KEGG   ENZYME: 1.13.11.58Help
Entry
EC 1.13.11.58               Enzyme                                 

Name
linoleate 9S-lipoxygenase;
9-lipoxygenase;
9S-lipoxygenase;
linoleate 9-lipoxygenase;
LOX1 (gene name);
9S-LOX
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
linoleate:oxygen 9S-oxidoreductase
Reaction(IUBMB)
linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate [RN:R07057]
Reaction(KEGG)
Substrate
linoleate [CPD:C01595];
O2 [CPD:C00007]
Product
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate [CPD:C14827]
Comment
Contains nonheme iron. A common plant lipoxygenase that oxidizes linoleate and alpha-linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C9 position with (S)-configuration. The enzyme plays a physiological role during the early stages of seedling growth. The enzyme from Arabidopsis thaliana shows comparable activity towards linoleate and linolenate [4]. EC 1.13.11.12 (linoleate 13S-lipoxygenase) catalyses a similar reaction at another position of these fatty acids.
History
EC 1.13.11.58 created 2011
Pathway
ec00591  Linoleic acid metabolism
Orthology
K15718  linoleate 9S-lipoxygenase
Genes
ATH: AT1G55020(LOX1) AT3G22400(LOX5)
ALY: 9319428 9327996
CRB: 17893758 17894417
CSAT: 104701021 104715474 104746689 104746690 104750191 104758943 104766136 104787362 104787405
EUS: EUTSA_v10020023mg EUTSA_v10023267mg
BRP: 103834572 103844546 103869043
BNA: 106352821 106376623 106388246 106433608 106433973 106453908 111198039
BOE: 106295789 106314534 106319746
RSZ: 108807444 108807735 108812350 108832554 108863125
THJ: 104801865 104806939 104820855 104823730 104825976
CPAP: 110814120 110814127 110815297 110817254 110817280 110819775
CIT: 102621545 102621914
CIC: CICLE_v10000236mg CICLE_v10004281mg
TCC: 18600365 18600367 18600368 18600369 18600371 18602959
GRA: 105781519 105783043 105792522 105792525 105796638 105800512
GHI: 107893644 107894329 107894336 107898380 107899102 107899106 107919998 107927619 107928543 107944366
GAB: 108457463 108464242 108468954 108470002 108474786
DZI: 111277300 111277932 111277933 111280136 111293906 111295420 111307953
EGR: 104414852 104415560 104415561 104415562 104415563 104415564 104429569
GMX: 100101853(VLXB) 100127399(LOX9) 100127400(LOX10) 100782558 100789019 100800451 100802459 100802685 100802887 100803358 100815477 100815550 100816880 547694 547774(LOX2) 547835 547836(LOXB1) 547856(VLXC) 547860(LOX7) 547869(LOX3) 547923(LOX1.1)
GSJ: 114370204 114372569 114375008 114375009 114376278 114376458 114386328 114388361 114388668 114403306 114407603 114417913 114418141 114418142 114419180 114422277 114422278 114422279 114422280 114423939
PVU: PHAVU_004G168400g PHAVU_005G156700g PHAVU_005G1568001 PHAVU_005G156900g PHAVU_005G157000g PHAVU_006G091400g PHAVU_007G055600g PHAVU_007G055800g PHAVU_007G179600g PHAVU_010G134700g PHAVU_010G134800g PHAVU_010G134900g PHAVU_010G135000g PHAVU_010G135300g PHAVU_010G135400g PHAVU_010G135500g PHAVU_010G135600g PHAVU_010G135700g PHAVU_010G135800g PHAVU_010G135900g
VRA: 106760770 106760780 106761927 106761928 106762003 106772236 106773082 106773083 106773084 106773085 106773086 106773087 106773712 106773713 106775016 106780386 106780387 111242517
VAR: 108320191 108320205 108320206 108320208 108320213 108320214 108323174 108323175 108323176 108323178 108323181 108323182 108324769 108326670 108332293 108334116 108334134 108334142 108334300 108341800 108345752
VUN: 114165654 114165656 114165728 114166339 114166341 114166734 114166735 114166737 114166739 114166740 114183038 114184324 114185546 114185686 114188176 114190244 114191620 114191794
CCAJ: 109795363 109796222 109801924 109801925 109802085 109802609 109805652 109805653 109806359 109806596 109813937
