Entry |
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Name |
linoleate 9S-lipoxygenase;
9-lipoxygenase;
9S-lipoxygenase;
linoleate 9-lipoxygenase;
LOX1 (gene name);
9S-LOX
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Class |
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
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Sysname |
linoleate:oxygen 9S-oxidoreductase
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Reaction(IUBMB) |
linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate [RN: R07057]
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Reaction(KEGG) |
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Substrate |
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Product |
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate [CPD: C14827]
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Comment |
Contains nonheme iron. A common plant lipoxygenase that oxidizes linoleate and alpha-linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C9 position with (S)-configuration. The enzyme plays a physiological role during the early stages of seedling growth. The enzyme from Arabidopsis thaliana shows comparable activity towards linoleate and linolenate [4]. EC 1.13.11.12 (linoleate 13S-lipoxygenase) catalyses a similar reaction at another position of these fatty acids.
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History |
EC 1.13.11.58 created 2011
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Pathway |
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Orthology |
K15718 | linoleate 9S-lipoxygenase |
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Genes |
» show all
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Reference |
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Authors |
Vellosillo T, Martinez M, Lopez MA, Vicente J, Cascon T, Dolan L, Hamberg M, Castresana C |
Title |
Oxylipins produced by the 9-lipoxygenase pathway in Arabidopsis regulate lateral root development and defense responses through a specific signaling cascade. |
Journal |
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Sequence |
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Reference |
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Authors |
Boeglin WE, Itoh A, Zheng Y, Coffa G, Howe GA, Brash AR |
Title |
Investigation of substrate binding and product stereochemistry issues in two linoleate 9-lipoxygenases. |
Journal |
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Reference |
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Authors |
Andreou AZ, Hornung E, Kunze S, Rosahl S, Feussner I |
Title |
On the substrate binding of linoleate 9-lipoxygenases. |
Journal |
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Sequence |
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Reference |
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Authors |
Bannenberg G, Martinez M, Hamberg M, Castresana C |
Title |
Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana. |
Journal |
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Sequence |
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Other DBs |
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