KEGG   ENZYME: 1.13.12.2Help
Entry
EC 1.13.12.2                Enzyme                                 

Name
lysine 2-monooxygenase;
lysine oxygenase;
lysine monooxygenase;
L-lysine-2-monooxygenase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
BRITE hierarchy
Sysname
L-lysine:oxygen 2-oxidoreductase (decarboxylating)
Reaction(IUBMB)
L-lysine + O2 = 5-aminopentanamide + CO2 + H2O [RN:R00449]
Reaction(KEGG)
Substrate
L-lysine [CPD:C00047];
O2 [CPD:C00007]
Product
5-aminopentanamide [CPD:C00990];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD). Also acts on other diamino acids.
History
EC 1.13.12.2 created 1972
Pathway
ec00310  Lysine degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K00468  lysine 2-monooxygenase
Genes
PAP: PSPA7_3191
PRE: PCA10_04900
PCQ: PcP3B5_32620(iaaM)
PPU: PP_0383(davB)
PPF: Pput_0407
PPG: PputGB1_0411
PPW: PputW619_4820
PPT: PPS_0377
PPB: PPUBIRD1_0418
PPI: YSA_05771
PPX: T1E_2171
PPUH: B479_02390
PPUT: L483_01950
PPUN: PP4_04120
PPUD: DW66_0391
PMON: X969_00210
PMOT: X970_00210
PSB: Psyr_4667
PSYR: N018_02455
PFL: PFL_5670
PPRC: PFLCHA0_c56220(iaaM)
PPRO: PPC_5615
PMAN: OU5_4020
PEN: PSEEN0401
PPUU: PputUW4_04962(iaaM)
PKC: PKB_2893
PSES: PSCI_1278
PSOS: POS17_5602
PANR: A7J50_5326
PSET: THL1_442
PSIL: PMA3_27685
GAI: IMCC3135_25895(iaaM)
HYB: Q5W_21180
RDE: RD1_1495
KRO: BVG79_p1000114(iaaM)
CID: P73_2156
SPSE: SULPSESMR1_04820(iaaM)
ACR: Acry_2670
MAB: MAB_0818
ASD: AS9A_4558
RER: RER_05790
REY: O5Y_02765
ROP: ROP_33250
RHB: NY08_2002
RFA: A3L23_00334(iaaM)
RHS: A3Q41_03073(iaaM)
GOM: D7316_04814(iaaM)
TPR: Tpau_1414
SCO: SCO1454(SCL6.11c)
SALB: XNR_5396
SGR: SGR_6070
SGB: WQO_05045
SCT: SCAT_5364
SFA: Sfla_5404
SHY: SHJG_2887
SVE: SVEN_1051
SALS: SLNWT_6481
STRP: F750_1215
SFI: SFUL_973
SALU: DC74_1908
SALL: SAZ_10120
STRE: GZL_07240
SPRI: SPRI_6108
SRW: TUE45_01867(iaaM)
SLE: sle_56450(sle_56450)
SRN: A4G23_00701(iaaM)
STRD: NI25_31935
SLAU: SLA_0954
SALJ: SMD11_5570
SLX: SLAV_08180(iaaM1) SLAV_30455(iaaM2)
SFK: KY5_1236c
ART: Arth_1110
ARR: ARUE_c11570(iaaM)
AAU: AAur_1221
ACH: Achl_1186
PSIM: KR76_13980
NDA: Ndas_3618
NAL: B005_0760
GOB: Gobs_1732
KRA: Krad_1432
AMD: AMED_6946
AMN: RAM_35635
AMM: AMES_6839
AMZ: B737_6839
PSEA: WY02_17480
PSEE: FRP1_25145
PSEH: XF36_24010
CAI: Caci_8157
 » show all
Taxonomy
Reference
1  [PMID:4624115]
  Authors
Nakazawa T, Hori K, Hayaishi O.
  Title
Studies on monooxygenases. V. Manifestation of amino acid oxidase activity by L-lysine monooxygenase.
  Journal
J Biol Chem 247:3439-44 (1972)
Reference
2  [PMID:5911646]
  Authors
Takeda H, Hayaishi O.
  Title
Crystalline L-lysine oxygenase.
  Journal
J Biol Chem 241:2733-6 (1966)
Reference
3  [PMID:5772467]
  Authors
Takeda H, Yamamoto S, Kojima Y, Hayaishi O.
  Title
Studies on monooxygenases. I. General properties of crystalline L-lysine monooxygenase.
  Journal
J Biol Chem 244:2935-41 (1969)
Other DBs
ExplorEnz - The Enzyme Database: 1.13.12.2
IUBMB Enzyme Nomenclature: 1.13.12.2
ExPASy - ENZYME nomenclature database: 1.13.12.2
BRENDA, the Enzyme Database: 1.13.12.2
CAS: 9031-22-5

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