

alpha-Linolenic acid metabolism

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K00454

lipoxygenase

Genes

ATH:	AT1G17420(LOX3) AT1G67560(LOX6) AT1G72520(LOX4) AT3G45140(LOX2)

ALY:	9313456 9323195 9323501 9329013

CRB:	17885306 17886469 17895615 17896557 17898539

CSAT:

104701360 104701936 104710269 104712857 104740437 104750555 104751101 104756072 104772992 104772994 104775852 104780363 104780364 104787768 104788700 104790766 104790767

EUS:	EUTSA_v10000639mg EUTSA_v10006732mg EUTSA_v10018089mg EUTSA_v10018091mg EUTSA_v10022540mg

BRP:	103830390 103830993 103830994 103830995 103830997 103831021 103835956 103842751 103852169 103852410 103852787

BNA:	106353334 106353868 106358574 106361173 106377836 106380862 106381296 106383072 106383749 106387621 106392120 106396874 106406325 106406326 106406355 106410673 106430278 106446190 111207131

BOE:	106300136 106300336 106300607 106311934 106312730 106320988 106321032 106322048 106327154 106327768

RSZ:	108817629 108817630 108817694 108818012 108818024 108818937 108822761 108827411 108843135

THJ:	104807897 104807899 104808056 104808057 104812216 104814043

CPAP:

110816034 110818329 110821650 110822645 110822659

CIT:	102614914 102620930 102621168 102622489 102625429 102625710 102625997 102626288 102629931

CIC:	CICLE_v10014199mg CICLE_v10014202mg CICLE_v10014204mg CICLE_v10014207mg CICLE_v10014209mg CICLE_v10014212mg CICLE_v10014260mg CICLE_v10017776mg CICLE_v10018178mg CICLE_v10024819mg CICLE_v10030653mg

PVY:	116106223 116112536 116120236 116126345 116126442 116139719 116141158 116141166

MINC:

123195906 123199278 123205647 123212173 123213756 123219356 123224787

TCC:	18589726 18589731 18589733 18596234 18596841 18596842 18596845 18609707 18612622 18612624

GRA:	105768828 105771510 105777156 105790506 105794530 105798973 105804169

GHI:	107886453 107886524 107892610 107904213 107906745 107909824 107915240 107916407 107954973 107959326 107960209 107961400 121219544 121230896

GAB:	108467580 108467586 108473970 108474384 108481128 108481129 108483796 108486930

DZI:	111274700 111275045 111280517 111284930 111285023 111314449 111314451 111317977 111318743

EGR:	104415702 104421559 104421561 104421562 104421563 104422979 104423495 104423496 104423499 104430084 104456477

GMX:	100782277 100785480 100786646 100787202 100791000 100793614 100793997 100794837 100795276 100797626 100797946 100800065 100809699 100810270 100811820 100814410 106794093

GSJ:	114374695 114376307 114377380 114378588 114381981 114382458 114389070 114390359 114399006 114402548 114402775 114403571 114406378 114407870 114418183 114419545 114421604

PVU:	PHAVU_002G175500g PHAVU_002G228700g PHAVU_006G016900g PHAVU_006G017100g PHAVU_006G185300g PHAVU_009G262900g PHAVU_010G032300g PHAVU_010G128800g PHAVU_011G056500g

VRA:	106756179 106760016 106766401 106768893 106773843 106774108 106774705 106776123

VAR:	108318688 108319146 108319980 108319986 108340288 108341692 108345553 108347100 108347472

VUN:	114164525 114165952 114166515 114169189 114177409 114178542 114187243 114188618

CCAJ:

109789563 109791111 109795078 109797325 109798367 109798417 109801182 109810207 109810726 109812601

APRC:

113850668 113851622 113852072 113854097 113857120 113857676 113858069 113863670 113864504 113864832

MTR:	11424953 11430427 11442192 11443018 25491116 25492621 25493161 25501722

CAM:	101490939 101491576 101491883 101492220 101499603 101499921 101505280 101512038

PSAT:

