Entry
Name
cysteamine dioxygenase;
ADO (gene name);
persulfurase;
cysteamine oxygenase;
cysteamine:oxygen oxidoreductase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
2-aminoethanethiol:oxygen oxidoreductase
Reaction(IUBMB)
cysteamine + O2 = hypotaurine [RN:
R02467 ]
Reaction(KEGG)
Substrate
Product
Comment
A non-heme iron protein that is involved in the biosynthesis of taurine. 3-Aminopropanethiol (homocysteamine) and 2-sulfanylethan-1-ol (2-mercaptoethanol) can also act as substrates, but glutathione, cysteine, and cysteine ethyl- and methyl esters are not good substrates [1,3].
History
EC 1.13.11.19 created 1972, modified 2006
Pathway
ec00430 Taurine and hypotaurine metabolism
Orthology
Genes
CCAN : 109676110 109700462(Ado)
DSP : 122121442 122122307(Ado)
PLOP : 125346365(Ado) 125355631
ORO : 101372697(ADO) 101378375
EJU : 114204659 114224771(ADO)
ZCA : 113923752(ADO) 113927339
GAS : 123234420(ADO) 123255166
PTEX : 113453519 113453520
XLA : 108697364(ado.S) 494774(ado.L)
DRE : 406474(adob) 494091(adoa)
SRX : 107719329 107732747 107739062 107745676 107745677
SANH : 107653960 107664434 107695516 107703543
SGH : 107561692 107593521 107596610 107596613
CCAR : 109052668 109100039 109107231 109107242
CAUA : 113056332 113060565 113111927 113117099
CGIB : 127933506 127968771 127976542 128012901 128024984
PTET : 122355099(adoa) 122362053(adob)
LROH : 127173709(adoa) 127180241(adob)
OMC : 131523728(adob) 131551161(adoa)
PPRM : 120464009(adoa) 120475812(adob)
RKG : 130080511(adoa) 130088316(adob)
MAMB : 125255674(adoa) 125268988(adob)
CIDE : 127498235 127523890
CERY : 137006428(adob) 137007719(adoa)
MASI : 127411352 127423396 127426761 127454881
TROS : 130560016(adob) 130569207(adoa)
TDW : 130437183(adob) 130439131(adoa)
MANU : 129418216(adob) 129421222(adoa)
IPU : 108270460(adob) 108273399(adoa)
IFU : 128612400(adob) 128617520(adoa)
PHYP : 113527133 113538746
SMEO : 124388383(adoa) 124390431(adob)
TFD : 113649369(adoa) 113659785(adob)
TVC : 132841613(adoa) 132852611(adob)
TRN : 134321675(adoa) 134325210(adob)
AMEX : 103032129(adob) 103046195(adoa)
CMAO : 118809191(adoa) 118823849(adob)
TRU : 101064686 101074983(ado)
TFS : 130533966(adob) 130539239(adoa)
TNG : GSTEN00008477G001 GSTEN00034580G001
NCC : 104946380(ado) 104965501
TBEN : 117473321(adoa) 117487231(adob)
CGOB : 115004579 115005543 115025114
PGEO : 117460002(adob) 117464982(adoa)
EMAC : 134858853(adob) 134870352(adoa)
ELY : 117247682(adoa) 117247798(adob)
EFO : 125881020(adoa) 125903726(adob)
PLEP : 121954598(adob) 121958737(adoa)
SLUC : 116056395(adob) 116067511(adoa)
ECRA : 117937217(adoa) 117960758
ESP : 116671545(ado) 116679137
PFLV : 114548267(ado) 114572434
GAT : 120819585(adoa) 120820282
PPUG : 119213270(adoa) 119213898(adob)
AFB : 129092310(adob) 129093520(adoa)
CLUM : 117743638(adob) 117749161(adoa)
PSWI : 130203377(adoa) 130206904(adob)
CANA : 137779482 137789625(adoa)
MSAM : 119912148(adob) 119916199(adoa)
SCHU : 122867856(adoa) 122884617(adob)
CUD : 121511504(adob) 121527922
ALAT : 119010434(adoa) 119034074
