KEGG   ENZYME: 1.13.12.3
Entry
EC 1.13.12.3                Enzyme                                 
Name
tryptophan 2-monooxygenase;
tms1 (gene name);
iaaM (gene name)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
Sysname
L-tryptophan:oxygen 2-oxidoreductase (decarboxylating)
Reaction(IUBMB)
L-tryptophan + O2 = (indol-3-yl)acetamide + CO2 + H2O [RN:R00679]
Reaction(KEGG)
R00679
Substrate
L-tryptophan [CPD:C00078];
O2 [CPD:C00007]
Product
(indol-3-yl)acetamide [CPD:C02693];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
The enzyme, studied from phytopathogenic bacteria such as Pseudomonas savastanoi, is involved in a pathway for the production of (indol-3-yl)acetate (IAA), the main auxin hormone in plants.
History
EC 1.13.12.3 created 1972
Pathway
ec00380  Tryptophan metabolism
ec01100  Metabolic pathways
Orthology
K00466  tryptophan 2-monooxygenase
Genes
DDDDda3937_01279(iaaM)
DZEDd1591_3740
DDQDDI_0143
XPOXPG1_3347(iaaM)
PPXT1E_2997(tms1)
PMOLCLJ08_06530
PSBPsyr_1536
PSAVPSA3335_04970 PSA3335_08060
PPUUPputUW4_04530
PSKU771_11280
PCHEY04_07115
PCPJM49_22735
PALKPSAKL28_12370
PFKPFAS1_16505 PFAS1_24260
PSILPMA3_04010
PKEDLD99_22935
PUMHGP31_05200
PGYAWU82_26715
PMOEHV782_023230
PTRTHU722_0011280
PXAKSS93_09455
PTZHU718_024505
PPRGHU725_005485
PANHHU763_018735
PASGKSS96_10575
PFAKKSS94_06230 KSS94_06240
PMUYKSS95_09070
PALVKSS97_05990
PZAHU749_024435
PIEHU724_023385
PLZS4054249_10845
CHROCXB49_19800
BVIBcep1808_4425
BVEAK36_4384
BCMBcenmc03_5898
BDFWI26_18500
BSEMWJ12_25165
BSTLBBJ41_18175
BUGBC1001_PA6282(iaaM)
BGFBC1003_3608
BUKMYA_4068
BUQAC233_33840
BXEBxe_C1245
BXBDR64_8566
BPHBphy_7769
BGEBC1002_6868
BPXBUPH_04753
PGPCUJ91_23665
PTSCUJ90_30820
PEWKZJ38_12030
CABASBC2_51600(iaaM)
MLNA9174_14565
MJREB229_14710
ATUAtu6011(tms1)
ATFAch5_51170(tms1)
AVIAvi_8288(tms1)
AROB0909_24545
ALFCFBP5473_23865
ARUIG6M88_25340
NENNCHU2750_55450(tms1)
LCCB488_04010
ECOGFIV45_03270
SNEANBZ79_18910
MVAGD0A34_16065
 » show all
Reference
1  [PMID:5916389]
  Authors
Kosuge T, Heskett MG, Wilson EE.
  Title
Microbial synthesis and degradation of indole-3-acetic acid. I. The conversion of L-tryptophan to indole-3-acetamide by an enzyme system from Pseudomonas savastanoi.
  Journal
J Biol Chem 241:3738-44 (1966)
Reference
2
  Authors
Kuo, T.T. and Kosuge, T.
  Title
Factors influencing the production and further metabolism of indole-3-acetic acid by Pseudomonas savastanoi.
  Journal
J Gen Appl Microbiol 15:51-63 (1969)
Reference
3  [PMID:3997822]
  Authors
Hutcheson SW, Kosuge T
  Title
Regulation of 3-indoleacetic acid production in Pseudomonas syringae pv. savastanoi. Purification and properties of tryptophan 2-monooxygenase.
  Journal
J Biol Chem 260:6281-7 (1985)
Reference
4
  Authors
Onckelen, H.V., Prinsen, E., Inze, D., Ruedeisheim, P., Lijsebettens, M.V., Follin, A., Schell, J., Montagu, M.V. and Greef, J.D.
  Title
AgrobacteriumT-DNA gene1codes for tryptophan 2-monooxygenase activity in tobacco crown gall cells.
  Journal
FEBS Lett 198:357-360 (1986)
Reference
5  [PMID:7893667]
  Authors
Emanuele JJ, Fitzpatrick PF
  Title
Mechanistic studies of the flavoprotein tryptophan 2-monooxygenase. 1. Kinetic mechanism.
  Journal
Biochemistry 34:3710-5 (1995)
DOI:10.1021/bi00011a028
Other DBs
ExplorEnz - The Enzyme Database: 1.13.12.3
IUBMB Enzyme Nomenclature: 1.13.12.3
ExPASy - ENZYME nomenclature database: 1.13.12.3
BRENDA, the Enzyme Database: 1.13.12.3
CAS: 37256-65-8

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