KEGG   ENZYME: 1.13.11.9
Entry
EC 1.13.11.9                Enzyme                                 
Name
2,5-dihydroxypyridine 5,6-dioxygenase;
2,5-dihydroxypyridine oxygenase;
pyridine-2,5-diol dioxygenase;
NicX
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase
Reaction(IUBMB)
2,5-dihydroxypyridine + O2 = N-formylmaleamic acid [RN:R09125]
Reaction(KEGG)
R09125
Substrate
2,5-dihydroxypyridine [CPD:C01059];
O2 [CPD:C00007]
Product
N-formylmaleamic acid [CPD:C18232]
Comment
Requires Fe2+.
History
EC 1.13.11.9 created 1965 as EC 1.13.1.9, transferred 1972 to EC 1.13.11.9, modified 2010
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K18028  2,5-dihydroxypyridine 5,6-dioxygenase
Genes
SMARSM39_1771
SMACSMDB11_1584
SMWSMWW4_v1c23260
SPESpro_2312
SRRSerAS9_2269
SRLSOD_c21420(nicX)
SRYM621_11735
SPLYQ5A_011870(nicX)
SRSSerAS12_2269
SRASerAS13_2270
SLQM495_11505
SERFL085_17115
SQUE4343_04630
SFJSAMEA4384070_2381
SOFNCTC11214_04488
SURIJ0X03_12365
GQUAWC35_02975
PAOPat9b_5175
TCIA7K98_12095
TPTYNCTC11468_02202
PPUPP_3945(nicX)
PPFPput_1892
PPGPputGB1_3580
PPWPputW619_2138
PPTPPS_4058
PPBPPUBIRD1_1863
PPIYSA_08963
PPXT1E_5122
PPUTL483_21715
PPUNPP4_17770
PFSPFLU_2800
PFBVO64_0127
PAZOAYR47_21620
PMEDE3Z27_20705
PFWPF1751_v1c24710
PFFPFLUOLIPICF724375
PFXA7318_11825
PLULFOB45_03920
PSKU771_14860
PFZAV641_08730
PANRA7J50_2717
PSILPMA3_12570
PYMAK972_2676
PGGFX982_03129
PVKEPZ47_21845
PEZHWQ56_12835
PWYHU734_022660
PTAENCTC10697_01684
AWUBEN71_18360
AGUAS4_40080
HAMHALO0548
HVNEI420_02005
HOLHORIV_64960
HAXIHAALTHF_14370n
HTTHZS52_07580
HSVHNO53_05730
HTXEKK97_06015
ADIB5T_02297
MARSA8C75_16295
RPJN234_04330 N234_24890
REHH16_A0925(h16_A0925) H16_B0813(h16_B0813)
CNCCNE_1c08750 CNE_2c07610
CUHBJN34_04910 BJN34_29420
REUReut_A2512 Reut_B3788
CTIRALTA_A0870
CBWRR42_s0171 RR42_s1172
CGDCR3_0803(ampS) CR3_3007(nicX)
CCUPBKK81_07370
CUPBKK80_06670
CUUBKK79_05480
CPAUEHF44_27015
COXE0W60_08960 E0W60_14770
BSAVWS86_30280
BCNBcen_4327
BCHBcen2424_4039
BCMBcenmc03_3486
BCJBCAM1142
BCENDM39_3879
BCEOI35_4989
BMUBmul_4550
BMKDM80_3720
BMULNP80_4069
BCEDDM42_3948
BCONNL30_06920
BSEMWJ12_25610
BPSLWS57_08415
BMECWJ16_24240
BSTGWT74_20825
BANNJFN94_22955 JFN94_25175
BGDbgla_1g12670
BGOBM43_2599
BYIBYI23_D006280 BYI23_D011200
BUEBRPE67_DCDS08100 BRPE67_DCDS13330
BGPBGL_1c11600
BPLAbpln_1g11120
BUMAXG89_36965
BUIAX768_15625
BURKDM992_20105
BXEBxe_C0216
BXBDR64_8215
BFNOI25_6799
BCAIK788_0007381
PTERC2L65_30585
PTROG5S35_31885
PPKU875_06205
PPNODA70_23280
PPNMLV28_07430
PRBX636_03370
PPULRO07_01615
PSPUNA29_10040 NA29_11640 NA29_13055
PAPISG18_01755
PVEUC34_12640 UC34_17850
POXMB84_21140 MB84_22640
PTXABW99_20545
PFGAB870_04880
PNRAT302_14240 AT302_20395
PANDDRB87_16370
PFIBPI93_010200
CABASBC2_37490(nicX_1) SBC2_53530(nicX_2)
BUOBRPE64_DCDS05940 BRPE64_DCDS10990
BPEBP0581 BP1957
BPCBPTD_0590 BPTD_1929
BPERBN118_0957 BN118_3486
BPETB1917_3473
BPEUQ425_15030 Q425_35680
BPARBN117_0269 BN117_1484
BPABPP0271 BPP2330