127076264 127076582 127083526 127083527 127083530 127108278 127108363

LJA:	Lj0g3v0005049.1(Lj0g3v0005049.1) Lj0g3v0092489.1(Lj0g3v0092489.1) Lj3g3v2576900.1(Lj3g3v2576900.1) Lj4g3v2528130.1(Lj4g3v2528130.1)

ADU:	107464862 107468333 107474788 107476778 107476782 107480797 107482108 107491873 107495645

AIP:	107605495 107616733 107617859 107627453 107628999 107629000 107631225 107632005 107646151

AHF:	112695228 112710263 112710496 112714587 112726540 112730234 112733497 112734832 112736764 112736765 112755910 112758622 112777604 112779871 112783250 112788858 112788860 112791475 112792576 112805953

LANG:

109325809 109332787 109334380 109340657 109351540 109351541 109351988 109359905 109363322

FVE:	101294042 101298571 101301208 101301283 101302634 101302672 101306996 101311411 105352790

RCN:	112165115 112166356 112167842 112167843 112170539 112175375 112186516 112190361 112190371 112191508 112196726 112197988

PPER:

18766622 18773995 18781374 18783171 18784763 18787140 18787524 18793349

PMUM:

103321981 103324771 103327618 103330513 103330561 103330562 103334687 103341815

PAVI:

110745804 110753142 110758819 110763971 110763981 110766786 110768882

PDUL:

117617277 117618943 117621049 117623958 117623975 117631060 117636506

MDM:	103416677 103418601 103422578 103428313 103434797 103438366 103446404 103447063 103449741 103452114 103453627 114825931

PXB:	103931981 103940836 103940837 103941411 103945829 103949566 103949909 103954602 103954616 103954903 103954907

ZJU:	107410360 107412635 107412653 107412655 107412659 107427730 107428338

MNT:	21383974 21390169 21391370 21391372 21392890 21401352

CSV:	101204952 101209041 101209343 101209531 101214639 101214880 101215361 101215600 101215837 101216079 101216318 101216566 101222906

CMO:	103488906 103491538(LOX10) 103491539(LOX13) 103491540 103491544 103491674 103491676 103492581 103500686 107990336 107991008

BHJ:	120081592 120085966 120086674 120087584 120087904 120088071 120088280 120088659 120088864

MCHA:

111013426 111017305 111017309 111017327 111017337 111019373 111019743 111021194 111021205 111021206 111021225

CMAX:

111483582 111483812 111488540 111490700 111491398 111492257 111494489 111497983

CMOS:

111448227 111448228 111456143 111458293 111459461 111459464 111459733 111460977 111464444

CPEP:

111776704 111777904 111778977 111779047 111794851 111795010 111800967 111806900

RCU:	8259705 8260968 8274392 8274394 8278422 8279511 8279513 8287142 8287572

JCU:	105628660 105631383 105644143 105650485 105650487 119369051

HBR:	110634276 110636351 110640479 110650582 110652710 110657974 110661258 110664582 110666854 110668852

MESC:

110603475 110603975 110613558 110618536 110618696 110624547 110624569 110625046 110626911 110628091 110628328

POP:	18094302 18094717 7463375 7475684 7477038 7489299 7494782 7496048 7496049 7496589 7497340

PEU:	105114480 105129345 105133430 105133968 105134952 105134953 105137488 105137846 105138627 105141868

PALZ:

118034839 118037984 118047238 118048807 118049740 118049741 118049807 118053297 118053845 118063407

JRE:	108985999 109001974 109002101 109002102 109006935 109011523 109013393 109019281 109019660 109021360

CILL:

122279742 122280673 122291432 122291544 122291546 122292175 122292176 122293185 122293511 122294211 122309741

QSU:	111990528 111990529 111990533 111997309 112001646 112001647 112015392 112018950 112032371

QLO:	115959793 115976223 115976234 115976243 115976254 115976262 115982279 115989795 115990463 115991611 115992985

TWL:	119991772 119993865 119995048 119996533 119996826 119997190 120000534 120000535 120002373 120007789 120016932

VVI:	100241150(LOXO) 100241684 100243312(LOXA) 100244202 100251934 100255333 100256749(LOXD) 100257867 100262173 100854792 109121418

