KEGG   ENZYME: 1.14.11.16
Entry
EC 1.14.11.16               Enzyme                                 
Name
peptide-aspartate beta-dioxygenase;
aspartate beta-hydroxylase;
aspartylpeptide beta-dioxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
peptide-L-aspartate + 2-oxoglutarate + O2 = peptide-3-hydroxy-L-aspartate + succinate + CO2 [RN:R04073]
Reaction(KEGG)
R04073
Substrate
peptide-L-aspartate;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
peptide-3-hydroxy-L-aspartate;
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+. Some vitamin K-dependent coagulation factors, as well as synthetic peptides based on the structure of the first epidermal growth factor domain of human coagulation factor IX or X, can act as acceptors.
History
EC 1.14.11.16 created 1992
Orthology
K00476  aspartate beta-hydroxylase
Genes
HSA444(ASPH)
PTR464202(ASPH)
PPS100977040(ASPH)
GGO101139593(ASPH)
PON100189667(ASPH)
NLE100581524(ASPH)
HMH116813254(ASPH)
MCC699884(ASPH)
MCF101925502(ASPH)
MTHB126961498
CSAB103236861(ASPH)
CATY105585190(ASPH)
PANU101012983(ASPH)
TGE112629696(ASPH)
MLEU105541230(ASPH)
RRO104660101(ASPH)
RBB108543145(ASPH)
TFN117079497(ASPH)
PTEH111549215(ASPH)
CANG105504480(ASPH)
CJC100403503(ASPH)
SBQ101045507(ASPH)
CIMI108288419 108317225
CSYR103264065(ASPH)
MMUR105857364(ASPH)
LCAT123644702(ASPH)
PCOQ105824089(ASPH)
OGA100956668(ASPH)
MMU65973(Asph)
MCAL110293480(Asph)
MPAH110338639(Asph)
RNO312981(Asph)
MCOC116088089(Asph)
ANU117698610(Asph)
MUN110562911(Asph)
CGE100755768(Asph)
MAUA101826336(Asph)
PROB127231660(Asph)
PLEU114707589(Asph)
MORG121451482(Asph)
MFOT126514840
AAMP119826126(Asph)
NGI103737741(Asph)
HGL101725986(Asph)
CPOC100726813(Asph)
CCAN109678257 109697332(Asph)
DORD105980430(Asph) 105980497
DSP122095555(Asph)
PLOP125341787 125341799 125360768(Asph)
NCAR124985242
OCU108176505
OPI101528643(ASPH)
TUP102478772(ASPH)
GVR103608013
CFA403846(ASPH)
CLUD112678508(ASPH)
VVP112932148 112932323(ASPH)
VLG121499037(ASPH)
NPO129505383(ASPH)
AML100479314(ASPH)
UMR103677467(ASPH)
UAH113268067(ASPH)
UAR123786704(ASPH)
ELK111155376 111155391
LLV125098875
MPUF101683071(ASPH)
ORO101373057(ASPH)
EJU114214147(ASPH)
ZCA113939883(ASPH)
MLX118014859(ASPH)
NSU110579064(ASPH)
LWW102728276
FCA105260207(ASPH)
PYU121038214(ASPH)
PCOO112859558(ASPH)
PBG122495447(ASPH)
LRUF124507679
PTG102960536(ASPH)
PPAD109250263(ASPH)
PUC125924663
AJU106973810
HHV120243102(ASPH)
BTA286771(ASPH)
BOM102285100(ASPH)
BIU109568307(ASPH)
BBUB102396221(ASPH)
BBIS104981292(ASPH)
CHX102189496(ASPH)
OAS101118195(ASPH)
BTAX128059420(ASPH)
ODA120878611(ASPH)
CCAD122451067(ASPH)
SSC100526167(ASPH)
CFR102505456(ASPH)
CBAI105081467(ASPH)
CDK105093932(ASPH)
VPC102540227(ASPH)
BACU103017679(ASPH)
LVE103068515(ASPH)
OOR101274120(ASPH)
DLE111185601(ASPH)
PCAD102987140(ASPH)
PSIU116742334(ASPH)
NASI112398138(ASPH)
ECB100065909(ASPH)
EPZ103547567(ASPH)
