KEGG   ENZYME: 1.13.12.4
Entry
EC 1.13.12.4                Enzyme                                 
Name
lactate 2-monooxygenase;
lactate oxidative decarboxylase;
lactate oxidase;
lactic oxygenase;
lactate oxygenase;
lactic oxidase;
L-lactate monooxygenase;
lactate monooxygenase;
L-lactate-2-monooxygenase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
Sysname
(S)-lactate:oxygen 2-oxidoreductase (decarboxylating)
Reaction(IUBMB)
(S)-lactate + O2 = acetate + CO2 + H2O [RN:R00319]
Reaction(KEGG)
R00319
Substrate
(S)-lactate [CPD:C00186];
O2 [CPD:C00007]
Product
acetate [CPD:C00033];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
A flavoprotein (FMN).
History
EC 1.13.12.4 created 1961 as EC 1.1.3.2, transferred 1972 to EC 1.13.12.4
Pathway
ec00620  Pyruvate metabolism
ec01100  Metabolic pathways
Orthology
K00467  lactate 2-monooxygenase
Genes
LAK106155094
QSU112002987 112040353
LTHKLTH0H16148g
TDLTDEL_0A08010(TDEL0A08010)
TGBHG536_0E00120 HG536_0G00120
PANPODANSg5965
TTTTHITE_2113301
MTMMYCTH_2137000
MGRMGG_16456
PPEIPpBr36_05228
TMNUCRPA7_7665
SSCKSPSK_03321
FGRFGSG_03439 FGSG_03984
FPUFPSE_05293 FPSE_08362
FVRFVEG_10135 FVEG_13676
FOXFOXG_11687 FOXG_16560
NHENECHADRAFT_104292 NECHADRAFT_82845
TRETRIREDRAFT_53302
TRRM419DRAFT_4620
MAWMAC_03786
MAJMAA_04225
CMTCCM_06299
PLJVFPFJ_05083
CFJCFIO01_10237
CLUPCLUP02_05750
CHIGCH63R_00806
PFYPFICI_01208 PFICI_08828
SSLSS1G_04795
BFUBCIN_01g02870
PSCOLY89DRAFT_669394 LY89DRAFT_777475
ANIAN8587.2 AN8744.2
AFMAFUA_1G00500 AFUA_6G02720 AFUA_8G06000
ACTACLA_059400 ACLA_097750
NFINFIA_049040 NFIA_098780
AORAO090003001007 AO090120000165
ANGANI_1_238014(An01g01880) ANI_1_998104(An12g08270)
AFVAFLA_000661 AFLA_009385
ALUCAKAW2_20378A AKAW2_61174A
ACHEACHE_10449S ACHE_50863A ACHE_60535A
APUUAPUU_10549A APUU_61297A APUU_61466S
PCSPc22g24130
PDPPDIP_26590
TMFPMAA_093230
TRGTRUGW13939_07118
PNOSNOG_07595
PTEPTT_11971
BZECOCCADRAFT_25134
BSCCOCSADRAFT_31848
BORCOCMIDRAFT_92461
AALTCC77DRAFT_402943 CC77DRAFT_949939
ZTRMYCGRDRAFT_100239 MYCGRDRAFT_75580
PFJMYCFIDRAFT_216799
FFUCLAFUR5_11374
BCOMBAUCODRAFT_37000
NPAUCRNP2_7524 UCRNP2_8491
SPOSPAPB1A11.03
TVSTRAVEDRAFT_32144
DSQDICSQDRAFT_141721
PCOPHACADRAFT_265499
SHSSTEHIDRAFT_110458 STEHIDRAFT_122144 STEHIDRAFT_131803
HIRHETIRDRAFT_440215(lmo1)
PSQPUNSTDRAFT_41912
ADLAURDEDRAFT_111456 AURDEDRAFT_188206
FMEFOMMEDRAFT_96364
GTRGLOTRDRAFT_121815 GLOTRDRAFT_139316
LBCLACBIDRAFT_230911
CCICC1G_03412
ABPAGABI1DRAFT106734(AGABI1DRAFT_106734) AGABI1DRAFT128349(AGABI1DRAFT_128349)
