KEGG   ENZYME: 1.13.11.57Help
Entry
EC 1.13.11.57               Enzyme                                 

Name
gallate dioxygenase;
GalA;
gallate:oxygen oxidoreductase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
3,4,5-trihydroxybenzoate:oxygen oxidoreductase
Reaction(IUBMB)
3,4,5-trihydroxybenzoate + O2 = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate [RN:R09565]
Reaction(KEGG)
R09565;
(other) R03550
Show
Substrate
3,4,5-trihydroxybenzoate [CPD:C01424];
O2 [CPD:C00007]
Product
(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate [CPD:C04434]
Comment
Contains non-heme Fe2+. The enzyme is a ring-cleavage dioxygenase that acts specifically on 3,4,5-trihydroxybenzoate to produce the keto-tautomer of 4-oxalomesaconate [1,2].
History
EC 1.13.11.57 created 2011
Pathway
ec00627  Aminobenzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K04099  gallate dioxygenase
Genes
KPN: KPN_04051
KPU: KP1_5420
KPM: KPHS_52210
KPP: A79E_0056
KPK: A593_10490
KPH: KPNIH24_25975
KPZ: KPNIH27_24960
KPV: KPNIH29_25920
KPW: KPNIH30_26315
KPY: KPNIH31_25390
KPE: KPK_0043
KPJ: N559_0092
KPX: PMK1_01557(galA)
KPNU: LI86_00280
KPNK: BN49_0056(pcaH)
KVA: Kvar_0048
CRO: ROD_31621
SPE: Spro_2096
SMAF: D781_1923
RAA: Q7S_13255
EAM: EAMY_1944(pcaH)
EAY: EAM_1902
EBI: EbC_05400
PCQ: PcP3B5_13930(galA)
PPU: PP_2518(glllA)
PPF: Pput_3200
PPI: YSA_00530
PPX: T1E_3395
PPUT: L483_20160
PPUN: PP4_26450
PSTT: CH92_18130
CSA: Csal_0323
PSE: NH8B_2725
RME: Rmet_3709
BCEN: DM39_6585
BCEO: I35_7835
BMU: Bmul_6041
BMJ: BMULJ_05486(ligB)
BMK: DM80_6492
BMUL: NP80_5253
BCED: DM42_7336(ligB)
BUB: BW23_4779
BTEI: WS51_29490
BPSL: WS57_17850
BGP: BGL_2c21000(ligB)
BGO: BM43_6953(ligB)
BPH: Bphy_6377
ACRA: BSY15_1204(ligA)
VEI: Veis_0170
CTES: O987_18260
OTK: C6570_16450(ligA)
BRA: BRADO1853(ligB)
BBT: BBta_2174(ligB)
SSY: SLG_03330(desB)
AAY: WYH_03044(galA)
SLAU: SLA_7098
KSK: KSE_75140(pcmA)
MHOS: CXR34_05670(ligA)
ART: Arth_4373
 » show all
Taxonomy
Reference
1  [PMID:16030014]
  Authors
Nogales J, Canales A, Jimenez-Barbero J, Garcia JL, Diaz E
  Title
Molecular characterization of the gallate dioxygenase from Pseudomonas putida KT2440. The prototype of a new subgroup of extradiol dioxygenases.
  Journal
J Biol Chem 280:35382-90 (2005)
DOI:10.1074/jbc.M502585200
Reference
2  [PMID:21219457]
  Authors
Nogales J, Canales A, Jimenez-Barbero J, Serra B, Pingarron JM, Garcia JL, Diaz E
  Title
Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida.
  Journal
Mol Microbiol 79:359-74 (2011)
DOI:10.1111/j.1365-2958.2010.07448.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.57
IUBMB Enzyme Nomenclature: 1.13.11.57
ExPASy - ENZYME nomenclature database: 1.13.11.57
UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.57
BRENDA, the Enzyme Database: 1.13.11.57

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