KEGG   ENZYME: 1.13.11.37
Entry
EC 1.13.11.37               Enzyme                                 

Name
hydroxyquinol 1,2-dioxygenase;
hydroxyquinol dioxygenase;
benzene-1,2,4-triol:oxygen 1,2-oxidoreductase (decyclizing);
benzene-1,2,4-triol:oxygen 1,2-oxidoreductase (ring-opening)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
hydroxyquinol:oxygen 1,2-oxidoreductase (ring-opening)
Reaction(IUBMB)
hydroxyquinol + O2 = maleylacetate [RN:R04061]
Reaction(KEGG)
R04061;
(other) R03891
Substrate
hydroxyquinol [CPD:C02814];
O2 [CPD:C00007]
Product
maleylacetate [CPD:C02222]
Comment
An iron protein. Highly specific; catechol and pyrogallol are acted on at less than 1% of the rate at which hydroxyquinol is oxidized.
History
EC 1.13.11.37 created 1989, modified 2013
Pathway
ec00361  Chlorocyclohexane and chlorobenzene degradation
ec00362  Benzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K04098  hydroxyquinol 1,2-dioxygenase
Genes
KMI: VW41_06390
EBT: EBL_c11380
CEM: LH23_12110
CEN: LH86_11520
EAME: GXP68_22265
PAP: PSPA7_3907
PRE: PCA10_31790
PCQ: PcP3B5_37680(npcC)
PPUN: PP4_21440
PPUD: DW66_3576 DW66_3593
PKC: PKB_3292(chqB)
GAI: IMCC3135_30335(chqB)
HBE: BEI_0308(chqB)
REH: H16_B0968(pcpA)
CGD: CR3_2773(chqB)
BUT: X994_6297(pnpC)
BCJ: BCAL1342
BCEW: DM40_4058(pnpC)
BCEO: I35_1237
BAM: Bamb_3333
BMU: Bmul_6070
BMK: DM80_6521(pnpC)
BMUL: NP80_5281(pnpC)
BCT: GEM_5252
BCED: DM42_367(chqB)
BCON: NL30_08950
BLAT: WK25_22605
BTEI: WS51_01155
BPSL: WS57_19045
BMEC: WJ16_21310
BGO: BM43_4098 BM43_5582(pnpC)
BPH: Bphy_5624
BFN: OI25_124(pnpC)
PPNO: DA70_09450
PPNM: LV28_21360
PSPU: NA29_21265
CABA: SBC2_61000(chqB) SBC2_61880(npcC)
POL: Bpro_2064
AAA: Acav_4141
VEI: Veis_4613
DAC: Daci_3128
LIH: L63ED372_01214(npcC)
LCH: Lcho_0834
SMI: BN406_06712(chqB)
ARA: Arad_7159
AVI: Avi_7443
RLG: Rleg_5533
BJA: bll2679
BRA: BRADO2272
RPB: RPB_3255
AZC: AZC_1414
MNO: Mnod_0748
PLEO: OHA_1_04030(npcC_1) OHA_1_04040(npcC_2)
MMED: Mame_00357(chqB)
DSH: Dshi_0961
PGD: Gal_04184
OAT: OAN307_c31220(pcaH)
OTM: OSB_07930(chqB)
MALG: MALG_01196
AHT: ANTHELSMS3_00943(chqB)
SPHK: SKP52_13005(chqB)
SPHD: HY78_16675
STAX: MC45_16620
SPHB: EP837_03834(catA)
SINB: SIDU_09280
SAMI: SAMIE_4000340(hqdE)
AAY: WYH_01879(npcC)
MSHG: MSG_03203
MVA: Mvan_4404
MCHT: MCHIJ_29990(catA_1)
MAUU: NCTC10437_00420(chqB_1) NCTC10437_01566(chqB_2)
CGL: NCgl2951(Cgl3056)
CGB: cg3385(catA3)
CGU: WA5_1113 WA5_2951(CatA3)
CGT: cgR_2941
CGM: cgp_1311 cgp_3385(catA3)
CGJ: AR0_14800
CGY: CGLY_10700(chqB)
CDX: CDES_03625(chqB)
NAD: NCTC11293_03317(chqB)
ROP: ROP_42970
RFA: A3L23_03379(npcC)
SBH: SBI_00376
SDV: BN159_7412(chqB)
SLE: sle_04030(sle_04030)
SGE: DWG14_00025(chqB_1) DWG14_00034(npcC_1) DWG14_00196(chqB_3) DWG14_01103(npcC_2)
PSIM: KR76_25510
STRR: EKD16_15900(chqB)
BSD: BLASA_2518(chqB) BLASA_2968(chqB2)
AMD: AMED_4854(catA)
AMN: RAM_24710
AMM: AMES_4795(catA)
AMZ: B737_4795(catA)
AMYY: YIM_23065(chqB)
PSEA: WY02_04130
PAUT: Pdca_03800 Pdca_10260(catA_1)
SESP: BN6_46850(chqB)
ACTN: L083_5615
CAI: Caci_4340
 » show all
Reference
1  [PMID:6539772]
  Authors
Sze IS, Dagley S.
  Title
Properties of salicylate hydroxylase and hydroxyquinol 1,2-dioxygenase purified from Trichosporon cutaneum.
  Journal
J Bacteriol 159:353-9 (1984)
DOI:10.1128/JB.159.1.353-359.1984
Reference
2  [PMID:15772073]
  Authors
Ferraroni M, Seifert J, Travkin VM, Thiel M, Kaschabek S, Scozzafava A, Golovleva L, Schlomann M, Briganti F
  Title
Crystal structure of the hydroxyquinol 1,2-dioxygenase from Nocardioides simplex  3E, a key enzyme involved in polychlorinated aromatics biodegradation.
  Journal
J Biol Chem 280:21144-54 (2005)
DOI:10.1074/jbc.M500666200
  Sequence
Reference
3  [PMID:16232466]
  Authors
Hatta T, Nakano O, Imai N, Takizawa N, Kiyohara H
  Title
Cloning and sequence analysis of hydroxyquinol 1,2-dioxygenase gene in 2,4,6-trichlorophenol-degrading Ralstonia pickettii DTP0602 and characterization  of its product.
  Journal
J Biosci Bioeng 87:267-72 (1999)
DOI:10.1016/S1389-1723(99)80030-9
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.37
IUBMB Enzyme Nomenclature: 1.13.11.37
ExPASy - ENZYME nomenclature database: 1.13.11.37
UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.37
BRENDA, the Enzyme Database: 1.13.11.37
CAS: 91847-14-2

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