| Entry |
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| Name |
protocatechuate 4,5-dioxygenase;
protocatechuate 4,5-oxygenase;
protocatechuic 4,5-dioxygenase;
protocatechuic 4,5-oxygenase;
protocatechuate:oxygen 4,5-oxidoreductase (decyclizing);
protocatechuate:oxygen 4,5-oxidoreductase (ring-opening)
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| Class |
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
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| Sysname |
3,4-dihydroxybenzoate:oxygen 4,5-oxidoreductase (ring-opening)
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| Reaction(IUBMB) |
3,4-dihydroxybenzoate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde [RN: R01632]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
4-carboxy-2-hydroxymuconate semialdehyde [CPD: C04484]
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| Comment |
Requires Fe2+.
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| History |
EC 1.13.11.8 created 1965 as EC 1.13.1.8, transferred 1972 to EC 1.13.11.8
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| Pathway |
| ec00624 | Polycyclic aromatic hydrocarbon degradation |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K04100 | protocatechuate 4,5-dioxygenase, alpha chain |
| K04101 | protocatechuate 4,5-dioxygenase, beta chain |
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| Genes |
| VNA: | PN96_18545 PN96_18550 |
| VEJ: | VEJY3_18111 VEJY3_18116 |
| VFL: | AL536_10310 AL536_10315 |
| VZI: | G5S32_20190 G5S32_20195 |
| VOS: | KNV97_07830 KNV97_07835 |
| VIB: | VspSTUT11_39060 VspSTUT11_39070(pcaH) |
| GKD: | K6Q96_09545 K6Q96_09550(ligA) |
| EMO: | DM558_04785 DM558_04790(ligA) |
| ENTO: | MTZ49_15300(ligA) MTZ49_15305 |
| PCAR: | PC2016_2100 PC2016_2101 |
| AAW: | AVL56_08860 AVL56_08865 |
| ALR: | DS731_01510 DS731_01515 |
| ALTO: | AltI4_14880(pcaH) AltI4_14890(ligA_1) |
| ALII: | QR722_00525(ligA) QR722_00530 |
| HARO: | R50071_20760 R50071_20770 R50071_39660 R50071_39670 |
| MPAF: | R5R33_07700(ligA) R5R33_07705 |
| MMW: | Mmwyl1_0508 Mmwyl1_0509 Mmwyl1_3920 Mmwyl1_3921 Mmwyl1_3938 Mmwyl1_3939 |
| MME: | Marme_0835 Marme_0836 |
| MPC: | Mar181_0383 Mar181_0384 |
| MPRI: | MP3633_0340 MP3633_0341 MP3633_0451 MP3633_0452 MP3633_3158 |
| MARD: | IBG28_02225(ligA) IBG28_02230 IBG28_02960 IBG28_02965 |
| MFOI: | JSY38_11025(ligA) JSY38_11030 JSY38_12245 JSY38_12250 |
| MPRF: | J8N69_06125 J8N69_06130 J8N69_09425(ligA) J8N69_09430 |