VRI:	117915560 117915603 117915604 117915616 117915954 117915956 117916870 117917725 117917829 117922205 117923587 117928650 117928981 117929396

SLY:	100301936(loxF) 101254936 101262081 101263024 544008(loxC) 544009(loxD)

SPEN:

107011715 107012058 107014949 107020487 107025511 107029284

SOT:	102583480 102586366 102588373 102594007 102596122(LOX-H1) 102596456 102597498(LOX-H3)

SSTN:

125857468 125866833 125868970 125869252 125871936 125872713 125872719

CANN:

107843096 107847668 107861665 107874182 107874197

NTA:	107771567 107775404 107794389 107800317 107800325 107814671(ACRE44) 107820064 107828143 107829038 107829039

NSY:	104221641 104222087 104226762 104239421 104247680

NTO:	104086420 104086421 104099694 104100503 104104553 104110911

NAU:	109219413 109220494 109234024 109234465

INI:	109148807 109173611 109188245 109192488 109194054

ITR:	115996574 116004539 116009747 116016699 116027205 116027957

SIND:

105157809 105163543 105163615 105168387

OEU:	111366164 111366779 111369299 111392344 111393078 111393284 111398858

EGT:	105951110 105951119 105951128 105951140 105951147 105951166 105970909 105975909

SSPL:

121752947 121752956 121761723 121764864 121768778 121771816 121791361 121791869 121792664 121794163 121794535 121797735 121798481 121801852 121808090

APAN:

127245521 127254321 127258906 127259149 127259150 127259151

HAN:	110876540 110878828 110878831 110880264 110883872 110898667 110898670 110898671 110898672 110898673 110898679 110927144 110927159 110927161 110927162 110935489

ECAD:

122580873 122581088 122581089 122584875 122586300 122596760 122606030 122606597

LSV:	111881537 111882177 111887871 111887887 111890113 111890168 111890186 111890201 111915189 111915226 111917350 111921376

CCAV:

112508500 112511247 112519000 112520856 112520926 112520927 112520928 112520930 112520960 112521264 112521358 112521642 112523391

DCR:	108195869 108196505 108198193 108205599 108206933 108223175

CSIN:

114258046 114268608 114301806 114306071 114318004

BVG:	104889932 104889933 104889934 104890263 104894250 104897618 104899745

SOE:	110794090 110802058 110802079 110803976

CQI:	110684391 110688078 110695975 110695976 110695977 110696152 110710574 110712524 110718504 110718526 110736160 110736162 110736163 110737176

NNU:	104591662 104597527 104600542 104603494 104603495 104605310 104609274

MING:

122060438 122061180 122071840 122083217 122086147 122088494 122088943 122089002 122089004 122089211 122091950

TSS:	122641650 122641655 122642300 122643837 122643838 122654785 122656748 122663274 122667970 122670626

PSOM:

113276569 113281479 113307862 113316483 113326638 113339920

OSA:	4328603 4331824 4338358 4345993 4345994 4352505 4352509 9267158

DOSA:

Os02t0194700-01(Os02g0194700) Os03t0179900-01(Os03g0179900) Os04t0447100-01(Os04g0447100) Os05t0304600-01(Os05g0304600) Os08t0508800-01(Os08g0508800) Os08t0509100-01(Os08g0509100) Os12t0559200-01(Os12g0559200)

OBR:	102703951 102709103 102710692 102714377 102716936 102720810

BDI:	100821730 100824090 100827591 100829163 100831197 100832776

ATS:	109731694 109734703 109740157 109753441 109763690 109766344 109782110 109782804

TDC:	119275272 119284545 119291638 119298757 119304175 119307007 119316472 119324206 119331583 119339070 119341611 119357938 119364412

TAES:

