KEGG   ENZYME: 1.13.11.34
Entry
EC 1.13.11.34               Enzyme                                 
Name
arachidonate 5-lipoxygenase;
leukotriene-A4 synthase;
Delta5-lipoxygenase;
5Delta-lipoxygenase;
arachidonic 5-lipoxygenase;
arachidonic acid 5-lipoxygenase;
C-5-lipoxygenase;
LTA synthase;
leukotriene A4 synthase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
arachidonate:oxygen 5-oxidoreductase
Reaction(IUBMB)
arachidonate + O2 = leukotriene A4 + H2O (overall reaction) [RN:R08527];
(1a) arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate [RN:R01595];
(1b) (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate = leukotriene A4 + H2O [RN:R03058]
Reaction(KEGG)
R01595 R03058 R08527
Substrate
arachidonate [CPD:C00219];
O2 [CPD:C00007];
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate [CPD:C05356]
Product
leukotriene A4 [CPD:C00909];
H2O [CPD:C00001];
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate [CPD:C05356]
History
EC 1.13.11.34 created 1984, modified 1990
Pathway
ec00590  Arachidonic acid metabolism
ec01100  Metabolic pathways
Orthology
K00461  arachidonate 5-lipoxygenase
Genes
HSA: 240(ALOX5)
PTR: 450428(ALOX5)
PPS: 100979027(ALOX5)
GGO: 101135686(ALOX5)
PON: 100460538(ALOX5)
PPYG: 129045132(ALOX5)
NLE: 100584513(ALOX5)
HMH: 116461149(ALOX5)
SSYN: 129480864(ALOX5)
MCC: 707926(ALOX5)
MCF: 102132853(ALOX5)
MTHB: 126963209
MNI: 105486634(ALOX5)
CSAB: 103215810(ALOX5)
CATY: 105576135(ALOX5)
PANU: 101004229(ALOX5)
TGE: 112632137(ALOX5)
MLEU: 105532332(ALOX5)
RRO: 104678173(ALOX5)
RBB: 108522174(ALOX5)
TFN: 117082071(ALOX5)
PTEH: 111529801(ALOX5)
CANG: 105517726(ALOX5)
CJC: 100386217(ALOX5)
SBQ: 101031793(ALOX5)
CIMI: 108296336(ALOX5)
ANAN: 105708099(ALOX5)
CSYR: 103256562(ALOX5)
MMUR: 105860128 105860129
LCAT: 123650024(ALOX5)
PCOQ: 105821653(ALOX5)
OGA: 100952067(ALOX5)
MMU: 11689(Alox5)
MCAL: 110297094(Alox5)
MPAH: 110315917(Alox5)
RNO: 25290(Alox5)
MCOC: 116099451(Alox5)
ANU: 117714890(Alox5)
MUN: 110563694(Alox5)
CGE: 100772492(Alox5)
MAUA: 101839970(Alox5)
PROB: 127236199(Alox5)
PLEU: 114689650(Alox5)
MORG: 121438814(Alox5)
MFOT: 126505462
AAMP: 119807525(Alox5)
NGI: 103737907(Alox5)
HGL: 101700210(Alox5)
CPOC: 100718093(Alox5)
CCAN: 109700324(Alox5)
DORD: 106001013(Alox5)
DSP: 122122367(Alox5)
PLOP: 125346580(Alox5)
NCAR: 124975507 124985161 124985243 124985624
MMMA: 107153379(Alox5)
OCU: 100341714
OPI: 101534185(ALOX5)
TUP: 102480526(ALOX5)
GVR: 103597659(ALOX5)
CFA: 477753(ALOX5)
CLUD: 112671999(ALOX5)
VVP: 112913415(ALOX5)
VLG: 121483983(ALOX5)
NPO: 129522715(ALOX5)
AML: 100476416(ALOX5)
UMR: 103668062(ALOX5)
UAH: 113243124(ALOX5)
UAR: 123800343(ALOX5)
ELK: 111144974
