KEGG   ENZYME: 1.13.11.58
Entry
EC 1.13.11.58               Enzyme                                 
Name
linoleate 9S-lipoxygenase;
9-lipoxygenase;
9S-lipoxygenase;
linoleate 9-lipoxygenase;
LOX1 (gene name);
9S-LOX
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
linoleate:oxygen 9S-oxidoreductase
Reaction(IUBMB)
linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate [RN:R07057]
Reaction(KEGG)
R07057
Substrate
linoleate [CPD:C01595];
O2 [CPD:C00007]
Product
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate [CPD:C14827]
Comment
Contains nonheme iron. A common plant lipoxygenase that oxidizes linoleate and alpha-linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C9 position with (S)-configuration. The enzyme plays a physiological role during the early stages of seedling growth. The enzyme from Arabidopsis thaliana shows comparable activity towards linoleate and linolenate [4]. EC 1.13.11.12 (linoleate 13S-lipoxygenase) catalyses a similar reaction at another position of these fatty acids.
History
EC 1.13.11.58 created 2011
Pathway
ec00591  Linoleic acid metabolism
Orthology
K15718  linoleate 9S-lipoxygenase
Genes
ATHAT1G55020(LOX1) AT3G22400(LOX5)
ALY9319428 9327996
CRB17893758 17894417
CSAT104701021 104715474 104746689 104746690 104750191 104758943 104766136 104787362 104787405
EUSEUTSA_v10020023mg EUTSA_v10023267mg
BRP103834572 103844546 103869043
BNA106352821 106376623 106388246 106433608 106433973 106453908
BOE106295789 106314534 106319746
RSZ108807444 108807735 108812350 108863125 130496708
THJ104801865 104806939 104820855 104823730 104825976
CPAP110814120 110814127 110815297 110817254 110817280 110819775
CIT102621545 102621914
CICCICLE_v10000236mg CICLE_v10004281mg
PVY116118850 116130512
MINC123208387 123211895 123220058 123220698
TCC18600365 18600367 18600368 18600369 18600371 18602959
GRA105783043 105792522 105792525 105796638 105800512
GHI107893644 107894329 107894336 107899106 107919998 107927619 107928543 107944366 121206339
GAB108457463 108464242 108468954 108470002 108474786
HSYR120123922 120124693 120149585 120151377 120153657 120162137 120164026 120176098 120176099 120213824
DZI111277300 111277932 111277933 111280136 111293906 111295420 111307953
EGR104414852 104415560 104415561 104415562 104415563 104415564 104429569
GMX100101853(VLXB) 100127399(LOX9) 100127400(LOX10) 100782558 100789019 100800451 100802459 100802685 100802887 100803358 100815477 100815550 100816880 547694 547774(LOX2) 547835 547836(LOXB1) 547856(VLXC) 547860(LOX7) 547869(LOX3) 547923(LOX1.1)
GSJ114370204 114372569 114375008 114375009 114376278 114376458 114386328 114388361 114388668 114403306 114407603 114417913 114418141 114418142 114419180 114422277 114422278 114422279 114422280 114423939
PVUPHAVU_004G168400g PHAVU_005G156700g PHAVU_005G1568001 PHAVU_005G156900g PHAVU_005G157000g PHAVU_006G091400g PHAVU_007G055600g PHAVU_007G055800g PHAVU_007G179600g PHAVU_010G134700g PHAVU_010G134800g PHAVU_010G134900g PHAVU_010G135000g PHAVU_010G135300g PHAVU_010G135400g PHAVU_010G135500g PHAVU_010G135600g PHAVU_010G135700g PHAVU_010G135800g PHAVU_010G135900g
VRA106760770 106760780 106761927 106761928 106762003 106772236 106773082 106773083 106773084 106773085 106773086 106773087 106773712 106773713 106775016 106780386 106780387 111242517
VAR108320191 108320205 108320206 108320208 108320213 108320214 108323174 108323175 108323176 108323178 108323181 108323182 108324769 108326670 108332293 108334116 108334134 108334142 108334300 108341800 108345752
VUN114165654 114165656 114165728 114166339 114166341 114166734 114166735 114166737 114166739 114166740 114183038 114184324 114185546 114185686 114188176 114190244 114191620 114191794
