KEGG   ENZYME: 1.14.11.27
Entry
EC 1.14.11.27               Enzyme                                 
Name
[histone H3]-dimethyl-L-lysine36 demethylase;
KDM2A (gene name);
KDM2B (gene name);
JHDM1A (gene name);
JHDM1B (gene name);
JmjC domain-containing histone demethylase 1A;
H3-K36-specific demethylase (ambiguous);
histone-lysine (H3-K36) demethylase (ambiguous);
histone demethylase (ambiguous);
protein-6-N,6-N-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase;
protein-N6,N6-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase;
[histone-H3]-lysine-36 demethylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
[histone H3]-N6,N6-dimethyl-L-lysine36,2-oxoglutarate:oxygen oxidoreductase
Reaction(IUBMB)
a [histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 = a [histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2 (overall reaction) [RN:R10056];
(1a) a [histone H3]-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 = a [histone H3]-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2 [RN:R09510];
(1b) a [histone H3]-N6-methyl-L-lysine36 + 2-oxoglutarate + O2 = a [histone H3]-L-lysine36 + succinate + formaldehyde + CO2 [RN:R09511]
Reaction(KEGG)
Substrate
[histone H3]-N6,N6-dimethyl-L-lysine36;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007];
[histone H3]-N6-methyl-L-lysine36
Product
[histone H3]-L-lysine36;
succinate [CPD:C00042];
formaldehyde [CPD:C00067];
CO2 [CPD:C00011];
[histone H3]-N6-methyl-L-lysine36
Comment
Requires iron(II). Of the seven potential methylation sites in histones H3 (K4, K9, K27, K36, K79) and H4 (K20, R3) from HeLa cells, the enzyme is specific for Lys36. Lysine residues exist in three methylation states (mono-, di- and trimethylated). The enzyme preferentially demethylates the dimethyl form of Lys36 (K36me2), which is its natural substrate, to form the monomethylated and unmethylated forms of Lys36. It can also demethylate monomethylated (but not the trimethylated) Lys36. cf. EC 1.14.11.69, [histone H3]-trimethyl-L-lysine36 demethylase.
History
EC 1.14.11.27 created 2006, modified 2019
Orthology
K10276  F-box and leucine-rich repeat protein 10/11
K16914  bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66
K24444  [histone H3]-dimethyl/trimethyl-L-lysine36 demethylase
Genes
HSA22992(KDM2A) 79697(RIOX1) 84678(KDM2B)
PTR104002100(RIOX1) 107967129(KDM2A) 465184(KDM2B)
PPS100983162(KDM2A) 100988129(KDM2B) 103787047(RIOX1)
GGO101140212(KDM2A) 101154151(KDM2B)
PON100434567(KDM2A) 100462645(KDM2B) 103892384(RIOX1)
NLE100579905(KDM2B) 100601545(KDM2A) 105739243(RIOX1)
MCC696773(RIOX1) 699938(KDM2B) 712907(KDM2A)
MCF102125851(KDM2B) 102135352(RIOX1) 102142242(KDM2A)
CSAB103219229(KDM2A) 103229309(RIOX1) 103239283(KDM2B)
CATY105577615(KDM2A) 105590967(KDM2B) 105599557
PANU101017786(KDM2A) 101023070(KDM2B) 103886364(RIOX1)
