KEGG   ENZYME: 1.13.11.86
Entry
EC 1.13.11.86               Enzyme                                 
Name
5-aminosalicylate 1,2-dioxygenase;
mabB (gene name)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
5-aminosalicylate:oxygen 1,2-oxidoreductase (ring-opening)
Reaction(IUBMB)
5-aminosalicylate + O2 = (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate [RN:R12147]
Reaction(KEGG)
R12147
Substrate
5-aminosalicylate [CPD:C07138];
O2 [CPD:C00007]
Product
(2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate [CPD:C21928]
Comment
Requires Fe(II). The enzyme, characterized from different bacteria, is a nonheme iron dioxygenase in the bicupin family.
History
EC 1.13.11.86 created 2018
Orthology
K23019  5-aminosalicylate 1,2-dioxygenase
Reference
1  [PMID:1554350]
  Authors
Stolz A, Nortemann B, Knackmuss HJ
  Title
Bacterial metabolism of 5-aminosalicylic acid. Initial ring cleavage.
  Journal
Biochem J 282 ( Pt 3):675-80 (1992)
DOI:10.1042/bj2820675
Reference
2  [PMID:29038259]
  Authors
Yu H, Zhao S, Guo L
  Title
Novel Gene Encoding 5-Aminosalicylate 1,2-Dioxygenase from Comamonas sp. Strain QT12 and Catalytic Properties of the Purified Enzyme.
  Journal
J Bacteriol 200:e00395-17 (2018)
DOI:10.1128/JB.00395-17
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.86
IUBMB Enzyme Nomenclature: 1.13.11.86
ExPASy - ENZYME nomenclature database: 1.13.11.86
BRENDA, the Enzyme Database: 1.13.11.86

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