KEGG   ENZYME: 1.13.12.2
Entry
EC 1.13.12.2                Enzyme                                 
Name
lysine 2-monooxygenase;
lysine oxygenase;
lysine monooxygenase;
L-lysine-2-monooxygenase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
Sysname
L-lysine:oxygen 2-oxidoreductase (decarboxylating)
Reaction(IUBMB)
L-lysine + O2 = 5-aminopentanamide + CO2 + H2O [RN:R00449]
Reaction(KEGG)
R00449
Substrate
L-lysine [CPD:C00047];
O2 [CPD:C00007]
Product
5-aminopentanamide [CPD:C00990];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD). Also acts on other diamino acids.
History
EC 1.13.12.2 created 1972
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00468  lysine 2-monooxygenase
Genes
PAP: PSPA7_3191
PRE: PCA10_04900
PFUW: KF707C_4430
PCQ: PcP3B5_32620(iaaM)
PMUI: G4G71_17665
PNT: G5B91_14560
PPAA: B7D75_14515
PPU: PP_0383(davB)
PPF: Pput_0407
PPG: PputGB1_0411
PPW: PputW619_4820
PPT: PPS_0377
PPB: PPUBIRD1_0418
PPI: YSA_05771
PPX: T1E_2171
PPUH: B479_02390
PPUT: L483_01950
PPUN: PP4_04120
PPUD: DW66_0391
PMON: X969_00210
PMOT: X970_00210
PPJ: RK21_04637
PMOL: CLJ08_14860
PALD: LU682_001855
PIX: RIN61_13740
PMOS: O165_025840
PST: PSPTO_0518
PSB: Psyr_4667
PSYR: N018_02455
PSP: PSPPH_4701
PSAV: PSA3335_02275
PAMG: BKM19_027110
PCI: PCH70_05900
PAVL: BKM03_02885
PVD: CFBP1590_0582
PCAB: JGS08_01800
PCOF: POR16_22965
PTRE: I9H09_22825
PSYI: MME58_23860
PAST: N015_24210
PLIJ: KQP88_02900
PFL: PFL_5670
PPRC: PFLCHA0_c56220(iaaM)
PPRO: PPC_5615
PFE: PSF113_5381
PZA: HU749_027315
PFN: HZ99_15135
PFO: Pfl01_5154
PFS: PFLU_5595 PFLU_5656
PFC: PflA506_4896
PPZ: H045_18360
PFB: VO64_2482 VO64_2537
PMAN: OU5_4020
PTV: AA957_17040
PCG: AXG94_12810
PVR: PverR02_28745 PverR02_29020
PAZO: AYR47_04170
POI: BOP93_23795
PRX: HRH33_24550
PMED: E3Z27_25810
PKR: AYO71_27665
PMUD: NCTC8068_04895
PTOL: I7845_26345
PMAB: U0037_28130 U0037_28430
PFW: PF1751_v1c50220
PFF: PFLUOLIPICF710880
PFX: A7318_24740
PEN: PSEEN0401
PBA: PSEBR_a5163
PBC: CD58_27095
PPUU: PputUW4_04962(iaaM)
PDR: H681_11755
PSV: PVLB_23330
PSK: U771_28955 U771_29220
PKC: PKB_2893
PCH: EY04_11230 EY04_32245
PCZ: PCL1606_05880 PCL1606_37330
PCP: JM49_03030 JM49_18715
PCHP: C4K32_5760
PFZ: AV641_02090
PLQ: AA042_07850
PALK: PSAKL28_04170
PRH: LT40_18260
PSW: LK03_07335
PPV: NJ69_16690
PSES: PSCI_1278
PSEM: TO66_12070 TO66_28745
PSEC: CCOS191_4943
