KEGG   ENZYME: 1.13.11.31
Entry
EC 1.13.11.31               Enzyme                                 
Name
arachidonate 12-lipoxygenase;
Delta12-lipoxygenase;
12-lipoxygenase;
12Delta-lipoxygenase;
C-12 lipoxygenase;
12S-lipoxygenase;
leukotriene A4 synthase;
LTA4 synthase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
arachidonate:oxygen 12-oxidoreductase
Reaction(IUBMB)
arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate [RN:R01596]
Reaction(KEGG)
R01596
Substrate
arachidonate [CPD:C00219];
O2 [CPD:C00007]
Product
(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate [CPD:C05965]
Comment
The product is rapidly reduced to the corresponding 12S-hydroxy compound.
History
EC 1.13.11.31 created 1983
Pathway
ec00590  Arachidonic acid metabolism
Orthology
K00458  arachidonate 12-lipoxygenase
Genes
HSA239(ALOX12)
PTR455242(ALOX12) 455243
PPS100992721(ALOX12) 100993999
GGO101138809 101140132(ALOX12)
PON100435170(ALOX12) 100448016
PPYG129016640(ALOX12) 129016885
NLE100599862 100605486(ALOX12)
HMH116458265(ALOX12) 116458366
SSYN129470763 129470764(ALOX12)
MCC713683 713748(ALOX12)
MCF102136652(ALOX12) 102137290
MTHB126939687 126939829
MNI105473015 105473037
CSAB103242262 103242265(ALOX12)
CATY105582822(ALOX12) 105584566
PANU101012580 101012932(ALOX12)
TGE112609056(ALOX12) 112609713
MLEU105549914(ALOX12) 105549919
RRO104673348(ALOX12) 104673354
RBB108514294 108514395(ALOX12)
TFN117067814(ALOX12) 117067819
PTEH111521261(ALOX12) 111521361
CANG105523573 105523575(ALOX12)
CJC100400641(ALOX12)
SBQ101051396(ALOX12)
CIMI108306615(ALOX12)
ANAN105720758(ALOX12)
CSYR103255116 103263245(ALOX12) 103263247
MMUR105878109(ALOX12) 105879294
LCAT123650840(ALOX12)
PCOQ105819472(ALOX12)
OGA100951876(ALOX12) 100961111
MMU11684(Alox12) 11685(Alox12e)
MCAL110304778(Alox12) 110305417
MPAH110331792(Alox12) 110332037
RNO287454(Alox12) 303252(Alox12e)
MCOC116077965
ANU117701406 117710866(Alox12) 117711132
ASYL127693548 127694629
MUN110540751 110541720
CGE100764620(Alox12) 100764916(Alox15)
MAUA101839190 101844629
PROB127219012 127219013(Alox12)
PLEU114693220(Alox12) 114693221
MORG121456507 121456764
MFOT126513995 126514127
AAMP119812811 119813474
NGI103752172(Alox12) 103752176
HGL101702123(Alox12)
CPOC100719400 100719677
CCAN109679529 109682903(Alox12)
DORD105983295 105983533(Alox12)
DSP122100378(Alox12)
PLOP125365503(Alox12)
NCAR124979056 124980537
MMMA107158059 107158101(Alox12)
ITI101963157 101963440
OCU100340525
OPI101518253(ALOX12)
TUP102493396(ALOX12) 102494779 102495183
GVR103587106(ALOX12) 103588407
CFA119871841 479476(ALOX12)
CLUD112647510
VVP112924804 112924805
VLG121500195
NPO129497890(ALOX12)
AML100471037(ALOX12)
UMR103660455(ALOX12)
UAH113271099(ALOX12)
UAR123792172(ALOX12)
ELK111161172
LLV125086719 125087074
MPUF101684639(ALOX12) 101685628
MNP132003859(ALOX12) 132004574
MLK131815812(ALOX12) 131816066
NVS122906679(ALOX12) 122907758
ORO101379600(ALOX12) 101379891
EJU114225417(ALOX12) 114225462
ZCA113907925(ALOX12) 113939134
MLX117999898 117999978(ALOX12)
NSU110584560(ALOX12)
LWW102750079(ALOX12)
FCA101094304
PYU121016040(ALOX12)
PCOO112856976
PBG122484839
PVIV125151243(ALOX12)
LRUF124519666
