KEGG   ENZYME: 1.13.11.80
Entry
EC 1.13.11.80               Enzyme                                 

Name
(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase;
DpgC
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
(3,5-dihydroxyphenyl)acetyl-CoA:oxygen oxidoreductase
Reaction(IUBMB)
(3,5-dihydroxyphenyl)acetyl-CoA + O2 = 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA [RN:R06624]
Reaction(KEGG)
R06624
Substrate
3,5-dihydroxyphenylacetyl-CoA [CPD:C12324];
O2 [CPD:C00007]
Product
2-(3,5-dihydroxyphenyl)-2-oxoacetate [CPD:C12325];
CoA [CPD:C00010]
Comment
The enzyme, characterized from bacteria Streptomyces toyocaensis and Amycolatopsis orientalis, is involved in the biosynthesis of (3,5-dihydroxyphenyl)glycine, a component of the glycopeptide antibiotic vancomycin.
History
EC 1.13.11.80 created 2015
Pathway
ec01055  Biosynthesis of vancomycin group antibiotics
ec01110  Biosynthesis of secondary metabolites
Orthology
K16427  (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase
Genes
SMAF: D781_2329
SERM: CLM71_12090
SRHZ: FO014_21620
RBAD: H2866_19115
XAL: XALC_1061
XTN: FD63_09800
NBR: O3I_032810
NTP: CRH09_30860 CRH09_31735
NAD: NCTC11293_04863(caiD_11)
NIE: KV110_15725
SMAL: SMALA_7753
SVE: SVEN_0495
KFL: Kfla_4130
NDA: Ndas_1737
NCX: Nocox_13285(noc6)
SACC: EYD13_07730(paaF)
AMYY: YIM_22215(caiD5)
AORI: SD37_33600
SESP: BN6_47880
 » show all
Reference
1  [PMID:11752437]
  Authors
Chen H, Tseng CC, Hubbard BK, Walsh CT
  Title
Glycopeptide antibiotic biosynthesis: enzymatic assembly of the dedicated amino acid monomer (S)-3,5-dihydroxyphenylglycine.
  Journal
Proc Natl Acad Sci U S A 98:14901-6 (2001)
DOI:10.1073/pnas.221582098
Reference
2  [PMID:17507985]
  Authors
Widboom PF, Fielding EN, Liu Y, Bruner SD.
  Title
Structural basis for cofactor-independent dioxygenation in vancomycin biosynthesis.
  Journal
Nature 447:342-5 (2007)
DOI:10.1038/nature05702
Reference
3  [PMID:18004875]
  Authors
Fielding EN, Widboom PF, Bruner SD
  Title
Substrate recognition and catalysis by the cofactor-independent dioxygenase DpgC.
  Journal
Biochemistry 46:13994-4000 (2007)
DOI:10.1021/bi701148b
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.80
IUBMB Enzyme Nomenclature: 1.13.11.80
ExPASy - ENZYME nomenclature database: 1.13.11.80
BRENDA, the Enzyme Database: 1.13.11.80

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