123045591 123051898 123053431 123084716 123093384 123098654 123101959 123110078 123114594 123119080 123119305 123127914 123132647 123136741 123142935 123144225 123152042 123159032 123169172 123181625 123189338

TUA:	125506862 125511466 125513340 125517581 125520124 125538417

LPER:

127294086 127296979 127307567 127307568 127307569 127311299 127316850 127335021 127341439

SBI:	110434540 8055177 8065259 8065835 8076652 8082015

ZMA:	100037806(lox9) 100037807(lox7) 100037808(ts1) 100037809(lox10) 100037810(lox11) 100037829(lox12) 103642039

SITA:

101772084 101772546 101778990 101783519 101784066 101785224

SVS:	117837168 117844140 117850875 117851960 117860436 117864503

PVIR:

120640728 120641145 120647117 120648869 120654961 120666195 120679282 120682362 120689760 120698837 120699265 120712798

PHAI:

112872608 112875310 112884139 112897406 112900116

PDA:	103698211 103703268 103705383 103708564 103708655 103719871 103723450 120111665

EGU:	105038631 105039460 105041807 105050486 105051386 105053112 105056718 105061262 105061263

MUS:	103968512 103973030 103977612 103977941 103989321 103995280 103997721 103998047

ZOF:	121971527 121976126 121991523 121991926 121993195 121995412 121995832 121997162 122008543 122014387 122018473 122018938 122019774 122023414 122023513 122023522 122023548 122023558 122024231 122025788 122051799 122054776 122054783 122054792 122056330

DCT:	110094199 110094663 110095381 110106362 110113631

PEQ:	110022556 110029159 110033226

AOF:	109823945 109827974 109833605 109846407 109846441

NCOL:

116246061 116248569 116254375 116259457

ATR:	18439494 18439842 18439847 18442037 18448550

SMO:	SELMODRAFT_140773(LOX4) SELMODRAFT_163446(LOX5) SELMODRAFT_168576(LOX7) SELMODRAFT_268169(LOX8) SELMODRAFT_402721 SELMODRAFT_402722(LOX12) SELMODRAFT_408153 SELMODRAFT_437605 SELMODRAFT_439024 SELMODRAFT_441081 SELMODRAFT_87745(LOX3)

PPP:	112289962 112292631 112292632 112292633 112292817

VCN:	VOLCADRAFT_105417

MNG:

MNEG_2334

CSL:	COCSUDRAFT_31564 COCSUDRAFT_67878

» show all

Reference

1 [PMID:5461103]

Authors

Christopher J, Pistorius E, Axelrod B

Title

Isolation of an isozyme of soybean lipoxygenase.

Journal

Biochim Biophys Acta 198:12-9 (1970)
DOI:10.1016/0005-2744(70)90028-8

Reference

2 [PMID:18907700]

Authors

THEORELL H, HOLMAN RT, AKESON A

Title

Crystalline lipoxidase.

Journal

Acta Chem Scand 1:571-6 (1947)
DOI:10.3891/acta.chem.scand.01-0571

Reference

3 [PMID:5447012]

Authors

Zimmerman DC, Vick BA.

Title

Specificity of flaxseed lipoxidase.

Journal

Lipids 5:392-7 (1970)
DOI:10.1007/BF02532104

Reference

4 [PMID:8702864]

Authors

Royo J, Vancanneyt G, Perez AG, Sanz C, Stormann K, Rosahl S, Sanchez-Serrano JJ

Title

Characterization of three potato lipoxygenases with distinct enzymatic activities and different organ-specific and wound-regulated expression patterns.

Journal

J Biol Chem 271:21012-9 (1996)
DOI:10.1074/jbc.271.35.21012

Sequence

[sot:102596122 102597498]

Reference

5 [PMID:12452441]

Authors

Bachmann A, Hause B, Maucher H, Garbe E, Voros K, Weichert H, Wasternack C, Feussner I

Title

Jasmonate-induced lipid peroxidation in barley leaves initiated by distinct 13-LOX forms of chloroplasts.

Journal

Biol Chem 383:1645-57 (2002)
DOI:10.1515/BC.2002.185