VUM124820787 124821152 124823787 124823788 124823789 124823790 124823791 124823792 124823793 124823794 124823795 124823796 124823798 124823799 124834165 124843314 124846678 124847332 124847333
CCAJ109795363 109796222 109801924 109801925 109802085 109802609 109805652 109805653 109806359 109806596 109813937
APRC113849062 113849063 113850555 113850556 113850558 113854776 113856262 113863959 113873505 113873685
MTR11409882 11418914 11420242 11422014 11423969 11423970 11424335 11424336 11424965 11426409 11428618 11428623 11429451 11429452 11431430 11431756 11434044 11435017 11441966 25489617 25500504
TPRA123883099 123885375 123885379 123885380 123885383 123885384 123885386 123885387 123885388 123890910 123894106 123894107 123894877 123909569 123911177
CAM101490986 101491283 101491298 101491605 101491624 101491931 101495975 101496167 101502002 101502735
PSAT127076330 127076331 127076333 127076334 127076335 127076336 127076338 127076339 127076340 127076341 127076345 127080206 127087314 127087315 127092431 127098542 127120011 127132364 127138079
VVO131610596 131616237 131616238 131616239 131616240 131616241 131616242 131616244 131618083 131618084 131618085 131621893 131621894 131623268 131623270 131623271 131623362 131623363 131623364 131623365 131623366 131623367 131633907 131643460 131644090 131646723 131653921 131653922
LJALj0g3v0057299.1(Lj0g3v0057299.1) Lj0g3v0255679.1(Lj0g3v0255679.1) Lj3g3v0324640.1(Lj3g3v0324640.1) Lj3g3v2659870.1(Lj3g3v2659870.1) Lj3g3v2661200.1(Lj3g3v2661200.1) Lj5g3v2056200.1(Lj5g3v2056200.1) Lj5g3v2056200.2(Lj5g3v2056200.2) Lj5g3v2056200.3(Lj5g3v2056200.3)
ADU107461392 107461394 107461395 107464433 107464479 107464749 107464753 107464854 107465391 107466861 107492121
AIP107612513 107613293 107617165 107617328 107617419 107617549 107617585 107617884 107617918 107645767 107645896
AHF112695520 112706546 112706548 112710190 112710191 112710462 112710463 112710465 112710832 112711806 112758131 112773062 112773063 112775199 112776097 112776420 112777366 112779426 112779892 112780083
LANG109329108 109333451 109334172 109342911 109345801 109346208 109346835 109347840 109347870 109347874 109351272 109356561
PCIN129287589 129287590 129288077 129288214 129288215 129288413 129289079 129291504 129296670 129299345 129305988 129309062 129318526 129319371
QSAO6P43_003382 O6P43_007512 O6P43_010085 O6P43_011110 O6P43_012103
FVE101293106 101293406 101301961 101311821
RCN112192081 112192269 112193452 112196194 112197257
PPER18773359 18774870 18774983 18774987 18775056 18788938
PMUM103324270 103344101 103344102 103344618 103344619 103344620 103344621 103344623 103344624
PAVI110759643 110759644 110759645 110759647 110759772 110762049
PDUL117630134 117631039 117631075 117631076 117631077 117631511 117631853
MDM103403905 103411221 103423655 103433945 103433947 103433949 103433950 103450936 103453113
MSYL126582618 126593283 126593284 126594423 126596572 126607012 126619021 126619022 126619024 126619025 126619026
PXB103935971 103955722 103955797 103956622 103965340 103965341 103965342 103965343 103965358 103965359 103965360 103965361
ZJU107411945 107412008 107412009 107423042
MNT21384383 21384679 21395587 21410719 21412472
CSAV115709296 115718693 115718785 115719336 115719608 115720291 115721132 115721268 115722275 115722276 115723988 115724062
CSV101206086 101206327 101207163 101207406 101207901 101208141 101211823 101215030(LOX9) 101222652 105434408 105434554(LOX2)
CMO103491403 103494836 103494845 103494856 103494864(LOX2) 103494874 103494895 103494902 103494917 103503184 103504417 127149413
BHJ120067292 120069352 120069357 120069359 120070059 120080124 120080250 120080269 120080303
MCHA111009757 111018834 111018836 111018837 111018853 111018861 111018866 111018876
CMAX111469465 111493488 111493533 111493534 111493535 111493536 111493537 111493538 111494274 111498962