LLV: 125085017
MPUF: 101684572(ALOX5)
MNP: 132016591(ALOX5)
MLK: 131828702(ALOX5)
NVS: 122900884(ALOX5)
ORO: 101381769(ALOX5)
EJU: 114205241(ALOX5)
ZCA: 113923418(ALOX5)
MLX: 118023026(ALOX5)
NSU: 110589221(ALOX5)
LWW: 102747716(ALOX5)
FCA: 101097422(ALOX5)
PYU: 121036944(ALOX5)
PCOO: 112854352(ALOX5)
PBG: 122492984(ALOX5)
PVIV: 125148229(ALOX5)
LRUF: 124506966
PTG: 102973009(ALOX5)
PPAD: 109264579(ALOX5)
PUC: 125933342
AJU: 106989649
HHV: 120232804(ALOX5)
BTA: 404074(ALOX5)
BOM: 102270550(ALOX5)
BIU: 109553923(ALOX5)
BBUB: 102400249(ALOX5)
BBIS: 104999056(ALOX5)
CHX: 102168425(ALOX5)
OAS: 101117390(ALOX5)
BTAX: 128048043(ALOX5)
ODA: 120865494(ALOX5)
CCAD: 122446293(ALOX5)
MBEZ: 129555613(ALOX5)
SSC: 100156205(ALOX5)
CFR: 102507744(ALOX5)
CBAI: 105075631(ALOX5)
CDK: 105093424(ALOX5)
VPC: 102544906(ALOX5)
BACU: 103009115(ALOX5)
BMUS: 118882474(ALOX5)
LVE: 103081267(ALOX5)
OOR: 101283796(ALOX5)
DLE: 111172567(ALOX5)
PCAD: 102987975(ALOX5) 114485528
PSIU: 116741371(ALOX5)
NASI: 112395753(ALOX5)
ECB: 100062042(ALOX5)
EPZ: 103553660(ALOX5)
EAI: 106846725(ALOX5)
MYB: 102249760(ALOX5)
MYD: 102754419(ALOX5)
MMYO: 118679341(ALOX5)
MLF: 102418693(ALOX5)
MDT: 132214738(ALOX5)
PKL: 118732103(ALOX5)
EFUS: 103292839(ALOX5)
MNA: 107527950(ALOX5)
DRO: 112305481(ALOX5)
SHON: 118994142(ALOX5)
AJM: 119035943(ALOX5)
PDIC: 114496046(ALOX5)
PHAS: 123821021(ALOX5)
MMF: 118632052(ALOX5)
PPAM: 129073187(ALOX5)
HAI: 109389501(ALOX5)
RFQ: 117036416(ALOX5)
PALE: 102898772(ALOX5)
PGIG: 120609662(ALOX5)
PVP: 105288958(ALOX5)
RAY: 107508911(ALOX5)
MJV: 108400689(ALOX5)
TOD: 119234526(ALOX5)
SARA: 101551293(ALOX5)
SETR: 126033671(ALOX5)
LAV: 100661336(ALOX5)
TMU: 101345496
ETF: 101653110(ALOX5)
DNM: 101433807(ALOX5)
MDO: 100013954(ALOX5)
GAS: 123236481(ALOX5)
SHR: 100932471(ALOX5)
PCW: 110213916(ALOX5)
TVP: 118828798(ALOX5)
OAA: 100077066(ALOX5)
GGA: 423769(ALOX5)
PCOC: 116238154(ALOX5)
MGP: 100542129(ALOX5)
CJO: 107315916(ALOX5)
TPAI: 128078157(ALOX5)
LMUT: 125692891(ALOX5)
NMEL: 110399270(ALOX5)
APLA: 101801930(ALOX5)
ACYG: 106049001(ALOX5)
CATA: 118254963(ALOX5)
AFUL: 116491605(ALOX5)
TGU: 100231888(ALOX5)
LSR: 110475663(ALOX5)
SCAN: 103813960(ALOX5)
PMOA: 120502228(ALOX5)
OTC: 121341694(ALOX5)
PRUF: 121350062(ALOX5)
GFR: 102035554(ALOX5)
FAB: 101813553(ALOX5)
OMA: 130254740(ALOX5)
PHI: 102112541(ALOX5)
PMAJ: 107207120(ALOX5)
CCAE: 111931122(ALOX5)
CCW: 104697933(ALOX5)
CBRC: 103624590(ALOX5)
ETL: 114054707(ALOX5)
ZAB: 102062876(ALOX5)
ZLE: 135449795(ALOX5)
ACHL: 103800605(ALOX5)
SVG: 106852593(ALOX5)
MMEA: 130578798(ALOX5)
HRT: 120756195(ALOX5)
SATI: 136364213(ALOX5)
FPG: 101914238(ALOX5)
FCH: 102053142(ALOX5)
CCRI: 104162138(ALOX5)
