KEGG ENZYME: 1.13.11.50

ENZYME: 1.13.11.50

Entry

EC 1.13.11.50 Enzyme

Name

acetylacetone-cleaving enzyme;
Dke1;
acetylacetone dioxygenase;
diketone cleaving dioxygenase;
diketone cleaving enzyme

Class

Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen

Sysname

acetylacetone:oxygen oxidoreductase

Reaction(IUBMB)

pentane-2,4-dione + O2 = acetate + 2-oxopropanal [RN:R07183]

Reaction(KEGG)

R07183

Substrate

pentane-2,4-dione [CPD:C15499];
O2 [CPD:C00007]

Product

acetate [CPD:C00033];
2-oxopropanal [CPD:C00546]

Comment

An Fe(II)-dependent enzyme. Forms the first step in the acetylacetone degradation pathway of Acinetobacter johnsonii. While acetylacetone is by far the best substrate, heptane-3,5-dione, octane-2,4-dione, 2-acetylcyclohexanone and ethyl acetoacetate can also act as substrates.

History

EC 1.13.11.50 created 2003

Orthology

K20148

acetylacetone-cleaving enzyme

Genes

BXE:

Bxe_A2876

BXB:	DR64_557(dke1)

BPX:	BUPH_08490

BUZ:	AYM40_26235

CABA:

SBC2_46810(dke1)

RHY:	RD110_03340

AAV:

Aave_3966

MPT:

Mpe_A3659

METP:

C1M51_08180

ALH:	G6N82_04105

TMO:	TMO_b0515(dke1)

» show all

Reference

1 [PMID:12379146]

Authors

Straganz GD, Glieder A, Brecker L, Ribbons DW, Steiner W

Title

Acetylacetone-cleaving enzyme Dke1: a novel C-C-bond-cleaving enzyme from Acinetobacter johnsonii.

Journal

Biochem J 369:573-81 (2003)
DOI:10.1042/BJ20021047

Sequence

[ag:AAN45859]

Other DBs

ExplorEnz - The Enzyme Database:

1.13.11.50

IUBMB Enzyme Nomenclature:

1.13.11.50

ExPASy - ENZYME nomenclature database:

1.13.11.50

BRENDA, the Enzyme Database:

1.13.11.50

CAS:	524047-53-8

DBGET integrated database retrieval system