KEGG   ENZYME: 1.13.11.71
Entry
EC 1.13.11.71               Enzyme                                 
Name
carotenoid-9',10'-cleaving dioxygenase;
BCO2 (gene name);
beta-carotene 9',10'-monooxygenase (misleading);
all-trans-beta-carotene:O2 oxidoreductase (9',10'-cleaving)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
all-trans-beta-carotene:oxygen oxidoreductase (9',10'-cleaving)
Reaction(IUBMB)
all-trans-beta-carotene + O2 = all-trans-10'-apo-beta-carotenal + beta-ionone [RN:R10559]
Reaction(KEGG)
R10559
Substrate
all-trans-beta-carotene [CPD:C02094];
O2 [CPD:C00007]
Product
all-trans-10'-apo-beta-carotenal [CPD:C20695];
beta-ionone [CPD:C12287]
Comment
Requires Fe2+. The enzyme catalyses the asymmetric oxidative cleavage of carotenoids. The mammalian enzyme can also cleave all-trans-lycopene.
History
EC 1.13.11.71 created 2012
Orthology
K10252  beta,beta-carotene 9',10'-dioxygenase
Genes
HSA83875(BCO2)
PTR451548(BCO2)
PPS100968503(BCO2)
GGO101146575(BCO2)
PON100434189(BCO2)
NLE100585752(BCO2)
MCC712095(BCO2)
MCF102136772(BCO2)
MTHB126935790
CSAB103248467(BCO2)
CATY105588685(BCO2)
PANU101012917(BCO2)
TGE112605578(BCO2)
RRO104677360(BCO2)
RBB108536440(BCO2)
PTEH111540139(BCO2)
CJC100397428(BCO2)
SBQ101053395(BCO2)
CSYR103268014(BCO2)
MMUR105862929(BCO2)
LCAT123641687(BCO2)
OGA100965214(BCO2)
MMU170752(Bco2)
MCAL110301582(Bco2)
MPAH110328471(Bco2)
RNO315644(Bco2)
MCOC116072914(Bco2)
MUN110555362
CGE100774947(Bco2)
MAUA101824677(Bco2)
PLEU114690241(Bco2)
MORG121438393
MFOT126509985
AAMP119810586(Bco2)
NGI103733876(Bco2)
HGL101704023(Bco2)
CPOC100716090(Bco2)
CCAN109699438(Bco2)
DORD105980704(Bco2)
DSP122110281(Bco2)
NCAR124958675
OCU100344631(BCO2)
OPI101518940(BCO2)
TUP102485450(BCO2)
GVR103596333(BCO2)
CFA479437(BCO2)
CLUD112671333(BCO2)
VVP112925989(BCO2)
VLG121500757(BCO2)
AML100482102(BCO2)
UMR103662381(SDHD)
UAH113260049(SDHD)
UAR123792567
ELK111153876
LLV125110331
MPUF101670802(BCO2)
ORO101370083(BCO2)
EJU114211316
ZCA113913825(BCO2)
MLX118013230
NSU110586389(BCO2)
FCA101095765(BCO2)
PYU121035380(BCO2)
PBG122482963(BCO2)
LRUF124506151
PPAD109278650
AJU106986370(BCO2)
HHV120229878(BCO2)
BTA514135(BCO2)
BOM102280946
BIU109569909(BCO2)
BBUB102400372(BCO2)
BBIS104981317(BCO2)
CHX102176146(BCO2)
ODA120876256(BCO2)
CCAD122450114(BCO2)
SSC100517547(BCO2)
CFR102520302(BCO2)
CBAI105080061(BCO2)
CDK105094181(BCO2)
VPC102539717(BCO2)
BACU103012517(BCO2)
LVE103086674(BCO2)
OOR101288737(BCO2)
DLE111166930(BCO2)
PCAD102976602(BCO2)
PSIU116758536(BCO2)
ECB100070518(BCO2)
EPZ103565878(BCO2)
EAI106840222(BCO2)
MYB102262734(BCO2)
MYD102756952(BCO2)
MMYO118664361(BCO2)
MLF102434515(BCO2)
MNA107531312(BCO2)