NNT: 104403581(ALOX5)
SHAB: 115608655(ALOX5)
ACUN: 113481652(ALOX5)
TALA: 104365651(ALOX5)
ACHC: 115348416(ALOX5)
HALD: 104320512(ALOX5)
HLE: 104829333(ALOX5)
AGEN: 126043077
GCL: 127017658
CSTI: 104560045(ALOX5)
MNB: 103781231(ALOX5)
DPUB: 104297702(ALOX5)
AVIT: 104276083(ALOX5)
BRHI: 104501850(ALOX5)
EGZ: 104129027(ALOX5)
NNI: 104014074(ALOX5)
PCRI: 104029677(ALOX5)
PCAO: 104042894(ALOX5)
PADL: 103914082(ALOX5)
AFOR: 103897820(ALOX5)
FGA: 104076430(ALOX5)
GSTE: 104256524(ALOX5)
CLV: 102085004(ALOX5)
MUI: 104535976(ALOX5)
PLET: 104626025(ALOX5)
EHS: 104506301(ALOX5)
CMAC: 104486519(ALOX5)
CUCA: 104067974(ALOX5)
BREG: 104631879(ALOX5)
OHA: 104330385(ALOX5)
ACAR: 104521858(ALOX5)
CPEA: 104391514(ALOX5)
CVF: 104289812(ALOX5)
RTD: 128911621(ALOX5)
AAM: 106497785(ALOX5)
AROW: 112963900(ALOX5)
NPD: 112957209(ALOX5)
TGT: 104577674(ALOX5)
DNE: 112990662(ALOX5)
SCAM: 104146056(ALOX5)
ASN: 102371605(ALOX5)
AMJ: 102568608(ALOX5)
CPOO: 109324293(ALOX5)
GGN: 109287144(ALOX5)
PSS: 102462244(ALOX5)
CMY: 102944803(ALOX5)
CCAY: 125640309(ALOX5)
DCC: 119859437(ALOX5)
CPIC: 101932214(ALOX5)
TST: 117880642(ALOX5)
CABI: 116823588(ALOX5)
MRV: 120369164(ALOX5)
ACS: 100556313(alox5)
ASAO: 132774296(ALOX5)
PVT: 110090785
SUND: 121927518(ALOX5)
PMUR: 107292379(ALOX5)
CTIG: 120300245(ALOX5)
TSR: 106553343(ALOX5)
PGUT: 117661247(ALOX5)
APRI: 131194940(ALOX5) 131195008
PTEX: 113448132(ALOX5)
NSS: 113426131(ALOX5)
VKO: 123029661(ALOX5)
PMUA: 114601080(ALOX5)
PRAF: 128417991(ALOX5)
ZVI: 118079372(ALOX5)
HCG: 128324892(ALOX5)
GJA: 107113129(ALOX5)
STOW: 125443871(ALOX5)
EMC: 129333365(ALOX5)
XLA: 108696220(alox5.L) 108697207(alox5.S) 121396266
XTR: 100036609(alox5)
NPR: 108800085(ALOX5)
RTEM: 120947174(ALOX5)
BBUF: 121004372(ALOX5)
BGAR: 122940049(ALOX5)
MUO: 115470372 115470373
GSH: 117358965 117358966
DRE: 567204(alox5a) 573013(alox5b.1) 724056(alox5b.2)
SRX: 107708393 107713771 107747471
SANH: 107671382 107677802 107678516 107684374 107690200
SGH: 107571808 107572920 107575181 107575442 107582511 107589586
CCAR: 109049814 109052610 109065335 109081069 109101776 109108493
CAUA: 113048375 113048377 113057166 113066049 113066078 113112941
CGIB: 127955930 127967689 127970034 128026407
PTET: 122342996 122342997 122342998 122343010 122357073(alox5a)
LROH: 127160167 127175177(alox5a)
OMC: 131538449 131538622 131538839 131539153 131539371 131552688(alox5a)
PPRM: 120460470 120463765 120463775 120478382 120479775(alox5a) 120492594
RKG: 130070411 130070412 130070436 130070437 130070439 130070440 130076720 130076750 130076753 130076754 130083106(alox5a)
MAMB: 125257158 125265844 125276632(alox5a) 125279367 125279782
CIDE: 127508776 127516455 127517370
