| Entry |
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| Name |
tetracenomycin-F1 monooxygenase;
tcmH (gene name)
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| Class |
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
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| Sysname |
tetracenomycin-F1:oxygen C5-monooxygenase
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| Reaction(IUBMB) |
tetracenomycin F1 + O2 = tetracenomycin D3 + H2O [RN: R06700]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme is involved in biosynthesis of the anthracycline antibiotic tetracenomycin C by the bacterium Streptomyces glaucescens.
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| History |
EC 1.13.12.21 created 2013
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| Pathway |
| ec01057 | Biosynthesis of type II polyketide products |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K15969 | tetracenomycin F1 monooxygenase |
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| Genes |
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| Reference |
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| Authors |
Shen B, Hutchinson CR |
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| Title |
Tetracenomycin F1 monooxygenase: oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin C in Streptomyces glaucescens. |
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| Journal |
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| Other DBs |
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