ABVAGABI2DRAFT119340(AGABI2DRAFT_119340) AGABI2DRAFT179188(AGABI2DRAFT_179188)
PCUBJR316_0006975
MRRMoror_11589
MOREE1B28_012807
SCMSCHCO_02244746(SCHCODRAFT_02244746) SCHCO_02498556(SCHCODRAFT_02498556)
CPUTCONPUDRAFT_144284 CONPUDRAFT_159793 CONPUDRAFT_159794
SLASERLADRAFT_449858
UMAUMAG_12269
PFPPFL1_03774
MGLMGL_4274
MRTMRET_3385 MRET_3388
NAXHC341_07450
SALNSALB1_1431
ATERMW290_09170
BBAEFRD01_06530
MESPC1M53_29045
MESOBSQ44_03655
NIYFQ775_18610
BVZBRAD3257_1893
BBARRHAL1_01593
PSTGE8M01_02990
CCRCC_1396
CCSCCNA_01462
CHQAQ619_13805
CAUFCSW63_13370
BGOEIFJ75_03175
TSVDSM104635_01034
CBOTATE48_15170
SGISGRAN_1891
SPHOC3E99_09600
STAXMC45_12445
SNJA7E77_08850
SMYBJP26_04730
SPHFDM480_02070
SPAIFPZ24_05885
SARIH5J25_03190
SSUAFPZ54_11690
SAERNEF64_17855
SPZRG5C33_13540
POQKZX46_02625
AEPAMC99_02085
EFVCHH26_10045
ELQGa0102493_111935
ERKCD351_13195
ERFFIU90_13055
PNSA9D12_00870
PORLBG023_112498
PHZCHX26_13775
POTE2E27_08390
BAOBAMF_2066(lldA)
BAZBAMTA208_07170(lldA)
BQLLL3_02170
BXHBAXH7_01458
BFDNCTC4823_01446
BBADK7T73_19440
BACOOXB_1571
BHKB4U37_21375
BCOHBC6307_00055 BC6307_20065
BKWBkAM31D_07910
BONA361_02260
BKOCKF48_06915
CGOTJ1899_19100
CFIRNAF01_02250
OCNCUC15_16050
LSPBsph_0911
LFUHR49_21515
LYSLBYS11_02320
LYBC3943_02925
LYGC1N55_10570
LPAKGDS87_02415
LAGRFJQ98_02770
LMACI6G82_16085
LCAPICJ70_22230
HHDHBHAL_5002
HMNHM131_02380
TAPGZ22_00630
TAIDKS242_01890
VIRX953_19540
VHLBME96_18650
VIMGWK91_05300
PSYHD0S48_03290 D0S48_10995
PSYOPB01_07965
GRCGI584_08935
RUEDT065_15660
SALEEPH95_15575
SCIBHUG20_03980
SCIAHUG15_05180
BVQFHE72_19350
GAJMY490_12440
SLMSMM221_07335
BBEBBR47_10990
BFMBP422_00845
BAGRBA6348_23275
BCHSJNE38_05790
PNPIJ22_14970
PKBB4V02_21435
PLYCGXP70_16545
AACAaci_0905
AADTC41_0915(lldD)
ACURJZ785_09490
PMARB0X71_01400
SPSYAZE41_00320
SPAEE2C16_10890
NTRB0W44_09070
KPULGXN76_05410
KEBGXN75_12685
CPROCPRO_00360(lldD)
THEPDYI95_006990
MPAMAP_2959c MAP_3486
MAOMAP4_0291 MAP4_0845
MAVIRC58_01375 RC58_04155
MAVURE97_01385 RE97_04155
MAVMAV_3747 MAV_4345
MITOCO_35830 OCO_42100
MIAOCU_35880 OCU_42020
MIDMIP_05418 MIP_06345
MYOOEM_36440 OEM_42450
MCHIAN480_18940 AN480_22085
MIROCQ_37050 OCQ_43370
MMALCKJ54_16950 CKJ54_20120
MLPMLM_2976
MMANMMAN_02010 MMAN_30200
MSAMycsm_02356 Mycsm_04358
MMIMMAR_1816(lldD1_1)
MMAEMMARE11_17430(lldD1_1)
MLIMULP_01974(lldD1_1)
MPSEMPSD_40160
MSHOMSHO_54070
MMCMmcs_1989
MKMMkms_2035
MJLMjls_1969
MMMW7S_17900 W7S_21070
MKNMKAN_20375 MKAN_24315
MYVG155_11870
MYEAB431_22605
MGOAFA91_20360 AFA91_26970
MHADB586_03080
MDXBTO20_22945
MSHGMSG_01679