| MRHI: | KDW99_17795 KDW99_17800 KDW99_17840 KDW99_17845 |
| MPON: | MACH16_03370 MACH16_03380(pcaH_1) MACH16_05320(ligA_1) MACH16_05330(pcaH_2) MACH16_05430 MACH16_05440(pcaH_3) |
| MATH: | THO17_19090 THO17_19100 |
| MGEO: | CFI10_06005 CFI10_14870 CFI10_14875 |
| MARL: | HH196_02855 HH196_02860 |
| AJP: | AMJAP_1182 AMJAP_1183(ligB) |
| GSN: | YC6258_04092 YC6258_04093 |
| RFO: | REIFOR_00545(ligA) REIFOR_00546(ligB) |
| GBI: | PG2T_11290 PG2T_11315 |
| NAQ: | D0T90_09305 D0T90_09310(ligA) |
| NBL: | GJV52_09125 GJV52_09130(ligA) |
| VFF: | VITFI_CDS0352 VITFI_CDS0353 VITFI_CDS3223 VITFI_CDS3224 |
| VIT: | ADP71_27560 ADP71_27570 |
| VST: | LVJ81_00710 LVJ81_00715(ligA) |
| VMS: | LVJ82_10325 LVJ82_10330(ligA) |
| AMAH: | DLM_2151 DLM_2152 DLM_2155 DLM_2156 |
| AQS: | DKK66_18640 DKK66_18645 DKK66_18665 DKK66_18670(ligA) |
| BPX: | BUPH_02687 BUPH_06639(ligA) |
| PARA: | BTO02_23045 BTO02_23050 |
| POLY: | PSHI2_17650 PSHI2_17660(pcaH) |
| POLN: | PSHI8_17660 PSHI8_17670(pcaH) |
| PTX: | ABW99_00710 ABW99_00715 |
| HYF: | DTO96_100892(ligA_1) DTO96_100893(ligB) |
| BOJ: | CBF45_01515 CBF45_01520 CBF45_11680 CBF45_13150 CBF45_13155 |
| PUD: | G9Q38_00385 G9Q38_01305 |
| CDN: | BN940_08481 BN940_08486 BN940_08551 BN940_08556 |
| AFQ: | AFA_05515 AFA_05520(ligA) |
| AAQU: | D3M96_07055 D3M96_07060(ligA) |
| ALCN: | MID00_01265(ligA) MID00_01270 |
| PHN: | PAEH1_07110 PAEH1_07115 |
| PIG: | EGT29_01985 EGT29_01990 EGT29_16575 EGT29_16580 EGT29_23920 |
| KGY: | EHF36_01700 EHF36_01705 EHF36_11935(ligA) EHF36_13170 EHF36_13175(ligA) |
| RFR: | Rfer_0294 Rfer_0295 Rfer_0330 Rfer_0331 |
| RSB: | RS694_12675 RS694_12680 |
| RHY: | RD110_08820 RD110_08825 RD110_16980 RD110_16985 |
| RHF: | EUB48_07540 EUB48_07545 EUB48_12925 EUB48_12930(ligA) |
| RHOA: | HZ993_17885 HZ993_17890(ligA) |
| RHOB: | HTY51_09895 HTY51_09900 HTY51_09960 HTY51_09965(ligA) |
| RMK: | RAN89_04805(ligA) RAN89_04810 |
| RLH: | MIZ03_2382 MIZ03_2383 MIZ03_2719 MIZ03_2720 |
| RHOF: | AB3G31_09655(ligA) AB3G31_09660 AB3G31_09750 AB3G31_09755 |
| PNA: | Pnap_2027 Pnap_2028 Pnap_2733 Pnap_2734 |
| PVAC: | HC248_00683(ligA_1) HC248_00684(ligB) |
| ACK: | C380_22700 C380_22705 C380_22805 C380_22810 |
| ACRA: | BSY15_1237 BSY15_1238 |
| ACID: | CBP33_05245 CBP33_05250 |
| ACIP: | CBP36_05695 CBP36_05700 CBP36_20285 CBP36_20290 |
| ACIN: | CBP34_05080 CBP34_05085 |
| ACIS: | CBP35_13245 CBP35_20360 CBP35_20365 |