MTR: MTR_1g083020 MTR_1g104650 MTR_2g099560 MTR_2g099570 MTR_3g081130 MTR_5g024020 MTR_7g113410 MTR_8g018420 MTR_8g018430 MTR_8g018450 MTR_8g018510 MTR_8g018520 MTR_8g018550 MTR_8g018570 MTR_8g018590 MTR_8g018620 MTR_8g018650 MTR_8g018690 MTR_8g018730 MTR_8g018735 MTR_8g020990
CAM: 101490986 101491283 101491298 101491605 101491624 101491931 101495975 101496167 101502002 101502735
LJA: Lj0g3v0057299.1(Lj0g3v0057299.1) Lj0g3v0255679.1(Lj0g3v0255679.1) Lj3g3v0324640.1(Lj3g3v0324640.1) Lj3g3v2659870.1(Lj3g3v2659870.1) Lj3g3v2661200.1(Lj3g3v2661200.1) Lj5g3v2056200.1(Lj5g3v2056200.1) Lj5g3v2056200.2(Lj5g3v2056200.2) Lj5g3v2056200.3(Lj5g3v2056200.3)
ADU: 107461392 107461394 107461395 107464433 107464479 107464749 107464753 107464854 107465391 107466861 107492121
AIP: 107612513 107613293 107617165 107617328 107617419 107617549 107617585 107617884 107617918 107645767 107645896
LANG: 109329108 109333451 109334172 109342911 109345801 109346208 109346835 109347840 109347870 109347874 109351272 109356561
FVE: 101293106 101293406 101301961 101311821
RCN: 112192081 112192269 112193452 112196194 112197257
PPER: 18773359 18774870 18774983 18774987 18775056 18788938
PMUM: 103324270 103344101 103344102 103344618 103344619 103344620 103344621 103344623 103344624
PAVI: 110759643 110759644 110759645 110759647 110759772 110762049
MDM: 103403905 103411221 103423655 103433945 103433947 103433949 103433950 103450936 103453113
PXB: 103935971 103955722 103955797 103956622 103965340 103965341 103965342 103965343 103965358 103965359 103965360 103965361
ZJU: 107411945 107412008 107412009 107423042 107423207
CSV: 101206086 101206327 101207163 101207406 101207901 101208141 101211823 101215030(LOX9) 101222652 105434408 105434554(LOX2)
CMO: 103491403 103494836 103494845 103494864(LOX2) 103494874 103494895 103494902 103494917
MCHA: 111009757 111018834 111018836 111018837 111018853 111018861 111018866 111018876
CMAX: 111469465 111493488 111493533 111493534 111493535 111493536 111493537 111493538 111494274 111498962
CMOS: 111436857 111450285 111450334 111450335 111450336 111450337 111450392 111450394 111450815 111460083 111464693
CPEP: 111778601 111782626 111804709 111804710 111804711 111804712 111804713 111804714 111804715 111804811 111804812 111805572 111805573 111806989
RCU: 8258686 8261460 8285570
JCU: 105631969 105647535 105647755
HBR: 110632826 110644513 110659976 110668153 110673184
MESC: 110601518 110616996 110620937 110623462 110623720
POP: 18098779 18098781 18098782 18109080 7473289 7473290 7480575 7498088
PEU: 105123587 105125032 105125034 105126930 105134181 105134182
JRE: 109005853 109008077 109008078 109009742 109009743 109010446
QSU: 111988550 111995669 112036712 112037399 112037400
VVI: 100232917(LOX) 100251097 100252850 104879631
SLY: 101244618 101256707 101257007 101263535 101266174 107648852 543818(TomloxE) 543994(LOX1.1) 543997(LOXB)
SPEN: 107007908 107014742 107014961 107025579 107027197 107028818 107031569
SOT: 102577615 102577714(POTLX-3) 102589305 102590288 102590626 102590972 102593728 102594942 102598541(LOX1) 102602192(LOX1) 102602528(LOX) 102603362
CANN: 107839570 107839571 107847934(DAD1) 107854880 107854882 107864114 107864538 107865522(LOX) 107876113(LOX1) 107879335 107879336
NTA: 107760301 107761738 107763327 107763616 107770253(LOX) 107784700 107803018 107806322(Lox1) 107806327 107820148 107821968 107822679 107830098 107830099
NSY: 104215707 104224166 104224167 104224294 104228802 104235514 104238212
NTO: 104093558 104104499 104113268 104116625 104116626 104116823 104116824
NAU: 109208420 109211626 109211630 109211631 109214964 109217855 109235566 109240031
INI: 109165994 109181728 109181729 109181753 109182100
SIND: 105168907 105171355 105172350
OEU: 111368968 111386480 111388392 111410046
HAN: 110885238 110890392 110890395 110890467 110929179 110929318 110937517
LSV: 111878912 111884545 111890758 111895776 111895782 111895793
