Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy

linoleate:oxygen 9S-oxidoreductase

linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate [RN:R07057]

R07057
Reaction

linoleate [CPD:C01595];
O2 [CPD:C00007]

Contains nonheme iron. A common plant lipoxygenase that oxidizes linoleate and alpha-linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C9 position with (S)-configuration. The enzyme plays a physiological role during the early stages of seedling growth. The enzyme from Arabidopsis thaliana shows comparable activity towards linoleate and linolenate [4]. EC 1.13.11.12 (linoleate 13S-lipoxygenase) catalyses a similar reaction at another position of these fatty acids.

EC 1.13.11.58 created 2011

1  [PMID:17369372]

Vellosillo T, Martinez M, Lopez MA, Vicente J, Cascon T, Dolan L, Hamberg M, Castresana C

Oxylipins produced by the 9-lipoxygenase pathway in Arabidopsis regulate lateral  root development and defense responses through a specific signaling cascade.

Plant Cell 19:831-46 (2007)
DOI:10.1105/tpc.106.046052

[ath:AT1G55020 AT3G22400]

2  [PMID:18795358]

Boeglin WE, Itoh A, Zheng Y, Coffa G, Howe GA, Brash AR

Investigation of substrate binding and product stereochemistry issues in two linoleate 9-lipoxygenases.

Lipids 43:979-87 (2008)
DOI:10.1007/s11745-008-3230-1

3  [PMID:19037675]

Andreou AZ, Hornung E, Kunze S, Rosahl S, Feussner I

On the substrate binding of linoleate 9-lipoxygenases.

Lipids 44:207-15 (2009)
DOI:10.1007/s11745-008-3264-4

[ath:AT1G55020] [ag:AAB31252]

4  [PMID:18949503]

Bannenberg G, Martinez M, Hamberg M, Castresana C

Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana.

Lipids 44:85-95 (2009)
DOI:10.1007/s11745-008-3245-7

[ath:AT1G55020 AT3G22400]