KEGG   ENZYME: 1.13.11.71
Entry
EC 1.13.11.71               Enzyme                                 
Name
carotenoid-9',10'-cleaving dioxygenase;
BCO2 (gene name);
beta-carotene 9',10'-monooxygenase (misleading);
all-trans-beta-carotene:O2 oxidoreductase (9',10'-cleaving)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
all-trans-beta-carotene:oxygen oxidoreductase (9',10'-cleaving)
Reaction(IUBMB)
all-trans-beta-carotene + O2 = all-trans-10'-apo-beta-carotenal + beta-ionone [RN:R10559]
Reaction(KEGG)
R10559
Substrate
all-trans-beta-carotene [CPD:C02094];
O2 [CPD:C00007]
Product
all-trans-10'-apo-beta-carotenal [CPD:C20695];
beta-ionone [CPD:C12287]
Comment
Requires Fe2+. The enzyme catalyses the asymmetric oxidative cleavage of carotenoids. The mammalian enzyme can also cleave all-trans-lycopene.
History
EC 1.13.11.71 created 2012
Orthology
K10252  beta,beta-carotene 9',10'-dioxygenase
Genes
HSA83875(BCO2)
PTR451548(BCO2)
PPS100968503(BCO2)
GGO101146575(BCO2)
PON100434189(BCO2)
PPYG129008263(BCO2)
NLE100585752(BCO2)
HMH116476945(BCO2)
SSYN129479651(BCO2)
MCC712095(BCO2)
MCF102136772(BCO2)
MTHB126935790
MNI105493606(BCO2)
CSAB103248467(BCO2)
CATY105588685(BCO2)
PANU101012917(BCO2)
TGE112605578(BCO2)
MLEU105537416(BCO2)
RRO104677360(BCO2)
RBB108536440(BCO2)
PTEH111540139(BCO2)
CANG105501026(BCO2)
CJC100397428(BCO2)
SBQ101053395(BCO2)
CIMI108300480(BCO2)
ANAN105729611(BCO2)
CSYR103268014(BCO2)
MMUR105862929(BCO2)
LCAT123641687(BCO2)
PCOQ105822199(BCO2)
OGA100965214(BCO2)
MMU170752(Bco2)
MCAL110301582(Bco2)
MPAH110328471(Bco2)
RNO315644(Bco2)
MCOC116072914(Bco2)
ANU117699211(Bco2)
MUN110555362(Bco2)
CGE100774947(Bco2)
MAUA101824677(Bco2)
PROB127231711(Bco2)
PLEU114690241(Bco2)
MORG121438393
MFOT126509985
AAMP119810586(Bco2)
NGI103733876(Bco2)
HGL101704023(Bco2)
CPOC100716090(Bco2)
CCAN109699438(Bco2)
DORD105980704(Bco2)
DSP122110281(Bco2)
PLOP125348038(Bco2)
NCAR124958675
MMMA107145851(Bco2)
OCU100344631
OPI101518940(BCO2)
TUP102485450(BCO2)
GVR103596333(BCO2)
CFA479437(BCO2)
CLUD112671333(BCO2)
VVP112925989(BCO2)
VLG121500757(BCO2)
NPO129496702(BCO2)
AML100482102(BCO2)
UMR103662381(SDHD)
UAH113260049
UAR123792567
ELK111153876
LLV125110331
MPUF101670802(BCO2)
MNP132028261
MLK131835831
NVS122912283(BCO2)
ORO101370083(BCO2)
EJU114211316
ZCA113913825(BCO2)
MLX118013230
NSU110586389(BCO2)
FCA101095765(BCO2)
PYU121035380(BCO2)
PCOO112866060(BCO2)
PBG122482963(BCO2)
PVIV125176281
LRUF124506151
PPAD109278650
PUC125909723
AJU106986370
HHV120229878(BCO2)
BTA514135(BCO2)
BOM102280946
BIU109569909(BCO2)
BBUB102400372(BCO2)
BBIS104981317(BCO2)
CHX102176146(BCO2)
OAS100286796(BCO2)
BTAX128060790(BCO2)
ODA120876256(BCO2)
CCAD122450114(BCO2)
MBEZ129554335(BCO2)
SSC100517547(BCO2)
CFR102520302(BCO2)
CBAI105080061(BCO2)
CDK105094181(BCO2)
