KEGG   ENZYME: 1.13.12.4Help
Entry
EC 1.13.12.4                Enzyme                                 

Name
lactate 2-monooxygenase;
lactate oxidative decarboxylase;
lactate oxidase;
lactic oxygenase;
lactate oxygenase;
lactic oxidase;
L-lactate monooxygenase;
lactate monooxygenase;
L-lactate-2-monooxygenase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
BRITE hierarchy
Sysname
(S)-lactate:oxygen 2-oxidoreductase (decarboxylating)
Reaction(IUBMB)
(S)-lactate + O2 = acetate + CO2 + H2O [RN:R00319]
Reaction(KEGG)
Substrate
(S)-lactate [CPD:C00186];
O2 [CPD:C00007]
Product
acetate [CPD:C00033];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
A flavoprotein (FMN).
History
EC 1.13.12.4 created 1961 as EC 1.1.3.2, transferred 1972 to EC 1.13.12.4
Pathway
ec00620  Pyruvate metabolism
Orthology
K00467  lactate 2-monooxygenase
Genes
PHD: 102318148
LTH: KLTH0H16148g
TDL: TDEL_0A08010(TDEL0A08010)
PAN: PODANSg5965
TTT: THITE_2113301
MTM: MYCTH_2137000
MGR: MGG_16456
TMN: UCRPA7_7665
SSCK: SPSK_03321
FGR: FGSG_03439 FGSG_03984
MAW: MAC_03786
MAJ: MAA_04225
CMT: CCM_06299
ANG: ANI_1_238014(An01g01880) ANI_1_998104(An12g08270)
PTE: PTT_11971
HIR: HETIRDRAFT_440215(lmo1)
ABP: AGABI1DRAFT106734(AGABI1DRAFT_106734) AGABI1DRAFT128349(AGABI1DRAFT_128349)
ABV: AGABI2DRAFT119340(AGABI2DRAFT_119340) AGABI2DRAFT179188(AGABI2DRAFT_179188)
MGL: MGL_4274
SALN: SALB1_1431
CCR: CC_1396
STAX: MC45_12445
BAO: BAMF_2066(lldA)
BAZ: BAMTA208_07170(lldA)
BQL: LL3_02170
BACO: OXB_1571
LSP: Bsph_0911
AAC: Aaci_0905
AAD: TC41_0915(lldD)
MLP: MLM_2976
MMC: Mmcs_1989
MKM: Mkms_2035
MJL: Mjls_1969
MMI: MMAR_1816(lldD1_1)
MMAE: MMARE11_17430(lldD1_1)
MLI: MULP_01974(lldD1_1)
MHAD: B586_03080
MVA: Mvan_2206
MGI: Mflv_4136
MVQ: MYVA_2110
MAB: MAB_2126
MABB: MASS_2049
MCHE: BB28_10665
MSTE: MSTE_02060
MJD: JDM601_2615(lldD1_1)
MTER: 4434518_02563(lldD1_1)
ASD: AS9A_0040
CVA: CVAR_1459(lldA)
CTER: A606_05680
NFA: NFA_2230
RER: RER_02640
REY: O5Y_01305
ROP: ROP_52640
REQ: REQ_15040
RHB: NY08_3449
GBR: Gbro_4523
GOR: KTR9_4459
TPR: Tpau_2282
SCO: SCO0763(SCF81.22)
SMA: SAVERM_7482(lldA)
SCB: SCAB_8821
SCT: SCAT_0021
SBH: SBI_05614
SHY: SHJG_8102
SVE: SVEN_0183
SALS: SLNWT_3990
SALU: DC74_388
SALL: SAZ_02415
SGU: SGLAU_30020(lldA)
STRE: GZL_08894
SLE: sle_05290(sle_05290)
STRD: NI25_02475
SLAU: SLA_6759
SFK: KY5_0994
LMOI: VV02_23890
XCE: Xcel_1699
NDK: I601_3983
KFL: Kfla_6271
PSIM: KR76_14650
NAL: B005_0442
TCU: Tcur_1619
MMAR: MODMU_0520(lldD)
SEN: SACE_2627(idiB_2) SACE_6523
AMD: AMED_6987
AMN: RAM_35840
AMM: AMES_6880
AMZ: B737_6880
AOI: AORI_1744(lldD)
PSEA: WY02_25940
PSEE: FRP1_06335
PSEH: XF36_16465
AMI: Amir_1074
SESP: BN6_12720
KAL: KALB_1408
ASE: ACPL_1974
ACTN: L083_4402
ACTS: ACWT_1852
CAI: Caci_4408
SNA: Snas_2374
RXY: Rxyl_1052
DGE: Dgeo_0626
TTH: TT_C1744
TAQ: TO73_0130
GBA: J421_2178
RMR: Rmar_1466
PTO: PTO1012
FAI: FAD_1093
CDIV: CPM_1628
NPH: NP_5124A
NMO: Nmlp_1127
HWA: HQ_2847A
HWC: Hqrw_3236
HTU: Htur_2905
SALI: L593_03975
 » show all
Taxonomy
Reference
1
  Authors
Hayaishi, O. and Sutton, W.B.
  Title
Enzymatic oxygen fixation into acetate concomitant with the enzymatic decarboxylation of L-lactate.
  Journal
J Am Chem Soc 79:4809-4810 (1957)
Reference
2  [PMID:13428772]
  Authors
SUTTON WB.
  Title
Mechanism of action and crystallization of lactic oxidative decarboxylase from Mycobacterium phlei.
  Journal
J Biol Chem 226:395-405 (1957)
Other DBs
ExplorEnz - The Enzyme Database: 1.13.12.4
IUBMB Enzyme Nomenclature: 1.13.12.4
ExPASy - ENZYME nomenclature database: 1.13.12.4
BRENDA, the Enzyme Database: 1.13.12.4
CAS: 9028-72-2

DBGET integrated database retrieval system