KEGG   ENZYME: 1.13.11.83Help
Entry
EC 1.13.11.83               Enzyme                                 

Name
4-hydroxy-3-prenylphenylpyruvate oxygenase;
CloR
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
3-dimethylallyl-4-hydroxyphenylpyruvate:oxygen 1,2-oxidoreductase (3-dimethylallyl-4-hydroxymandelate forming)
Reaction(IUBMB)
3-dimethylallyl-4-hydroxyphenylpyruvate + O2 = 3-dimethylallyl-4-hydroxymandelate + CO2 [RN:R06758]
Reaction(KEGG)
Substrate
3-dimethylallyl-4-hydroxyphenylpyruvate [CPD:C12456];
O2 [CPD:C00007]
Product
3-dimethylallyl-4-hydroxymandelate [CPD:C12457];
CO2 [CPD:C00011]
Comment
Requires non-heme-Fe(II). Isolated from the bacterium Streptomyces roseochromogenes DS 12976. A bifunctional enzyme involved in clorobiocin biosynthesis that also catalyses the activity of EC 1.13.12.23, 3-dimethylallyl-4-hydroxybenzoate synthase.
History
EC 1.13.11.83 created 2017
Pathway
ec00401  Novobiocin biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K12708  4-hydroxy-3-prenylphenylpyruvate oxygenase / 4-hydroxy-3-prenylbenzoate synthase
Genes
NGV: CDO52_02235
Taxonomy
Reference
1  [PMID:12777382]
  Authors
Pojer F, Kahlich R, Kammerer B, Li SM, Heide L.
  Title
CloR, a bifunctional non-heme iron oxygenase involved in clorobiocin biosynthesis.
  Journal
J Biol Chem 278:30661-8 (2003)
DOI:10.1074/jbc.M303190200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.83
IUBMB Enzyme Nomenclature: 1.13.11.83
ExPASy - ENZYME nomenclature database: 1.13.11.83
BRENDA, the Enzyme Database: 1.13.11.83

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