KEGG   ENZYME: 1.13.11.9Help
Entry
EC 1.13.11.9                Enzyme                                 

Name
2,5-dihydroxypyridine 5,6-dioxygenase;
2,5-dihydroxypyridine oxygenase;
pyridine-2,5-diol dioxygenase;
NicX
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase
Reaction(IUBMB)
2,5-dihydroxypyridine + O2 = N-formylmaleamic acid [RN:R09125]
Reaction(KEGG)
Substrate
2,5-dihydroxypyridine [CPD:C01059];
O2 [CPD:C00007]
Product
N-formylmaleamic acid [CPD:C18232]
Comment
Requires Fe2+.
History
EC 1.13.11.9 created 1965 as EC 1.13.1.9, transferred 1972 to EC 1.13.11.9, modified 2010
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K18028  2,5-dihydroxypyridine 5,6-dioxygenase
Genes
GQU: AWC35_02975
SPE: Spro_2312
SRR: SerAS9_2269
SRL: SOD_c21420(nicX)
SRY: M621_11735
SPLY: Q5A_011870(nicX)
SRS: SerAS12_2269
SRA: SerAS13_2270
SMW: SMWW4_v1c23260
SMAR: SM39_1771
SERF: L085_17115
PPU: PP_3945(nicX)
PPF: Pput_1892
PPT: PPS_4058
PPI: YSA_08963
PPX: T1E_5122
PPUT: L483_21715
PPUN: PP4_17770
PFS: PFLU_2800
PFB: VO64_0127
PANR: A7J50_2717
PSIL: PMA3_12570
HAM: HALO0548
ADI: B5T_02297
REH: H16_A0925(h16_A0925) H16_B0813(h16_B0813)
CGD: CR3_0579(ampS) CR3_0803(ampS) CR3_3007(nicX)
BCN: Bcen_4327
BCJ: BCAM1142
BCEN: DM39_3879
BCEO: I35_4989
BMU: Bmul_4550
BMK: DM80_3720
BMUL: NP80_4069
BCED: DM42_3948
BCON: NL30_06920
BSEM: WJ12_25610
BPSL: WS57_08415
BMEC: WJ16_24240
BSTG: WT74_20825
BGO: BM43_2599
BXE: Bxe_C0216
BXB: DR64_8215
BFN: OI25_6799
PPNO: DA70_23280
PPNM: LV28_07430
PPUL: RO07_01615
PAPI: SG18_01755
BPET: B1917_3473
AFQ: AFA_13575 AFA_14965(nicX) AFA_15135(picD) AFA_18565(hpaX)
ODI: ODI_R3898
AAV: Aave_3930
AAA: Acav_3827
DAC: Daci_1850
CTES: O987_23190
LIM: L103DPR2_00582(nicX)
LIH: L63ED372_00060(nicX)
HYB: Q5W_22175
RLG: Rleg_6046
SHZ: shn_30285
OCH: CES85_3503(nicX)
BRS: S23_21870
AOL: S58_52840
BRAD: BF49_5545
PHL: KKY_3788
PLEO: OHA_1_03169(nicX)
HDI: HDIA_0234(nicX)
CID: P73_3892
LVS: LOKVESSMR4R_03232(nicX)
GXL: H845_1042
KEU: S101446_01672(nicX)
KSC: CD178_02878(nicX)
MVQ: MYVA_3797
RFA: A3L23_03312(nicX)
RHS: A3Q41_00020(nicX)
SALU: DC74_1449
SALL: SAZ_07780
STRE: GZL_07763
SMAL: SMALA_0613
FAL: FRAAL6169
AOI: AORI_4776
AJA: AJAP_15760(nicX)
PSEA: WY02_22100
PSEE: FRP1_20590
PSEH: XF36_05315
 » show all
Taxonomy
Reference
1  [PMID:13475371]
  Authors
BEHRMAN EJ, STANIER RY.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
J Biol Chem 228:923-45 (1957)
Reference
2  [PMID:5578917]
  Authors
Gauthier JJ, Rittenberg SC.
  Title
The metabolism of nicotinic acid. I. Purification and properties of 2,5-dihydroxypyridine oxygenase from Pseudomonas putida N-9.
  Journal
J Biol Chem 246:3737-42 (1971)
  Sequence
[ppu:PP_3945]
Reference
3  [PMID:5578918]
  Authors
Gauthier JJ, Rittenberg SC.
  Title
The metabolism of nicotinic acid. II. 2,5-dihydroxypyridine oxidation, product formation, and oxygen 18 incorporation.
  Journal
J Biol Chem 246:3743-8 (1971)
  Sequence
[ppu:PP_3945]
Reference
4  [PMID:18678916]
  Authors
Jimenez JI, Canales A, Jimenez-Barbero J, Ginalski K, Rychlewski L, Garcia JL, Diaz E
  Title
Deciphering the genetic determinants for aerobic nicotinic acid degradation: the  nic cluster from Pseudomonas putida KT2440.
  Journal
Proc Natl Acad Sci U S A 105:11329-34 (2008)
DOI:10.1073/pnas.0802273105
  Sequence
[ppu:PP_3945]
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.9
IUBMB Enzyme Nomenclature: 1.13.11.9
ExPASy - ENZYME nomenclature database: 1.13.11.9
UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.9
BRENDA, the Enzyme Database: 1.13.11.9
CAS: 9029-57-6

DBGET integrated database retrieval system