TGE112606108(KDM2A) 112629404(RIOX1) 112634202(KDM2B)
RRO104656344(RIOX1) 104664750(KDM2A) 104666275(KDM2B)
RBB108518607(KDM2A) 108529633(KDM2B) 108536225(RIOX1)
TFN117069369(RIOX1) 117080583(KDM2A) 117089271(KDM2B)
PTEH111520542(RIOX1) 111522325(KDM2A) 113219552(KDM2B)
CJC100397900(KDM2B) 100403232(KDM2A) 100404196(RIOX1)
SBQ101044630(KDM2B) 101049444(KDM2A) 104650789
CSYR103258730(KDM2A) 103264052(KDM2B) 103273243(RIOX1)
MMUR105858343(RIOX1) 105867478(KDM2A) 105880908(KDM2B)
OGA100940651(KDM2A) 100951584(KDM2B) 105886713(RIOX1)
MMU225876(Kdm2a) 30841(Kdm2b) 71952(Riox1)
MCAL110285231(Kdm2a) 110294179(Kdm2b) 110307186(Riox1)
MPAH110324497(Riox1) 110337427(Kdm2a) 110339091(Kdm2b)
RNO304495(Kdm2b) 314300(Riox1) 361700(Kdm2a)
MCOC116080287(Riox1) 116103333(Kdm2a) 116104643(Kdm2b)
MUN110545328(Kdm2b) 110558535(Riox1) 110560366(Kdm2a)
CGE100763039(Kdm2a) 100767158(Kdm2b)
PLEU114683642 114686005(Kdm2a) 114686154 114698396(Riox1) 114704550(Kdm2b)
NGI103725573(Kdm2a) 103739068(Kdm2b) 103747411(Riox1)
HGL101696346(Kdm2b) 101712659(Riox1) 101713712(Kdm2a)
CPOC100726076(Kdm2b) 100729659(Riox1) 100732285(Kdm2a)
CCAN109684942 109684944(Kdm2a) 109686393(Kdm2b) 109691362(Riox1)
DORD105982898 105989077(Kdm2a) 105990689(Kdm2b)
DSP122098481(Kdm2b) 122104659(Kdm2a) 122118818(Riox1)
OCU100349603(KDM2B) 100352993(KDM2A) 103351690(RIOX1)
OPI101523726(KDM2A) 101536451(KDM2B) 105941772(RIOX1)
TUP102482421(KDM2A) 102484507(RIOX1) 102488934(KDM2B)
CFA106559177(RIOX1) 483702(KDM2A) 486262(KDM2B)
VVP112924192(KDM2A) 112927248(RIOX1) 112935168(KDM2B)
VLG121471969(KDM2A) 121475384(KDM2B) 121493577(RIOX1)
AML100467038(KDM2B) 100468557(RIOX1) 100469601(KDM2A)
UMR103661272(KDM2B) 103673481(RIOX1) 103679509(KDM2A)
UAH113244041(KDM2A) 113266944(KDM2B) 113270360(RIOX1)
UAR123778525(KDM2A) 123779338(KDM2B) 123799008(RIOX1)
ELK111148493 111149677 111156340
LLV125080086 125082678 125103705
MPUF101671929 101686934(KDM2B) 101690280(KDM2A)
ORO101368497(KDM2B) 101379219 101385046(KDM2A)
EJU114199294(RIOX1) 114219056(KDM2B) 114220547(KDM2A)
ZCA113909018(RIOX1) 113912625(KDM2B) 113913959(KDM2A)
MLX118002325(RIOX1) 118016115(KDM2A) 118018441(KDM2B)
FCA101090549(KDM2A) 101094455(KDM2B) 102900260(RIOX1)
PYU121010451(KDM2B) 121023707(KDM2A) 121032016(RIOX1)
PBG122469294(RIOX1) 122470195(KDM2B) 122484041(KDM2A)
PTG102959050(KDM2A) 102960977(RIOX1) 102971585(KDM2B)
PPAD109246832(KDM2A) 109253798(CUNH14orf169) 109277681(KDM2B)
AJU106967547(KDM2B) 106971187(KDM2A) 106974332(RIOX1)
HHV120231486(KDM2B) 120231954(RIOX1) 120233876(KDM2A)
BTA511031(RIOX1) 540141(KDM2A) 614487(KDM2B)
BOM102274509(KDM2B) 102285244(RIOX1) 102286032(KDM2A)
BIU109554334(KDM2A) 109565323(RIOX1) 109571124(KDM2B)
BBUB102398958(KDM2B) 102399656(RIOX1) 102407952(KDM2A)
CHX102173094(RIOX1) 102180467(KDM2A) 102180525(KDM2B)
OAS101103759(KDM2B) 101108003(KDM2A) 105606501(RIOX1)