VPC102539717(BCO2)
BACU103012517(BCO2)
BMUS118899982(BCO2)
LVE103086674(BCO2)
OOR101288737(BCO2)
DLE111166930(BCO2)
PCAD102976602
PSIU116758536(BCO2)
NASI112405751(BCO2)
ECB100070518(BCO2)
EPZ103565878(BCO2)
EAI106840222(BCO2)
MYB102262734(BCO2)
MYD102756952(BCO2)
MMYO118664361(BCO2)
MLF102434515(BCO2)
PKL118713718(BCO2)
EFUS103293847(BCO2)
MNA107531312(BCO2)
DRO112314195(BCO2)
SHON119000537(BCO2)
AJM119056528(BCO2)
PDIC114500447(BCO2)
PHAS123818795(BCO2)
MMF118628225(BCO2)
PPAM129085973(BCO2)
HAI109394784(BCO2)
PALE102884496(BCO2)
PGIG120621997(BCO2)
PVP105295629(BCO2)
TOD119240676(BCO2)
SARA101559301(BCO2)
SETR126015835(BCO2)
TMU101357485
DNM101428202(BCO2)
MDO100032246(BCO2)
GAS123239046(BCO2)
SHR100919673(BCO2)
AFZ127554981
PCW110210673(BCO2)
TVP118837724(BCO2)
OAA100087018(BCO2)
GGA419792(BCO2)
PCOC116233205(BCO2)
MGP100549031(BCO2)
CJO107324119(BCO2)
TPAI128087476(BCO2)
LMUT125703547(BCO2)
NMEL110387562(BCO2)
APLA101802069(BCO2)
ACYG106039773(BCO2)
CATA118252392(BCO2)
AFUL116497842(BCO2)
TGU100217865(BCO2)
LSR110470468(BCO2)
SCAN103822982(BCO2)
PMOA120508362
OTC121340907(BCO2)
PRUF121355745(BCO2)
GFR102041586(BCO2)
FAB101819010(BCO2)
OMA130262479(BCO2)
PHI102105953(BCO2)
PMAJ107214399(BCO2)
CCAE111939279(BCO2)
CCW104692076(BCO2)
CBRC103618512(BCO2)
ETL114065634(BCO2)
ZAB102066047(BCO2)
ZLE135457415(BCO2)
ACHL103798975(BCO2)
SVG106858173(BCO2)
MMEA130585569(BCO2)
HRT120762660(BCO2)
FPG101911275(BCO2)
FCH102054794(BCO2)
CLV102093604(BCO2)
EGZ104125905(BCO2)
NNI104019042(BCO2)
PCRI104025476(BCO2)
PLET104623737(BCO2)
EHS104503812(BCO2)
PCAO104039947(BCO2)
ACUN113488510(BCO2)
TALA104356059(BCO2)
PADL103921541(BCO2)
AFOR103895864(BCO2)
ACHC115345006(BCO2)
HALD104311424(BCO2)
HLE104836412(BCO2)
AGEN126038188
GCL127025848
CCRI104155524(BCO2)
CSTI104549437(BCO2)
CMAC104474033(BCO2)
MUI104534314(BCO2)
BREG104637347(BCO2)
FGA104070897(BCO2)
GSTE104251417(BCO2)
LDI104341333(BCO2)
MNB103767968(BCO2)
OHA104338598(BCO2)
NNT104400025(BCO2)
SHAB115616292(BCO2)
DPUB104299898(BCO2)
PGUU104458814(BCO2)
ACAR104518663(BCO2)
CPEA104388530(BCO2)
AVIT104268241(BCO2)
CVF104284163(BCO2)
RTD128918682
CUCA104067197(BCO2)
TEO104370393(BCO2)
BRHI104500384(BCO2)
AAM106495924(BCO2)
AROW112967464(BCO2)
NPD112948747(BCO2)
TGT104572267(BCO2)
DNE112986540
SCAM104141089(BCO2)
ASN102369219(BCO2)
AMJ102569970(BCO2)
CPOO109318086(BCO2)
GGN109292960(BCO2)
PSS102463932(BCO2)
CMY102946859
CCAY125625434(BCO2)
DCC119846631(BCO2)
CPIC101953792(BCO2)
TST117868527(BCO2)
CABI116824037(BCO2)
MRV120375603 120375719
ACS100568148(bco2)
ASAO132782335(BCO2)
PVT110078727(BCO2)
SUND121934414(BCO2)
PBI103051556(BCO2)
PMUR107284512(BCO2)
CTIG120311258(BCO2)
PGUT117658496(BCO2) 117659305
APRI131203595(BCO2)
PTEX113453695(BCO2)
NSS113420916(BCO2)
VKO123036882(BCO2)
PMUA114585324(BCO2)