PKL118713718(BCO2)
HAI109394784(BCO2)
DRO112314195(BCO2)
SHON119000537(BCO2)
AJM119056528(BCO2)
PDIC114500447(BCO2)
PHAS123818795(BCO2)
MMF118628225(BCO2)
PALE102884496(BCO2)
PGIG120621997(BCO2)
PVP105295629(BCO2)
TOD119240676(BCO2)
SARA101559301(BCO2)
TMU101357485
DNM101428202(BCO2)
MDO100032246(BCO2)
GAS123239046(BCO2)
SHR100919673(BCO2)
PCW110210673(BCO2)
OAA100087018(BCO2)
GGA419792(BCO2)
PCOC116233205(BCO2)
MGP100549031(BCO2)
CJO107324119(BCO2)
NMEL110387562(BCO2)
APLA101802069(BCO2)
ACYG106039773(BCO2)
AFUL116497842(BCO2)
TGU100217865(BCO2)
LSR110470468(BCO2)
SCAN103822982(BCO2)
PMOA120508362
OTC121340907(BCO2)
PRUF121355745(BCO2)
GFR102041586(BCO2)
FAB101819010(BCO2)
PHI102105953(BCO2)
PMAJ107214399(BCO2)
CCAE111939279(BCO2)
CCW104692076(BCO2)
CBRC103618512(BCO2)
ETL114065634(BCO2)
ZAB102066047(BCO2)
ACHL103798975(BCO2)
FPG101911275(BCO2)
FCH102054794(BCO2)
CLV102093604(BCO2)
EGZ104125905(BCO2)
NNI104019042(BCO2)
PLET104623737(BCO2)
PCRI104025476(BCO2)
PCAO104039947(BCO2)
ACUN113488510(BCO2)
TALA104356059(BCO2)
PADL103921541(BCO2)
AFOR103895864(BCO2)
ACHC115345006(BCO2)
HALD104311424(BCO2)
HLE104836412(BCO2)
AGEN126038188
GCL127025848
CCRI104155524(BCO2)
CSTI104549437(BCO2)
EHS104503812(BCO2)
CMAC104474033(BCO2)
MUI104534314(BCO2)
FGA104070897(BCO2)
GSTE104251417(BCO2)
LDI104341333(BCO2)
MNB103767968(BCO2)
OHA104338598(BCO2)
NNT104400025(BCO2)
DPUB104299898(BCO2)
PGUU104458814(BCO2)
ACAR104518663(BCO2)
CPEA104388530(BCO2)
AVIT104268241(BCO2)
CVF104284163(BCO2)
CUCA104067197(BCO2)
TEO104370393(BCO2)
BRHI104500384(BCO2)
AAM106495924(BCO2)
AROW112967464(BCO2)
NPD112948747(BCO2)
TGT104572267(BCO2)
DNE112986540
SCAM104141089(BCO2)
ASN102369219(BCO2)
AMJ102569970(BCO2)
CPOO109318086(BCO2)
GGN109292960(BCO2)
PSS102463932(BCO2)
CMY102946859
CPIC101953792(BCO2)
TST117868527(BCO2)
CABI116824037(BCO2)
MRV120375603 120375719
ACS100568148(bco2)
PVT110078727(BCO2)
SUND121934414(BCO2)
PBI103051556(BCO2)
PMUR107284512(BCO2)
CTIG120311258(BCO2)
PGUT117657473 117658496 117659305
VKO123036882(BCO2)
PMUA114585324(BCO2)
ZVI118097073(BCO2)
GJA107116138(BCO2)
STOW125441656(BCO2)
XLA108696498(bco2l.L) 446869(bco2.L)
XTR100487224(bco2l) 448408(bco2)
NPR108799722 108799726
RTEM120915486 120915488
BBUF120989235 120996556
BGAR122926287 122928948(BCO2)
DRE678554(bco2b) 793849(bco2a) 84041(bco2l)
SRX107709124 107709687 107717256 107744484
SANH107657247 107677445 107681253(bco2)
SGH107586303 107587333 107595022 107597692 107601714
CCAR109073585 109103192 109104806
CAUA113049328 113049898 113074920 113115538
PPRM120469954(bco2a) 120478471(bco2b) 120478981(bco2l)
MAMB125248832(bco2b) 125266686(bco2l) 125266748
IPU108260373 108260375