ODA120853602(RIOX1) 120856438 120871025(KDM2B) 120874763(KDM2A)
CCAD122423797(KDM2B) 122431484(KDM2A)
SSC100294703(KDM2A) 100512074(KDM2B) 100523074(RIOX1)
CFR102503719(KDM2B) 102505373(RIOX1) 102523384(KDM2A)
CBAI105070323(KDM2A) 105075429 105080628(KDM2B)
CDK105086126(RIOX1) 105102511(KDM2B) 105104438(KDM2A)
VPC102539900(KDM2B) 102543069(KDM2A) 102544596(RIOX1)
BACU103004183(KDM2B) 103010328 103014019(RIOX1) 103019182(KDM2A)
LVE103069841(RIOX1) 103076521(KDM2A) 103088952(KDM2B)
OOR101275960 101280158(KDM2B)
DLE111176276(RIOX1) 111183686(KDM2A) 111186955(KDM2B)
PCAD102978197(KDM2B) 102980914(RIOX1) 102995738(KDM2A)
PSIU116749506(RIOX1) 116755922 116757832(KDM2A) 116765072(KDM2B)
ECB100052955(KDM2A) 100059690(KDM2B) 100146448(RIOX1)
EPZ103541690(KDM2B) 103559839(KDM2A) 103567990(RIOX1)
EAI106827705(RIOX1) 106833507(KDM2A) 106842217(KDM2B)
MYB102249116(KDM2A) 102253219(KDM2B) 102256784(RIOX1)
MYD102751904(KDM2B) 102757410(RIOX1) 102768553(KDM2A)
MMYO118657792(RIOX1) 118665231(KDM2A) 118678173(KDM2B)
MLF102419266(KDM2B) 102433104(KDM2A) 102439028 102440102(RIOX1)
MNA107529559(KDM2B) 107533472 107533588(KDM2A)
PKL118706967(KDM2A) 118715502(RIOX1) 118725299(KDM2B)
HAI109381570(RIOX1) 109384201(KDM2A) 109386110(KDM2B)
DRO112310458(KDM2B) 112311546(RIOX1) 112317322(KDM2A)
SHON118976654(RIOX1) 118991072(KDM2B) 118991803(KDM2A)
AJM119036137(RIOX1) 119041861(KDM2A) 119048704(KDM2B)
PDIC114492357(RIOX1) 114499250(KDM2A) 114509357(KDM2B)
PHAS123808581(RIOX1) 123823004(KDM2B) 123829280(KDM2A)
MMF118616455(RIOX1) 118628053(KDM2A) 118639803(KDM2B)
RFQ117017373(KDM2B) 117022753(RIOX1) 117031282(KDM2A)
PALE102883377(KDM2B) 102887644(RIOX1) 102893981(KDM2A)
PGIG120584774(KDM2A) 120616077(KDM2B) 120619476(RIOX1)
PVP105289380(KDM2B) 105299251(RIOX1) 105309915
RAY107503783(KDM2A) 107505016 107515252(KDM2B)
MJV108390401(KDM2B) 108393149(KDM2A) 108397196(CUNH14orf169)
TOD119239267(RIOX1) 119245013(KDM2B) 119249920(KDM2A)
SARA101547993(KDM2A) 101556894(KDM2B) 105943148
LAV100668526(RIOX1) 100669609(KDM2B) 100672180(KDM2A)
TMU101346594 101348103 101348575 111821051
DNM101425403(KDM2A) 101437091(RIOX1) 101447492(KDM2B)
MDO100015947(KDM2B) 100024523(RIOX1) 100029240(KDM2A) 103104734
GAS123235838(RIOX1) 123251245(KDM2A) 123255833 123256857
SHR100925042(KDM2A) 105750349(RIOX1)
PCW110195381(KDM2A) 110196804(KDM2B) 110208359(RIOX1)
OAA100079482(KDM2B) 100084241(KDM2A) 100086314(RIOX1)
GGA416844(KDM2B) 423249(C5H14ORF169) 425999(KDM2A)
PCOC116228612(KDM2B) 116229243(RIOX1) 116243004(KDM2A)
MGP100544042(KDM2B) 100545882(RIOX1) 100551270(KDM2A)
CJO107314187(KDM2A) 107314864(RIOX1) 107321115(KDM2B)
NMEL110400817(KDM2A) 110401899(RIOX1) 110406580(KDM2B)
APLA101791557(KDM2B) 101795359 101796505(RIOX1)
ACYG106029324(KDM2A) 106031144(KDM2B) 106040700
AFUL116489571(RIOX1) 116490040(KDM2A) 116496229(KDM2B)
