KEGG ENZYME: 1.13.11.12

ENZYME: 1.13.11.12

Entry

EC 1.13.11.12 Enzyme

Name

linoleate 13S-lipoxygenase;
13-lipoxidase;
carotene oxidase;
13-lipoperoxidase;
fat oxidase;
13-lipoxydase;
lionoleate:O2 13-oxidoreductase

Class

Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen

Sysname

linoleate:oxygen 13-oxidoreductase

Reaction(IUBMB)

(1) linoleate + O2 = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate [RN:R03626];
(2) alpha-linolenate + O2 = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate [RN:R07869]

Reaction(KEGG)

R03626 R07869;
(other) R07864

Substrate

linoleate [CPD:C01595];
O2 [CPD:C00007];
alpha-linolenate [CPD:C06427]

Product

(9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate;
(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate

Comment

Contains nonheme iron. A common plant lipoxygenase that oxidizes linoleate and alpha-linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C-13 position with (S)-configuration. This enzyme produces precursors for several important compounds, including the plant hormone jasmonic acid. EC 1.13.11.58, linoleate 9S-lipoxygenase, catalyses a similar reaction at the second available position of these fatty acids.

History

EC 1.13.11.12 created 1961 as EC 1.99.2.1, transferred 1965 to EC 1.13.1.13, transferred 1972 to EC 1.13.11.12, modified 2011, modified 2012

Pathway

ec00591

Linoleic acid metabolism

ec00592

alpha-Linolenic acid metabolism

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K00454

lipoxygenase

Genes

ATH:	AT1G17420(LOX3) AT1G67560(LOX6) AT1G72520(LOX4) AT3G45140(LOX2)

ALY:	ARALYDRAFT_471947 ARALYDRAFT_475859 ARALYDRAFT_476385 ARALYDRAFT_484907

CRB:	17885306 17886469 17895615 17896557 17898539

CSAT:

104701360 104701936 104710269 104712857 104740437 104750555 104751101 104756072 104772992 104772994 104775852 104780363 104780364 104787768 104788700 104790766 104790767

EUS:	EUTSA_v10000639mg EUTSA_v10006732mg EUTSA_v10018089mg EUTSA_v10018091mg EUTSA_v10022540mg

BRP:	103830390 103830993 103830995 103830997 103831021 103835956 103842751 103852169 103852410 103852787

BNA:	106353334 106353868 106358574 106361173 106377834 106377835 106377836 106380862 106381296 106383072 106383749 106387621 106392120 106396874 106403712 106406325 106406326 106406355 106410653 106410673 106430278 106446190 111207131 111211798

BOE:	106300136 106300336 106300607 106311934 106312730 106320988 106321032 106321232 106321402 106321533 106322048 106327154 106327768

THJ:	104807897 104807899 104808056 104808057 104812216 104814043

CPAP:

110816034 110817847 110818329 110821650 110822645 110822659

CIT:	102614914 102620930 102621168 102622489 102625429 102625710 102625997 102626288 102629931

CIC:	CICLE_v10014199mg CICLE_v10014202mg CICLE_v10014204mg CICLE_v10014207mg CICLE_v10014209mg CICLE_v10014212mg CICLE_v10014260mg CICLE_v10017776mg CICLE_v10018178mg CICLE_v10024819mg CICLE_v10027295mg CICLE_v10030653mg

TCC:	18589726 18589731 18589733 18596234 18596841 18596842 18596845 18609707 18612622 18612624

GRA:	105768828 105771510 105777156 105790506 105794530 105798973 105804169

GHI:	107886453 107886524 107892610 107904213 107906745 107909824 107915240 107916407 107954973 107959326 107960209 107961400 107961446

DZI:	111274700 111275045 111280517 111284930 111285023 111314449 111314451 111317977 111318743

EGR:	104415702 104421559 104421561 104421562 104421563 104422979 104423495 104423496 104423499 104430084 104456477

GMX:	100782277 100785480 100786646 100787202 100791000 100793614 100793997 100794837 100795276 100797626 100797946 100800065 100809699 100810270 100811820 100814410 100817322 106794093 106796402

PVU:	PHAVU_002G175500g PHAVU_002G228700g PHAVU_006G016900g PHAVU_006G017100g PHAVU_006G185300g PHAVU_009G262900g PHAVU_010G032300g PHAVU_010G128800g PHAVU_011G056500g

VRA:	106756179 106760016 106766401 106768893 106773843 106774108 106774705 106776123

VAR:	108318688 108319146 108319980 108319986 108340288 108341692 108345553 108347100 108347472

CCAJ:

109789562 109789563 109791111 109795078 109797325 109798367 109798417 109801182 109810207 109810726 109812601

