Entry |
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Name |
tetracenomycin-F1 monooxygenase;
tcmH (gene name)
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Class |
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
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Sysname |
tetracenomycin-F1:oxygen C5-monooxygenase
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Reaction(IUBMB) |
tetracenomycin F1 + O2 = tetracenomycin D3 + H2O [RN: R06700]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
The enzyme is involved in biosynthesis of the anthracycline antibiotic tetracenomycin C by the bacterium Streptomyces glaucescens.
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History |
EC 1.13.12.21 created 2013
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Pathway |
ec01057 | Biosynthesis of type II polyketide products |
ec01110 | Biosynthesis of secondary metabolites |
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Orthology |
K15969 | tetracenomycin F1 monooxygenase |
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Genes |
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Reference |
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Authors |
Shen B, Hutchinson CR |
Title |
Tetracenomycin F1 monooxygenase: oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin C in Streptomyces glaucescens. |
Journal |
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Other DBs |
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