Entry
Name
persulfide dioxygenase;
sulfur oxygenase (incorrect);
sulfur:oxygen oxidoreductase (incorrect);
sulfur dioxygenase (incorrect)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
S-sulfanylglutathione:oxygen oxidoreductase
Reaction(IUBMB)
S-sulfanylglutathione + O2 + H2O = glutathione + sulfite + 2 H+ (overall reaction) [RN:
R08678 ];
(1a) S-sulfanylglutathione + O2 = S-sulfinatoglutathione + H+ [RN:
R11946 ];
(1b) S-sulfinatoglutathione + H2O = glutathione + sulfite + H+ (spontaneous) [RN:
R11947 ]
Reaction(KEGG)
Substrate
Product
Comment
An iron protein. Perthiols, formed spontaneously by interactions between thiols and elemental sulfur or sulfide, are the only acceptable substrate to the enzyme. The sulfite that is formed by the enzyme can be further converted into sulfate, thiosulfate or S-sulfoglutathione (GSSO3-) non-enzymically [2].
History
EC 1.13.11.18 created 1972, modified 2015
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
Genes
RRO : 104669456(ETHE1) 115892008
ZCA : 113935762(ETHE1) 113936293
BMUS : 118885487 118885655
GAS : 123232530 123255619(ETHE1)
CMY : 102932629 102948016(ETHE1)
CPIC : 101936154 101940172
MRV : 120390485 120390717(ETHE1)
XLA : 108704965(ethe1.S) 379091(ethe1.L)
BGAR : 122924051 122941254
GSH : 117345666(ETHE1) 117350775
MASI : 127453204 127453665
AMEX : 111197379 125781328(ethe1)
TNG : GSTEN00008830G001 GSTEN00008831G001
MZE : 101473226 101473515 101473809
OAU : 116325105 116325120(ethe1) 116325138
PRET : 103477883 103477884
PFOR : 103139263 103139265
PLAI : 106960403 106960419
PMEI : 106917689 106917690
GAF : 122830758 122830762(ethe1)
PPRL : 129370827 129370831(ethe1)
CTUL : 119797857(ethe1) 119797897
GMU : 124865946(ethe1) 124866340
KMR : 108240304 108240315(ethe1)
ALIM : 106530059 106530060(ethe1)
NWH : 119409891(ethe1) 119409892
MALB : 109954710 109954711
BSPL : 114843311 114843312 114843313(ethe1) 114843314 121201627
SASA : 106582613(ETHE1) 106605166
STRU : 115177078 115177328
SALP : 111959205 111965185
CCLU : 121558831 121566207
PSPA : 121298709 121304407
ARUT : 117433799 117964786
PSEX : 120536908 120540111(ethe1)
CPLA : 122545715 122546059
BBEL : 109470999 109478675
CIN : 100175617 100177990 100187477
SCLV : 120326270 120326907 120327117
SKO : 100376690 100376840 100376992
DME : Dmel_CG30022(CG30022) Dmel_CG30023(sprt)
DSI : Dsimw501_GD25902(Dsim_GD25902) Dsimw501_GD28368(Dsim_GD28368)
DPO : 15382869 6898752 6898753
DPE : 113565232 6591053 6591054
DMN : 108160408 108160409 117193580 117193581 117193725
DMO : Dmoj_GI21050 Dmoj_GI26579
CCAT : 101453109 101453291
RZE : 108367628 108376811 108381955
TDA : 119673977 119673979 119679737 119679738 119681595
SCAC : 106087582 106087583
ECOE : 129949627 129949628
CLON : 129607257 129607701
ACOZ : 120947320 120950987
AARA : 120895108 120895970
AMER : 121592521 121602963
ASTE : 118502580 118511952
AFUN : 125763106 125770092
AMOU : 128301191 128301519
AALI : 118460329 118465017
ASUA : 134215897 134219738
BCOO : 119073486 119074387
ACER : 107994512 107995393
ALAB : 122710437 122710504
AFLR : 100869658 100871762
BBIF : 117209618 117210684
BVAN : 117158602 117164157
BTER : 100647153 100650307
BAFF : 126916223 126926149
BPYO : 122565688 122571733
BPAS : 132904821 132909320
CCAL : 108622501 108622883
MGEN : 117220314 117221889
NMEA : 116426316 116435232
CGIG : 122400858 122402610
MPHA : 105830436 105837011
ACEP : 105618240 105620490
PBAR : 105428401 105433983
LHU : 105668800(sprt) 105676593
PFUC : 122514742 122515085
VCRB : 124430896 124431338
CSOL : 105366511 105367773
CGLO : 123264266 123266312
AGIF : 122853218 122857142
CCIN : 107264356 107267778
AROA : 105683564 105692464
CSET : 123314253 123315461
PPYR : 116168343 116172678
BMOR : 101745571 105841811
BMAN : 114242414 114247046
MSEX : 115450664 115452929
BANY : 112046677 112052722
PMAC : 106713947 106718974
PRAP : 110995493 110999564
CCRC : 123691502 123697451
AAGE : 121731958 121734640