EAI106843667(ASPH)
MYB102255804(ASPH)
MYD102769038(ASPH)
MMYO118670878(ASPH)
MLF102418625(ASPH) 102438511
MNA107526441 107526448(ASPH)
PKL118718299(ASPH)
HAI109377781
DRO112315321
SHON118995503(ASPH)
AJM119065411(ASPH)
PDIC114514403(ASPH)
PHAS123833323(ASPH) 123833325
MMF118631388(ASPH)
RFQ117034001(ASPH)
PALE102885216(ASPH)
PGIG120607211(ASPH)
PVP105291439(ASPH)
RAY107519658(ASPH)
MJV108395459(ASPH)
TOD119241118(ASPH)
SARA101544390(ASPH)
LAV100670793(ASPH)
TMU101360914
ETF101650909(ASPH)
DNM101432331(ASPH)
MDO100029689(ASPH) 103102349
GAS123253436
SHR100923835
AFZ127543827
PCW110219026(ASPH)
OAA100082566(ASPH)
GGA421142(ASPH)
PCOC116242265(ASPH)
MGP100540272(ASPH)
CJO107310216(ASPH)
TPAI128091391(ASPH)
NMEL110394980(ASPH)
APLA101796017(ASPH)
ACYG106039040(ASPH)
AFUL116485364(ASPH)
TGU105759899(ASPH)
LSR110484743 116183121
SCAN103812527(ASPH)
PMOA120499310(ASPH)
OTC121340216(ASPH)
PRUF121356871(ASPH)
GFR102038570(ASPH)
FAB101809173(ASPH)
PHI102100401(ASPH)
PMAJ107199898(ASPH)
CCAE111924696(ASPH)
CCW104690358
CBRC103625516(ASPH)
ETL114062629(ASPH)
ZAB102075050(ASPH)
ACHL103799476(ASPH)
SVG106851249(ASPH)
FPG101911221(ASPH)
FCH102046157(ASPH)
CLV102097223(ASPH)
EGZ104127600(ASPH)
NNI104019734(ASPH)
PLET104624372(ASPH)
PCRI104034202
PCAO104042234(ASPH)
ACUN113476412(ASPH)
TALA104363350(ASPH)
PADL103923683(ASPH)
AFOR103904087(ASPH)
ACHC115340531(ASPH)
HALD104314539(ASPH)
HLE104841323(ASPH)
AGEN126035803 126050521
GCL127013870
CCRI104169291(ASPH)
CSTI104557737
EHS104514923(ASPH)
CMAC104483633
MUI104535359(ASPH)
BREG104636546(ASPH)
FGA104075831(ASPH) 104080313
GSTE104257149
LDI104354102(ASPH)
MNB103782536(ASPH)
OHA104332310(ASPH)
NNT104405881(ASPH)
SHAB115607733
DPUB104303512(ASPH)
PGUU104468573
ACAR104532901
CPEA104386870(ASPH)
AVIT104269378
CVF104290660(ASPH)
CUCA104061345(ASPH)
TEO104384603(ASPH)
BRHI104496189(ASPH)
AAM106494372(ASPH)
AROW112978656
NPD112944779(ASPH)
TGT104567035(ASPH) 104575587
DNE112991440
SCAM104143168(ASPH)
ASN102387833 102388086
AMJ102572092(ASPH)
CPOO109315466(ASPH)
GGN109298764 109304915
PSS102460072(ASPH)
CMY102937266
CPIC101934659(ASPH)
CABI116818243(ASPH) 116823980
MRV120397066(ASPH)
ACS100563401(asph)
PVT110088966(ASPH)
SUND121928673(ASPH)
PBI103048046(ASPH)
PMUR107294151 114923083
CTIG120304769(ASPH)
TSR106550102(ASPH) 106556479
PGUT117672832(ASPH)
PTEX113440013
NSS113429733
VKO123020301(ASPH)
PMUA114600572 114600573
ZVI118078745 118078746 118090397(ASPH)
HCG128321974
GJA107114049(ASPH)
STOW125438772(ASPH)
XLA100137711(asph.L) 108695316
XTR548451(asph)
NPR108791345(ASPH) 108796606
RTEM120917056 120941029(ASPH)
BGAR122939107(ASPH)
DRE559236(unm_hu7910)
SRX107714857 107729161 107730121 107731609 107731610
SANH107664966 107674369 107688512
SGH107559844(asph) 107561526 107584723 107602531
CCAR109051355 109056380 109056419 109086645 109086653 109106218
CAUA113045953 113051632 113106320(asph) 113117451
