KEGG ENZYME: 1.13.11.31

ENZYME: 1.13.11.31

Entry

EC 1.13.11.31               Enzyme

Name

arachidonate 12-lipoxygenase;
Delta12-lipoxygenase;
12-lipoxygenase;
12Delta-lipoxygenase;
C-12 lipoxygenase;
12S-lipoxygenase;
leukotriene A4 synthase;
LTA4 synthase

Class

Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen

Sysname

arachidonate:oxygen 12-oxidoreductase

Reaction(IUBMB)

arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate [RN:R01596]

Reaction(KEGG)

R01596

Substrate

arachidonate [CPD:C00219];
O2 [CPD:C00007]

Product

(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate [CPD:C05965]

Comment

The product is rapidly reduced to the corresponding 12S-hydroxy compound.

History

EC 1.13.11.31 created 1983

Pathway

ec00590

Arachidonic acid metabolism

Orthology

K00458

arachidonate 12-lipoxygenase

Genes

HSA:	239(ALOX12)

PTR:	455242(ALOX12) 455243

PPS:	100992721(ALOX12) 100993999

GGO:	101140132(ALOX12)

PON:	100435170 100448016

NLE:	100605486(ALOX12)

MCC:	713748(ALOX12)

MCF:	102136652(ALOX12) 102137290

CSAB:

103242265(ALOX12)

CATY:

105582822(ALOX12)

PANU:

101012932(ALOX12)

TGE:	112609056(ALOX12) 112609713

RRO:	104673348(ALOX12)

RBB:	108514395(ALOX12)

TFN:	117067814(ALOX12)

PTEH:

111521261(ALOX12)

CJC:	100400641(ALOX12)

SBQ:	101051396(ALOX12)

CSYR:

103255116 103263245(ALOX12) 103263247

MMUR:

105878109(ALOX12) 105879294

OGA:	100951876(ALOX12) 100961111

MMU:	11684(Alox12) 11685(Alox12e)

MCAL:

110304778(Alox12)

MPAH:

110331792(Alox12)

RNO:	287454(Alox12) 303252(Alox12e)

MCOC:

116077965

MUN:	110540751(Alox12)

CGE:	100764620(Alox12)

PLEU:

114693220(Alox12)

NGI:	103752172(Alox12)

HGL:	101702123(Alox12)

CPOC:

100719400

CCAN:

109682903(Alox12)

DORD:

105983295 105983533(Alox12)

DSP:	122100378(Alox12)

NCAR:

124979056 124980537

OCU:	100340525(ALOX12)

OPI:	101518253(ALOX12)

TUP:	102493396(ALOX12) 102494779

CFA:	479476(ALOX12)

VVP:

112924805

VLG:

121500195

AML:	100471037(ALOX12)

UMR:	103660455(ALOX12)

UAH:	113271099(ALOX12)

UAR:	123792172(ALOX12)

ELK:

111161172

LLV:	125086719 125087074

MPUF:

101684639(ALOX12)

ORO:	101379600(ALOX12)

EJU:	114225417(ALOX12)

ZCA:	113907925(ALOX12) 113939134

MLX:	117999898 117999978(ALOX12)

FCA:

101094304

PYU:	121016040(ALOX12)

PBG:

122484839

PTG:	102969788(ALOX12)

PPAD:

109245992

AJU:

106972408

HHV:	120231410(ALOX12)

BTA:	407169(ALOX12) 787450(ALOX12E)

BOM:	102284543(ALOX12)

BIU:	109574004(ALOX12)

BBUB:

102395651(ALOX12)

CHX:	102187263(ALOX12)

OAS:	101113685(ALOX12)

ODA:	120866088(ALOX12)

CCAD:

122446320 122446338(ALOX12)

SSC:	100620614(ALOX12)

CFR:	102504047(ALOX12)

CBAI:

105077467(ALOX12)

CDK:	105103060(ALOX12)

VPC:	102533742(ALOX12)

BACU:

103020542(ALOX12)

LVE:	103074060(ALOX12)

OOR:	101279538(ALOX12)

DLE:	111185974(ALOX12)

PCAD:

102977395(ALOX12)

PSIU:

116745598(ALOX12)

ECB:

100072916

EPZ:	103561430(ALOX12)

EAI:	106844160(ALOX12)

MYB:	102246619 102248372 102248722 102248980 102249269 102249301 102249603 102249899 102254447(ALOX12) 102255394

MYD:	102753778 102755565 102755847 102768484 102769301 102769599

MMYO:

