KEGG   ENZYME: 1.13.11.46
Entry
EC 1.13.11.46               Enzyme                                 
Name
4-hydroxymandelate synthase;
4-hydroxyphenylpyruvate dioxygenase II
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
(S)-4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)
Reaction(IUBMB)
4-hydroxyphenylpyruvate + O2 = (S)-4-hydroxymandelate + CO2 [RN:R06632]
Reaction(KEGG)
R06632;
(other) R05778
Substrate
4-hydroxyphenylpyruvate [CPD:C01179];
O2 [CPD:C00007]
Product
(S)-4-hydroxymandelate [CPD:C03198];
CO2 [CPD:C00011]
Comment
Requires Fe2+. Involved in the biosynthesis of the vancomycin group of glycopeptide antibiotics.
History
EC 1.13.11.46 created 2001
Pathway
ec00261  Monobactam biosynthesis
ec01055  Biosynthesis of vancomycin group antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K16421  4-hydroxymandelate synthase
Genes
MSDMYSTI_03600
MFBMFUL124B02_19465
AGEAA314_04078
CFUSCYFUS_002913
THAACFI11_12525
NTPCRH09_30890(hppD)
NHUH0264_30685(hppD)
SCOSCO3229(SCE63.04)
SVLStrvi_8789
SRCM271_09160 M271_27680
SBHSBI_01126
SALUDC74_563
SALLSAZ_03310
SLVSLIV_21545
SVTSVTN_32165 SVTN_32295
STREGZL_08687
SLCSL103_26560
STRCAA958_31850
SAMBSAM23877_5652
SRWTUE45_06938
SPAVSpa2297_02915 Spa2297_26610 Spa2297_32985
STSIA4E84_04200 A4E84_32820
SKYD0C37_28235(hppD)
SALWCP975_31965(hppD)
SNRSNOUR_39385
SPLULK06_002715 LK06_031630
SSIAA7J05_04105
SLAUSLA_6884
STROSTRMOE7_29130
SFKKY5_6265c KY5_6719 KY5_7437c
SCYAEJ357_01680(hppD)
SKACP970_03010(hppD) CP970_07050(hppD) CP970_09760(hppD)
SRKFGW37_00515(hppD)
SGALCP966_31740
SVRCP971_02370(hppD) CP971_08110(hppD)
SFYGFH48_02890(hppD) GFH48_36325(hppD)
SBYH7H31_03515(hppD)
SRIMCP984_06500(hppD)
SFUGCNQ36_25575(hppD)
STSUB7R87_00120 B7R87_00865
SCHACP983_01445(hppD) CP983_10855(hppD)
SGXH4W23_38355(hppD)
SATAC5746_00990(hppD) C5746_42245(hppD)
SAUHSU9_002080(hppD)
SANUK7396_35155(hppD)
KSKKSE_65080 KSE_67340
KAUB6264_28345
KITCFP65_1222
KFLKfla_6066
THAONI17_008240(hppD)
AGRAAGRA3207_002325 AGRA3207_007458
SROSros_6970
NOABKM31_54205
NCXNocox_13265(noc2)
NGNLCN96_07790(hppD) LCN96_24325(hppD)
FRAFrancci3_2454
AOIAORI_1495(hppD)
AJAAJAP_32040
AMYBBKN51_28930 BKN51_41520
AORISD37_16610 SD37_33645
AMIAmir_4590
SSYIEKG83_29580(hppD) EKG83_30955(hppD)
KALKALB_6132
ACTIUA75_15380
ACADUA74_14810
ACTAC1701_23410(hppD)
STPStrop_2490 Strop_2727
SAQSare_2673
MAUMicau_3482
MILML5_4909
MICBMicB006_2537
MTUACSH63_07635(hppD)
MICHFJK98_16440(hppD)
MTEMGCE86_13405(hppD)
MCABHXZ27_18210(hppD)
MSAGGCM10017556_53780
VMAVAB18032_22230
PFLAPflav_007570
PSUUPsuf_064610
ATLAthai_13960
PRYPrubr_36840 Prubr_65200
CATICS0771_77170
DVCDvina_13810(hppD) Dvina_18685(hppD)
CAICaci_3256
HAUHaur_1888
 » show all
Reference
1  [PMID:11137816]
  Authors
Hubbard BK, Thomas MG, Walsh CT
  Title
Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics.
  Journal
Chem Biol 7:931-42 (2000)
DOI:10.1016/S1074-5521(00)00043-0
  Sequence
Reference
2
  Authors
Choroba, O.W., Williams, D.H. and Spencer, J.B.
  Title
Biosynthesis of the vancomycin group of antibiotics: involvement of an unusual dioxygenase in the pathway to (S)-4-hydroxyphenylglycine.
  Journal
J Am Chem Soc 122:5389-5390 (2000)
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.46
IUBMB Enzyme Nomenclature: 1.13.11.46
ExPASy - ENZYME nomenclature database: 1.13.11.46
BRENDA, the Enzyme Database: 1.13.11.46
CAS: 280566-04-3

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