TGU100218907(KDM2B) 100219109(RIOX1) 100230512(KDM2A)
LSR110471756(KDM2B) 110472176(RIOX1) 110484936(KDM2A)
SCAN103818165(KDM2B) 103822131(KDM2A) 103826967(RIOX1)
PMOA120499553(KDM2A) 120500278(RIOX1) 120509578(KDM2B)
OTC121334309(RIOX1) 121339022(KDM2B) 121339269(KDM2A)
PRUF121349550(RIOX1) 121355161(KDM2A) 121364831(KDM2B)
GFR102033306(KDM2A) 102035608(RIOX1) 102045075(KDM2B)
FAB101813982(KDM2B) 101818982(KDM2A) 101819482(RIOX1)
PHI102111633(RIOX1) 102113870(KDM2B) 102114250(KDM2A)
PMAJ107205486(C5H14orf169) 107206215(KDM2A) 107211564(KDM2B)
CCAE111930251(RIOX1) 111930406(KDM2A) 111936391(KDM2B)
CCW104684132(KDM2A) 104688287(RIOX1) 104688702(KDM2B)
ETL114054942(KDM2B) 114055505(RIOX1) 114067858(KDM2A)
ZAB102060487(RIOX1) 102061355(KDM2A) 102062662(KDM2B)
FPG101912390(KDM2B) 101914594(KDM2A) 101922675(RIOX1)
FCH102050781(KDM2B) 102052310(KDM2A) 102052952(RIOX1)
CLV102084883(KDM2B) 102085791(RIOX1) 102096388(KDM2A)
EGZ104129653(KDM2A) 104130143(KDM2B) 104132280
NNI104009386(KDM2A) 104019494(KDM2B) 104020430
ACUN113480503(RIOX1) 113486070(KDM2B) 113490447(KDM2A)
TALA104357502(RIOX1) 104358065(KDM2A) 104364770(KDM2B)
PADL103912835 103914528(KDM2B) 103925836(KDM2A)
ACHC115338395(RIOX1) 115345468(KDM2B) 115351840(KDM2A)
AAM106493402(KDM2A) 106495671(KDM2B) 106498095(RIOX1)
AROW112962552(KDM2B) 112964060(RIOX1) 112966994(KDM2A)
NPD112945877 112954257(KDM2A)
DNE112980748(RIOX1) 112988614(KDM2A) 112991810(KDM2B)
ASN102376489(RIOX1) 102379559(KDM2B) 102388715(KDM2A)
AMJ102560036(RIOX1) 102565389(KDM2A) 106736919(KDM2B)
CPOO109312625(KDM2B) 109321529(CUNH14orf169) 109324605(KDM2A)
GGN109290598(KDM2B) 109298811(CUNH14orf169)
PSS102446014(KDM2B) 102450180(RIOX1) 102452607 102454325 102464032(KDM2A)
CMY102933242(RIOX1) 102933550(KDM2B) 102946953(KDM2A)
CPIC101941489(KDM2B) 101944320(KDM2A) 101944414(RIOX1)
TST117876034(KDM2A) 117876967(RIOX1) 117887903(KDM2B)
CABI116825381(RIOX1) 116833413(KDM2A) 116836761(KDM2B)
MRV120386209(KDM2B) 120393433(KDM2A) 120404335(RIOX1)
ACS100555582(kdm2a) 100557128(kdm2b) 100557464(riox1)
PVT110083885(KDM2B) 110085628(KDM2A) 110088098(RIOX1)
SUND121916509(KDM2B) 121919007(RIOX1) 121926140(KDM2A)
PBI103055385(KDM2B) 103064072(RIOX1) 103064363(KDM2A)
PMUR107286966(KDM2B) 107290099(RIOX1) 107296660(KDM2A)
TSR106540035 106547428 106551961 106555402
PGUT117665617(RIOX1) 117667174(KDM2A) 117672213(KDM2B)
VKO123026708(RIOX1) 123027328(KDM2A) 123028685(KDM2B)
PMUA114586201(KDM2B) 114594532(RIOX1) 114601850(KDM2A)
ZVI118076389(KDM2B) 118090145(KDM2A) 118097647(RIOX1)
GJA107109113(KDM2A) 107111814(RIOX1) 107115913
XLA108696323(kdm2a.L) 108697539 108707160(kdm2b.S) 108716657(riox1.L) 444267(kdm2b.L)
XTR100488246(riox1) 448624(kdm2b) 496596(kdm2a)
NPR108787819(KDM2B) 108788943(CUNH14orf169) 108801104(KDM2A)
RTEM120909275(KDM2A) 120933591(KDM2B) 120937491(RIOX1)
