KEGG   ENZYME: 1.13.12.22Help
Entry
EC 1.13.12.22               Enzyme                                 

Name
deoxynogalonate monooxygenase;
SnoaB (gene name);
12-deoxynogalonic acid oxidoreductase;
[4,5-dihydroxy-10-oxo-3-(3-oxobutanoyl)-9,10-dihydroanthracen-2-yl]acetate oxidase;
[4,5-dihydroxy-10-oxo-3-(3-oxobutanoyl)-9,10-dihydroanthracen-2-yl]acetate monooxygenase;
deoxynogalonate oxidoreductase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
BRITE hierarchy
Sysname
deoxynogalonate:oxygen oxidoreductase
Reaction(IUBMB)
deoxynogalonate + O2 = nogalonate + H2O [RN:R09327]
Reaction(KEGG)
Substrate
deoxynogalonate [CPD:C18629];
O2 [CPD:C00007]
Product
nogalonate [CPD:C12416];
H2O [CPD:C00001]
Comment
The enzyme, characterized from the bacterium Streptomyces nogalater, is involved in the biosynthesis of the aromatic polyketide nogalamycin.
History
EC 1.13.12.22 created 2015
Pathway
ec01057  Biosynthesis of type II polyketide products
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K15941  deoxynogalonate / 12-deoxyaklanonic acid monooxygenase
Genes
MAU: Micau_3995
MIL: ML5_4426
Taxonomy
Reference
1  [PMID:19255477]
  Authors
Koskiniemi H, Grocholski T, Schneider G, Niemi J.
  Title
Expression, purification and crystallization of the cofactor-independent monooxygenase SnoaB from the nogalamycin biosynthetic pathway.
  Journal
Acta Crystallogr Sect F Struct Biol Cryst Commun 65:256-9 (2009)
DOI:10.1107/S1744309109001389
  Sequence
Reference
2  [PMID:20052967]
  Authors
Grocholski T, Koskiniemi H, Lindqvist Y, Mantsala P, Niemi J, Schneider G.
  Title
Crystal structure of the cofactor-independent monooxygenase SnoaB from Streptomyces nogalater: implications for the reaction mechanism.
  Journal
Biochemistry 49:934-44 (2010)
DOI:10.1021/bi901985b
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.13.12.22
IUBMB Enzyme Nomenclature: 1.13.12.22
ExPASy - ENZYME nomenclature database: 1.13.12.22
BRENDA, the Enzyme Database: 1.13.12.22

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