MTR:	MTR_3g079420 MTR_3g079450 MTR_3g479460 MTR_4g066170 MTR_4g088810 MTR_6g452500 MTR_8g011340 MTR_8g020970 MTR_8g080230

CAM:	101490939 101491576 101491883 101492220 101499603 101499921 101501374 101505280 101512038

LJA:

Lj0g3v0005049.1(Lj0g3v0005049.1) Lj0g3v0090849.1(Lj0g3v0090849.1) Lj0g3v0092489.1(Lj0g3v0092489.1) Lj0g3v0209939.1(Lj0g3v0209939.1) Lj3g3v2576900.1(Lj3g3v2576900.1) Lj3g3v3281570.1(Lj3g3v3281570.1) Lj4g3v0451290.1(Lj4g3v0451290.1) Lj4g3v2528130.1(Lj4g3v2528130.1) Lj6g3v1038780.1(Lj6g3v1038780.1) Lj6g3v2019810.1(Lj6g3v2019810.1)

ADU:	107464862 107468333 107474788 107476778 107476782 107480797 107482108 107491873 107495645

AIP:	107605495 107616733 107617859 107627453 107628999 107629000 107631225 107632005 107637234 107646151

LANG:

109325809 109332787 109334380 109340657 109351540 109351541 109351988 109359905 109363322

FVE:	101294042 101298571 101301208 101301283 101302634 101302672 101306996 101311411 105352790

PPER:

18766622 18773995 18781374 18783171 18784763 18787140 18787524 18793349

PMUM:

103321981 103324771 103327618 103330513 103330561 103330562 103334687 103341815

PAVI:

110745804 110753142 110758819 110763971 110763977 110763981 110766786 110768882

MDM:	103416677(LOX8a) 103418601(LOX5b) 103419741 103422578(LOX6b) 103427024 103427900 103428313(LOX9a) 103434797 103435078 103438366(LOX5a) 103438492 103442166 103446404 103447063(LOX6a) 103449741(LOX2a) 103452114(LOX8b) 103453627(LOX2b)

PXB:	103931981 103940836 103940837 103941411 103945829 103949566 103949909 103954602 103954616 103954903 103954907

ZJU:	107409504 107409898 107410360 107412635 107412653 107412655 107412659 107427730 107428338

CSV:	101204952 101209041 101209343 101209531 101214639 101214880 101215116 101215361 101215600 101215837 101216079 101216318 101216566 101222906

CMO:	103488906 103491538(LOX10) 103491539(LOX13) 103491540 103491544 103491674 103491676 103491677 103492581 103500686 107990326 107990336 107991008 107991017 107992326

MCHA:

111013426 111017305 111017309 111017327 111017337 111019373 111019743 111020132 111021194 111021205 111021206 111021225

CMAX:

111483582 111483812 111488540 111490700 111491398 111492257 111494489 111497983

CMOS:

111448227 111448228 111456143 111458293 111459461 111459464 111459733 111464444

CPEP:

111776704 111777904 111778977 111779047 111794851 111795010 111800967 111806900

RCU:	8259705 8260968 8274392 8274394 8278422 8279511 8279513 8287142 8287572

JCU:	105628660 105631383 105644143 105650485 105650487 110008913

HBR:	110634276 110636351 110640479 110646073 110650582 110652710 110657974 110661258 110664582 110666854 110668852

POP:	18094302 18094717 18109826 7463375 7475684 7477038 7489299 7494782 7496048 7496049 7496589 7497340

JRE:	108982818 108985999 109001974 109002101 109002102 109002105 109006935 109010895 109011521 109011523 109013393 109015223 109016209 109016747 109019281 109019660 109021360

VVI:	100241150(LOXO) 100241684 100242477 100243312(LOXA) 100244202 100251934 100255333 100256749(LOXD) 100257867 100262173 100854792 104877287 109121418

SLY:	100301936(loxF) 101244897 101254936 101262081 101263024 544008(TomloxC) 544009(loxD)

SPEN:

107011715 107012058 107014949 107020487 107025511 107029284

SOT:	102583480 102586366 102588373 102594007 102596122(LOX-H1) 102596456 102597498(LOX-H3)

CANN:

107843096 107847668 107861665(LOX2) 107874182(LOXc) 107874197(LOX)

NTA:	107763642 107771567 107775404 107777293 107794389 107800317 107800325 107814671(ACRE44) 107820064 107820590 107828143 107829038 107829039

NSY:	104221641 104222087 104226762 104227470 104239421 104247680

NTO:	104086420 104086421 104099694 104100503 104104553 104110719 104110911

INI:	109148807 109173611 109188245 109192488 109194054

SIND:

105157809 105163543 105163615 105168387

OEU:	111366164 111366779 111369299 111392344 111393078 111393284 111398858

HAN:	110876540 110878828 110878831 110880264 110883872 110898667 110898670 110898671 110898672 110898673 110898679 110927144 110927159 110927161 110927162 110935489