BBUF120988579(KDM2B) 120998764(RIOX1) 121003262(KDM2A)
BGAR122924538 122934417(RIOX1) 122940172(KDM2A)
DRE100536129 560815(riox1) 571851(kdm2aa) 799441(kdm2ab)
SRX107712479 107719421 107742705 107746202 107746404 107753096 107754453 107758663(kdm2b)
SANH107658591 107661934 107665255 107669424 107674221 107679864 107687979 107689109 107703170 107704066
SGH107548410 107550974 107551394 107554421(kdm2b) 107556790 107557667 107558119 107559126 107588325 107602054
CCAR109052892 109063698 109063751 109065515 109068503 109080177 109081363 109091792 109094893 109097580
CAUA113054555 113068568 113068613 113069569 113070766 113073855 113078599 113107738 113110259 113113665 113120605
IPU108257725(riox1) 108262769(kdm2aa) 108264901(kdm2ba) 108268705(kdm2ab)
PHYP113532105(riox1) 113539151 113542768(kdm2a)
SMEO124377246(riox1) 124386061(kdm2ab) 124398976(kdm2aa) 124400426(kdm2ba)
AMEX103024695 103030174 103034250(kdm2b) 103035470(riox1) 103039345(kdm2a)
EEE113567668(kdm2b) 113570717(kdm2a) 113571493 113571701(riox1) 113586912
TRU101063174 101067040(kdm2a) 101069081(riox1) 101071235 101075964
TNGGSTEN00004828G001 GSTEN00011934G001 GSTEN00017289G001 GSTEN00017290G001 GSTEN00023017G001 GSTEN00024626G001
LCO104930843(riox1) 104931175 104933677 104936293 104937673(kdm2a)
NCC104940908 104950067 104950965 104953326(kdm2b) 104958708(kdm2a)
CGOB115006789 115013687 115014563(kdm2a) 115016689
ELY117252886(kdm2ba) 117255507(kdm2aa) 117261494(kdm2ab) 117269663 117270465(riox1)
PLEP121941507(kdm2aa) 121944340(kdm2ba) 121947896(kdm2ab) 121955439(riox1) 121959647
SLUC116034958 116046932(kdm2aa) 116052404(kdm2ab) 116062323(kdm2ba) 116066116(riox1)
ECRA117951958(kdm2ab) 117958690(kdm2aa) 117959062 117961991(riox1)
PFLV114555585 114562811 114566068 114570709(kdm2b) 114572971(riox1)
GAT120807956(riox1) 120817446(kdm2ab) 120825039(kdm2aa) 120830320(kdm2ba) 120832110
PPUG119194751(riox1) 119210553(kdm2ab) 119218122(kdm2aa) 119224524(kdm2ba) 119226294
MSAM119888500(kdm2ab) 119891286(kdm2ba) 119908808(riox1) 119914202(kdm2aa) 119914573
CUD121508395(kdm2aa) 121509709(kdm2ba) 121516335(kdm2ab) 121521468(riox1) 121524960
MZE101465495 101466884(riox1) 101468357(kdm2a) 101486102 101487519
ONL100691565 100692165 100695561(kdm2a) 100701413 100712195(riox1)
OAU116312736(riox1) 116322426 116323655(kdm2ba) 116326954(kdm2aa) 116331600(kdm2ab)
OLA101161646 101163098 101163704(riox1) 101164160(kdm2a) 101171056
OML112137427(kdm2aa) 112148273(kdm2ba) 112152128 112153468(kdm2ab) 112157677(riox1) 112163128
XMA102219164(kdm2a) 102224704 102226754 102228067 102237385
XCO114139543(kdm2a) 114145414 114149281 114154635 114158239
XHE116714885(kdm2a) 116720224 116724159 116729590 116734273(riox1)
PRET103457383 103470449 103470607 103471745(kdm2a) 103473724
PFOR103133537 103146746 103147495(kdm2a) 103148830 103153626 103153631