HAW : 110374899(sprT) 110384575
SLIU : 111351572 111356651
ATRA : 106130296 106139128
LGLY : 125227967 125235532
CFEL : 113389153 113389182
CCRN : 123295288 123304969
BTAB : 109029662 109044173
CLEC : 106664851 106668154
HHAL : 106685531(sprt) 106688663
NLU : 111047256 111058613 120349617
HVI : 124356783 124367916 124372851
PHU : Phum_PHUM102450 Phum_PHUM613050
TPAL : 117642665 117651961
CSEC : 111865818 111874193
BROR : 134531541 134532660
DPX : DAPPUDRAFT_231232 DAPPUDRAFT_311442
DMK : 116922748 116926549 116930812
PMOO : 119579451 119597324
HAME : 121854161 121861028 121861050
PCLA : 123765850 123773948 123773949
PTRU : 123504488 123512857
HAZT : 108667826 108676556 108679602
PPOI : 119091418 119094287 119101196
LPOL : 106462787 106473072
CEL : CELE_C33A12.7(ethe-1)
CBR : CBG_20009(Cbr-ethe-1)
BMY : BM_BM2530(Bma-ethe-1)
LAK : 106154017 106160274 106160912
SMM : Smp_080670 Smp_165640
ATEN : 116287652 116292690
CSAT : 104742878 104758709 104778293
BNA : 106349619 106360391 106377307 106451483
BOE : 106296222 106300310 106331433
RSZ : 108817777 108819351 130506320
MINC : 123201305 123201971
HSYR : 120123836 120127880 120159138 120160424
GMX : 100780846(GLYII-6) 100796796(GLYII-10)
TPRA : 123895004 123918441
LANG : 109337499 109348067
QSA : O6P43_021060 O6P43_029271
ZJU : 107416115 107432744 107433189 132799256 132799370 132803443
CSAV : 115699572 115704680
CMAX : 111477087 111481087
CMOS : 111443326 111446332
CPEP : 111788546 111797437
PALZ : 118027485 118061739
CAVE : 132181460 132181895
SPEN : 107005965 107025358
SSTN : 125868205 125876289
SDUL : 129870583 129892558
CANN : 107863776 107878548
NTA : 107770044 107771480 107815688 107831711
SSPL : 121769448 121772545
SMIL : 131017797 131026393
APAN : 127241878 127265806
CSIN : 114301011 114302140 114310884
PSOM : 113287351 113295567
TAES : 123061718 123070308 123078759
MFLO : 136450263 136458677
PVIR : 120675639 120710108
ZOF : 122037296 122042013 122046529
MSIN : 131240834 131245573
NCOL : 116246928 116263726 116264912
SMO : SELMODRAFT_76878 SELMODRAFT_95147
PTI : PHATRDRAFT_16707(GLO_1)
EHX : EMIHUDRAFT_436379 EMIHUDRAFT_68628
GTT : GUITHDRAFT_155822 GUITHDRAFT_166280 GUITHDRAFT_96377
NGR : NAEGRDRAFT_82995 NAEGRDRAFT_83261
LSS : NCTC12082_00079(pksB)
MDN : JT25_002715 JT25_013110
TTC : FOKN1_1013 FOKN1_1105
CGD : CR3_1292 CR3_2791(gloB)
BFN : OI25_2781(ethe1) OI25_7880 OI25_8246(ethe1)
CABA : SBC2_41690(blh_1) SBC2_43200(gloB_4) SBC2_52500(blh_2)
RAC : RA876_03210 RA876_09745
HPSE : HPF_03375(blh1) HPF_22135(blh2)
MASW : AM586_11260 AM586_15420
MTIM : DIR46_19905 DIR46_25650
SNIV : SFSGTM_21040(gly3_1) SFSGTM_22010(gly3_2)
ACOM : CEW83_01795 CEW83_04450
NPN : JI59_20275 JI59_23255 JI59_26055
SPYG : YGS_C2P0168 YGS_C2P0609
ACZ : Acaty_c2122 Acaty_c2445
AFJ : AFERRID_11360 AFERRID_20700 AFERRID_21730
MYM : A176_001044 A176_006817
MMAS : MYMAC_000190 MYMAC_001815 MYMAC_005639
AGE : AA314_00822 AA314_09499
AVM : JQX13_08000 JQX13_12080
MBD : MEBOL_002518 MEBOL_005093
LET : O77CONTIG1_04743(blh_1) O77CONTIG1_04749(blh_2)
THEU : HPC62_11520 HPC62_11550
» show all
Taxonomy
Reference
Authors
Suzuki I, Silver M.
Title
The initial product and properties of the sulfur-oxidizing enzyme of thiobacilli.
Journal
Reference
Authors
Rohwerder T, Sand W.
Title
The sulfane sulfur of persulfides is the actual substrate of the sulfur-oxidizing enzymes from Acidithiobacillus and Acidiphilium spp.
Journal
Reference
Authors
Liu H, Xin Y, Xun L
Title
Distribution, diversity, and activities of sulfur dioxygenases in heterotrophic bacteria.
Journal
Reference
Authors
Holdorf MM, Owen HA, Lieber SR, Yuan L, Adams N, Dabney-Smith C, Makaroff CA
Title
Arabidopsis ETHE1 encodes a sulfur dioxygenase that is essential for embryo and endosperm development.
Journal
Sequence
Reference
Authors
Pettinati I, Brem J, McDonough MA, Schofield CJ
Title
Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy.
Journal
Sequence
Other DBs