MFJMFLOJ_16240
MSTOMSTO_17740
MSIMMSIM_06990 MSIM_46600
MSAKMSAS_53980
MKUI2456_01065 I2456_09140
MGROFZ046_07485 FZ046_16250
MXEMYXE_32880
MNVMNVI_13100 MNVI_32110
MPAGC0J29_10565
MNMMNVM_34320
MGORH0P51_10095
MCOOMCOO_00500
MBAIMB901379_01632
MSEOMSEO_04670
MHEKJMUB5695_03279
MGAUMGALJ_06840
MBRDMBRA_19040 MBRA_47500
MKRMKOR_16820
MDFK0O62_11390
MMAMK3U93_08050
MHOLK3U96_16700
MHERK3U94_14910
MSENK3U95_17940
MPAEK0O64_22190
MOTLTS72_15725
MVMMJO54_14915
MRFMJO55_09985
MPAAMKK62_16125
MCROMI149_22575
MSMMSMEG_2512 MSMEG_3962
MSGMSMEI_2453 MSMEI_3870
MSBLJ00_12505 LJ00_19690
MSNLI99_12505 LI99_19695
MSHLI98_12510 LI98_19700
MVAMvan_2206
MGIMflv_4136
MSPMspyr1_34790
MCBMycch_1962 Mycch_5226
MNED174_11200
MYNMyAD_10985
MFTXA26_24420
MPHLMPHLCCUG_02156 MPHLCCUG_03229
MVQMYVA_2110
MLLB1R94_07495
MRHMycrhN_5780
MTHN4412656_01635
MHASMHAS_00210 MHAS_02543
MDUMDUV_22960
MCHTMCHIJ_27650
MDRMDOR_13790
MAUUNCTC10437_02058
MMAGMMAD_21890
MMORMMOR_42480
MFXMFAL_39590
MAICMAIC_40150
MIJMINS_36830
MALVMALV_14880
MTYMTOK_01750
MPSCMPSYJ_44590
MARZMARA_18350 MARA_41370(lctB)
MGADMGAD_17190
MSARMSAR_29110
MANYMANY_23540
MAUBMAUB_55030
MPOFMPOR_25350
MPHUMPHO_14110
MMUCC1S78_011225
MMATMMAGJ_54710
MBOKMBOE_50540
MFGK6L26_20375
MSEIMSEDJ_34190
MFLVNCTC10271_03306
MCEEMCEL_15270
MBRML2Z93_000960
MABMAB_2126
MMVMYCMA_1114
MABBMASS_2049
MABLMMASJCM_2075
MCHEBB28_10665
MIZBAB75_11395
MSTEMSTE_02060
MSAOMYCSP_09070
MSALDSM43276_01841
MJDJDM601_2615(lldD1_1)
MTER4434518_02563(lldD1_1)
MMINMMIN_03160
MHIBMHIB_20560
ASDAS9A_0040
MPAKMIU77_12450
CVACVAR_1459(lldA)
CTERA606_05680
CGYCGLY_08565
CCYCSCMU_04630
NFANFA_2230
NFRERS450000_04015
NCYNOCYR_0180
NBRO3I_025715
NNONONO_c21530
NSLBOX37_23865
NSRNS506_00840 NS506_04199
NTPCRH09_01015
NOZDMB37_05110
NODFOH10_10575 FOH10_30525
NAHF5544_01080
NADNCTC11293_05745
NWLNWFMUON74_01680
NIEKV110_00925 KV110_22270 KV110_25410
NTCKHQ06_06990
NHUH0264_02265 H0264_30695 H0264_36405
NYALTV02_29740 LTV02_30520
NGPLTT66_13810 LTT66_28285
RHARHA1_ro05214
RERRER_02640
REYO5Y_01305
REBXU06_01345 XU06_29405
RQIC1M55_01325
ROPROP_52640
ROAPd630_LPD01739
RPYY013_03270
RBYCEJ39_14010
RHBNY08_3449
RFAA3L23_01610
RHSA3Q41_01746
RHWBFN03_00855
RRZCS378_21680
RHUA3Q40_03612
RHQIM25_17215
RHODAOT96_11905
RRT4535765_02427
RCRNCTC10994_00722
RTMG4H71_12930
RKOJWS14_28565
RGOKYT97_20895
ROZCBI38_25245
RPSKJWS13_16020
REQREQ_15040
GBRGbro_4523
GPOGPOL_c05270
GORKTR9_4459
GOQACH46_19670
GTABCM27_23440
GOCCXX93_03955
GITC6V83_00820
GRUGCWB2_22440
GOMD7316_03007
GAVC5O27_05985
GODGKZ92_21420