PRAF128402679(BCO2) 128402847
ZVI118097073(BCO2)
HCG128333616(BCO2)
GJA107116138(BCO2)
STOW125441656(BCO2)
EMC129342729(BCO2)
XLA108696498(bco2l.L) 446869(bco2.L)
XTR100487224(bco2l) 448408(bco2)
NPR108799722 108799726
RTEM120915486 120915488
BBUF120989235 120996556
BGAR122926287 122928948(BCO2)
DRE678554(bco2b) 793849(bco2a) 84041(bco2l)
SRX107709124 107709687 107717256 107744484
SANH107657247 107677445 107681253(bco2)
SGH107586303 107587333 107595022 107597692 107601714
CCAR109073585 109103192 109104806
CAUA113049328 113049898 113074920 113115538
CGIB127933522 127958531 127958552 127972918 128008517
PTET122345816(bco2a) 122346128(bco2l) 122358962(bco2b)
LROH127164715(bco2l) 127164873(bco2a) 127176848(bco2b)
OMC131540335(bco2a) 131541592(bco2l) 131554198(bco2b)
PPRM120469954(bco2a) 120478471(bco2b) 120478981(bco2l)
RKG130070739 130070749 130079392(bco2a) 130096713(bco2b)
MAMB125248832(bco2b) 125266686(bco2l) 125266748
CIDE127495433 127512566 127513069
MASI127424914 127429737 127440189
TROS130546764(bco2l) 130564899(bco2b) 130567036(bco2a)
TDW130419244(bco2a) 130419383(bco2l) 130428363(bco2b)
MANU129437967(bco2b) 129440060(bco2l) 129440181(bco2a)
IPU108260373 108260375
IFU128603379(bco2a) 128603381
PHYP113531529 113531654
SMEO124379110(bco2a) 124379477
TFD113655076(bco2a) 113655077
TVC132840974 132841255
TRN134303072(bco2a)
AMEX103028302(bco2a) 103030035(bco2b) 103041536(bco2l)
CMAO118797741(bco2b) 118814740(bco2a) 118827232(bco2l)
EEE113570248(bco2)
CHAR105893730(bco2b) 105902726(bco2l) 105906619(bco2a)
TRU101073779 101074587 115247638
TFS130525953(bco2l) 130535155(bco2b) 130537065
TNGGSTEN00006488G001 GSTEN00022116G001
LCO104917970 104922805
NCC104941263 104942314 104948304
TBEN117468986(bco2b) 117490461 117490462 117496760(bco2l)
CGOB115013641 115017917(bco2) 115018482
PGEO117452999(bco2l) 117457757(bco2b) 117458955
GACU117561153(bco2l) 117562165(bco2b) 117562697
EMAC134871552 134873521(bco2l) 134880282(bco2b)
ELY117252000(bco2l) 117260097(bco2b) 117268778(bco2a)
EFO125888422(bco2b) 125890186(bco2l) 125898819(bco2a)
PLEP121943153 121944461(bco2l) 121952681
SLUC116039036(bco2b) 116054421(bco2l) 116064962
ECRA117942170(bco2b) 117944447(bco2l) 117955648
ESP116687067(bco2) 116690194 116700618
PFLV114552708(bco2) 114555882 114566784
GAT120822014(bco2a) 120829416(bco2b) 120830626(bco2l)
PPUG119213922(bco2b) 119215150 119225548(bco2l)
AFB129093105(bco2b) 129100854(bco2l) 129113578
CLUM117736241(bco2l) 117741183(bco2b) 117742643
PSWI130197108(bco2l) 130211771(bco2a)
MSAM119882622 119891991(bco2l) 119895289
SCHU122876993(bco2l) 122879525 122888861
CUD121510121(bco2l) 121518372 121524502
ALAT119007313 119019879(bco2l) 119031869
MZE101470456 101478921 101485476 101485762
ONL100692914 100698224 100708996 109194197
OAU116313085 116313923(bco2l) 116330510 116336183