LSV:	111881537 111882177 111887871 111887887 111889501 111890113 111890168 111890186 111890201 111915189 111915226 111917350 111921376

CCAV:

112508500 112511247 112519000 112520856 112520926 112520927 112520928 112520930 112520960 112521264 112521358 112521642 112523391

DCR:	108195869 108196505 108198193 108205599 108206933 108223175

BVG:	104889932 104889933 104889934 104890263 104894250 104897618 104899745

SOE:	110794090 110802058 110802079 110803976

NNU:	104591662 104597527 104600542 104603494 104603495 104605310 104609274

OSA:	4328603 4331824 4338358 4345993 4345994 4352505 4352509 9267158

DOSA:

Os02t0194700-01(Os02g0194700) Os03t0179900-01(Os03g0179900) Os04t0447100-01(Os04g0447100) Os05t0304600-01(Os05g0304600) Os08t0508800-01(Os08g0508800) Os08t0509100-01(Os08g0509100) Os12t0559200-01(Os12g0559200) Os12t0559934-00(Os12g0559934)

OBR:	102703951 102709103 102710692 102714377 102716936 102720810

BDI:	100821730 100824090 100827591 100829163 100831197 100832776

ATS:	109731694(LOC109731694) 109734703(LOC109734703) 109740157(LOC109740157) 109745563(LOC109745563) 109753441(LOC109753441) 109763690(LOC109763690) 109766344(LOC109766344) 109782110(LOC109782110) 109782804(LOC109782804)

SBI:	110434540 8055177 8065259 8065835 8076652 8082015

ZMA:	100037806(lox9) 100037807(lox7) 100037808(ts1) 100037809(lox10) 100037810(lox11) 100037829(LOX12) 103642039

SITA:

101772084 101772546 101778990 101783519 101784066 101785224

PDA:	103698211 103702133 103703268 103705383 103708564 103708655 103719871 103723450

EGU:	105038631 105039460 105041807 105050486 105051386 105053112 105056718 105061262 105061263

MUS:	103968512 103973030 103977612 103977941 103989321 103995280 103997721 103998047

DCT:	110094199 110094663 110095381 110106362 110113631

PEQ:	110022556 110029159 110033226

AOF:	109823945 109827974 109833605 109846407 109846441

ATR:	18439494 18439842 18439847 18442037 18448550

SMO:	SELMODRAFT_140773(LOX4) SELMODRAFT_163446(LOX5) SELMODRAFT_168576(LOX7) SELMODRAFT_268169(LOX8) SELMODRAFT_402721 SELMODRAFT_402722(LOX12) SELMODRAFT_408153 SELMODRAFT_437605 SELMODRAFT_439024 SELMODRAFT_441081 SELMODRAFT_87745(LOX3)

PPP:	112284555 112289962 112292631 112292632 112292633 112292817

VCN:	VOLCADRAFT_105417

MNG:

MNEG_2334

CSL:	COCSUDRAFT_31564 COCSUDRAFT_67878

CVR:	CHLNCDRAFT_33552

» show all

Reference

1 [PMID:5461103]

Authors

Christopher J, Pistorius E, Axelrod B

Title

Isolation of an isozyme of soybean lipoxygenase.

Journal

Biochim Biophys Acta 198:12-9 (1970)
DOI:10.1016/0005-2744(70)90028-8

Reference

2 [PMID:18907700]

Authors

THEORELL H, HOLMAN RT, AKESON A

Title

Crystalline lipoxidase.

Journal

Acta Chem Scand 1:571-6 (1947)

Reference

3 [PMID:5447012]

Authors

Zimmerman DC, Vick BA.

Title

Specificity of flaxseed lipoxidase.

Journal

Lipids 5:392-7 (1970)
DOI:10.1007/BF02532104

Reference

4 [PMID:8702864]

Authors

Royo J, Vancanneyt G, Perez AG, Sanz C, Stormann K, Rosahl S, Sanchez-Serrano JJ

Title

Characterization of three potato lipoxygenases with distinct enzymatic activities and different organ-specific and wound-regulated expression patterns.

Journal

J Biol Chem 271:21012-9 (1996)
DOI:10.1074/jbc.271.35.21012

Sequence

[sot:102596122 102597498]

Reference

5 [PMID:12452441]

Authors

Bachmann A, Hause B, Maucher H, Garbe E, Voros K, Weichert H, Wasternack C, Feussner I

Title

Jasmonate-induced lipid peroxidation in barley leaves initiated by distinct 13-LOX forms of chloroplasts.

Journal

Biol Chem 383:1645-57 (2002)
DOI:10.1515/BC.2002.185