CERY: 137020394(alox5a) 137025213 137026174 137026175
MASI: 127412305 127413837 127420989 127420992
TROS: 130559644(alox5a) 130565158
TDW: 130417024 130421067 130430244 130430247 130430795 130431384(alox5a)
MANU: 129415496(alox5a) 129439374 129439376 129439390 129439603 129439605 129439607 129439610 129439611
IPU: 108263823(alox5a)
IFU: 128605533(alox5a)
PHYP: 113546154(alox5)
SMEO: 124378204(alox5a)
TFD: 113639934(alox5a)
TVC: 132847235(alox5a)
TRN: 134314514(alox5a)
AMEX: 103035394(alox5a)
CMAO: 118810335(alox5a)
EEE: 113587960(alox5)
CHAR: 105909748(alox5a)
TRU: 101066485 101077167(alox5) 101077844 115249685
TFS: 130533608 130533609 130533610 130533611 130533612
TNG: GSTEN00016500G001
LCO: 104930113(alox5)
NCC: 104946287(alox5)
TBEN: 117499400(alox5a)
CGOB: 115020076(alox5)
PGEO: 117459737(alox5a)
GACU: 117538242(alox5a)
EMAC: 134858448(alox5a)
ELY: 117248563
EFO: 125903456(alox5a)
PLEP: 121954568 121954569
SLUC: 116054107(alox5a)
ECRA: 117960578(alox5a)
ESP: 116704939(alox5)
PFLV: 114572645(alox5)
GAT: 120820912(alox5a)
PPUG: 119213967(alox5a)
AFB: 129092018(alox5a)
CLUM: 117743732 117743733
PSWI: 130206923(alox5a)
MSAM: 119916966(alox5a)
SCHU: 122884911
CUD: 121510776 121511083 121511143 121511190
ALAT: 119034095(alox5a)
MZE: 101482427(alox5)
ONL: 100693453(alox5)
OAU: 116316616(alox5a)
OLA: 101160835(alox5) 101165738
OML: 112162158(alox5a)
CSAI: 133463919(alox5a)
XMA: 102230376(alox5)
XCO: 114137934(alox5)
XHE: 116712547(alox5)
PRET: 103476884(alox5)
PFOR: 103147712(alox5)
PLAI: 106955189(alox5)
PMEI: 106907603(alox5)
GAF: 122843057(alox5a)
PPRL: 129360011(alox5a)
CVG: 107091526(alox5)
CTUL: 119788547(alox5a)
GMU: 124858722(alox5a)
NFU: 107375698(alox5)
KMR: 108243211
ALIM: 106529456(alox5)
NWH: 119418429(alox5a)
AOCE: 111564375(alox5)
MCEP: 125018433(alox5a)
CSEM: 103387317(alox5)
POV: 109631496(alox5)
SSEN: 122781462(alox5a)
HHIP: 117775306(alox5a)
HSP: 118118901(alox5a)
PPLT: 128453708(alox5a)
SMAU: 118284164(alox5a)
LCF: 108884347(alox5a)
SDU: 111235185(alox5)
SLAL: 111654678(alox5)
XGL: 120796514(alox5a)
HCQ: 109509924 109509925(alox5)
SSCV: 125978684 125978685
SBIA: 133509411(alox5a) 133510141
PEE: 133409389 133409390(alox5a)
PTAO: 133485328 133485329
BPEC: 110164412(alox5)
MALB: 109961016(alox5)
BSPL: 114870428(alox5a)
SJO: 128372695(alox5a)
SASA: 100194803(lox5) 106613187
STRU: 115153372 115193564
OTW: 112253187 112256283
OMY: 110502637 110532793
OGO: 124037261 124041114
ONE: 115113091 115134961
OKI: 109890066 109899823
OKE: 118366116(alox5a) 118369426
SALP: 111978799
SNH: 120017762 120045686
CCLU: 121553196 121583968
ELS: 105010608(alox5)
SFM: 108921027(alox5) 108937538
PKI: 111837191 111846223 111846232 111849566(alox5)
