KEGG   ENZYME: 1.13.11.25
Entry
EC 1.13.11.25               Enzyme                                 
Name
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase;
steroid 4,5-dioxygenase;
3-alkylcatechol 2,3-dioxygenase;
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (ring-opening)
Reaction(IUBMB)
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate [RN:R04597]
Reaction(KEGG)
R04597
Substrate
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione [CPD:C04793];
O2 [CPD:C00007]
Product
3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate [CPD:C04844]
Comment
Requires Fe2+. Also acts on 3-isopropylcatechol and 3-tert-butyl-5-methylcatechol.
History
EC 1.13.11.25 created 1972
Pathway
ec00984  Steroid degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K16049  3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
Genes
VAFD1115_22660
PREPCA10_13380
PFUWKF707C_11930
PPUTL483_14230
PPUNPP4_26930
PVRPverR02_11720
PPUUPputUW4_01687
PKCPKB_4267(hsaC)
PFZAV641_10715
PLQAA042_19960
PPSYAOC04_08020
PSETTHL1_1410
PSILPMA3_11800
PKEDLD99_14645
PUMHGP31_20700
PPSHG5J76_13970
PLALFXN65_06300
PKHJLK41_05795
PAZEKSS91_19160
PPHABVH74_17675
PTAENCTC10697_02092(hsaC)
PCAVD3880_11855 D3880_17225
SPLSpea_2153
SHLShal_2124
COLWA3Q33_18685
CBERB5D82_11140
PHAPSHAa0900(tesB)
PTNPTRA_a1032(hsaC)
PNGPNIG_a1084(hsaC)
SNANI6N98_01460 I6N98_10755
ZALAZF00_12080
HJABST95_13315
HALCEY643_09155
AFUSEYZ66_12950
KAKKalk_07830
MSECLN244_05120
ENWMJO57_22800
SOKD0B54_05280
SINIGT972_08460
FCEJN531_005450
GPBHDN1F_27360(bphC1)
RINACS15_4384(hsaC)
REHH16_B0654(bphC)
CNCCNE_2c06010(bphC)
CUHBJN34_30715
REUReut_A1557
CTIRALTA_B0496(bphC)
CBWRR42_s2336
COXE0W60_08215
BURBcep18194_B1431
BCJBCAM1637
BCENDM39_6216(hsaC)
BCEOI35_5498
BCTGEM_4079
BCEDDM42_6321(hsaC)
BCEPAPZ15_31025
BPYRABD05_27685
BCONNL30_03995
BDFWI26_21320
BTEIWS51_05820
BPSLWS57_05915
BMECWJ16_26910
BSTLBBJ41_21475
BANNJFN94_25820
BURKDM992_32505
BFNOI25_4609
PVEUC34_06925
CABASBC2_48810(hsaC)
CTTCtCNB1_1275
CTESO987_07285
DIHG7047_10915
AZDCDA09_09620
THUAC731_008515
NTDEGO55_13435 EGO55_13700
NARSaro_3647 Saro_3750
NPPPP1Y_Mpl3065
NOVTQ38_027275
NOTC7W88_20680 C7W88_20750
SWISwit_1826 Swit_1848 Swit_3298
SPHDHY78_09060 HY78_16340 HY78_16450
RDICMV14_16840
SPHMG432_04775
SSANNX02_14735
SPKCKC8_01090 KC8_05325 KC8_16655 KC8_19655
SPHAD3Y57_15480
SLANGV829_01880
SPHBEP837_03390(hsaC)
PHAOHF685_05540
SMICSmB9_10410(hsaC)
ERRDVR09_05400
PHZCHX26_05295
MTURv3568c(hsaC)