PHYP113531529 113531654
SMEO124379110(bco2a) 124379477
TFD113655076(bco2a) 113655077
AMEX103028302 103030035(bco2) 103041536
EEE113570248(bco2)
TRU101073779 101074587 115247638
TNGGSTEN00006488G001 GSTEN00022116G001
LCO104917970 104922805
NCC104941263 104942314 104948304
CGOB115013641 115017917(bco2) 115018482
ELY117252000(bco2l) 117260097(bco2b) 117268778(bco2a)
EFO125888422(bco2b) 125890186(bco2l) 125898819(bco2a)
PLEP121943153 121944461(bco2l) 121952681
SLUC116039036(bco2b) 116054421(bco2l) 116064962
ECRA117942170(bco2b) 117944447(bco2l) 117955648
ESP116687067(bco2) 116690194 116700618
PFLV114552708(bco2) 114555882 114566784
GAT120822014(bco2a) 120829416(bco2b) 120830626(bco2l)
PPUG119213922(bco2b) 119215150 119225548(bco2l)
MSAM119882622 119891991(bco2l) 119895289
CUD121510121(bco2l) 121518372 121524502
ALAT119007313 119019879(bco2l) 119031869
MZE101470456 101478921 101485476 101485762
ONL100692914 100698224 100708996 109194197
OAU116313085 116313923(bco2l) 116330510 116336183
OLA101159767 101160828(bco2) 101170850
OML112142706(bco2a) 112148480(bco2l) 112149801(bco2b)
XMA102216602 102227947 102235330
XCO114133655 114153023 114155276
XHE116728287 116729130 116737583(bco2)
PRET103470486 103475801 103475802
PFOR103145662 103147097 103147103
PLAI106941789 106941799 106959573
PMEI106915735 106928038
GAF122827976(bco2l) 122832387(bco2b) 122844836(bco2a)
CVG107083819 107099243(bco2) 107103837
CTUL119776413(bco2l) 119791847(bco2b) 119797910
GMU124876082 124877740(bco2l) 124883668(bco2b)
NFU107380750(bco2) 107386477 107393786
KMR108236467(bco2l) 108245248(bco2a)
ALIM106516351
NWH119413456(bco2l) 119420144
AOCE111570765 111571487(bco2) 111575208
MCEP125012024(bco2l) 125013019(bco2b) 125021675
CSEM103377768(bco2) 103398249
POV109628365 109633856 109639361(bco2)
SSEN122770118(bco2l) 122773125 122780126
HHIP117767457(bco2l) 117773094(bco2b) 117774501
HSP118106791(bco2b) 118115556(bco2l) 124854849
LCF108878660(bco2l) 108893913 108899889(bco2b)
SDU111229717 111234576 111234786(bco2)
SLAL111663912 111666238 111671321(bco2)
XGL120803158 120805849(bco2l)
HCQ109510777(bco2) 109512427 109512430 109512432 109525362
BPEC110158495 110161952(bco2) 110169833
MALB109957023 109959541(bco2)
BSPL114862817(bco2l) 114869224(bco2a)
SASA101448036(bco2a) 101448037(bco2b) 101448038 106585363 106602811 106612548
STRU115154949 115154950 115163243 115164791 115206182
OTW112228999 112234693(bco2l) 112265401 112266923
OMY110503763 110507165 110525113 110534238 110534240
OGO123993960 124004791 124005302 124034505(bco2l)
ONE115111382 115135407 115136873 115141707
SALP111951109 111959902 111974295 111982597
SNH120018273 120029197 120053353(bco2l) 120057368(bco2a)