CMOS111436857 111450285 111450334 111450335 111450336 111450337 111450392 111450394 111450815 111460083 111464693
CPEP111778601 111782626 111804709 111804710 111804711 111804712 111804713 111804714 111804715 111804811 111804812 111805572 111805573 111806989
RCU8258686 8261460 8285570
JCU105631969 105647535 105647755
HBR110632826 110644513 110659976 110668153 110673184
MESC110601518 110616996 110620937 110623462 110623720
POP18098779 18098781 18098782 7473290 7480575 7498088
PEU105123587 105125032 105125034 105126930 105134181 105134182
PALZ118045050 118045055 118046620 118055808 118060796 118060797
JRE109005853 109008077 109008078 109009742 109009743 109010446
CILL122275176 122300549 122314898 122314899 122318427 122318428
CAVE132169987 132170277 132170278 132190053 132191407
QSU111988550 111995669 112036712 112037399 112037400
QLO115979595 115979596 115979598 115981619 115981620 115981969 115993804
TWL120009577 120013468
VVI100232917(LOX) 100251097 100252850
VRI117914704 117929787 117929788
SLY101244618 101256707 101257007 101263535 101266174 107648852 543818(TomloxE) 543994(LOX1.1) 543997(LOXB)
SPEN107007908 107014742 107014961 107025579 107027197 107028818 107031569
SOT102577615 102577714(POTLX-3) 102589305 102590288 102590626 102590972 102593728 102594942 102598541(LOX1) 102602192(LOX1) 102602528(LOX) 102603362
SSTN125842138 125842153 125842182 125842227 125853100 125853292 125871422 125871423 125876895 125876904 125876920 125876929 125876961
SDUL129881808 129882996 129886182 129886183 129888735 129888736 129888963 129900524
CANN107839570 107847934 107854880 107854882 107864114 107864538 107865522 107876113 107879335 107879336
LBB132603936 132603939 132609097 132609108 132609411 132610720 132645915 132645916 132645917 132645918 132645919 132645920
NTA107760301 107761738 107763327 107763616 107770253(LOX) 107784700 107803018 107806322(Lox1) 107806327 107820148 107821968 107822679 107830098 107830099
NSY104215707 104224166 104224167 104224294 104228802 104235514 104238212
NTO104093558 104104499 104113268 104116625 104116626 104116823 104116824
NAU109208420 109211626 109211630 109211631 109214964 109217855 109235566 109240031
INI109165994 109181728 109181729 109181753 109182100
ITR116005581 116006926 116007679 116016833
SIND105168907 105171355 105172350
OEU111368968 111386480 111388392 111410046
EGT105952561 105953334 105970234
SSPL121749206 121774707 121775098 121777182 121777325 121777757 121783783 121792334 121795868 121808600
SMIL130991503 130991504 130996920 131008914
SHIS125192970 125196667 125197298 125200846 125201156 125201157 125221936 125224437
APAN127247809 127249270 127260716 127260905 127262173
HAN110885238 110890392 110890395 110890467 110929179 110929318 110937517
ECAD122583170 122591252 122594113 122594164 122594977 122596863 122602264
LSV111878912 111878925 111884545 111890758 111895776 111895782 111895793
CCAV112499841 112500096 112503534 112504390 112505089 112516522
DCR108199891 108200212 108203125 108206848 108225558
CSIN114258339 114259967 114261869 114287060
RVL131310168 131321654 131334424 131334425
AEW130764394 130771819 130782963 130783954 130794664 130794665
BVG104884450 104890828 104890829 104890831 104890834
SOE110791738 110791739 110791741 110791742 110799291
CQI110685047 110708631 110708632 110708633 110708634 110713336 110736902 110736903 110736904 110736905
ATRI130796711 130796721 130796829 130817661 130825162
MOF131152011 131152685 131152686 131152695
NNU104596509 104611974
MING122071222 122071238 122077795 122079067 122091235
TSS122642514 122642515 122642516 122664805 122664813 122668787
PSOM113277899 113277907 113278788 113290221 113290293 113303475 113304704 113316453 113345387 113347840 113348965 113350553 113355139