| ACIO: | EAG14_01090 EAG14_01095 EAG14_01255(ligA) EAG14_01260 |
| ARAD: | KI609_21440 KI609_21445(ligA) |
| ATEM: | PQV96_01120(ligA) PQV96_01125 |
| ACIQ: | ACDW_40050 ACDW_40060(ligA) ACDW_40340 ACDW_40350 |
| ACIV: | EXV95_14925 EXV95_14930(ligA) EXV95_15030 EXV95_15035 |
| AMON: | H9L24_06080 H9L24_06085(ligA) |
| DAC: | Daci_0914 Daci_0915 Daci_3813 Daci_3814 Daci_4445 Daci_4446 |
| DEL: | DelCs14_1672 DelCs14_1673 DelCs14_2358 DelCs14_2359 DelCs14_3008 DelCs14_3009 DelCs14_5611 DelCs14_5612 |
| DTS: | BI380_01390 BI380_01395 BI380_05115 BI380_05120 BI380_20115 BI380_20120 |
| DHK: | BO996_04630 BO996_04635 BO996_17335 BO996_17340 BO996_20100 BO996_20105 |
| DLA: | I6G47_02130(ligA) I6G47_02135 I6G47_05175(ligA) I6G47_05180 I6G47_20060 I6G47_20065 |
| CTT: | CtCNB1_2414 CtCNB1_2415 CtCNB1_2741 CtCNB1_2742 |
| CTES: | O987_16260 O987_16265 |
| COF: | FOZ74_08485(ligA) FOZ74_08490 |
| AANT: | HUK68_10975 HUK68_10980(ligA) |
| CRJ: | QMY55_10900(ligA) QMY55_10905 |
| CENP: | M9799_00850 M9799_00855(ligA) |
| COMB: | MJ205_10685 MJ205_10690(ligA) |
| CSQU: | N4T19_01940(ligA) N4T19_01945 |
| RTEA: | HK414_00075 HK414_20760 HK414_26085 |
| LIM: | L103DPR2_01497(ligA_1) L103DPR2_01498(ligB_1) L103DPR2_01514(ligA_2) L103DPR2_01515(ligB_2) |
| LIH: | L63ED372_01144(ligA_1) L63ED372_01145(ligB) |
| LIMI: | LINBF2_10140 LINBF2_10150(pcaH_1) LINBF2_10490 LINBF2_10500(pcaH_2) |
| HYR: | BSY239_1242 BSY239_1243(ligA) BSY239_2222 BSY239_2223(ligA) |
| HYB: | Q5W_06745 Q5W_06750 Q5W_10740 Q5W_10745 |
| HYL: | LPB072_15985 LPB072_15990 LPB072_16065 LPB072_16070 |
| HYC: | E5678_08755 E5678_08760(ligA) |
| HPSE: | HPF_08080(ligA1) HPF_08085(ligB1) HPF_08185(ligA2) HPF_08190(ligB2) |
| HYN: | F9K07_12200(ligA) F9K07_12205 F9K07_15790 F9K07_15795 |
| HTN: | KI616_18035 KI616_18040 KI616_18170 KI616_18175(ligA) |
| HCZ: | G9Q37_09990 G9Q37_09995(ligA) |
| HYY: | JNX00_11380(ligA) JNX00_11385 |
| HYDR: | SOM08_11680(ligA) SOM08_11685 SOM08_20760 SOM08_20765(ligA) |
| HYDA: | ABSY19_03000 ABSY19_13260(ligA) ABSY19_13265 ABSY19_24595(ligA) ABSY19_24600 |
| DIH: | G7047_27835(ligA) G7047_27840 |
| DIM: | K2L43_12770 K2L43_12775(ligA) K2L43_18890(ligA) K2L43_18895 |
| CBAA: | SRAA_1066 SRAA_1067 SRAA_1350 SRAA_1351 |
| CBAB: | SMCB_0794 SMCB_0795 SMCB_0831 SMCB_0832 |
| HGR: | DW355_09710(ligA) DW355_09715 DW355_11085 DW355_11090 |
| SNN: | EWH46_19140(ligA) EWH46_19145 |
| SMIO: | CATMQ487_08070 CATMQ487_08080(pcaH_1) CATMQ487_08200 CATMQ487_08210(pcaH_2) |
