| Entry |
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| Name |
4-hydroxyphenylpyruvate dioxygenase;
p-hydroxyphenylpyruvic hydroxylase;
p-hydroxyphenylpyruvate hydroxylase;
p-hydroxyphenylpyruvate oxidase;
p-hydroxyphenylpyruvic oxidase;
p-hydroxyphenylpyruvate dioxygenase;
p-hydroxyphenylpyruvic acid hydroxylase;
4-hydroxyphenylpyruvic acid dioxygenase
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| Class |
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
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| Sysname |
4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating)
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| Reaction(IUBMB) |
4-hydroxyphenylpyruvate + O2 = homogentisate + CO2 [RN: R02521]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The Pseudomonas enzyme contains one Fe3+ per mole of enzyme; the enzymes from other sources may contain essential iron or copper.
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| History |
EC 1.13.11.27 created 1961 as EC 1.99.1.14, transferred 1965 to EC 1.14.2.2, transferred 1972 to EC 1.13.11.27
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| Pathway |
| ec00130 | Ubiquinone and other terpenoid-quinone biosynthesis |
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| Orthology |
| K00457 | 4-hydroxyphenylpyruvate dioxygenase |
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| Genes |
» show all
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| Reference |
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| Authors |
Lindstedt S, Rundgren M. |
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| Title |
Blue color, metal content, and substrate binding in 4-hydroxyphenylpyruvate dioxygenase from Pseudomonas sp. strain P. J. 874. |
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| Journal |
J Biol Chem 257:11922-31 (1982) |
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| Reference |
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| Authors |
Roche PA, Moorehead TJ, Hamilton GA. |
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| Title |
Purification and properties of hog liver 4-hydroxyphenylpyruvate dioxygenase. |
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| Journal |
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| Other DBs |
| UM-BBD (Biocatalysis/Biodegradation Database): | 1.13.11.27 |
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