AANG: 118218047 118218049 118218050 118218460
LOC: 102697549(alox5)
PSPA: 121325182(alox5a)
ARUT: 117416027 117417615(alox5a)
PSEX: 120516309(alox5a)
LCM: 102353934(ALOX5)
CMK: 103185827(alox5a)
RTP: 109921931(alox5a)
CPLA: 122541744
HOC: 132835112(alox5a)
LERI: 129694146 129713061 129713062
PMRN: 116938187 116938188 116938189 116945048(ALOX5) 116946267 116954498 116954558
LRJ: 133340592 133341923 133357456 133357457 133357459 133357461 133357468
BFO: 118407044 118407190 118410745 118416628 118419219 118419222 118423903 118424144
BBEL: 109463619 109467523 109473009 109474494 109474550 109474633 109476869 109478405 109478532 109479429 109480412 109481529 109483336 109486824 109487021 109487229 109487274 109487288
CIN: 100176198 100176411 100176744 100178151 100178342 100178563 100179479
SCLV: 120327656 120328067 120330915 120339739 120339931 120339932 120342283 120342991
SPU: 115918885 574670 575389 579368 583823 584481 584789 585142 591845 754628 763828 764400
LPIC: 129260605 129274105 129274606 129275104 129276415 129276420 129276477 129276781
APLC: 110975305 110975972 110976201 110977737 110977751
ARUN: 117299969 117299972 117300117 117300200 117300341
SKO: 100369676 100369827 102805620
IEL: 124162033
PVM: 113804806
HAME: 121878425
PCLA: 123760292
PTRU: 123516860
ESN: 127001279
MNZ: 135211017
PPOI: 119091807 119096450
DSV: 119449406
RSAN: 119382445
RMP: 119178021
CSCU: 111636555 111636558
CVS: 136986727 136987859 136987897 136987900
PTEP: 107442379
ABRU: 129960253
UDV: 129231431
SDM: 118200660
LPOL: 106471422
PMEO: 129593708
HRO: HELRODRAFT_66521
LGI: LOTGIDRAFT_137999 LOTGIDRAFT_171808 LOTGIDRAFT_209217 LOTGIDRAFT_224684
PVUL: 126829853 126829854
PCAN: 112558951
BGT: 106067963 106069395
GAE: 121374655 121392860
HRF: 124111845 124113998 124114830 124115001 124115002 124123794 124143720
HRJ: 124254639 124259952 124261755 124261766 124285520
CRG: 105319481 105324873 105327235 105327236 105327296 105327652 105333405 105333406 105336201 117683956
CANU: 128163050 128163051 128175011 128175263 128177600 128177852 128177871 128178663 128184671 128184672 128184673 128192060
CVN: 111100560 111104171 111125061 111131676
OED: 125650846 125652902 125652924 125652925 125681975 130054742
MYI: 110457288 110457778 110458666 110458669 110458670 110458673 110458677 110458678
PMAX: 117322747 117324142 117324143 117329167 117329376 117329377 117329378 117329966
MMER: 123539768 123540524 123541567 123553096 123557731
RPHI: 132725606 132736951 132754139 132757137 132759084
DPOL: 127832686 127836363 127838598 127841037
MAEA: 128204556 128204580 128212062 128212090 128212091 128212092 128227279 128233189 128233746 128235785 128236825 128238403