PPSY: AOC04_22275
PSOS: POS17_5602
PFK: PFAS1_13880
PANR: A7J50_5326
PSET: THL1_442
PSIL: PMA3_27685
PYM: AK972_0332
PKE: DLD99_26305
PUM: HGP31_28600
POJ: PtoMrB4_05620
PGG: FX982_01132
PPSH: G5J76_05060
PGY: AWU82_09110
PLAL: FXN65_02360
PVK: EPZ47_27210
PEZ: HWQ56_26295
PBZ: GN234_20975
PATA: JWU58_03245
PDW: BV82_1886
PZE: HU754_027565
PMOE: HV782_026615
PSEP: C4K39_4005
PPII: QL104_28690
PVW: HU752_029785
PTRT: HU722_0026995 HU722_0027275
PXA: KSS93_05305
PSAM: HU731_013105
PTZ: HU718_027800
PQI: KH389_15910 KH389_24750
PSHH: HU773_025540
PXN: HU772_002040
PHV: HU739_026525
PPRG: HU725_001910
PANH: HU763_001780
PASG: KSS96_26175
PFAK: KSS94_02185
PMUY: KSS95_01035
PMAM: KSS90_02065
PAZE: KSS91_26375
PALV: KSS97_26550
PCAS: LOY40_26525
PORY: EJA05_02060
PTK: EXN22_25295 EXN22_25680
PTW: TUM18999_06990
PIE: HU724_025755
PTAE: NCTC10697_00440
PGF: J0G10_28150
PJU: L1P09_01790
PIZ: LAB08_R55580
PPEG: KUA23_27375
PSII: NF676_24700
PSIH: LOY51_02145
PFIT: KJY40_27660
PASI: LG197_07045
PKM: PZ739_01975
PNB: NK667_30320
PSOA: PSm6_25960
PTAI: ICN73_04600
PKK: QQ992_01890
PKJ: Q1W70_12715
PHYG: JTY93_24785 JTY93_25055
PHOM: KJF94_23960
PCUC: PSH97_25545
PTRL: OU419_13310
PPAE: LDL65_08480
PPAO: K3169_27645
PRHZ: CRX69_23975
PSJY: AA098_25675
PSKU: KUIN1_46720
PSHS: JJN09_20390
PHEF: PSH57_26335
PLIS: NN484_04100
PSNC: C0058_29720
PFOU: OZ911_02040
PBEJ: PSH84_25955
PKV: QYQ93_26640 QYQ93_26930
PSKP: KU43P_49010
PDEN: F1C79_05860
GAI: IMCC3135_25895(iaaM)
BCM: Bcenmc03_4304
PLG: NCTC10937_04967
ACHR: C2U31_20870
RHG: EXZ61_17005
RMK: RAN89_02260
HYR: BSY239_3752
HYB: Q5W_21180
HYL: LPB072_12110
HYC: E5678_15835
HPSE: HPF_21750(iaaM)
HYN: F9K07_27130
HTN: KI616_24530
HYY: JNX00_01725
TTW: LCC91_12495
LNE: FZC33_28930
AUZ: Sa4125_42610
NOH: G5V57_10515
RDE: RD1_1495
RLI: RLO149_c032070
KRO: BVG79_p1000114(iaaM)
CID: P73_2156
CEH: CEW89_04465
CBAK: DA792_19885
SUAM: BOO69_20305
SPSE: SULPSESMR1_04820(iaaM)
RPEL: N7U68_10230
PAMI: JCM7686_2738
PZH: CX676_20255
PFIS: JHX87_02530
THW: BMG03_02595
TEC: AKL02_019605
HML: HmaOT1_17940
PSEB: EOK75_04320
PPRU: FDP22_08075
PAED: G5B38_13710
MON: G8E03_11995
POZ: I0K15_15880
NSM: JO391_03695
ACR: Acry_2670
AMV: ACMV_29960
PARH: I5S86_26925
MAUB: MAUB_03580
MPHU: MPHO_09260
MMUC: C1S78_013580
MAB: MAB_0818
MMV: MYCMA_0419
MIZ: BAB75_04605
ASD: AS9A_4558