CCLU121567619(bco2b) 121579700(bco2a) 121584640
ELS105008707 105014498 105024037(bco2)
SFM108928652(bco2) 108936233
PKI111846258(bco2)
AANG118209519 118236232
LOC102691774(bco2)
PSPA121309427(bco2a)
ARUT117397252 117966694
PSEX120535824
LCM102356793(BCO2)
CMK103190786(bco2b)
RTP109938812(bco2)
BFO118405340 118422787 118426367 118430143
BBEL109462202 109466559 109478965 109479070 109480113 109485646
APLC110986828 110986847
AJC117101819
SKO100374086 100378360 102806764
CLEC106669856
CSEC111863845
FCD110846408 110855460
DMK116930445 123475909
PVM113807452 113807453 113828381
PJA122253355 122253356 122253357 122254393 122254963 122256731
PCHN125025090 125025091 125039792 125041119
HAME121865949 121869974
PCLA123746051 123756717
HAZT108680500
LSM121114674 121119773
PPOI119100134 119100135 119101855
ISCIscW_ISCW014970
DSV119446536
RSAN119389398 119389708
RMP119182499
TUT107362151 107365605 107365606 107368310
DFR124490815
CSCU111637280
PTEP107444254 107449852 122270228
SDM118195594
BGT106057071 106059088
HRF124131617
HRJ124291782
CRG105341121 105348216 117684251
PMAX117345001
MMER123527023 123527545 123527854 123542144 123546058 123546755 123547836 123561717
OSN115216492 115225810
LAK106163250 106178001 106181210
ATEN116295436
ADF107351383
AMIL114956767
PDAM113671272 113672890 113677527
SPIS111339979 111345287 111345292
DGT114517012 114523451 114523478 114523479 114528168
XEN124436554
CHIGCH63R_03541
CBCCbuK_0831
EBSECTOBSL9_0925
DAFDesaf_2674
PCAYFRD00_12875
BICLMTR13_23100
MCWA8L33_06720
BSOLFSW04_09655
CWOCwoe_0091
KBSEPA93_05040 EPA93_13485 EPA93_29360
SNGSNE_A20730
PLSVT03_22730
SRUSRU_0127
SRMSRM_00147
HJEHacjB3_07615
HAQDU484_05645
HAJDU500_06120
HAEhalTADL_0038
HALGHUG10_09945
HDFAArcSl_1160
HSALJMJ58_15175
NMGNmag_4083
NAJB1756_04285
NAGAArcMg_2884
NANAArc1_0818
NASGCU68_16745
NDVNDEV_1113
 » show all
Reference
1  [PMID:11278918]
  Authors
Kiefer C, Hessel S, Lampert JM, Vogt K, Lederer MO, Breithaupt DE, von Lintig J
  Title
Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A.
  Journal
J Biol Chem 276:14110-6 (2001)
DOI:10.1074/jbc.M011510200
  Sequence
[hsa:83875] [mmu:170752] [dre:84041]
Reference
2  [PMID:15983114]
  Authors
Lindqvist A, He YG, Andersson S
  Title
Cell type-specific expression of beta-carotene 9',10'-monooxygenase in human tissues.
  Journal
J Histochem Cytochem 53:1403-12 (2005)
DOI:10.1369/jhc.5A6705.2005
  Sequence
[hsa:83875]
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.71
IUBMB Enzyme Nomenclature: 1.13.11.71
ExPASy - ENZYME nomenclature database: 1.13.11.71
BRENDA, the Enzyme Database: 1.13.11.71

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