MTVRVBD_3568c
MTCMT3673
MRAMRA_3607(bphC)
MTFTBFG_13601
MTBTBMG_03607
MTKTBSG_03634
MTZTBXG_003582
MTGMRGA327_22030
MTIMRGA423_22550
MTECCDC5079_3309
MTURCFBS_3785(bphC)
MTLCCDC5180_3261
MTOMTCTRI2_3633(bphC)
MTDUDA_3568c(bphC)
MTNERDMAN_3915(bphC)
MTJJ112_19215
MTUBMT7199_3631
MTUCJ113_24990
MTUEJ114_19085
MTXM943_18350
MTULTBHG_03509
MTUTHKBT1_3770(bphC)
MTUUHKBT2_3779(bphC)
MTQHKBS1_3782(bphC)
MBOBQ2027_MB3599C(hsac)
MBBBCG_3633c(bphC)
MBTJTY_3634(bphC)
MBMBCGMEX_3631c(bphC)
MBKK60_037060
MBXBCGT_3435
MAFMAF_35810(bphC)
MMICRN08_3945
MCEMCAN_35811(bphC)
MCQBN44_110063(hsaC)
MCVBN43_90069(hsaC)
MCXBN42_90066(hsaC)
MCZBN45_100082(hsaC)
MPAMAP_0499
MAOMAP4_3368
MAVIRC58_16705
MAVURE97_16740
MAVMAV_0593 MAV_3021
MITOCO_05020 OCO_28570
MIAOCU_05060 OCU_28440
MIDMIP_00943 MIP_03717
MYOOEM_05080 OEM_27030
MCHIAN480_02505 AN480_14935
MIROCQ_05170 OCQ_27150
MMALCKJ54_02435 CKJ54_12980(bphC)
MLPMLM_0737 MLM_2413
MMANMMAN_10310 MMAN_21330 MMAN_47960(hsaC)
MSAMycsm_04159 Mycsm_05838
MULMUL_4139(bphC)
MMCMmcs_0317 Mmcs_4707
MKMMkms_0327 Mkms_4793
MJLMjls_0308 Mjls_5092
MMIMMAR_5063(bphC)
MMAEMMARE11_48780(bphC)
MMMW7S_02450 W7S_13845
MLIMULP_05321(bphC)
MKNMKAN_12120
MYVG155_04250 G155_26475
MYEAB431_15175 AB431_15235 AB431_26550
MGOAFA91_10590
MHADB586_04455
MDXBTO20_04385
MSHGMSG_02471 MSG_04561(hsaC)
MFJMFLOJ_07940 MFLOJ_40670(hsaC)
MSTOMSTO_09180 MSTO_44620(hsaC)
MSIMMSIM_29110(hsaC) MSIM_53020
MSAKMSAS_05590 MSAS_29150(hsaC)
MKUI2456_25675
MGROFZ046_02940
MXEMYXE_05080(hsaC) MYXE_06660
MNVMNVI_11570 MNVI_12510(hsaC)
MPAGC0J29_19280 C0J29_27825
MNMMNVM_19350 MNVM_23440(hsaC)
MGORH0P51_17855 H0P51_25865
MCOOMCOO_26120 MCOO_27310(hsaC)
MBAIMB901379_04452(hsaC)
MSEOMSEO_12710 MSEO_34550(hsaC)
MPSEMPSD_52640(hsaC)
MSHOMSHO_05470(hsaC)
MHEKJMUB5695_00469(hsaC_1) JMUB5695_00575
MGAUMGALJ_22850 MGALJ_38560
MLJMLAC_47240(hsaC)
MBRDMBRA_20010(hsaC) MBRA_21120
MSHJMSHI_38540(hsaC)
MKRMKOR_35330(hsaC) MKOR_36400
MDFK0O62_15785(bphC) K0O62_25965
MMAMK3U93_11795(bphC) K3U93_22685
MHOLK3U96_03080 K3U96_09635(bphC)
MHERK3U94_21025
MSENK3U95_12875 K3U95_25510
MPAEK0O64_14655(bphC) K0O64_14700(bphC) K0O64_26060
MSPGF6B93_20485
MOTLTS72_27920
MVMMJO54_20920
MRFMJO55_24175
MPAAMKK62_02395 MKK62_02910(bphC)
MCROMI149_15510(bphC) MI149_15560(bphC) MI149_26360
MSMMSMEG_2891 MSMEG_6036
MSGMSMEI_2817(bphC) MSMEI_5875(bphC)
MSBLJ00_14380 LJ00_29840
MSNLI99_14385 LI99_29845
MSHLI98_14390 LI98_29850
MVAMvan_2891 Mvan_5306