GAMGII34_01635
GJIH1R19_21580
GOILK459_10770
GHNMVF96_22220
GAMIIHQ52_05465
GMGNWF22_12615
SPINKV203_01105
TPRTpau_2282
TSMASU32_12395
TPULTPB0596_23030
DTMBJL86_0920
DITC3V38_00770
DIZCT688_10955
DPCA6048_11480
DLUA6035_10620
DKNNHB83_10925
TOYFO059_15810
SCOSCO0763(SCF81.22)
SMASAVERM_7482(lldA)
SCBSCAB_8821
SVLStrvi_4645 Strvi_8701
SHYSHJG_8102
SHOSHJGH_7864
SRCM271_28160
SMALSMALA_3394 SMALA_4952
SSOII1A49_20760
SBHSBI_05614
SVESVEN_0183
SDVBN159_1048
SALSSLNWT_3990
SCIB446_32605
SALUDC74_388
SALLSAZ_02415
SLVSLIV_34115
SGUSGLAU_30020(lldA)
STREGZL_08894
SCWTU94_31440
SLCSL103_22100
STRCAA958_28090
SAMBSAM23877_6765
SCXAS200_06200
SRWTUE45_00333
STRFASR50_32450
SLEsle_05290(sle_05290)
SPAVSpa2297_29895
STRTA8713_29410
SGSAVL59_17545 AVL59_25835
STSIA4E84_37790
SALWCP975_00250
SGMGCM10017557_07720
SCADDN051_06020
SPHWNFX46_14325
SLSSLINC_7725
SNRSNOUR_40435
STRDNI25_02475
SAUOBV401_20455 BV401_28520
SSIAA7J05_30470
SPUNBFF78_11655
SLAUSLA_6759
SALFSMD44_00094
STROSTRMOE7_33315
SFKKY5_0994
SNZDC008_31480
SGEDWG14_00937
SRJSRO_4269
SDXC4B68_01180 C4B68_03190
SGDELQ87_02855
SCYAEJ357_03205
SASTCD934_32020
SKACP970_37915
SHAWCEB94_37920
SRKFGW37_00555
SFICEIZ62_29170
SGALCP966_32740
SFYGFH48_05230
SAQUEJC51_41510
SGFHEP81_04438
SSEOD0Z67_27740
SRIMCP984_36800
SPHVF9278_43340
SCINCP977_02720
SFUGCNQ36_02710
SPACB1H29_03260
STSUB7R87_31910
SCHACP983_03025
SCOECP976_39170
SBATG4Z16_24965
SSPBCP982_04575
SPLACP981_33950
SBROGQF42_01295 GQF42_35715 GQF42_39355
STUIGCM10017668_04430
SCHFIPT68_33150
SCYGS1361_35290
SFEUIM697_20635
SDWK7C20_32440
SAUHSU9_030415
SMOBJ7W19_31580
SPRACP972_32820
SROIIAG44_36905
SXNIAG42_03880
SHKJ2N69_04490 J2N69_28875
SANUK7396_04645
SACTDMT42_34920
SINEKI385_38290
SLFJEQ17_06575
SDECL3078_41225
SAOVG3H79_08220 G3H79_39115
SDURM4V62_03590
SCTSCAT_0021
SCYSCATT_00230
KITCFP65_5988
STRIC7M71_024050
STRHGXP74_15260
ABRYNYE86_15255
LEIFHF024_07050
LSEF1C12_06215
MPRTET475_04200
AGYATC03_00620
AGFET445_03105
CPHYB5808_00200
HUMDVJ78_02310
HUWFPZ11_13795
LYDD7I47_12495
ACITHPK19_06905
LMOIVV02_23890
YIMJ5M86_01515
ALXLVQ62_06010
XCEXcel_1699
XYLET495_04965
XYAET471_14510
ICAIntca_3557
JTEASJ30_00660
JMEEEW87_013015
JAYH7A72_00695
TEHGKE56_10390
PHWG7075_02885
PEIH9L10_08525
ORZFNH13_00165
NDKI601_3983
NOOFE634_12005
NBEBack2_29100
NANOG5V58_20965
NAROCFH99_13750
NAQUENKNEFLB_03096
NPSKRR39_09045
PSIMKR76_14650
AEZC3E78_15370
AEFGEV26_15460
KFLKfla_6271
KQIF1D05_16040
NDANdas_3352
NALB005_0442
NGVCDO52_13295
NEXNE857_13020
TCUTcur_1619
ACTWF7P10_07310