PLAI106939770 106942325(kdm2a) 106953534 106954487 106961357 106962978
PMEI106907836 106911368 106920843 106921087 106924284 106924929
GAF122825053(riox1) 122827808(kdm2ba) 122829166(kdm2aa) 122836685(kdm2ab) 122847192
CVG107080779 107085686(kdm2a) 107091301 107092765 107102329
CTUL119771556(riox1) 119772942(kdm2aa) 119784952(kdm2ba) 119788321(kdm2ab) 119789003
GMU124859998(kdm2ab) 124868248(kdm2aa) 124872752 124878386(kdm2ba) 124882140(riox1)
NFU107376672(kdm2a) 107377721 107382424 107389061 107393666 107395465
KMR108232715 108233352(riox1) 108236516(kdm2ba) 108243031(kdm2ab) 108249790(kdm2aa)
ALIM106511523 106514481 106516297(kdm2a) 106516710 106525670 106533572 106536986
NWH119408440(kdm2ab) 119418309(riox1) 119422629(kdm2aa) 119424379
AOCE111568501 111571796 111576508(kdm2a) 111581378 111581834
CSEM103381232(c7h14orf169) 103384305 103390456 103390943(kdm2a) 103398071(kdm2b)
POV109626186 109626832(kdm2a) 109627364 109636096 109641108
SSEN122758210 122764768 122769343(kdm2ba) 122770914(kdm2aa) 122778912(kdm2ab) 122784601(riox1)
HHIP117758517(riox1) 117768461(kdm2ba) 117769016(kdm2ab) 117771518 117771754(kdm2aa)
LCF108872906 108873507(cunh14orf169) 108878302(kdm2a) 108878436 108879821
SDU111226470 111230448 111232726 111234153 111237580(riox1)
SLAL111644944 111646478 111647621 111655174 111661395(riox1) 111662809(kdm2a)
XGL120785238(kdm2ab) 120788910(riox1) 120799999(kdm2aa) 120805096(kdm2ba) 120805980
HCQ109511586 109512629 109514677(riox1) 109521726 109524342(kdm2a)
BPEC110160460 110163356(kdm2a) 110164233(riox1) 110164352 110169850
MALB109951304 109954947 109955525(kdm2a) 109962343 109972565
SASA106564592(kdm2b) 106568226 106571660 106579932 106585505 106602582 106604673 106608197 106609898(kdm2a) 106611679
OTW112217927 112219441 112220949(kdm2ab) 112231599(kdm2aa) 112248375 112250477 112256247 112257585 112262401 112263010
OMY110488821(kdm2ab) 110497438 110505025 110522552 110522926 110525561 110529775 110534441(kdm2aa) 110535930 110537201
OGO123990907 123993412(kdm2ab) 123995725 124000176 124001532 124010402 124012101 124034392 124036216 124048818
ONE115105816 115107911 115111514 115124675 115129464 115130050 115137354 115139161 115139949 115145773
SALP111954191 111958253 111961481 111965740 111967492 111971338 111974223 111980664 112069089
SNH120019127 120024164 120025936 120034948(kdm2aa) 120045037 120048096(kdm2ab) 120052890 120062298 120063180 120063786
ELS105014887 105017561(riox1) 105022887 105024850(kdm2b) 105028557(kdm2a)
SFM108921847 108924117(riox1) 108925897 108935024 108935906
PKI111836283 111839265(kdm2b) 111841139(riox1) 111842213 111861052
AANG118206992 118212759 118228247(kdm2aa) 118229175(riox1) 118232420(kdm2ab)
LOC102690247(clg1h14orf169) 102691817(kdm2a) 102698511(kdm2b)
PSPA121296893 121299711 121302361 121307226 121307716 121317174(riox1)
ARUT117411433(riox1) 117426610 117428465