CGIB127961195 128017691
PTET122348539(unm_hu7910) 122349803
LROH127167840(unm_hu7910)
PPRM120480166(unm_hu7910)
MAMB125265879(unm_hu7910)
CIDE127516563
MASI127424201 127454087
IPU108267575(unm_hu7910)
PHYP113525363 113540138(asph)
SMEO124387087(unm_hu7910)
TFD113657448(unm_hu7910)
AMEX103023508(asph) 103042371
CMAO118825690(unm_hu7910)
EEE113576477 113579299(asph)
CHAR105894731(unm_hu7910) 116224367
TRU101061760 101072889
TNGGSTEN00012782G001 GSTEN00012785G001
LCO104932208
NCC104957580
CGOB115022451
ELY117265014(unm_hu7910) 117272284
EFO125881517(unm_hu7910) 125901731(asph)
PLEP121951090(asph) 121960952
SLUC116036902 116040045 116043914(asph)
ECRA117938302 117941189 117954619(asph)
PFLV114548951 114565287
GAT120813001
PPUG119198515(unm_hu7910) 119198516 119204275(asph)
MSAM119895086 119895394 119902612
SCHU122866446(unm_hu7910)
CUD121519823(asph) 121527265
ALAT119009064(unm_hu7910) 119009090 119010859(asph)
MZE101470710 101480497 112432813 112433101
ONL100701393 100703580
OAU116321936 116335722(unm_hu7910)
OLA101156606 101167495
OML112142277(unm_hu7910) 112144237(asph)
XMA102218642 102221881
XCO114136426 114146039
XHE116712096 116712098 116721209
PRET103456947(asph)
PFOR103129444 103131754(asph)
PLAI106937679(asph) 106947909
PMEI106916021 106916023 106917814
GAF122824385 122840764(asph)
CVG107089110 107098908(asph) 107098913
CTUL119795166(asph) 119796944(unm_hu7910)
GMU124858096(unm_hu7910) 124869790
NFU107384363 107395322(asph)
KMR108250906(asph) 108251691(unm_hu7910)
ALIM106527660(asph) 106536003
NWH119426739(unm_hu7910)
AOCE111569010(asph) 111580824
MCEP124995579(unm_hu7910)
CSEM103377197 103396808(asph)
POV109641506 109642720
SSEN122768290 122777016(asph) 122780483
HHIP117753751(unm_hu7910) 117777773(asph)
HSP118098960(unm_hu7910) 118117376(asph)
LCF108884981(unm_hu7910)
SDU111233829 111237396(asph)
SLAL111648389 111651459 111652358
XGL120789881(unm_hu7910) 120798551(asph)
HCQ109515224(asph)
SSCV125985655
BPEC110163976(asph)
MALB109971402 109972756
BSPL114844708(asph) 114853130(unm_hu7910)
SASA106568874 106579584 106590366 106599166
STRU115150347 115169866 115195553
OTW112227023 112227765 112232689 112260387
OMY110489730(unm_hu7910) 110508822 110530208(asph) 110535277
OGO123991364 124009277 124038966 124039608 124041947
ONE115103174 115104886 115130185
SALP111953589 111953870 111972783 111979344 112067901
SNH120020424 120027869 120051018 120051019 120056295
CCLU121549650 121569191
ELS105030616(asph) 105031615
SFM108929627(asph) 108937737
PKI111847235(asph)
AANG118225427(unm_hu7910) 118233927
LOC102693894(asph)
PSPA121313375 121314303
ARUT117394552 117399998 117435698
PSEX120530250(unm_hu7910)
LCM102355776 102356049
CMK103180766(unm_hu7910)
RTP109932114
CPLA122549457(unm_hu7910)
BFO118405073
BBEL109473111
CIN100185342
SCLV120335740
SPU593797
APLC110979582
SKO100369952
DMEDmel_CG8421(Asph)