AGRAAGRA3207_001596
NOWGBF35_37210
FRIFraEuI1c_1375
GOBGobs_0453
BSDBLASA_0435
BLAPMVA48_14240
MMARMODMU_0520(lldD)
SENSACE_2627(idiB_2) SACE_6523
SACGFDZ84_30675
SVISvir_13410
SACCEYD13_07255
AMDAMED_6987
AMNRAM_35840
AMMAMES_6880
AMZB737_6880
AOIAORI_1744(lldD)
AJAAJAP_30775
AMQAMETH_5351
AMYCCU254_37755
AMYBBKN51_00925
AABA4R43_19070
AMYYYIM_10680
AORISD37_32470
AACDLWP59_31385
APRTMUY14_01635
AROONQK81_14315
PSEAWY02_25940
PSEEFRP1_06335
PSEHXF36_16465
PSEQAD006_13955
PECQAD017_21780
PAUTPdca_46180
PBROHOP40_25275
APRECNX65_05400
AMIAmir_1074
SESPBN6_12720
SSYIEKG83_06315
KALKALB_1408
KPHYAOZ06_10565
LEDBBK82_05460
ALOCRK55031
PMADBAY61_09355
SACEGIY23_02800
ACTUActkin_01244
MTEMGCE86_14420
ASEACPL_1974
AMSAMIS_24980
ACTNL083_4402
ACTSACWT_1852
AIHAiant_63170
ATLAthai_65440
ASERAsera_09780
DVCDvina_35305
CAICaci_4408
SNASnas_2374
NAVJQS30_12705
AEYCDG81_11185
RXYRxyl_1052
RRDRradSPS_0932
PARNNBH00_19490
AQZKSP35_21630
DGEDgeo_0626
DMRDeima_0416
DSWQR90_04690
DEZDKM44_01910
DEINDAAJ005_07855
DRBN0D28_04325
TTHTT_C1744
TTSThthe16_0143
TTLTtJL18_0155
THCTCCBUS3UF1_20520
TOSTheos_1524
TAQTO73_0130
TBCA0O31_00937
GGRHKW67_00060
GBAJ421_2178
RMRRmar_1466
RMGRhom172_1523
RBARAWN76_008385
HHYHalhy_0614
SPIKEXU85_17030
CHRWKA713_19200
RSIRunsl_4987
RUNDR864_05785
RUPDTQ70_07420
CHKD4L85_14435
SALRFQU85_08505
HAADMW046_02350
HALXM0R89_15725
HAXZM0R88_16070
SALIL593_03975
NPHNP_5124A
NMONmlp_1127
NHOHWV23_04385 HWV23_10120
NSALHWV07_03610 HWV07_13570
HALIBV210_14655
HSNDV733_02330
HDOMUK72_08850
SSAIN0B31_09635 N0B31_19175
HWAHQ_2847A
HWCHqrw_3236
HAZZKI388_03410
SRUBC2R22_17190
HALGHUG10_11850
HTUHtur_2905
HDABB347_09095
HSALJMJ58_13915
HLOJ0X27_01030
HAKZJ0X25_01180
NAYHYG81_05870
HALYHYG82_07630
HRUHalru_0473
HLRHALLA_15205
HLCCHINAEXTREME02330
NAJB1756_05245
SAWLNGM29_05390
PTOPTO1012
FACFACI_IFERC01G0179
FAIFAD_1093
CDIVCPM_1628
 » show all
Reference
1
  Authors
Hayaishi, O. and Sutton, W.B.
  Title
Enzymatic oxygen fixation into acetate concomitant with the enzymatic decarboxylation of L-lactate.
  Journal
J Am Chem Soc 79:4809-4810 (1957)
Reference
2  [PMID:13428772]
  Authors
SUTTON WB.
  Title
Mechanism of action and crystallization of lactic oxidative decarboxylase from Mycobacterium phlei.
  Journal
J Biol Chem 226:395-405 (1957)
Other DBs
ExplorEnz - The Enzyme Database: 1.13.12.4
IUBMB Enzyme Nomenclature: 1.13.12.4
ExPASy - ENZYME nomenclature database: 1.13.12.4
BRENDA, the Enzyme Database: 1.13.12.4
CAS: 9028-72-2

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