CYZ: C3B44_10390
RHA: RHA1_ro03531
RER: RER_05790
REY: O5Y_02765
REB: XU06_03020
RQI: C1M55_03275
ROP: ROP_33250
ROA: Pd630_LPD07918
RHB: NY08_2002
RHOD: AOT96_13615
RKO: JWS14_18540
RGO: KYT97_22355
RPSK: JWS13_25940
RHOP: D8W71_12410
RHOO: RA302_03130
RHOJ: JVH1_19375
RFA: A3L23_00334(iaaM)
RHS: A3Q41_03073(iaaM)
GPO: GPOL_c37600
GOQ: ACH46_10800
GOC: CXX93_12150
GOM: D7316_04814(iaaM)
GAM: GII34_08380
GPD: GII33_07800
GOI: LK459_15080
GMG: NWF22_04040
GSI: P5P27_09960
TPR: Tpau_1414
TSM: ASU32_08035
TPUL: TPB0596_31240
TSD: MTP03_16210
TOY: FO059_17000
SCO: SCO1454(SCL6.11c)
SALB: XNR_5396
SMA: SAVERM_6893
SGR: SGR_6070
SGB: WQO_05045
SFI: SFUL_973
SANL: KZO11_04665
SGRF: SGFS_093350
SCYE: R2B67_31380
SCB: SCAB_75511
SSX: SACTE_0868
SVL: Strvi_3092 Strvi_7983
SHY: SHJG_2887
SHO: SHJGH_2651
SRC: M271_10065 M271_31700
SMAL: SMALA_2699 SMALA_6565
SSOI: I1A49_17425 I1A49_36625
SFA: Sfla_5404
SBH: SBI_00391 SBI_02339
SVE: SVEN_1051
SDV: BN159_7134
SALS: SLNWT_6481
STRP: F750_1215
SCI: B446_07515
SLV: SLIV_30495
SGU: SGLAU_05850
SVT: SVTN_06660
STRE: GZL_07240
SCW: TU94_06000
SLD: T261_6481 T261_6801
SLC: SL103_12270
STRM: M444_04775 M444_07415
STRC: AA958_33330
SAMB: SAM23877_1515
SPRI: SPRI_6108
SCZ: ABE83_30770
SCX: AS200_36385
SRW: TUE45_01867(iaaM)
STRF: ASR50_06875
SLE: sle_56450(sle_56450)
SRN: A4G23_00701(iaaM)
SPAV: Spa2297_05485
STRT: A8713_04935
SCLF: BB341_24500
SGS: AVL59_33725
STSI: A4E84_07150
SKY: D0C37_29005
SALW: CP975_05400 CP975_27365
SGM: GCM10017557_68710
SCAD: DN051_31405
SPHW: NFX46_27760
SLS: SLINC_1640
SNR: SNOUR_33165
SALU: DC74_1908
SALL: SAZ_10120
SPLU: LK06_003985
STRD: NI25_31935
SNW: BBN63_29450
SAUO: BV401_17055 BV401_36765
SSIA: A7J05_29765
SVU: B1H20_04230
SPUN: BFF78_34345
SGV: B1H19_09260 B1H19_30785
SLAU: SLA_0954
SALF: SMD44_01484 SMD44_07575
SALJ: SMD11_5570
SLX: SLAV_08180(iaaM1) SLAV_30455(iaaM2)
STRO: STRMOE7_07825
SFK: KY5_1236c
SNZ: DC008_05320
SGE: DWG14_07044(iaaM)
SRJ: SRO_6028
SLK: SLUN_06565
SDX: C4B68_33600
SGD: ELQ87_32500
SQZ: FQU76_04085
SCYA: EJ357_08035
SAST: CD934_28455
SNQ: CP978_06815
STIR: DDW44_11275
SKA: CP970_36610
SGZ: C0216_20655
SVN: CP980_27695
SNK: CP967_29140
SHAW: CEB94_07595
SRK: FGW37_05775
SFIC: EIZ62_27970
SGAL: CP966_05645
SSPO: DDQ41_11325
SPAD: DVK44_03165 DVK44_35645
SFY: GFH48_33265
SAQU: EJC51_09830
SGF: HEP81_06337
