Entry |
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Name |
linoleate 13S-lipoxygenase;
13-lipoxidase;
carotene oxidase;
13-lipoperoxidase;
fat oxidase;
13-lipoxydase;
lionoleate:O2 13-oxidoreductase
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Class |
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
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Sysname |
linoleate:oxygen 13-oxidoreductase
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Reaction(IUBMB) |
(1) linoleate + O2 = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate [RN: R03626];
(2) alpha-linolenate + O2 = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate [RN: R07869]
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Reaction(KEGG) |
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Substrate |
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Product |
(9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate;
(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate
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Comment |
Contains nonheme iron. A common plant lipoxygenase that oxidizes linoleate and alpha-linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C-13 position with (S)-configuration. This enzyme produces precursors for several important compounds, including the plant hormone jasmonic acid. EC 1.13.11.58, linoleate 9S-lipoxygenase, catalyses a similar reaction at the second available position of these fatty acids.
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History |
EC 1.13.11.12 created 1961 as EC 1.99.2.1, transferred 1965 to EC 1.13.1.13, transferred 1972 to EC 1.13.11.12, modified 2011, modified 2012
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Pathway |
ec00592 | alpha-Linolenic acid metabolism |
ec01110 | Biosynthesis of secondary metabolites |
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Orthology |
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Genes |
» show all
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Reference |
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Authors |
Christopher J, Pistorius E, Axelrod B |
Title |
Isolation of an isozyme of soybean lipoxygenase. |
Journal |
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Reference |
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Authors |
THEORELL H, HOLMAN RT, AKESON A |
Title |
Crystalline lipoxidase. |
Journal |
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Reference |
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Authors |
Zimmerman DC, Vick BA. |
Title |
Specificity of flaxseed lipoxidase. |
Journal |
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Reference |
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Authors |
Royo J, Vancanneyt G, Perez AG, Sanz C, Stormann K, Rosahl S, Sanchez-Serrano JJ |
Title |
Characterization of three potato lipoxygenases with distinct enzymatic activities and different organ-specific and wound-regulated expression patterns. |
Journal |
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Sequence |
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Reference |
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Authors |
Bachmann A, Hause B, Maucher H, Garbe E, Voros K, Weichert H, Wasternack C, Feussner I |
Title |
Jasmonate-induced lipid peroxidation in barley leaves initiated by distinct 13-LOX forms of chloroplasts. |
Journal |
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Sequence |
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Other DBs |
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