LGF123604282(ALOX12)
AJU106972408
PTG102969788(ALOX12)
PPAD109245992
PUC125927078
PLEZ122207135
HHV120231410(ALOX12)
BTA407169(ALOX12) 787450(ALOX12E)
BOM102284543(ALOX12) 102285373
BIU109574004(ALOX12) 109574010
BBUB102395651(ALOX12) 102396987
BBIS104993944 104993949(ALOX12)
CHX102178853 102187263(ALOX12)
OAS101113251 101113685(ALOX12)
BTAX128064757 128065118
CSUM138082931 138082934(ALOX12)
ODA120866088(ALOX12) 120866093
CCAD122446320 122446338(ALOX12)
MREE136148951(ALOX12)
OVR110150098(ALOX12) 110150170
MBEZ129542462(ALOX12) 129542473
SSC100620614(ALOX12)
CFR102504047(ALOX12)
CBAI105077467(ALOX12)
CDK105103060(ALOX12)
VPC102533742(ALOX12)
BACU103020542(ALOX12)
BMUS118887046(ALOX12)
LVE103074060(ALOX12)
OOR101279538(ALOX12)
LALB132510728(ALOX12)
DLE111185974(ALOX12)
PCAD102977395(ALOX12)
PSIU116745598(ALOX12)
PPHC136138966(ALOX12)
NASI112390424(ALOX12)
ECB100072916
EPZ103561430
EAI106844160(ALOX12)
MYB102246619 102248372 102248722 102248980 102249269 102249301 102249603 102249899 102254447(ALOX12) 102255394
MYD102753778 102755565 102755847 102768484 102769301 102769599
MMYO118672025 118672026 118672027 118672028
MLF102428351 102428552 102428668 102428965 102429158 102429663 102429971 102432805 102433118 102435623
MDT132217774 132218122(ALOX12) 132218123 132218124 132218125 132218132 132218133 132219275
MYUM138993684(ALOX12) 138993781 138994097 138994102 138994103 138994106 138994107 138995077
PKL118726716(ALOX12) 118726717 118726718 118726720 118726721 118727040 118727041 118727042
EFUS103296941(ALOX12) 103296942 103296943 103296944 103296945 103296946 103296985 103296986 114227056 129147359 129147360
MNA107544244(ALOX12)
DRO112308919(ALOX12)
SHON118979425(ALOX12)
AJM119037160(ALOX12)
PHAS123809459
MMF118634472 118634597 118634882
PPAM129072205(ALOX12)
HAI109394599(ALOX12)
RFQ117013802(ALOX12)
PALE102897481(ALOX12)
PGIG120612187(ALOX12)
PVP105291977(ALOX12)
RAY107509504(ALOX12)
MJV108401224
TOD119231062 119232717
SARA101547220(ALOX12) 101547484
SFUM130024396(ALOX12) 130024405
SETR126011028 126027317 126027412
LAV100656524
TMU101341400
ETF101643858(ALOX12)
DNM101444550
MDO100015746(ALOX12) 100015831 100015867 100015906 100015945
GAS123243728 123247715
SHR100933073
AFZ127560919
PCW110194257
TVP118856523
PBRV138142176
OAA100079469
TACU119947209
PWL138267270
MUO115458185(ALOX12)
GSH117350677(ALOX12)
DRE322732(alox12)
SRX107749792 107750578
SANH107669199
SGH107593795
CCAR109050063
CAUA113052069 113052070 113052072 113105799
CGIB127961063 128017081 128017082
PTET122348592(alox12)
LROH127167780(alox12)
OMC131543981(alox12)
PPRM120487640
RKG130102666(alox12)
MAMB125264591(alox12)
CIDE127515195
CERY137031061(alox12)
MASI127413609 127446982
TROS130570780(alox12)
TDW130422185(alox12)
MANU129441089(alox12)
PDAB135730838(alox12)
IPU108267744 108267745(alox12)
IFU128610027 128610036
PHYP113539915
SMEO124387847 124387880 124388151
TFD113635137(alox12)
TVC132848618(alox12)
CGAR128520938 128524921 128528886 128528985
NGRA132886932 132887076 132895347(alox12)
TRN134311562 134311917 134311918
AMEX103037595(alox12)
CMAO118801227 118801228
EEE113580793
CHAR105889668(alox12)
SPIL134059954(alox12)
TRU101070898