OLA101159767 101160828(bco2) 101170850
OML112142706(bco2a) 112148480(bco2l) 112149801(bco2b)
CSAI133442220 133451258(bco2l) 133459694
XMA102216602 102227947 102235330
XCO114133655 114153023 114155276
XHE116728287 116729130 116737583(bco2)
PRET103470486 103475801 103475802
PFOR103145662 103147097 103147103
PLAI106941789 106941799 106959573
PMEI106915735 106928038
GAF122827976(bco2l) 122832387(bco2b) 122844836(bco2a)
PPRL129368707(bco2a) 129372133(bco2l)
CVG107083819 107099243(bco2) 107103837
CTUL119776413(bco2l) 119791847(bco2b) 119797910
GMU124876082 124877740(bco2l) 124883668(bco2b)
NFU107380750(bco2) 107386477 107393786
KMR108236467(bco2l) 108245248(bco2a)
ALIM106516351
NWH119413456(bco2l) 119420144
AOCE111570765 111571487(bco2) 111575208
MCEP125012024(bco2l) 125013019(bco2b) 125021675
CSEM103377768(bco2) 103398249
POV109628365 109633856 109639361(bco2)
SSEN122770118(bco2l) 122773125 122780126
HHIP117767457(bco2l) 117773094(bco2b) 117774501
HSP118106791(bco2b) 118115556(bco2l) 124854849
PPLT128438799(bco2l) 128440785 128456838
SMAU118295074 118301269 118314288(bco2l)
LCF108878660(bco2l) 108893913 108899889(bco2b)
SDU111229717 111234576 111234786(bco2)
SLAL111663912 111666238 111671321(bco2)
XGL120803158 120805849(bco2l)
HCQ109510777(bco2) 109512427 109512430 109512432 109525362
SSCV125965862 125972782 125982120 125982121
SBIA133492074 133499172(bco2l) 133504378(bco2b)
PEE133400632(bco2l) 133405442 133415579 133415580 133415787
PTAO133467698 133467699 133467700 133475013(bco2l) 133482205(bco2b)
BPEC110158495 110161952(bco2) 110169833
MALB109957023 109959541(bco2)
BSPL114862817(bco2l) 114869224(bco2a)
SJO128360426(bco2b) 128365184(bco2l) 128371228
SASA101448036(bco2a) 101448037(bco2b) 101448038 106585363 106602811 106612548
STRU115154949 115154950 115163243 115164791 115206182
OTW112228999 112234693(bco2l) 112265401 112266923
OMY110503763 110507165 110525113 110534238 110534240
OGO123993960 124004791 124005302 124034505(bco2l)
ONE115111382 115135407 115136873 115141707
OKI109873345 109876965 109906067 109909388
OKE118370613(bco2l) 118373665 118390597(bco2a) 118397333
SALP111951109 111959902 111974295 111982597
SNH120018273 120029197 120053353(bco2l) 120057368(bco2a)
CCLU121567619(bco2b) 121579700(bco2a) 121584640
ELS105008707 105014498 105024037(bco2)
SFM108928652(bco2) 108936233
PKI111846258(bco2)
AANG118209519 118236232
LOC102691774(bco2)
PSPA121309427(bco2a)
ARUT117397252 117966694
PSEX120535824
LCM102356793(BCO2)
CMK103190786(bco2b)
RTP109938812
CPLA122540603
HOC132829727
LERI129712237
PMRN116948197
LRJ133341967 133342110
BFO118405340 118422787 118426367 118430143
BBEL109462202 109466559 109478965 109479070 109480113 109485646
LPIC129275072 129282301
APLC110986828 110986847
ARUN117291312 117303598 117303780