| LCH: | Lcho_3636 Lcho_3637 Lcho_3698 Lcho_3699 |
| SHD: | SUTH_01241 SUTH_01242 SUTH_01245 SUTH_01246 |
| ABRE: | pbN1_38930 pbN1_38940 |
| AZO: | azo2522(ligB1) azo2523(ligA1) azo2537(ligB2) azo2538(ligA2) |
| AOA: | dqs_2679 dqs_2680 dqs_2694 dqs_2695 |
| AZR: | CJ010_15915 CJ010_15920 CJ010_16060 CJ010_16065(ligA) |
| THU: | AC731_016805 AC731_016810 AC731_016885 AC731_016890 |
| THAU: | C4PIVTH_0864(ligB) C4PIVTH_0865 C4PIVTH_0880(ligB) C4PIVTH_0881 |
| TAK: | Tharo_1102 Tharo_1103 |
| DDZ: | DSYM_13550 DSYM_13560 |
| ORM: | HTY61_00090 HTY61_00095 HTY61_01660(ligA) HTY61_01665 |
| NGL: | RG1141_CH01050 RG1141_CH01060 |
| NGG: | RG540_CH00990 RG540_CH01000 |
| BRA: | BRADO2341(ligA) BRADO2342(ligB) BRADO2379 BRADO2380(mhpB) |
| BBT: | BBta_2701(ligA) BBta_2702(ligB) BBta_2733 BBta_2734(mhpB) |
| AOL: | S58_52220 S58_52230 S58_52570 S58_52580 |
| BRO: | BRAD285_4958(ligB) BRAD285_4959(ligA) BRAD285_4995(ligB) BRAD285_4996(ligA) |
| BSEI: | KMZ68_25390 KMZ68_25395 KMZ68_25430 KMZ68_25435(ligA) |
| BOY: | LQG66_12435 LQG66_12440 LQG66_12610 LQG66_12615(ligA) |
| RPA: | TX73_005175 TX73_005180 TX73_024425(ligA) TX73_024430 |
| RPB: | RPB_0872 RPB_0873 RPB_1060 RPB_1061 |
| RPT: | Rpal_1198 Rpal_1199 Rpal_5182 Rpal_5183 |
| RPX: | Rpdx1_1168 Rpdx1_1169 Rpdx1_4876 Rpdx1_4877 |
| RHOL: | RBJ75_17735(ligA) RBJ75_17740 RBJ75_25060 RBJ75_25065 |
| RHZ: | RHPLAN_00100 RHPLAN_00110 RHPLAN_69860 RHPLAN_69870 |
| MAAD: | AZF01_14285 AZF01_20305 AZF01_20310 |
| MLUT: | JET14_00505 JET14_00510 JET14_15920 |
| BRN: | D1F64_20790 D1F64_22045 D1F64_22050 |
| BSB: | Bresu_2114 Bresu_2115 |
| BGOE: | IFJ75_11175 IFJ75_11180(ligA) |
| MALG: | MALG_02286 MALG_02287 |
| OCD: | FHY55_07525 FHY55_07530 FHY55_07565(ligA) FHY55_07570 FHY55_12780 FHY55_12785 |
| TGL: | HFZ77_17690 HFZ77_17695(ligA) HFZ77_17790 HFZ77_17795 |
| PARO: | CUV01_03890 CUV01_03895 |
| SEDI: | EBB79_03595 EBB79_03600 EBB79_22515 |
| PPSO: | QPJ95_03900 QPJ95_03905 |
| PSHQ: | F3W81_00050 F3W81_00400 F3W81_00405 |
| CACT: | HZ995_05415 HZ995_05420 |
| PBAE: | P8S53_03165 P8S53_03170 |
| RBG: | BG454_07640 BG454_07645 |
| FRB: | AB6B37_07320(ligA) AB6B37_07325 |
| NAR: | Saro_1233 Saro_1234 Saro_2812 Saro_2813 |
| NPP: | PP1Y_Mpl10353 PP1Y_Mpl10356 PP1Y_Mpl10445 PP1Y_Mpl10448 PP1Y_Mpl6650 PP1Y_Mpl6658 |
| NPN: | JI59_12230 JI59_20190 JI59_20195 JI59_20845 JI59_20850 JI59_20895 JI59_20900 JI59_21750 JI59_21840 |
| NOV: | TQ38_025020 TQ38_025025(ligA) TQ38_028410(ligA) TQ38_028415 |