OSA4333818 4333821 4333823 4334049 4350766
DOSAOs03t0699700-01(Os03g0699700) Os03t0700700-01(Os03g0700700) Os03t0738600-01(Os03g0738600) Os11t0575600-01(Os11g0575600)
OBR102699485 102710961 102722753 102723035
OGL127766496 127768470 127768471 127768645
BDI100821461 100831787 100833634 100845752
ATS109751942 109755494 109765406 109766078 109767522 109774264 109781224 109781225 109787375
TDC119286965 119292455 119294745 119294746 119303063 119303065 119303066 119303067 119311742 119311743 119311744 119311745 119311747 119311748 119311749 119322730 119344048 119356912 119366161
TAES100313965 100313966 100682480 123047197 123055004 123056064 123056066 123067109 123072903 123090789 123090791 123095797 123095798 123104947 123104949 123104951 123104952 123113250 123113251 123122756 123122758 123123631 123132351 123132353 123136398 123190851
TUA125510538 125510543 125510544 125515877 125515882 125516594 125540143 125550427 125553004
LPER127292961 127293303 127293305 127308238 127308239 127308240 127308250
LRD124691233 124691738 124700529 124700530 124703965 124703966 124703967
SBI110431916 8056098 8063420 8064218 8070256 8078665
ZMA100037802(lox2) 100037803(lox4) 100037804(lox5) 100037805(lox6) 541856(lox1) 542495(lox3)
SITA101755932 101756871 101757274 101757730 101758142 101779081
SVS117836611 117837112 117837920 117838364 117854454 117855018
PVIR120650087 120650088 120693127
PHAI112873951 112877880 112877881 112893939
PDA103697518 103715746 120109566
EGU105032459 105054692 105055039
MUS103974527 103974528 103989036 103989037 103989775 103989776 103990202 103996519 103998404
ZOF121971742 121975911 122002246 122002247 122002248 122002251 122006508 122006509 122006510 122006513 122006514
DCT110096882 110107728 110108000 110108011 110111010
PEQ110018528 110020829 110024558 110031792
AOF109819934 109820941 109822273 109822383 109826305 109834563 109834564 109851469 109851585
MSIN131222595 131222597
NCOL116246452 116248359 116262776 116263617
ATR18428895 18439893
SMOSELMODRAFT_109226(LOX9) SELMODRAFT_112468(LOX14) SELMODRAFT_112556(LOX2) SELMODRAFT_170977 SELMODRAFT_178158(LOX1) SELMODRAFT_178856(LOX6) SELMODRAFT_234610 SELMODRAFT_439120(LOX10) SELMODRAFT_439121(LOX11) SELMODRAFT_446634 SELMODRAFT_446635
PPP112282145 112288202 112291149 112291557 112294414
CRECHLRE_12g512300v5
VCNVOLCADRAFT_105416 VOLCADRAFT_97557 VOLCADRAFT_97558
 » show all
Reference
1  [PMID:17369372]
  Authors
Vellosillo T, Martinez M, Lopez MA, Vicente J, Cascon T, Dolan L, Hamberg M, Castresana C
  Title
Oxylipins produced by the 9-lipoxygenase pathway in Arabidopsis regulate lateral  root development and defense responses through a specific signaling cascade.
  Journal
Plant Cell 19:831-46 (2007)
DOI:10.1105/tpc.106.046052
  Sequence
Reference
2  [PMID:18795358]
  Authors
Boeglin WE, Itoh A, Zheng Y, Coffa G, Howe GA, Brash AR
  Title
Investigation of substrate binding and product stereochemistry issues in two linoleate 9-lipoxygenases.
  Journal
Lipids 43:979-87 (2008)
DOI:10.1007/s11745-008-3230-1
Reference
3  [PMID:19037675]
  Authors
Andreou AZ, Hornung E, Kunze S, Rosahl S, Feussner I
  Title
On the substrate binding of linoleate 9-lipoxygenases.
  Journal
Lipids 44:207-15 (2009)
DOI:10.1007/s11745-008-3264-4
  Sequence
[ath:AT1G55020] [ag:AAB31252]
Reference
4  [PMID:18949503]
  Authors
Bannenberg G, Martinez M, Hamberg M, Castresana C
  Title
Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana.
  Journal
Lipids 44:85-95 (2009)
DOI:10.1007/s11745-008-3245-7
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.58
IUBMB Enzyme Nomenclature: 1.13.11.58
ExPASy - ENZYME nomenclature database: 1.13.11.58
BRENDA, the Enzyme Database: 1.13.11.58

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