BBHBN112_1734 BN112_3143
BBRBB0274 BB1781
BBMBN115_0259 BN115_1683
BBXBBS798_0269 BBS798_1682
BAVBAV1529 BAV2742
BHZACR54_00920(nicX)
BTRMSAMEA390648701508
BBROBAU06_10300 BAU06_12295 BAU06_25035
BFZBAU07_14190 BAU07_23450 BAU07_25070
BPDZBBN53_17720
BOHAKI39_11515
BGMCAL15_11470 CAL15_12490
AXYAXYL_02466 AXYL_02843
AXONH44784_051911
AXNAX27061_3327
AXXERS451415_03307
ADTAPT56_16400
AISBUW96_02610 BUW96_04275 BUW96_28750
ASWCVS48_09645
ACHRC2U31_23370
ACHBDVB37_25110
PUDG9Q38_03255 G9Q38_04180 G9Q38_04670
AKATKWG_00615 TKWG_01105 TKWG_19790
AMIMMIM_c02050 MIM_c31080
AFAUZ73_03775 UZ73_10785 UZ73_14565 UZ73_14765
AFQAFA_13575 AFA_14965(nicX) AFA_15135(picD) AFA_18565(hpaX)
AAQUD3M96_14525 D3M96_15895 D3M96_16075
AAMMFE795_12525 FE795_13825 FE795_14000
PHNPAEH1_03580
ODIODI_R3898
PIGEGT29_00800 EGT29_02745 EGT29_03390
PACRFXN63_06615
RHFEUB48_20920
AAVAave_3930
AAAAcav_3827
ACKC380_17105
DACDaci_1850
DELDelCs14_4788
DTSBI380_15400
DHKBO996_08760
DLAI6G47_15030
VAPVapar_4293
VAMC4F17_28025
CTESO987_23190
HYBQ5W_22175
HYLLPB072_00950
HYCE5678_16815
HPSEHPF_00905(nicX)
HYNF9K07_01290 F9K07_02925 F9K07_21765
HSEHsero_1325
HSZACP92_06630
HEEhmeg3_19265
HFRG5S34_06840
MTIMDIR46_21155
XYKGT347_17965
BBAYA4V04_02455
AZRCJ010_02410 CJ010_22080
DHYDESAM_20934
MLNA9174_33965
MAMOA6B35_09700
MESPC1M53_21410
MESRFGU64_17615
HOEIMCC20628_03533
AAKAA2016_6001 AA2016_6584
SIXBSY16_4976
ATAAWN88_01320
RLGRleg_6046
RTRRTCIAT899_PC08580
RADCO657_35880
RIIFFM53_028515
RRGJ3P73_36855
NEOCYG48_18935 CYG48_18980
SHZshn_30285
OCHCES85_3503(nicX)
BJUBJ6T_36210
BJPRN69_17555
BRABRADO2312
BRSS23_21870
AOLS58_52840
BRCBCCGELA001_25855
BRADBF49_5545
BROBRAD285_5030
BRKCWS35_28865
BOTCIT37_06750
BRQCIT40_22420
BGQX265_13550
BGZXH91_11115
BSYMCIT39_21615
BBETF8237_26010
BARHWN72_44280
BVZBRAD3257_3041
BELBE61_17030
BQBJ4P68_0007725
RBKE0H22_02850
TRBHB776_11430
SNOSnov_3511
STARG3545_21930
ANCGBB76_12105
HMCHYPMC_0203
RHZRHPLAN_69100
NTDEGO55_05275
PHLKKY_3788
PLEOOHA_1_03169(nicX)
HDIHDIA_0234(nicX)
AUBLXB15_07185
PSINCAK95_12375 CAK95_14180 CAK95_27070
PPHRAPZ00_25430
SIWGH266_12020
OAROA238_c08170
CIDP73_3892
CEHCEW89_08860
CONTQ29_12570 TQ29_12770 TQ29_16070
PABYGa0080574_TMP31
SAGUCDO87_22440
MALUKU6B_06560
PYEA6J80_00020 A6J80_23200
DAAAKL17_3241
LVSLOKVESSMR4R_03232(nicX)
SALOEF888_14950
PALWPSAL_024210(nicX)
FAPGR316_10985
GCEKYE46_03215
NSMJO391_01895
SNJA7E77_04545
SMYBJP26_14900
SBARH5V43_21650(ndpE)
ELQGa0102493_111595
GOYGLS_c14230
GALA0U94_10315
GTIFXF46_02575
GSPIGS75_12410
GXLH845_1042
KEUS101446_01672(nicX)
KSCCD178_02878(nicX)
KREGWK63_12515
APTAPA01_23760
APWAPA42C_23760
APFAPA03_23760
APUAPA07_23760
APGAPA12_23760
APQAPA22_23760
APXAPA26_23760
APZAPA32_23760
APKAPA386B_1210
ASVWG31_11905
APOMCPF11_08775
ATOCIW82_09425
AASCA4S02_13830
ACETDS739_11635
ROSCTJ15_00290
RMUCFOB66_01435
KHAIFJ82_11095
ALIAZOLI_p20433
ABSAZOBR_p480011
ABQABAZ39_30180
ABFAMK58_25905
ATIAL072_30665
AZTTSH58p_19530
AZMDM194_20100 DM194_21870