MGIMflv_1465 Mflv_4549
MSPMspyr1_39490 Mspyr1_47020
MCBMycch_1590 Mycch_4673
MNED174_24700
MYNMyAD_24235
MFTXA26_08070 XA26_53610
MPHLMPHLCCUG_00493(hsaC_1) MPHLCCUG_02627(hsaC_2)
MVQMYVA_1664 MYVA_5216
MLLB1R94_12250 B1R94_20085 B1R94_25460
MRHMycrhN_2245 MycrhN_4259
MTHN4412656_00959(bphC) 4412656_04092(hsaC)
MHASMHAS_02457(hsaC_1) MHAS_03777(hsaC_2)
MDUMDUV_26660 MDUV_49010
MCHTMCHIJ_12760 MCHIJ_19310
MAUUNCTC10437_02739(hsaC_2) NCTC10437_05067(hsaC_3)
MMAGMMAD_48570
MMORMMOR_11760 MMOR_26800
MFXMFAL_32600
MAICMAIC_05180 MAIC_26790 MAIC_26930
MIJMINS_00690
MALVMALV_29230 MALV_42140
MTYMTOK_22000
MPSCMPSYJ_15770
MARZMARA_47440
MGADMGAD_01100 MGAD_37680
MHEVMHEL_27650 MHEL_50120 MHEL_50220
MSARMSAR_10970 MSAR_41300 MSAR_41350
MANYMANY_12800 MANY_33050
MAUBMAUB_27090 MAUB_54790
MPOFMPOR_53990
MPHUMPHO_14370 MPHO_43380
MMUCC1S78_011095(bphC) C1S78_019250(bphC) C1S78_025610
MMATMMAGJ_33780
MBOKMBOE_04960 MBOE_20110
MFGK6L26_05345 K6L26_16790 K6L26_27685(bphC)
MSEIMSEDJ_02510
MFLVNCTC10271_00467(hsaC_1) NCTC10271_02187(hsaC_2)
MCEEMCEL_06120 MCEL_37740
MABMAB_0076 MAB_0585
MMVMYCMA_0047 MYCMA_0298
MABBMASS_0078 MASS_0554
MABLMMASJCM_0079 MMASJCM_0574
MCHEBB28_00370 BB28_02790
MIZBAB75_00670 BAB75_03540
MSTEMSTE_00542(hsaC)
MSAOMYCSP_02495
MSALDSM43276_00503(hsaC)
MJDJDM601_3853(bphC) JDM601_4250(bphC)
MTER4434518_03728(bphC)
MMINMMIN_06700 MMIN_12530
MHIBMHIB_23840 MHIB_31170(hsaC)
ASDAS9A_0926
MPAKMIU77_01970
NFANFA_40980 NFA_4720
NFRERS450000_03764(hsaC_1) ERS450000_05815(hsaC_2)
NCYNOCYR_0501 NOCYR_2418(bphC)
NBRO3I_002665
NNONONO_c05030(hsaC1) NONO_c44720 NONO_c58760(hsaC2)
NSLBOX37_02175 BOX37_11855
NSRNS506_01260(hsaC) NS506_06778(etbC)
NTPCRH09_03305
NOZDMB37_23590
NODFOH10_22595 FOH10_28745
NAHF5544_02630
NADNCTC11293_01245(hsaC_1) NCTC11293_04394(hsaC_2)
NWLNWFMUON74_04930
NIEKV110_03025
NTCKHQ06_03675 KHQ06_24085 KHQ06_26960 KHQ06_35110
NHUH0264_03850 H0264_34220
NYALTV02_28890 LTV02_38700
NGPLTT66_15420 LTT66_28770
RHARHA1_ro02488 RHA1_ro04541(hsaC) RHA1_ro05803
RERRER_07570 RER_13780 RER_51660
REYO5Y_03680 O5Y_06490 O5Y_24430
REBXU06_03920 XU06_06750 XU06_24850
RQIC1M55_04160 C1M55_06995(bphC) C1M55_26050(bphC)
ROPROP_22150 ROP_44560 ROP_58640
ROAPd630_LPD00993 Pd630_LPD02422 Pd630_LPD06714
REQREQ_01430 REQ_06820 REQ_40140 REQ_43800
RPYY013_19035 Y013_19285
RBYCEJ39_05400 CEJ39_05650 CEJ39_21895(bphC)
RAVAAT18_03975 AAT18_22060
RHWBFN03_15190
RRZCS378_10115(bphC) CS378_11825(bphC) CS378_19615