| NOT: | C7W88_02265 C7W88_02270(ligA) C7W88_08690 C7W88_08695 |
| NOR: | FA702_07550 FA702_07555(ligA) FA702_13245 FA702_13250 |
| NDR: | HT578_07800(ligA) HT578_07805 HT578_08935 HT578_08940(ligA) HT578_09425 HT578_09430 HT578_09605(ligA) HT578_09610 |
| NHUM: | PQ457_02265 PQ457_02270 PQ457_10890 PQ457_10895(ligA) |
| NOL: | NSDW_09560(ligA) NSDW_09570 |
| NCP: | U0041_07860 U0041_07865 U0041_18295 U0041_18300(ligA) |
| NOVO: | IM701_02455(ligA) IM701_02460 IM701_11995 IM701_12000 |
| SMAZ: | LH19_17690 LH19_17695 |
| SINA: | KNJ79_13850 KNJ79_13855(ligA) |
| SPFD: | SPYCA_3669 SPYCA_3670 |
| RDI: | CMV14_06885(ligA) CMV14_06890 |
| SPHI: | TS85_18515 TS85_18520 |
| SSAN: | NX02_17500 NX02_17505 |
| SPAN: | AWL63_08165 AWL63_08170 |
| SKR: | BRX40_12185 BRX40_12190 |
| SPHC: | CVN68_17240 CVN68_17245(ligA) |
| SPII: | G7077_01510 G7077_01515(ligA) |
| SSUA: | FPZ54_06145 FPZ54_06150(ligA) FPZ54_17705 FPZ54_17710(ligA) |
| SBIN: | SBA_ch2_7410 SBA_ch2_7420(pcaH) |
| SGLC: | M1K48_07900(ligA) M1K48_07905 |
| SHAN: | PPZ50_15785(ligA) PPZ50_15790 |
| SNOS: | K8P63_14320(ligA) K8P63_14325 |
| SDON: | M9980_11035 M9980_11040(ligA) |
| SAAP: | E2E30_05175(ligA) E2E30_05180 E2E30_05495 E2E30_05500(ligA) |
| SCH: | Sphch_3898 Sphch_3899 |
| SSY: | SLG_01790 SLG_01800 SLG_12500(ligB) SLG_12510(ligA) SLG_37520 SLG_37530 |
| SPHB: | EP837_03493 EP837_03494(ligB) |
| SPHR: | BSY17_3446(ligB) BSY17_3447(ligA) |
| SHYD: | CJD35_16820(ligA) CJD35_16825 CJD35_19575(ligA) CJD35_19580 |
| SYA: | A6768_17475 A6768_17480(ligA) |
| SPYG: | YGS_C2P1459 YGS_C2P1460 |
| SAMI: | SAMIE_1030390 SAMIE_1030400 |
| SPAG: | sphantq_03930(ligB_1) sphantq_03931(ligA_2) sphantq_04497(ligA_3) sphantq_04498(ligB_2) |
| SPCA: | GL174_18730(ligA) GL174_18735 GL174_21700 GL174_21705(ligA) |
| SPWT: | N6H05_08815(ligA) N6H05_08820 |
| SPHG: | AZE99_04500 AZE99_04505 |
| SFLA: | SPHFLASMR4Y_02362(ligB) SPHFLASMR4Y_02987(ligA) SPHFLASMR4Y_02988(ligB) |
| SPHY: | CHN51_00890 CHN51_00895(ligA) |
| BLAS: | BSY18_3523(ligA) BSY18_3524(ligB) |
| BFW: | B5J99_08410 B5J99_08415 |
| ACOB: | P0Y56_05475(ligA) P0Y56_05480 P0Y56_05925 P0Y56_05930 P0Y56_12110 P0Y56_12115(ligA) P0Y56_16110 |
| SPHS: | ETR14_07925 ETR14_07930(ligA) |
| POQ: | KZX46_07330 KZX46_07335(ligA) |
| PMEA: | KTC28_03825(ligA) KTC28_03830 KTC28_12040 KTC28_12045(ligA) |
| ALB: | AEB_P0242 AEB_P0243 AEB_P1349 AEB_P1350 AEB_P2996 AEB_P2997 |