OBI: 106867440 106867441 106867443 106873090 106873091 106873092
OSN: 115215746 115215749 115215753 115221275 115221688 115226898 115227054
LJP: 135473490 135473749 135473750
LAK: 106150754 106166490 106170509 106178940
OVI: T265_15039
LLON: 135482588 135482589 135482590 135487105 135487106 135488980 135492370 135493491
NVE: 5499732 5504404 5514194 5514339
EPA: 110239121 110242596 110248339 110250751 110253407
ATEN: 116286796 116290323 116294452 116296880 116301055 116304961 116304967
ADF: 107327113 107341953 107341972 107345340 107350206 107352928
AMIL: 114958630 114959396 114968909 114970008 114971001
PDAM: 113664617 113665281 113666770 113675130 113675559 113675883 113682318 113683498 113685341
SPIS: 111321744 111326629 111326882 111326890 111328829 111341264
DGT: 114516532 114516794 114521367 114521368 114527546 114529580 114531948 114541102
XEN: 124433523 124439795 124443860 124444372 124444381 124444382 124450812 124454266
HMG: 100200947 100209770 100213618 100215649
HSY: 130622682 130630034 130630315 130630536 130647477
RES: 135682413 135687175 135689805
TAD: TRIADDRAFT_50085 TRIADDRAFT_63720
AQU: 100635761
CCP: CHC_T00008739001
MXA: MXAN_1744
MSD: MYSTI_02579
MFB: MFUL124B02_14090
CCX: COCOR_02733(loxA)
MBD: MEBOL_004947
 » show all
Reference
1  [PMID:2829172]
  Authors
Matsumoto T, Funk CD, Radmark O, Hoog JO, Jornvall H, Samuelsson B
  Title
Molecular cloning and amino acid sequence of human 5-lipoxygenase.
  Journal
Proc Natl Acad Sci U S A 85:26-30 (1988)
DOI:10.1073/pnas.85.1.26
  Sequence
[hsa:240]
Reference
2  [PMID:3038871]
  Authors
Ohishi N, Izumi T, Minami M, Kitamura S, Seyama Y, Ohkawa S, Terao S, Yotsumoto H, Takaku F, Shimizu T.
  Title
Leukotriene A4 hydrolase in the human lung. Inactivation of the enzyme with leukotriene A4 isomers.
  Journal
J Biol Chem 262:10200-5 (1987)
Reference
3  [PMID:3012557]
  Authors
Shimizu T, Izumi T, Seyama Y, Tadokoro K, Radmark O, Samuelsson B.
  Title
Characterization of leukotriene A4 synthase from murine mast cells: evidence for its identity to arachidonate 5-lipoxygenase.
  Journal
Proc Natl Acad Sci U S A 83:4175-9 (1986)
DOI:10.1073/pnas.83.12.4175
Reference
4  [PMID:6322165]
  Authors
Shimizu T, Radmark O, Samuelsson B.
  Title
Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid.
  Journal
Proc Natl Acad Sci U S A 81:689-93 (1984)
DOI:10.1073/pnas.81.3.689
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.34
IUBMB Enzyme Nomenclature: 1.13.11.34
ExPASy - ENZYME nomenclature database: 1.13.11.34
BRENDA, the Enzyme Database: 1.13.11.34
CAS: 80619-02-9

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