KEGG   ENZYME: 1.13.12.23Help
Entry
EC 1.13.12.23               Enzyme                                 

Name
4-hydroxy-3-prenylbenzoate synthase;
CloR;
novR (gene name)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
BRITE hierarchy
Sysname
3-dimethylallyl-4-hydroxymandelate:oxygen oxidoreductase (3-dimethylallyl-4-hydroxybenzoate forming)
Reaction(IUBMB)
3-dimethylallyl-4-hydroxymandelate + O2 = 3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O [RN:R06759]
Reaction(KEGG)
Substrate
3-dimethylallyl-4-hydroxymandelate [CPD:C12457];
O2 [CPD:C00007]
Product
3-dimethylallyl-4-hydroxybenzoate [CPD:C12458];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
Isolated from the bacterium Streptomyces roseochromogenes DS 12976. A bifunctional enzyme involved in clorobiocin biosynthesis that also catalyses the activity of EC 1.13.11.83, 3-dimethylallyl-4-hydroxyphenylpyruvate oxygenase.
History
EC 1.13.12.23 created 2017
Pathway
ec00401  Novobiocin biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K12708  4-hydroxy-3-prenylphenylpyruvate oxygenase / 4-hydroxy-3-prenylbenzoate synthase
Genes
NGV: CDO52_02235
Taxonomy
Reference
1  [PMID:12777382]
  Authors
Pojer F, Kahlich R, Kammerer B, Li SM, Heide L.
  Title
CloR, a bifunctional non-heme iron oxygenase involved in clorobiocin biosynthesis.
  Journal
J Biol Chem 278:30661-8 (2003)
DOI:10.1074/jbc.M303190200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.13.12.23
IUBMB Enzyme Nomenclature: 1.13.12.23
ExPASy - ENZYME nomenclature database: 1.13.12.23
BRENDA, the Enzyme Database: 1.13.12.23

DBGET integrated database retrieval system