SCAV: CVT27_03865
SSEO: D0Z67_04190
SBY: H7H31_03770 H7H31_05640
SRIM: CP984_34420
SSUB: CP968_27340
SPHV: F9278_06750
SCIN: CP977_06250
SFUG: CNQ36_05825
SPAC: B1H29_30325
STSU: B7R87_04060
SCHA: CP983_35925
SGX: H4W23_07170
SCOE: CP976_08235
SBAT: G4Z16_29730
SSPB: CP982_08605 CP982_34935
SNF: JYK04_02077(iaaM_1) JYK04_07278(iaaM_2)
SPLA: CP981_04500 CP981_06945
SBRO: GQF42_09830
STUI: GCM10017668_10290
SATA: C5746_07755
SCHF: IPT68_06350
SHUN: DWB77_06298(iaaM_2)
SCYG: S1361_08065(iaaM)
SFEU: IM697_15435
SLIA: HA039_28955
SDW: K7C20_06045
SVD: CP969_08230
SCAL: I6J39_04415
SAUH: SU9_005005
SFB: CP974_03685
SMOB: J7W19_04790
SPRA: CP972_06305
SROI: IAG44_33300
SXN: IAG42_29810
SGJ: IAG43_04625
SHK: J2N69_05330
SANU: K7396_29765
STRY: EQG64_03855
SDD: D9753_29615
SACT: DMT42_06215
SGOB: test1122_00480
SINE: KI385_09355
SLF: JEQ17_38525
SDEC: L3078_08300
SAOV: G3H79_02390 G3H79_03845 G3H79_31475
SDUR: M4V62_34815
SYAN: NRK68_06195
SRUG: F0345_03300
SAKB: K1J60_37155
STAA: LDH80_32265
SNIG: HEK616_21040
SVIO: HWN34_27225
SCAE: IHE65_37260
STUB: MMF93_04935
SSPN: LXH13_07210
SCIR: STRCI_001500
SXT: KPP03845_101655(iaaM)
SLON: LGI35_10455
SDRZ: NEH16_26810
STUD: STRTU_005980
STEE: F3L20_10585
SENG: OJ254_21195
SGK: PET44_03345 PET44_06005
SANT: QR300_08415 QR300_27920
SYUN: MOV08_33525
SARG: HKX69_28950
SJN: RI060_35240
SCYN: N8I84_07945
SOV: QZH56_07110 QZH56_30235
SFIY: F0344_31260
SHAU: K9S39_35895
SKG: KJK29_32115
SCOA: QU709_36470
SLAI: P8A22_32730
SROC: RGF97_28795
SFP: QUY26_04820 QUY26_33860
SCHG: NRO40_04070
STTN: BSL84_05880
SINN: ABB07_31555
STRZ: OYE22_03620 OYE22_05450
SCAY: PYS65_30100
KBU: Q4V64_08970 Q4V64_44590
SARM: DVA86_12425
SLUO: PS467_15440 PS467_34045
STPB: QR97_29880
SRPA: HEP86_06015 HEP86_08125
SMIB: SMIR_32705
SCAJ: O1G22_34520
STRW: QHG49_28970
STRL: HEP84_12200
SRPZ: HEP85_08010
SCT: SCAT_5364
SCY: SCATT_53630
KAB: B7C62_03830
ABRY: NYE86_12525
AGLA: OIE69_32355
FRP: AX769_07645
ART: Arth_1110
ARR: ARUE_c11570(iaaM)
ARE: AL755_05460
ARW: MB46_01795
ARH: AHiyo8_18570 AHiyo8_18580
ARQ: BWQ92_04225
ARN: CGK93_06470
ARX: ARZXY2_2790
ACRY: AC20117_05745
ARTH: C3B78_05455
ARTP: E5206_17715
AWW: G8758_00920
AOD: Q8Z05_13410
ARTZ: FCN77_06495
AAU: AAur_1221
PUE: FV140_06155
PNV: JMY29_05780
PAYJ: HMI59_15545
PAGO: IRJ34_05920
ARZ: AUT26_05370
ACH: Achl_1186
APN: Asphe3_11460
