KEGG   ENZYME: 1.13.12.3Help
Entry
EC 1.13.12.3                Enzyme                                 

Name
tryptophan 2-monooxygenase;
tms1 (gene name);
iaaM (gene name)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
BRITE hierarchy
Sysname
L-tryptophan:oxygen 2-oxidoreductase (decarboxylating)
Reaction(IUBMB)
L-tryptophan + O2 = (indol-3-yl)acetamide + CO2 + H2O [RN:R00679]
Reaction(KEGG)
Substrate
L-tryptophan [CPD:C00078];
O2 [CPD:C00007]
Product
(indol-3-yl)acetamide [CPD:C02693];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
The enzyme, studied from phytopathogenic bacteria such as Pseudomonas savastanoi, is involved in a pathway for the production of (indol-3-yl)acetate (IAA), the main auxin hormone in plants.
History
EC 1.13.12.3 created 1972
Pathway
ec00380  Tryptophan metabolism
Orthology
K00466  tryptophan 2-monooxygenase
Genes
DDD: Dda3937_01279(iaaM)
DZE: Dd1591_3740
DDQ: DDI_0143
XPO: XPG1_3347(iaaM)
PSB: Psyr_1536
PCH: EY04_07115
PCP: JM49_22735
PFK: PFAS1_24260
PLZ: S4054249_10845
CHRO: CXB49_19800
BVE: AK36_4384
BSEM: WJ12_25165
BUG: BC1001_PA6282(iaaM)
BUK: MYA_4068
BXE: Bxe_C1245
BXB: DR64_8566
BPH: Bphy_7769
ATU: Atu6011(tms1)
ATF: Ach5_51170(tms1)
AVI: Avi_8288(tms1)
NEN: NCHU2750_55450(tms1)
 » show all
Taxonomy
Reference
1  [PMID:5916389]
  Authors
Kosuge T, Heskett MG, Wilson EE.
  Title
Microbial synthesis and degradation of indole-3-acetic acid. I. The conversion of L-tryptophan to indole-3-acetamide by an enzyme system from Pseudomonas savastanoi.
  Journal
J Biol Chem 241:3738-44 (1966)
Reference
2
  Authors
Kuo, T.T. and Kosuge, T.
  Title
Factors influencing the production and further metabolism of indole-3-acetic acid by Pseudomonas savastanoi.
  Journal
J Gen Appl Microbiol 15:51-63 (1969)
Reference
3  [PMID:3997822]
  Authors
Hutcheson SW, Kosuge T
  Title
Regulation of 3-indoleacetic acid production in Pseudomonas syringae pv. savastanoi. Purification and properties of tryptophan 2-monooxygenase.
  Journal
J Biol Chem 260:6281-7 (1985)
Reference
4
  Authors
Onckelen, H.V., Prinsen, E., Inze, D., Ruedeisheim, P., Lijsebettens, M.V., Follin, A., Schell, J., Montagu, M.V. and Greef, J.D.
  Title
AgrobacteriumT-DNA gene1codes for tryptophan 2-monooxygenase activity in tobacco crown gall cells.
  Journal
FEBS Lett 198:357-360 (1986)
Reference
5  [PMID:7893667]
  Authors
Emanuele JJ, Fitzpatrick PF
  Title
Mechanistic studies of the flavoprotein tryptophan 2-monooxygenase. 1. Kinetic mechanism.
  Journal
Biochemistry 34:3710-5 (1995)
Other DBs
ExplorEnz - The Enzyme Database: 1.13.12.3
IUBMB Enzyme Nomenclature: 1.13.12.3
ExPASy - ENZYME nomenclature database: 1.13.12.3
BRENDA, the Enzyme Database: 1.13.12.3
CAS: 37256-65-8

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