DER6548855
DSIDsimw501_GD11159(Dsim_GD11159)
DYADyak_GE11752
DSR110188931
DPO4805634
DPE6601342
DMN108160291
DWI6640106
DGR6560822
DMODmoj_GI19152
DAZ108615400
DNV108654292
DHE111594021
CCAT101456066
BOD106627812
MDE101896755
SCAC106096373
LCQ111683951
LSQ119611587
ACOZ120947908
AARA120895874
ASTE118511474
AAG5566108
AALB109409693
CQUCpipJ_CPIJ002076 CpipJ_CPIJ002077
CPII120428684
CNS116342262
BCOO119081724
ALAB122719267
BVK117242663
BVAN117156434
BTER110119633
BPYO122571308
CCAL108626981
OBB114873782
MGEN117223408
NMEA116429391
CGIG122402113
SOC105197879
MPHA105829628 114253958
AEC105151125
ACEP105619868
HST105187020
DQU106744918
CFO105258212
FEX115239544
LHU105675763
PGC109863593
OBO105286120
PCF106788602
PFUC122522053
VPS122636562
NVI100118520
CSOL105368488
MDL103568298
CGLO123262553
DAM107036132
AGIF122860778
CCIN107271813
TCA656627
DPA109540998
SOY115887117
ATD109598090
CSET123322246
AGB108916991
LDC111506246
NVL108563626
APLN108739281
PPYR116166270
OTU111425682
BMOR101746449
BMAN114246592
MSEX115444966
DPLKGM_201739
BANY112053742
PMAC106709062
PPOT106100716
PXU106124303
PRAP110994810
ZCE119829247 119829248
HAW110383774
HZE124634985
TNL113496816
SLIU111353472
OFU114364406
PXY105385547 105387115
BTAB109041531
DCI103514494 108252154
CLEC106670352
HHAL106680737
NLU111057384
PHUPhum_PHUM407110
FOC113203876
TPAL117652470
ZNE110834569
CSEC111869205
DPXDAPPUDRAFT_191117
PVM113812951
PJA122249785
PCHN125042389
HAME121864659
PTRU123500094
HAZT108676961
EAF111705469 111707259
LSM121114215 121132505
PPOI119101189
ISCIscW_ISCW016886
DSV119435761 119460578
RSAN119396993
RMP119175056
CSCU111635377
PTEP107438443
SDM118194893
LPOL106465137
CELCELE_K09A9.6(K09A9.6)
CBRCBG_07728
BMYBM_BM4944(Bm4944)
LOALOAG_00363
NAINECAME_08484
TSPTsp_03380
LGILOTGIDRAFT_144765
PCAN112561951
BGT106067756
GAE121377700
HRF124113450 124149275
HRJ124256357
CRG105324538
MYI110454515
PMAX117316775 117338931
MMER123540156
DPOL127847702 127847703
OBI106878285
OSN115209472
LAK106164016
NVE5505006
EPA110241474
ATEN116307172
ADF107336775
AMIL114961233
PDAM113669792
SPIS111326569
DGT114527612
XEN124459544
TADTRIADDRAFT_31864
AQU105313175 105314922 109580481
OTAOT_ostta10g00170
SREPTSG_01068 PTSG_01282
BBIGBBBOND_0205490
TETTTHERM_001228989
SMINv1.2.008170.t1(symbB.v1.2.008170.t1) v1.2.009162.t1(symbB.v1.2.009162.t1) v1.2.016784.t2(symbB.v1.2.016784.t2) v1.2.017558.t1(symbB.v1.2.017558.t1) v1.2.017824.t1(symbB.v1.2.017824.t1) v1.2.034247.t1(symbB.v1.2.034247.t1) v1.2.039705.t1(symbB.v1.2.039705.t1)
AAFAURANDRAFT_61626 AURANDRAFT_64261
EHXEMIHUDRAFT_216081 EMIHUDRAFT_419689 EMIHUDRAFT_426226
GTTGUITHDRAFT_102072
TVATVAG_2v0666740
SMARSM39_2723
SMACSMDB11_2493
SMWSMWW4_v1c32500
SPESpro_3198
SRRSerAS9_3315
SRLSOD_c30910
SRYM621_16855
SPLYQ5A_016760
SRSSerAS12_3316
SRASerAS13_3318
SLQM495_16335
SERFL085_12380
SERSSERRSCBI_15735
SQUE4343_00015 E4343_24820
