KEGG   ENZYME: 1.13.11.69
Entry
EC 1.13.11.69               Enzyme                                 
Name
carlactone synthase;
CCD8 (gene name);
MAX4 (gene name);
NCED8 (gene name)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
9-cis-10'-apo-beta-carotenal:oxygen oxidoreductase (14,15-cleaving, carlactone-forming)
Reaction(IUBMB)
9-cis-10'-apo-beta-carotenal + 2 O2 = carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal [RN:R10558]
Reaction(KEGG)
R10558
Substrate
9-cis-10'-apo-beta-carotenal [CPD:C20692];
O2 [CPD:C00007]
Product
carlactone [CPD:C20693];
(2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal [CPD:C20694]
Comment
Requires Fe2+. The enzyme participates in a pathway leading to biosynthesis of strigolactones, plant hormones involved in promotion of symbiotic associations known as arbuscular mycorrhiza. Also catalyses EC 1.13.11.70, all-trans-10'-apo-beta-carotenal 13,14-cleaving dioxygenase, but 10-fold slower.
History
EC 1.13.11.69 created 2012
Pathway
ec00906  Carotenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K17913  carlactone synthase / all-trans-10'-apo-beta-carotenal 13,14-cleaving dioxygenase
Genes
GAE121381261
ATHAT4G32810(CCD8)
ALY9303300
CRB17880263
CSAT104716888 104721542 104729987
EUSEUTSA_v10024788mg
BRP103850421
BNA106371158 106372794 106375326
BOE106297618 106329062
RSZ108842462
THJ104820078
CPAP110825785
CIT102611969 102612266
CICCICLE_v100080502m CICLE_v10010609mg
PVY116140704
MINC123199959
TCC18587976
GRA105762895 105772277
GHI107897099 107900521 107901528 107953845
GAB108456530 108484843
DZI111285387
EGR104437781 104439926
GMX100794831(CCD8) 100814148
GSJ114409123 114415154
PVUPHAVU_009G109700g
VRA106761448
VAR108321824
VUN114164054
CCAJ109799996
APRC113865831
MTRMTR_3g109610 MTR_7g063800
CAM101497957
LJALj1g3v2068760.1(Lj1g3v2068760.1)
ADU107470782
AIP107623923
AHF112716107 112784190
LANG109339284
FVE101301466
RCN112174794
PPER18789175
PMUM103320239
PAVI110761281
PDUL117615262
MDM103415461 103441305
PXB103957092
ZJU107420451
MNT21393994
CSV101216826
CMO103488182(CCD8)
BHJ120075818
CMAX111492518 111496443
CMOS111462801
CPEP111799272 111805686
RCU8275656
JCU105638200
HBR110648761
MESC110603430
POP7462922 7470743
PEU105115287 105122413
PALZ118030684 118053670
JRE108979513 109009492
QSU112029967
QLO115970744
TWL119996237 120006063
VVI100250765
VRI117913640
SLY101254620
SPEN107028115
SOT102595155
SSTN125867805
CANN107839011
NTA107812793(MAX4) 107821949
NSY104228402
NTO104117083
NAU109209147
INI109179896
ITR116007402
SIND105156117 105165056
OEU111368646 111382711
EGT105977052
SSPL121778526 121780680 121781645 121781646 121781647
HAN110923712 110926648
ECAD122583226 122583924 122586050
LSV111877582 111891276
CCAV112520444 112521686
DCR108215310
CSIN114275767
BVG104885388
SOE110787413
CQI110683157 110705573 110728350
NNU104592092
MING122072068 122089718
TSS122654905
PSOM113353973
NCOL116244921
OSA4326177 4327933
DOSAOs01t0566500-01(Os01g0566500) Os01t0746400-00(Os01g0746400)
OBR102709984
BDI100831734
ATS109738648 109753493 109753519 109758391
TDC119271872 119271874 119271875 119279309 119281469 119357533
TAES123056732 123058519 123065607 123067325 123074700 123133128 123191449
TUA125530689 125540847 125548561
SBI8057987 8062181 8064382
ZMA100502522
SITA101763948 101767361 101767759 101774274
SVS117855476 117855776 117858388 117866430
PVIR120672308 120674971 120684890 120708023 120708024
PHAI112894589 112894614 112903092
PDA103717867 103722026
EGU105041959 105047448
MUS103975947 103989799
DCT110092372
PEQ110030749
AOF109842452
ATR18441191 18443367
SMOSELMODRAFT_127411(MAX4-2) SELMODRAFT_173016(MAX4-1)
PPP112283943
CRECHLRE_02g073900v5 CHLRE_02g073950v5 CHLRE_08g365851v5
VCNVOLCADRAFT_107173 VOLCADRAFT_108590 VOLCADRAFT_108622 VOLCADRAFT_108677
MNGMNEG_9548
CSLCOCSUDRAFT_67504
AAFAURANDRAFT_69593
 » show all
Reference
1  [PMID:12815068]
  Authors
Sorefan K, Booker J, Haurogne K, Goussot M, Bainbridge K, Foo E, Chatfield S, Ward S, Beveridge C, Rameau C, Leyser O
  Title
MAX4 and RMS1 are orthologous dioxygenase-like genes that regulate shoot branching in Arabidopsis and pea.
  Journal
Genes Dev 17:1469-74 (2003)
DOI:10.1101/gad.256603
  Sequence
[ath:AT4G32810]
Reference
2  [PMID:15342640]
  Authors
Schwartz SH, Qin X, Loewen MC
  Title
The biochemical characterization of two carotenoid cleavage enzymes from Arabidopsis indicates that a carotenoid-derived compound inhibits lateral branching.
  Journal
J Biol Chem 279:46940-5 (2004)
DOI:10.1074/jbc.M409004200
  Sequence
[ath:AT4G32810]
Reference
3  [PMID:22422982]
  Authors
Alder A, Jamil M, Marzorati M, Bruno M, Vermathen M, Bigler P, Ghisla S, Bouwmeester H, Beyer P, Al-Babili S
  Title
The path from beta-carotene to carlactone, a strigolactone-like plant hormone.
  Journal
Science 335:1348-51 (2012)
DOI:10.1126/science.1218094
  Sequence
[ath:AT4G32810] [osa:4326177]
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.69
IUBMB Enzyme Nomenclature: 1.13.11.69
ExPASy - ENZYME nomenclature database: 1.13.11.69
BRENDA, the Enzyme Database: 1.13.11.69

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