| Entry |
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| Name |
2,5-dihydroxypyridine 5,6-dioxygenase;
2,5-dihydroxypyridine oxygenase;
pyridine-2,5-diol dioxygenase;
NicX
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| Class |
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
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| Sysname |
2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase
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| Reaction(IUBMB) |
2,5-dihydroxypyridine + O2 = N-formylmaleamic acid [RN: R09125]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
N-formylmaleamic acid [CPD: C18232]
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| Comment |
Requires Fe2+.
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| History |
EC 1.13.11.9 created 1965 as EC 1.13.1.9, transferred 1972 to EC 1.13.11.9, modified 2010
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| Pathway |
| ec00760 | Nicotinate and nicotinamide metabolism |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K18028 | 2,5-dihydroxypyridine 5,6-dioxygenase |
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| Genes |
| RPJ: | N234_04330 N234_15835 N234_24890 |
| REH: | H16_A0925(h16_A0925) H16_A2810(h16_A2810) H16_B0813(h16_B0813) |
| CNC: | CNE_1c08750 CNE_1c27100 CNE_2c07610 |
| CUH: | BJN34_04910 BJN34_15135 BJN34_29420 |
| REU: | Reut_A2512 Reut_B3788 |
| CTI: | RALTA_A0870 RALTA_A2299 |
| CBW: | RR42_m3126 RR42_s0171 RR42_s1172 |
| CGD: | CR3_0579(ampS) CR3_0803(ampS) CR3_3007(nicX) |
| CCUP: | BKK81_07370 BKK81_15650 |
| CUP: | BKK80_06670 BKK80_16605 |
| CUU: | BKK79_05480 BKK79_16350 |
| COX: | E0W60_08960 E0W60_14770 E0W60_23265 |
| CCAX: | KZ686_07225 KZ686_20175 |
| CUK: | KB879_04570 KB879_08785 KB879_26000 |
| BANN: | JFN94_22955 JFN94_25175 |
| BARI: | NLX30_32985 NLX30_38905 |
| BYI: | BYI23_D006280 BYI23_D011200 |
| BUE: | BRPE67_DCDS08100 BRPE67_DCDS13330 |
| PSPU: | NA29_10040 NA29_11640 NA29_13055 |
| PVE: | UC34_12640 UC34_17850 |
| POX: | MB84_21140 MB84_22640 |
| PNR: | AT302_14240 AT302_20395 |
| CABA: | SBC2_37490(nicX_1) SBC2_53530(nicX_2) |
| BUO: | BRPE64_DCDS05940 BRPE64_DCDS10990 |
| BPER: | BN118_0957 BN118_3486 |
| BPEU: | Q425_15030 Q425_35680 |
| BPAR: | BN117_0269 BN117_1484 |
| BBH: | BN112_1734 BN112_3143 |
| BBM: | BN115_0259 BN115_1683 |
| BBX: | BBS798_0269 BBS798_1682 |
| BBRO: | BAU06_10300 BAU06_12295 BAU06_25035 |
| BFZ: | BAU07_14190 BAU07_23450 BAU07_25070 |
| BGM: | CAL15_11470 CAL15_12490 |
| AIS: | BUW96_02610 BUW96_28750 |
| PUD: | G9Q38_03255 G9Q38_04180 G9Q38_04670 |
| AKA: | TKWG_00615 TKWG_01105 TKWG_19790 |
| AMIM: | MIM_c02050 MIM_c31080 |
| AFA: | UZ73_03775 UZ73_10785 UZ73_14565 UZ73_14765 |
| AFQ: | AFA_13575 AFA_14965(nicX) AFA_15135(picD) AFA_18565(hpaX) |
| AAQU: | D3M96_14525 D3M96_15895 D3M96_16075 |
| AAMM: | FE795_12525 FE795_13825 FE795_14000 |
| PIG: | EGT29_00800 EGT29_02745 EGT29_03390 |
| LIM: | L103DPR2_00582(nicX) |
| LIH: | L63ED372_00060(nicX) |
| HYN: | F9K07_01290 F9K07_02925 F9K07_21765 |
| AZR: | CJ010_02410 CJ010_22080 |
| AAK: | AA2016_6001 AA2016_6584 |
| BOT: | CIT37_06750 CIT37_23840 |
| BGQ: | X265_12340 X265_13550 |
| BARH: | WN72_34005 WN72_44280 |
| RBK: | E0H22_02850 E0H22_16390 |
| PSIN: | CAK95_12375 CAK95_14180 CAK95_27070 |
| CON: | TQ29_12570 TQ29_12770 TQ29_16070 |
| PYE: | A6J80_00020 A6J80_23200 |
| LVS: | LOKVESSMR4R_03232(nicX) |
| AZM: | DM194_20100 DM194_21870 |
| HADH: | FRZ61_39250 FRZ61_46310 |
| SBAE: | DSM104329_02297(nicX_1) DSM104329_02308(nicX_2) DSM104329_02367(nicX_3) DSM104329_02480(nicX_4) DSM104329_03697(nicX_5) DSM104329_03708(nicX_6) |
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| Reference |
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| Authors |
BEHRMAN EJ, STANIER RY. |
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| Title |
The bacterial oxidation of nicotinic acid. |
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| Journal |
J Biol Chem 228:923-45 (1957) |
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| Reference |
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| Authors |
Gauthier JJ, Rittenberg SC |
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| Title |
The metabolism of nicotinic acid. I. Purification and properties of 2,5-dihydroxypyridine oxygenase from Pseudomonas putida N-9. |
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| Journal |
J Biol Chem 246:3737-42 (1971) |
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| Sequence |
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| Reference |
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| Authors |
Gauthier JJ, Rittenberg SC. |
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| Title |
The metabolism of nicotinic acid. II. 2,5-dihydroxypyridine oxidation, product formation, and oxygen 18 incorporation. |
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| Journal |
J Biol Chem 246:3743-8 (1971) |
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| Sequence |
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| Reference |
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| Authors |
Jimenez JI, Canales A, Jimenez-Barbero J, Ginalski K, Rychlewski L, Garcia JL, Diaz E |
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| Title |
Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 1.13.11.9 |
| UM-BBD (Biocatalysis/Biodegradation Database): | 1.13.11.9 |
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