118672025 118672026 118672027 118672028

MLF:	102428351 102428552 102428668 102428965 102429158 102429663 102429971 102432805 102433118 102435623

MNA:	107544244(ALOX12)

PKL:	118726716(ALOX12) 118726717 118726718 118726720 118726721 118727040 118727041 118727042

HAI:	109394599(ALOX12)

DRO:	112308919(ALOX12)

SHON:

118979425(ALOX12)

AJM:	119037160(ALOX12)

PHAS:

123809459

MMF:	118634472 118634597 118634882

RFQ:	117013802(ALOX12)

PALE:

102897481(ALOX12)

PGIG:

120612187(ALOX12)

PVP:	105291977(ALOX12)

RAY:	107509504(ALOX12)

MJV:	108401224(ALOX12)

TOD:

119232717

SARA:

101547220(ALOX12) 101547484

LAV:

100656524

TMU:

101341400

DNM:

101444550

MDO:	100015746(ALOX12) 100015831 100015867 100015906 100015945

GAS:	123243728 123247715

SHR:

100933073

PCW:

110194257

OAA:

100079469

DRE:	322732(alox12)

SRX:	107749792 107750578

SANH:

107669199

SGH:

107593795

CCAR:

109050063

CAUA:

113052069 113052070 113052072 113105799

PPRM:

120487640

MAMB:

125264591(alox12)

IPU:	108267744 108267745(alox12)

PHYP:

113539915

SMEO:

124387847 124387880 124388151

TFD:	113635137(alox12)

AMEX:

103037595

EEE:

113580793

TRU:

101070898

LCO:

104937156

NCC:

104948188

CGOB:

115023433

ELY:	117272669(alox12)

PLEP:

121962177(alox12)

SLUC:

116043997(alox12)

ECRA:

117934769(alox12)

PFLV:

114545687

GAT:	120822087(alox12)

PPUG:

119222432(alox12)

MSAM:

119912247(alox12)

CUD:	121506630(alox12)

MZE:

101479810

ONL:

100698983

OAU:	116321155(alox12)

OLA:

101174953

OML:	112155872(alox12)

XMA:

102224924

XCO:

114157899

XHE:

116733267

PRET:

103480141

PFOR:

103148853

PLAI:

106946955

PMEI:

106917266

GAF:	122820467(alox12)

CVG:

107103814

CTUL:

119775005(alox12)

GMU:	124880055(alox12)

NFU:	107384708(alox15)

KMR:	108242243(alox12)

ALIM:

106526983

NWH:	119414629(alox12)

AOCE:

111564179

POV:

109637629

SSEN:

122766699(alox12)

HHIP:

117751994(alox12)

LCF:	108879679 108895226

SDU:

111223569

SLAL:

111667993

XGL:	120797417(alox12)

BPEC:

110170766

MALB:

109957267

SASA:

100380705(lox12) 106608934

OTW:	112214522(alox12) 112259738

OMY:	110500350(alox12) 110531448

OGO:	124008639 124013533(alox12)

ONE:	115122959 115133313

SALP:

111952161

SNH:	120030395 120049296(alox12)

ELS:

105027651

SFM:

108922837

PKI:

111846328

AANG:

118223344(alox12)

LOC:	102685586(alox12)

PSPA:

121305733 121306538

ARUT:

117426941

CMK:	103190915(alox12)

RTP:

109926716

MMER:

123540522

ATEN:

116304963

XEN:

124443531

» show all

Reference

1 [PMID:4215079]

Authors

Hamberg M, Samuelsson B.

Title

Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets.

Journal

Proc Natl Acad Sci U S A 71:3400-4 (1974)
DOI:10.1073/pnas.71.9.3400

Reference

2 [PMID:804329]

Authors

Nugteren DH.

Title

Arachidonate lipoxygenase in blood platelets.

Journal

Biochim Biophys Acta 380:299-307 (1975)
DOI:10.1016/0005-2760(75)90016-8

Reference

3 [PMID:6783111]

Authors

Wallach DP, Brown VR.

Title

A novel preparation of human platelet lipoxygenase. Characteristics and inhibition by a variety of phenyl hydrazones and comparisons with other lipoxygenases.

Journal

Biochim Biophys Acta 663:361-72 (1981)
DOI:10.1016/0005-2760(81)90165-X

Other DBs

ExplorEnz - The Enzyme Database:

1.13.11.31

IUBMB Enzyme Nomenclature:

1.13.11.31

ExPASy - ENZYME nomenclature database:

1.13.11.31

BRENDA, the Enzyme Database:

1.13.11.31

CAS:	82391-43-3

DBGET integrated database retrieval system