PSUL: AU252_04545 AU252_09225 AU252_13885
PSNI: NIBR502771_19895
PSEY: GU243_22225
PDEL: JCQ34_05505
POK: SMD14_05930
PSLS: KTR40_05445
PSFE: NG819_19140
GAR: AOZ07_00795
GCR: GcLGCM259_0537
GMI: NMP99_00890
GLM: N6V40_01895
KPL: KPaMU14_03965
MLY: CJ228_008960
MTEU: R3I42_02550
AUL: DCC27_008990 DCC27_010520
AIG: QDX25_08920 QDX25_10500
CMUA: P8192_14180
PAEY: KUF55_14615
DNI: HX89_12990
DAY: FV141_12400
DERM: H7F30_04980
NOO: FE634_14640
NBE: Back2_10550
PSIM: KR76_13980
NDA: Ndas_3618
NAL: B005_0760
NGV: CDO52_09335
NEX: NE857_27230
NAKE: KGD83_07095
NCG: KGD84_06415
SNAH: OUQ99_05910
GOB: Gobs_1732
BSD: BLASA_1708
KRA: Krad_1432
AMD: AMED_6946
AMN: RAM_35635
AMM: AMES_6839
AMZ: B737_6839
AOI: AORI_2933 AORI_4877
AJA: AJAP_12350 AJAP_15180
AMYC: CU254_28105
AMYB: BKN51_07110 BKN51_16800
AAB: A4R43_38290
AMYY: YIM_39760(iaaM)
AORI: SD37_24115 SD37_26610
APRT: MUY14_01825
AROO: NQK81_07630 NQK81_42530
ARHD: VSH64_12465 VSH64_24170
AMOG: QRX60_24320
ACOR: LCL61_04105 LCL61_30890
PSEA: WY02_17480
PSEE: FRP1_25145
PSEH: XF36_24010
PSEQ: AD006_04325
PECQ: AD017_12145
PHH: AFB00_09870
PAUT: Pdca_02760
UME: RM788_38700
PFLA: Pflav_056910
PSUU: Psuf_016500
CAI: Caci_8157
 » show all
Reference
1  [PMID:4624115]
  Authors
Nakazawa T, Hori K, Hayaishi O.
  Title
Studies on monooxygenases. V. Manifestation of amino acid oxidase activity by L-lysine monooxygenase.
  Journal
J Biol Chem 247:3439-44 (1972)
Reference
2  [PMID:5911646]
  Authors
Takeda H, Hayaishi O.
  Title
Crystalline L-lysine oxygenase.
  Journal
J Biol Chem 241:2733-6 (1966)
Reference
3  [PMID:5772467]
  Authors
Takeda H, Yamamoto S, Kojima Y, Hayaishi O.
  Title
Studies on monooxygenases. I. General properties of crystalline L-lysine monooxygenase.
  Journal
J Biol Chem 244:2935-41 (1969)
Other DBs
ExplorEnz - The Enzyme Database: 1.13.12.2
IUBMB Enzyme Nomenclature: 1.13.12.2
ExPASy - ENZYME nomenclature database: 1.13.12.2
BRENDA, the Enzyme Database: 1.13.12.2
CAS: 9031-22-5

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Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (618)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (573)   
   KEGG MGENES (44)   
Protein sequence (22)   
   UniProt (22)   
DNA sequence (152)   
   GenBank (77)   
   EMBL (75)   
All databases (806)   

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