AJC117101819
SKO100374086 100378360 102806764
CLEC106669856
CSEC111863845
FCD110846408 110855460
DMK116930445 123475909
PVM113807452 113807453 113828381
PJA122253355 122253356 122253357 122254393 122254963 122256731
PCHN125025090 125025091 125039792 125041119
PMOO119572849 119592077 119592078
HAME121865949 121869974
PCLA123746051 123756717
CQD128691552
MNZ135199410 135199471 135205838 135207713 135208667
HAZT108680500
LSM121114674 121119773
TCF131881213 131881657 131881659 131890591
PPOI119100134 119100135 119101855
DSV119446536
RSAN119389398 119389708
RMP119182499
TUT107362151 107365605 107365606 107368310
DFR124490815
CSCU111637280
PTEP107444254 107449852 122270228
ABRU129988112 129989206
UDV129225938 129226334
SDM118195594
LPOL106462687 106463062 106463116 106463584 106465040
PVUL126809677 126827130
BGT106057071 106059088
HRF124131617
HRJ124291782
CRG105341121 105348216 117684251
CANU128161360 128163877
CVN111115810
OED125665943 125672772
PMAX117345001
MMER123527023 123527545 123527854 123546058 123546755 123547836
RPHI132724619 132724621 132726963 132728193 132728197 132728201 132750779 132752490 132754376
DPOL127832108 127832109 127842167 127881918
MAEA128203172 128238245 128243501
OSN115216492 115225810
LJP135465579
LAK106163250 106178001 106181210
LLON135492120
ATEN116295436
ADF107351383
AMIL114956767
PDAM113671272 113672890 113677527
SPIS111339979 111345287 111345292
DGT114517012 114523451 114523478 114523479 114528168
XEN124436554
RES135691911 135691912
FFCNCS54_01302000
FKRNCS57_01288200
CHIGCH63R_03541
CBCCbuK_0831
EBSECTOBSL9_0925
ENUPYH37_001782
BICLMTR13_23100
DAFDesaf_2674
PCAYFRD00_12875
MCWA8L33_06720
BSOLFSW04_09655
CWOCwoe_0091
KBSEPA93_05040 EPA93_13485 EPA93_29360
SNGSNE_A20730
PLSVT03_22730
SRUSRU_0127
SRMSRM_00147
HJEHacjB3_07615
HAQDU484_05645
HAJDU500_06120
HAEhalTADL_0038
HALGHUG10_09945
HDFAArcSl_1160
HSALJMJ58_15175
NMGNmag_4083
NAJB1756_04285
NAGAArcMg_2884
NANAArc1_0818
NASGCU68_16745
NDVNDEV_1113
 » show all
Reference
1  [PMID:11278918]
  Authors
Kiefer C, Hessel S, Lampert JM, Vogt K, Lederer MO, Breithaupt DE, von Lintig J
  Title
Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A.
  Journal
J Biol Chem 276:14110-6 (2001)
DOI:10.1074/jbc.M011510200
  Sequence
[hsa:83875] [mmu:170752] [dre:84041]
Reference
2  [PMID:15983114]
  Authors
Lindqvist A, He YG, Andersson S
  Title
Cell type-specific expression of beta-carotene 9',10'-monooxygenase in human tissues.
  Journal
J Histochem Cytochem 53:1403-12 (2005)
DOI:10.1369/jhc.5A6705.2005
  Sequence
[hsa:83875]
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.71
IUBMB Enzyme Nomenclature: 1.13.11.71
ExPASy - ENZYME nomenclature database: 1.13.11.71
BRENDA, the Enzyme Database: 1.13.11.71

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