SFJSAMEA4384070_3276
SSURATE40_012790
SURIJ0X03_07720
SENPKHA73_15840
SNEMNLX84_16250
GQUAWC35_20975
XHRXJ27_08505
XGABI317_07705
XPHXppCFBP6546_04870(XppCFBP6546P_04870)
XANAC801_06705
XARXB05_01525
XHYFZ025_10550
XHDLMG31886_30130
PMEXH4W19_09235
LABLA76x_1483
LAQGLA29479_4354
LCPLC55x_1225
LGULG3211_1127
LEZGLE_1103
LEMLEN_3809
LUEDCD74_00670
LUSE5843_13105
LUGFPZ22_05845
RHDR2APBS1_0409
DJICH75_07715
DJAHY57_12575
DTXATSB10_34480
DYEEO087_11465
DCSISN74_20890
DTLH8F01_19220
DTADYST_00480
XBAC7S18_09360 C7S18_20005
LALAT746_03015
KIMG3T16_08865
BMABMAA0571
BMLBMA10229_0896
BMNBMA10247_A1863
BMAIDM57_12665
BMAFDM51_4292
BMAZBM44_4841
BMABBM45_4892
BPSBPSS1421
BPMBURPS1710b_A0445
BPLBURPS1106A_A1927
BPDBURPS668_A2019
BPSEBDL_4728
BPSMBBQ_4727
BPSUBBN_4866
BPSDBBX_3891
BPZBP1026B_II1513
BPQBPC006_II1907
BPKBBK_4030
BPSHDR55_3854
BPSABBU_4617
BPSOX996_3642
BUTX994_5697
BTEBTH_II0971
BTQBTQ_4266
BTJBTJ_5304
BTZBTL_3766
BTDBTI_3913
BTVBTHA_4117
BTHEBTN_3892
BTHMBTRA_3763
BTHADR62_3934
BTHLBG87_3722
BOKDM82_5577
BOCBG90_5033
BUUWS70_24740
BSAVWS86_26220
BHGI6G56_20890
BVIBcep1808_3464
BVEAK36_3296
BURBcep18194_B0466
BCMBcenmc03_5116
BCHBcen2424_5163
BCJBCAM2401
BCENDM39_5439
BCEWDM40_3067
BCEOI35_6299
BAMBamb_4559
BACBamMC406_5084
BMUBmul_3492
BMKDM80_4883
BMULNP80_5043
BCTGEM_3287
BCEDDM42_5585
BCEPAPZ15_22450
BDLAK34_3415
BPYRABD05_23620
BCONNL30_00395
BUBBW23_3625
BDFWI26_24820
BLATWK25_27910
BTEIWS51_08995
BSEMWJ12_31980
BPSLWS57_02085
BMECWJ16_30505
BSTLBBJ41_25940
BANNJFN94_29890
BARINLX30_25160
BGLbglu_2g04810
BGUKS03_5435
BGDbgla_2g06280
BGOBM43_4267
BUKMYA_3088
BULBW21_5907
BGPBGL_2c05750
BPLAbpln_2g06330
BUDAQ610_23670
BURKDM992_23580
PARABTO02_29420
PMEGFNZ07_01755
PEWKZJ38_33840
CARIFNU76_17425
MASWAM586_06655
MASYDPH57_13790
MASZC9I28_08190
MPLIE1742_21955
TCTPX653_14865
PKTAT984_11480
UPLDSM104440_01279
MLOmll1937
MLNA9174_16955
MHUAMCHK_3497
MJREB229_17195
MERDEB233_14365
AALKLGT41_0013410
HBCAEM38_04800
NOGGKE62_11650
SPHMG432_08360
STAXMC45_05500
SSANNX02_26400
SPHFDM480_12820
SLUTH9L13_00355
SSEDH9L14_11905
SSYSLG_02380
SYAA6768_21615
SPHSETR14_11745
SANDH3309_03770
NAOY958_13705 Y958_27515
NCBC0V82_08515 C0V82_22150
STRCAA958_19365
SCXAS200_45500
SGVB1H19_04675
SGDELQ87_36070
SACGFDZ84_23320
SYDSyncc9605_0306
SYESyncc9902_2038
SYNRKR49_10525
SYNDKR52_00915
SYNWSynWH8103_00338
SYWSYNW0309
 » show all
Reference
1  [PMID:2187868]
  Authors
Gronke RS, Welsch DJ, VanDusen WJ, Garsky VM, Sardana MK, Stern AM, Friedman PA.
  Title
Partial purification and characterization of bovine liver aspartyl beta-hydroxylase.
  Journal
J Biol Chem 265:8558-65 (1990)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.16
IUBMB Enzyme Nomenclature: 1.14.11.16
ExPASy - ENZYME nomenclature database: 1.14.11.16
BRENDA, the Enzyme Database: 1.14.11.16
CAS: 122544-66-5

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