KEGG   ENZYME: 1.13.11.50
Entry
EC 1.13.11.50               Enzyme                                 
Name
acetylacetone-cleaving enzyme;
Dke1;
acetylacetone dioxygenase;
diketone cleaving dioxygenase;
diketone cleaving enzyme
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
acetylacetone:oxygen oxidoreductase
Reaction(IUBMB)
pentane-2,4-dione + O2 = acetate + 2-oxopropanal [RN:R07183]
Reaction(KEGG)
R07183
Substrate
pentane-2,4-dione [CPD:C15499];
O2 [CPD:C00007]
Product
acetate [CPD:C00033];
2-oxopropanal [CPD:C00546]
Comment
An Fe(II)-dependent enzyme. Forms the first step in the acetylacetone degradation pathway of Acinetobacter johnsonii. While acetylacetone is by far the best substrate, heptane-3,5-dione, octane-2,4-dione, 2-acetylcyclohexanone and ethyl acetoacetate can also act as substrates.
History
EC 1.13.11.50 created 2003
Orthology
K20148  acetylacetone-cleaving enzyme
Genes
PSEPC4K39_2447
BXEBxe_A2876
BXBDR64_557(dke1)
BPXBUPH_08490
BUZAYM40_26235
PDIOPDMSB3_1622(dke)
CABASBC2_46810(dke1)
RHYRD110_03340
AAVAave_3966
MPTMpe_A3659
METPC1M51_08180
ALHG6N82_04105
TMOTMO_b0515(dke1)
 » show all
Reference
1  [PMID:12379146]
  Authors
Straganz GD, Glieder A, Brecker L, Ribbons DW, Steiner W
  Title
Acetylacetone-cleaving enzyme Dke1: a novel C-C-bond-cleaving enzyme from Acinetobacter johnsonii.
  Journal
Biochem J 369:573-81 (2003)
DOI:10.1042/BJ20021047
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.50
IUBMB Enzyme Nomenclature: 1.13.11.50
ExPASy - ENZYME nomenclature database: 1.13.11.50
BRENDA, the Enzyme Database: 1.13.11.50
CAS: 524047-53-8

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