| AAY: | WYH_01045(ligB_1) WYH_01046(ligA_2) WYH_01908(ligA_3) WYH_01909(ligB_2) WYH_03214(ligB_3) WYH_03215(ligA_4) |
| ADO: | A6F68_01079(ligB) A6F68_01080(ligA_1) |
| CMAN: | A9D14_17240 A9D14_17245 |
| POT: | E2E27_18120(ligA) E2E27_18125 |
| ABS: | AZOBR_p310188(mhpB) AZOBR_p310189 |
| ABQ: | ABAZ39_27960 ABAZ39_27965 |
| AZT: | TSH58p_32565 TSH58p_32570 |
| AARE: | D3093_31930 D3093_31935 |
| NCB: | C0V82_22495(ligA) C0V82_22500 |
| MAGX: | XM1_1094 XM1_1095(ligB) |
| MAGN: | WV31_13630 WV31_13635 |
| MAGQ: | MGMAQ_2661(ligB) MGMAQ_2662(ligA) MGMAQ_2669(ligA) MGMAQ_2670(ligB) |
| APB: | SAR116_0935 SAR116_0936 |
| SNEA: | NBZ79_04460 NBZ79_04465 |
| GSO: | PH603_12840(ligA) PH603_12845 |
| AVP: | AVENP_2164(ligB) AVENP_2165(ligD) |
| SGRF: | SGFS_099590 SGFS_099600 |
| SSOI: | I1A49_02890 I1A49_02895 |
| SGM: | GCM10017557_16490(ligA) GCM10017557_16500(pcaH) |
| SLS: | SLINC_7426 SLINC_7427 |
| SAUO: | BV401_03165 BV401_03170 |
| SAKB: | K1J60_39125 K1J60_39130 |
| MAUR: | BOH66_06355 BOH66_06360 |
| MSF: | IT882_15440 IT882_15445(ligA) |
| AMIN: | AUMI_19380 AUMI_19390 |
| AUM: | AURMO_01268 AURMO_01269 AURMO_01295 AURMO_01296 |
| AUW: | AURUGA1_00419(ligA_1) AURUGA1_00420(ligB) |
| AUT: | AINA4_04040 AINA4_04050(pcaH) |
| ACAO: | NF551_03855 NF551_03860 |
| AGEG: | MUG94_01475 MUG94_03645 MUG94_03650 |
| ARZ: | AUT26_02300 AUT26_02305 |
| NAKA: | H7F38_22080 H7F38_22085 |
| BSD: | BLASA_2598(ligA) BLASA_2599(ligB) |
| BBRG: | U6N30_09145(ligA) U6N30_09150 |
| MMAR: | MODMU_2843(ligB) MODMU_2844(ligA) MODMU_3384 |
| SVI: | Svir_38360 Svir_38370 |
| AMQ: | AMETH_2153(mhpB) AMETH_2829 AMETH_2830 |
| AACD: | LWP59_22355 LWP59_22705 LWP59_22710 |
| ARHD: | VSH64_22995 VSH64_23000 |
| ACAB: | QRX50_16380(ligA) QRX50_16385 |
| AMYD: | K1T34_38895 K1T34_38900 |
| ABAR: | AMYBAR_001161 AMYBAR_002585 |
| PDX: | Psed_2465 Psed_2466 Psed_6533 |
| PAUT: | Pdca_48140(pcaH_2) Pdca_48150 |
| PFLA: | Pflav_029930 Pflav_029940(pcaH_1) |
| JTL: | M6D93_14075 M6D93_14080(ligA) |
| VAB: | WPS_31660 WPS_31670(pcaH) |
|
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| Reference |
1 |
|---|
| Authors |
Trippett S, Dagley S, Stopher DA. |
|---|
| Title |
The bacterial oxidation of nicotinic acid. |
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| Journal |
Biochem J 76:9 (1960) |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 1.13.11.8 |
| UM-BBD (Biocatalysis/Biodegradation Database): | 1.13.11.8 |
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