RHQIM25_02765 IM25_08885
RHODAOT96_05860 AOT96_14555 AOT96_17390
RRT4535765_00584(hsaC_1) 4535765_00631(hsaC_2) 4535765_04055(hsaC_4)
RCRNCTC10994_02089(hsaC_1) NCTC10994_02136(hsaC_2) NCTC10994_03239(hsaC_3) NCTC10994_03314(hsaC_4)
RTMG4H71_04575(bphC) G4H71_07385 G4H71_13740(bphC)
RKOJWS14_13060(bphC) JWS14_24495 JWS14_31735(bphC)
RGOKYT97_11700(bphC) KYT97_15280 KYT97_15685(bphC) KYT97_23245
GBRGbro_0921
GPOGPOL_c41080(hsaC) GPOL_c41220
GORKTR9_0821(hsaC)
GOQACH46_03105 ACH46_03245
GTABCM27_04770 BCM27_05115
GOCCXX93_06465
GITC6V83_04280
GRUGCWB2_04180(hsaC)
GOMD7316_02454(hsaC_1) D7316_02467(hsaC_2) D7316_02567(hsaC_3)
GAVC5O27_00855 C5O27_10720(bphC)
GODGKZ92_03975 GKZ92_16410(bphC)
GAMGII34_18805
GPDGII33_03935
GJIH1R19_04055 H1R19_12675(bphC)
GOILK459_05080 LK459_05165(bphC)
GHNMVF96_04255
GAMIIHQ52_06835
SPINKV203_17340
TPRTpau_3843
TSMASU32_21895
DTMBJL86_0699
DITC3V38_09270
DIZCT688_03190
DPCA6048_03135
DLUA6035_02405 A6035_03430
TOYFO059_01335(bphC) FO059_14005 FO059_16385
SSOII1A49_45975
SALUDC74_7447
SALLSAZ_38440
SVTSVTN_35915
SLXSLAV_27440(hsaC)
SNKCP967_03280
SGXH4W23_38550
SROIIAG44_02090
SXNIAG42_26655
SDECL3078_00990 L3078_04205
ARLAFL94_16970
ARYATC04_01210
ASUNKG104_04195
GPRJQN66_16975
PAEYKUF55_17985
NCANoca_2774
NDKI601_0578(hsaC_1) I601_3468(hsaC_2)
NBEBack2_27220
NANOG5V58_09770
NAROCFH99_13520
NPIG7071_12490 G7071_15935
NPCKUV85_04290
PSIMKR76_14470 KR76_27095
AEBC6I20_03270
TCUTcur_3516
ACTWF7P10_28360
AMDAMED_2524
AMNRAM_12830
AMMAMES_2496
AMZB737_2497
AOIAORI_2486(bphC)
AJAAJAP_26395(hsaC)
AMQAMETH_4836
AMYCCU254_10470 CU254_23455
AMYBBKN51_05030
AABA4R43_16035
AMYYYIM_14460(hsaC1) YIM_36675(hsaC2)
AORISD37_13495
AACDLWP59_29190
KALKALB_5122
KPHYAOZ06_42780
LEDBBK82_38915
ALOCRK57812 CRK59592
PMADBAY61_10965
SACEGIY23_13330
STPStrop_2669
SAQSare_2877
AMSAMIS_19200
AIHAiant_18870
AYMYM304_33710
 » show all
Reference
1  [PMID:5908121]
  Authors
Gibson DT, Wang KC, Sih CJ, Whitlock H Jr.
  Title
Mechanisms of steroid oxidation by microorganisms. IX. On the mechanism of ring A cleavage in the degradation of 9,10-seco steroids by microorganisms.
  Journal
J Biol Chem 241:551-9 (1966)
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.25
IUBMB Enzyme Nomenclature: 1.13.11.25
ExPASy - ENZYME nomenclature database: 1.13.11.25
UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.25
BRENDA, the Enzyme Database: 1.13.11.25
CAS: 37256-63-6

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