TFS130522950(alox12)
LCO104937156
NCC104948188
TBEN117497588(alox12)
CGOB115023433
PGEO117463440(alox12)
GACU117535413(alox12)
EMAC134876050(alox12)
ELY117272669(alox12)
EFO125884070(alox12)
PLEP121962177(alox12)
SLUC116043997(alox12)
ECRA117934769(alox12)
ESP116707176
PFLV114545687
GAT120822087(alox12)
PPUG119222432(alox12)
AFB129093703(alox12)
CLUM117747621(alox12)
PSWI130212060(alox12)
CANA137792430(alox12)
MSAM119912247(alox12)
SCHU122869982(alox12)
CUD121506630(alox12)
SPUL138600736(alox12)
LMIX132958591(alox12)
ALAT119026959(alox12)
MZE101479810
ONL100698983
OAU116321155(alox12)
OLA101174953
OML112155872(alox12)
XMA102224924
XCO114157899
XHE116733267
PRET103480141
PFOR103148853
PLAI106946955
PMEI106917266
GAF122820467(alox12)
PPRL129378384(alox12)
CVG107103814
CTUL119775005(alox12)
GMU124880055(alox12)
NFU107384708(alox15)
KMR108242243(alox12)
ALIM106526983
NWH119414629(alox12)
AOCE111564179(alox12)
EJA138215617(alox12)
BFRE138636618(alox12)
MCEP125000804(alox12)
POV109637629
SSEN122766699(alox12)
SSOE131456885(alox12)
HHIP117751994(alox12)
HSP118102186(alox12)
PPLT128430339(alox12)
SMAU118302281(alox12)
LCF108879679 108895226(alox12)
SDU111223569
SLAL111667993
XGL120797417(alox12)
PEE133398110(alox12)
PTAO133473005(alox12)
BPEC110170766
ENY140371609(alox12)
MALB109957267
BSPL114849198(alox12)
SJO128383885(alox12)
SSCO134005423(alox12)
SASA100380705(lox12) 106608934
STRU115194626 115198574
OTW112214522(alox12) 112259738
OMY110500350(alox12) 110531448
OGO124008639 124013533(alox12)
ONE115122959 115133313
OKI109882634 109896866
OKE118378215 118392202(alox12)
OMM135510332 135516115(alox12)
OCLA139379375 139415907
SALP111952161
SNH120030395 120049296(alox12)
CCLU121554183 121571287(alox12)
ELS105027651
OEP134009542(alox12)
SFM108922837
PKI111846328
AANG118223344(alox12)
AROT135251233(alox12)
CCOG133123336 133124791
LOC102685586(alox12)
PSPA121305733 121306538
ARUT117426941
PSEX120525266(alox12) 120525267 120525269 120525271 120526494 120526784
CMK103190915(alox12)
RTP109926716
CPLA122544334 122544390
HOC132835132(alox12) 132835215
HAKA140729282 140729283 140729284(alox12)
LPIC129282967
PFLL139147929
MMER123540522
XEN124443531
 » show all
Reference
1  [PMID:4215079]
  Authors
Hamberg M, Samuelsson B.
  Title
Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets.
  Journal
Proc Natl Acad Sci U S A 71:3400-4 (1974)
DOI:10.1073/pnas.71.9.3400
Reference
2  [PMID:804329]
  Authors
Nugteren DH.
  Title
Arachidonate lipoxygenase in blood platelets.
  Journal
Biochim Biophys Acta 380:299-307 (1975)
DOI:10.1016/0005-2760(75)90016-8
Reference
3  [PMID:6783111]
  Authors
Wallach DP, Brown VR.
  Title
A novel preparation of human platelet lipoxygenase. Characteristics and inhibition by a variety of phenyl hydrazones and comparisons with other lipoxygenases.
  Journal
Biochim Biophys Acta 663:361-72 (1981)
DOI:10.1016/0005-2760(81)90165-X
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.31
IUBMB Enzyme Nomenclature: 1.13.11.31
ExPASy - ENZYME nomenclature database: 1.13.11.31
BRENDA, the Enzyme Database: 1.13.11.31
CAS: 82391-43-3

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