ASTR : 137588303 137603507(adob)
OAU : 116320181(adoa) 116335532
OML : 112162102(adob) 112162338(adoa)
CSAI : 133418974(adoa) 133463945
XHE : 116712955 116713785 116727712(ado)
PRET : 103477378 103482206(ado)
PFOR : 103131660 103149020
PLAI : 106939641 106959984
PMEI : 106909231 106916187
GAF : 122823103(adoa) 122842818(adob)
PPRL : 129352225(adoa) 129354244 129355175
CVG : 107087618(ado) 107097159
CTUL : 119787357 119795757(adoa)
GMU : 124858916(adob) 124875432(adoa)
NFU : 107373913 107396840(ado)
KMR : 108245155(adoa) 108246615(adob)
ALIM : 106527984 106534741
NWH : 119419747(adob) 119424088
AOCE : 111562823 111569200
MCEP : 125018610(adoB) 125022991(adoA)
POV : 109627147(ado) 109647914
SSEN : 122760055(adoa) 122763063
HHIP : 117752399(adoa) 117776051(adob)
HSP : 118101046(adoa) 118119295(adob)
PPLT : 128426595(adoa) 128453254(adob)
SMAU : 118283767(adob) 118287777(adoa)
LCF : 108872892 108876784(adoa)
SDU : 111224250 111237081(ado)
SLAL : 111653567 111664279(ado)
XGL : 120794894(adoa) 120796542(adob)
HCQ : 109510061 109529318(ado)
SSCV : 125978213 125990977(adoa)
SBIA : 133495762(adoa) 133509706(adob)
PEE : 133409572(adob) 133417887(adoa)
PTAO : 133469397(adoa) 133486087(adob)
BPEC : 110153143 110154204(ado)
MALB : 109953420 109966662
BSPL : 114846396(adoa) 114870686(adob)
SJO : 128354669(adob) 128381688(adoa)
SASA : 100195766(aedo) 106591225 106607859 106613884
STRU : 115153286 115189551 115189552 115193671
OTW : 112240379 112253109 112255237
OMY : 110502543 110511817 110519246 110529936
OGO : 124017094 124021820 124040740
ONE : 115113168 115121207 115135035
OKI : 109883661 109890005 109899763 116362192
OKE : 118369795 118399564 127925245
SALP : 111951991 111978610 112078271
SNH : 120017949 120038386 120039584 120046591
CCLU : 121553524(adob) 121583264 121584714 123490653
ELS : 105010537 105026306(ado)
SFM : 108932788 108939586(ado)
PKI : 111853679(ado) 111858150
AANG : 118218263(adob) 118219457(adoa)
PSPA : 121321451 121325108
ARUT : 117415303 117418085
DSI : Dsimw501_GD13021(Dsim_GD13021)
AALB : 109405169 109408026
CCAL : 108622031 108628408
PBAR : 105424153 105428986
APLN : 108736482 112906418
HASI : 137258456 137265432
DDI : DDB_G0273031 DDB_G0274043
PTM : GSPATT00002373001 GSPATT00006838001 GSPATT00032915001
» show all
Taxonomy
Reference
Authors
Cavallini D, De Marco C, Scandurra R, Dupre S, Graziani MT.
Title
The enzymatic oxidation of cysteamine to hypotaurine. Purification and properties of the enzyme.
Journal
J Biol Chem 241:3189-96 (1966)
Reference
Authors
Wood JL, Cavallini D.
Title
Enzymic oxidation of cysteamine to hypotaurine in the absence of a cofactor.
Journal
Reference
Authors
Cavallini D, Federici G, Ricci G, Dupre S, Antonucci A.
Title
The specificity of cysteamine oxygenase.
Journal
Reference
Authors
Richerson RB, Ziegler DM.
Title
Cysteamine dioxygenase.
Journal
Reference
Authors
Dominy JE Jr, Simmons CR, Hirschberger LL, Hwang J, Coloso RM, Stipanuk MH
Title
Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase.
Journal
Other DBs