KEGG ENZYME: 1.13.11.31

ENZYME: 1.13.11.31

Entry

EC 1.13.11.31 Enzyme

Name

arachidonate 12-lipoxygenase;
Delta12-lipoxygenase;
12-lipoxygenase;
12Delta-lipoxygenase;
C-12 lipoxygenase;
12S-lipoxygenase;
leukotriene A4 synthase;
LTA4 synthase

Class

Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen

Sysname

arachidonate:oxygen 12-oxidoreductase

Reaction(IUBMB)

arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate [RN:R01596]

Reaction(KEGG)

R01596

Substrate

arachidonate [CPD:C00219];
O2 [CPD:C00007]

Product

(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate [CPD:C05965]

Comment

The product is rapidly reduced to the corresponding 12S-hydroxy compound.

History

EC 1.13.11.31 created 1983

Pathway

ec00590

Arachidonic acid metabolism

Orthology

K00458

arachidonate 12-lipoxygenase

Genes

HSA:	239(ALOX12)

PTR:	455242(ALOX12) 455243

PPS:	100992721(ALOX12)

GGO:	101140132(ALOX12)

PON:	100435170 100448016

NLE:	100605486(ALOX12)

MCC:	713683 713748(ALOX12)

MCF:	102136652(ALOX12)

CSAB:

103242265(ALOX12)

RRO:	104673348(ALOX12)

RBB:	108514395(ALOX12)

CJC:	100400641(ALOX12)

SBQ:	101051396(ALOX12)

MMU:	11684(Alox12) 11685(Alox12e)

RNO:	287454(Alox12) 303252(Alox12e)

CGE:	100764620(Alox12)

NGI:	103752172(Alox12)

HGL:	101702123(Alox12)

CCAN:

109682903(Alox12)

OCU:	100340525(ALOX12)

TUP:	102493396(ALOX12)

CFA:	479476(ALOX12)

AML:	100471037(ALOX12)

UMR:	103660455(ALOX12)

ORO:	101379600(ALOX12)

FCA:

101094304

PTG:	102969788(ALOX12)

AJU:

106972408

BTA:	407169(ALOX12) 787450(ALOX12E)

BOM:	102284543(ALOX12)

BIU:	109574004(ALOX12)

PHD:	102339750(ALOX12)

CHX:	102187263(ALOX12)

OAS:	101113685(ALOX12)

SSC:	100620614(ALOX12)

CFR:	102504047(ALOX12)

CDK:	105103060(ALOX12)

BACU:

103020542(ALOX12)

LVE:	103074060(ALOX12)

OOR:	101279538(ALOX12)

ECB:

100072916

EPZ:	103561430(ALOX12)

EAI:	106844160(ALOX12)

MYB:	102254447(ALOX12)

MYD:

102753778

HAI:	109394599(ALOX12)

RSS:	109439024(ALOX12)

PALE:

102897481(ALOX12)

LAV:

100656524

TMU:

101341400

MDO:	100015746(ALOX12) 100015831

SHR:	100933073(ALOX12)

OAA:

100079469

DRE:	322732(alox12)

SASA:

100380705(lox12) 106608934

» show all

Reference

1 [PMID:4215079]

Authors

Hamberg M, Samuelsson B.

Title

Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets.

Journal

Proc Natl Acad Sci U S A 71:3400-4 (1974)
DOI:10.1073/pnas.71.9.3400

Reference

2 [PMID:804329]

Authors

Nugteren DH.

Title

Arachidonate lipoxygenase in blood platelets.

Journal

Biochim Biophys Acta 380:299-307 (1975)
DOI:10.1016/0005-2760(75)90016-8

Reference

3 [PMID:6783111]

Authors

Wallach DP, Brown VR.

Title

A novel preparation of human platelet lipoxygenase. Characteristics and inhibition by a variety of phenyl hydrazones and comparisons with other lipoxygenases.

Journal

Biochim Biophys Acta 663:361-72 (1981)
DOI:10.1016/0005-2760(81)90165-X

Other DBs

ExplorEnz - The Enzyme Database:

1.13.11.31

IUBMB Enzyme Nomenclature:

1.13.11.31

ExPASy - ENZYME nomenclature database:

1.13.11.31

BRENDA, the Enzyme Database:

1.13.11.31

CAS:	82391-43-3

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