| Entry |
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| Name |
acetylacetone-cleaving enzyme;
Dke1;
acetylacetone dioxygenase;
diketone cleaving dioxygenase;
diketone cleaving enzyme
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| Class |
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
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| Sysname |
acetylacetone:oxygen oxidoreductase
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| Reaction(IUBMB) |
pentane-2,4-dione + O2 = acetate + 2-oxopropanal [RN: R07183]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
An Fe(II)-dependent enzyme. Forms the first step in the acetylacetone degradation pathway of Acinetobacter johnsonii. While acetylacetone is by far the best substrate, heptane-3,5-dione, octane-2,4-dione, 2-acetylcyclohexanone and ethyl acetoacetate can also act as substrates.
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| History |
EC 1.13.11.50 created 2003
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| Orthology |
| K20148 | acetylacetone-cleaving enzyme |
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| Genes |
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| Reference |
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| Authors |
Straganz GD, Glieder A, Brecker L, Ribbons DW, Steiner W. |
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| Title |
Acetylacetone-cleaving enzyme Dke1: a novel C-C-bond-cleaving enzyme from Acinetobacter johnsonii. |
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| Journal |
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| Sequence |
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| Other DBs |
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