AOZHUE56_08300
HTQFRZ44_10730 FRZ44_18690
HADHFRZ61_10410 FRZ61_39250 FRZ61_46310
MGMMmc1_1162
APBSAR116_0287
BFDNCTC4823_03704
BACAFAY30_11695
PARHI5S86_12070
BKOCKF48_07615
PBUTDTO10_23015
PGQFK545_05510
SPSYAZE41_18245
GFEGferi_18530
CSOCLS_30390
DCADesca_0623
DRMDred_0394 Dred_2649
FWADCMF_07490 DCMF_07495 DCMF_07525 DCMF_11680 DCMF_11685 DCMF_11690 DCMF_11695 DCMF_22955
BPRMCL3_19660
CHYCHY_0589
TPZTph_c17040 Tph_c22840
HASHalsa_0295
KMEH0A61_00935(nicX_1) H0A61_01515(nicX_3)
KPARJL105_08635
PUFUFO1_4548
MSAMycsm_01808
MVQMYVA_3797
MLLB1R94_28810
MTYMTOK_30950
ROAPd630_LPD07329
RFAA3L23_03312(nicX)
RHSA3Q41_00020(nicX)
RCRNCTC10994_03415
SVLStrvi_4768
SRCM271_44585
SMALSMALA_0613
SSOII1A49_06645
SALUDC74_1449
SALLSAZ_07780
STREGZL_07763
SNRSNOUR_35470
SAUOBV401_06895
SNKCP967_04305
SBATG4Z16_06625
SINEKI385_04355
JMEEEW87_000025
SAIUJ4H86_13115
NOABKM31_01960
NOWGBF35_36050
NCXNocox_29325
NGNLCN96_40350
FALFRAAL6169
AOIAORI_4776
AJAAJAP_15760(nicX)
AMQAMETH_3951
AMYCCU254_15755
AMYYYIM_29130(nicX)
AACDLWP59_17615
PSEAWY02_22100
PSEEFRP1_20590
PSEHXF36_05315
PSEQAD006_28010
PECQAD017_07605
PHHAFB00_17850
PAUTPdca_13590
PBROHOP40_05480
MICHFJK98_12770
PSUUPsuf_015390
OPROcepr_1819
TPAVHRQ91_10130
FVAFV113G1_05960
FULC4N20_03270
FCII6I83_10130
AMOAnamo_1947
CPORBED41_02630
FLMMY04_5148
TLETlet_1501
PHYAJ81_08300
PHOPH1046(PH1046)
PYNPNA2_0476 PNA2_0486 PNA2_1569
TLTOCC_03863
THSTES1_1600
TCHCHITON_1768
THHCDI07_07260
TRLA3L10_07725
HAADMW046_15080
HAQDU484_10530
HAJDU500_10800
HAERDU502_08045 DU502_08085
SRUBC2R22_21800
HALGHUG10_06850
HALUHUG12_00315
NAJB1756_11045
MJNMjAS7_2157
CLGCalag_0202
KCRKcr_0404
BARCAOA65_1270
 » show all
Reference
1  [PMID:13475371]
  Authors
BEHRMAN EJ, STANIER RY.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
J Biol Chem 228:923-45 (1957)
Reference
2  [PMID:5578917]
  Authors
Gauthier JJ, Rittenberg SC
  Title
The metabolism of nicotinic acid. I. Purification and properties of 2,5-dihydroxypyridine oxygenase from Pseudomonas putida N-9.
  Journal
J Biol Chem 246:3737-42 (1971)
  Sequence
[ppu:PP_3945]
Reference
3  [PMID:5578918]
  Authors
Gauthier JJ, Rittenberg SC.
  Title
The metabolism of nicotinic acid. II. 2,5-dihydroxypyridine oxidation, product formation, and oxygen 18 incorporation.
  Journal
J Biol Chem 246:3743-8 (1971)
  Sequence
[ppu:PP_3945]
Reference
4  [PMID:18678916]
  Authors
Jimenez JI, Canales A, Jimenez-Barbero J, Ginalski K, Rychlewski L, Garcia JL, Diaz E
  Title
Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440.
  Journal
Proc Natl Acad Sci U S A 105:11329-34 (2008)
DOI:10.1073/pnas.0802273105
  Sequence
[ppu:PP_3945]
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.9
IUBMB Enzyme Nomenclature: 1.13.11.9
ExPASy - ENZYME nomenclature database: 1.13.11.9
UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.9
BRENDA, the Enzyme Database: 1.13.11.9
CAS: 9029-57-6

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