KEGG   ENZYME: 1.13.11.62Help
Entry
EC 1.13.11.62               Enzyme                                 

Name
linoleate 10R-lipoxygenase;
10R-DOX;
(10R)-dioxygenase;
10R-dioxygenase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
linoleate:oxygen (10R)-oxidoreductase
Reaction(IUBMB)
linoleate + O2 = (8E,10R,12Z)-10-hydroperoxy-8,12-octadecadienoate [RN:R09811]
Reaction(KEGG)
Substrate
linoleate [CPD:C01595];
O2 [CPD:C00007]
Product
(8E,10R,12Z)-10-hydroperoxy-8,12-octadecadienoate [CPD:C19937]
Comment
The enzyme is involved in biosynthesis of oxylipins, which affect sporulation, development, and pathogenicity of Aspergillus spp.
History
EC 1.13.11.62 created 2011
Pathway
ec00591  Linoleic acid metabolism
Orthology
K17862  linoleate 10R-lipoxygenase
Genes
QSU: 111989810 112005764
NTE: NEUTE1DRAFT86742(NEUTE1DRAFT_86742)
SMP: SMAC_09193
PAN: PODANSg1229
MTM: MYCTH_2094824
CTHR: CTHT_0019380
TMN: UCRPA7_3198
SSCK: SPSK_03862
FGR: FGSG_02668 FGSG_10960
FPU: FPSE_00375 FPSE_10969
MAW: MAC_00208
MAJ: MAA_04954
CMT: CCM_08032
ANI: AN5028.2
ANG: ANI_1_1118024(An02g07930)
ABE: ARB_07881
TVE: TRV_00942
TVS: TRAVEDRAFT_64780(LDO2)
DSQ: DICSQDRAFT_80992(LDO1)
ABP: AGABI1DRAFT114975(AGABI1DRAFT_114975) AGABI1DRAFT90139(AGABI1DRAFT_90139)
ABV: AGABI2DRAFT143643(AGABI2DRAFT_143643) AGABI2DRAFT195360(AGABI2DRAFT_195360)
CPUT: CONPUDRAFT_83601(LDO2)
 » show all
Taxonomy
Reference
1  [PMID:19289462]
  Authors
Garscha U, Oliw EH
  Title
Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis oF (10R)-dioxygenase  with epoxyalcohol synthase activity.
  Journal
J Biol Chem 284:13755-65 (2009)
DOI:10.1074/jbc.M808665200
  Sequence
Reference
2  [PMID:20045744]
  Authors
Jerneren F, Garscha U, Hoffmann I, Hamberg M, Oliw EH
  Title
Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus.
  Journal
Biochim Biophys Acta 1801:503-7 (2010)
DOI:10.1016/j.bbalip.2009.12.012
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.62
IUBMB Enzyme Nomenclature: 1.13.11.62
ExPASy - ENZYME nomenclature database: 1.13.11.62
BRENDA, the Enzyme Database: 1.13.11.62

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