CCAV: 112499841 112500096 112503534 112504390 112505089 112516522
DCR: 108199891 108200212 108203125 108206848 108225558 108227730
BVG: 104884450 104890828 104890829 104890831 104890834
SOE: 110791738 110791739 110791741 110791742 110799291
CQI: 110685047 110708631 110708632 110708633 110708634 110713336 110736902 110736903 110736904 110736905
NNU: 104596509 104611974
PSOM: 113277899 113277907 113278788 113290221 113290293 113303475 113304704 113316453 113345387 113347840 113348965 113350553 113355139
OSA: 4333818 4333821 4333823 4334049 4350766
DOSA: Os03t0699700-01(Os03g0699700) Os03t0700700-01(Os03g0700700) Os03t0738600-01(Os03g0738600) Os11t0575600-01(Os11g0575600)
OBR: 102699485 102710961 102722753 102723035
BDI: 100821461 100831787 100833634 100845752
ATS: 109751942(LOC109751942) 109755494(LOC109755494) 109765406(LOC109765406) 109766078(LOC109766078) 109767522(LOC109767522) 109774264(LOC109774264) 109781224(LOC109781224) 109781225(LOC109781225) 109787375(LOC109787375)
SBI: 110431916 8056098 8063420 8064218 8070256 8078665
ZMA: 100037802(lox2) 100037803(lox4) 100037804(lox5) 100037805(lox6) 541856(lox1) 542495(lox3)
SITA: 101755932 101756871 101757274 101757730 101758142 101779081
PDA: 103697518 103715746
EGU: 105032459 105054692 105055039
MUS: 103974527 103974528 103989036 103989037 103989775 103989776 103990202 103996519 103998404
DCT: 110096882 110107728 110108000 110108011 110111010
PEQ: 110018528 110020829 110024558 110031792
AOF: 109819934 109820941 109822273 109822383 109826305 109834563 109834564 109851469 109851585
ATR: 18428895 18439893
SMO: SELMODRAFT_109226(LOX9) SELMODRAFT_112468(LOX14) SELMODRAFT_112556(LOX2) SELMODRAFT_170977 SELMODRAFT_178158(LOX1) SELMODRAFT_178856(LOX6) SELMODRAFT_234610 SELMODRAFT_439120(LOX10) SELMODRAFT_439121(LOX11) SELMODRAFT_446634 SELMODRAFT_446635
PPP: 112282145 112288202 112291149 112291557 112294414
CRE: CHLREDRAFT_144677
VCN: VOLCADRAFT_105416 VOLCADRAFT_97557 VOLCADRAFT_97558
 » show all
Taxonomy
Reference
1  [PMID:17369372]
  Authors
Vellosillo T, Martinez M, Lopez MA, Vicente J, Cascon T, Dolan L, Hamberg M, Castresana C
  Title
Oxylipins produced by the 9-lipoxygenase pathway in Arabidopsis regulate lateral  root development and defense responses through a specific signaling cascade.
  Journal
Plant Cell 19:831-46 (2007)
DOI:10.1105/tpc.106.046052
  Sequence
Reference
2  [PMID:18795358]
  Authors
Boeglin WE, Itoh A, Zheng Y, Coffa G, Howe GA, Brash AR
  Title
Investigation of substrate binding and product stereochemistry issues in two linoleate 9-lipoxygenases.
  Journal
Lipids 43:979-87 (2008)
DOI:10.1007/s11745-008-3230-1
Reference
3  [PMID:19037675]
  Authors
Andreou AZ, Hornung E, Kunze S, Rosahl S, Feussner I
  Title
On the substrate binding of linoleate 9-lipoxygenases.
  Journal
Lipids 44:207-15 (2009)
DOI:10.1007/s11745-008-3264-4
  Sequence
[ath:AT1G55020] [ag:AAB31252]
Reference
4  [PMID:18949503]
  Authors
Bannenberg G, Martinez M, Hamberg M, Castresana C
  Title
Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana.
  Journal
Lipids 44:85-95 (2009)
DOI:10.1007/s11745-008-3245-7
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.58
IUBMB Enzyme Nomenclature: 1.13.11.58
ExPASy - ENZYME nomenclature database: 1.13.11.58
BRENDA, the Enzyme Database: 1.13.11.58

  All links  
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (877)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (702)   
   KEGG MGENES (50)   
   RefGene (124)   
Protein sequence (117)   
   UniProt (55)   
   SWISS-PROT (30)   
   RefSeq(pep) (19)   
   PDBSTR (13)   
DNA sequence (34)   
   RefSeq(nuc) (19)   
   GenBank (8)   
   EMBL (7)   
3D Structure (7)   
   PDB (7)   
All databases (1042)   

Download RDF
DBGET integrated database retrieval system