LCM102352369(RIOX1) 102358334(KDM2A) 102363992(KDM2B)
CMK103180532 103181758(riox1) 103184391
RTP109913950(kdm2b) 109917965 109921777(riox1) 109925258(kdm2a)
BFO118413074 118426751
BBEL109463838 109480680 109480681 109484918
CIN100179691 778852(zf(cxxc)-1)
SCLV120327006 120342191
SPU574799 577190
APLC110976555 110982530
SKO100371879 100375112
DMEDmel_CG11033(Kdm2) Dmel_CG2982(NO66)
DER6550993 6552450
DSE6607159
DSIDsimw501_GD18594(Dsim_GD18594)
DYADyak_GE16340 Dyak_GE25927
DAN6499376
DSR110176117 110186505
DPODpse_GA27865 Dpse_GA27866 Dpse_GA30197 Dpse_GA31970
DPE113566194 6591794 6597402
DMN108154942 108164587 117187195 117187196 117187199 117187200 117190646
DWI6647996 6652943
DGR6563071 6565600
DMODmoj_GI16410 Dmoj_GI22556
DAZ108608577 108618020
DNV108653004 108657567
DHE111591852 111604808
DVI6629815
CCAT101450076 101462013
BOD106618051 106618530
MDE101891741 101894252
SCAC106081790 106091915
LCQ111683814 111688372
AGAAgaP_AGAP001895 AgaP_AGAP001938
ACOZ120951463 120952293
AARA120897878 120903074
AAG110680236 5570227 5571894
AALB109407084 109426325 109426359 109621627 115268888
CQUCpipJ_CPIJ008371 CpipJ_CPIJ008401
CPII120414310 120414325
CNS116339439 116344626
AME410848 411568
ACER107996957 108002708
ALAB122717612 122719543
BIM100743608 100749187
BBIF117206763 117216404
BVK117233553 117236965
BVAN117154730 117157575
BTER100650431 100650659
BPYO122574469 122574496
CCAL108623065 108624157
OBB114874494 114876411
MGEN117226998
NMEA116427982 116434741
CGIG122397658 122403328
SOC105195163 105197100
MPHA105830462 105839651
AEC105148346 105148932
ACEP105622879 105626314
PBAR105431133 105432615
VEM105567104 105568858
HST105181653 105188521
DQU106740689 106745310
CFO105252240 105256776
FEX115232796 115233656
LHU105669936 105674731
PGC109852495 109852596
OBO105284028 105284273
PCF106785092 106787506
PFUC122519508 122524395
VPS122631693 122637277
NVI100114113 100122421
CSOL105361242 105368275
TPRE106650151 106658971
MDL103569265 103569639
CGLO123260654 123261002
FAS105267041 105269920
DAM107039223 107041676
AGIF122848746 122848926
CCIN107263919 107266661
TCA659466 663248
DPA109536781 109546828
SOY115879320 115881558
ATD109604615 109605029
CSET123310038 123319881
AGB108905622 108908622
LDC111505542 111516081
NVL108566151 108567342
APLN108739321 108740416
PPYR116161098 116169446
OTU111415343 111425061
BMOR101739566 101739693
BMAN114246951
MSEX115441256 115441364
DPLKGM_206885 KGM_214532
BANY112050888 112053444
PMAC106709104 106709696
PPOT106105778 106108319
PXU106117909 106122209
PRAP110993211 111002362
ZCE119833100 119833109 119833729 119833950
HAW110370794 110376084
TNL113502805 113505739
OFU114360506 114361897
PXY105380251 105381154
API100167047 100169407
DNX107165474 107171100
AGS114125970 114132286
RMD113549623 113555479
BTAB109041551 109042139
DCI103507167 103514594
CLEC106660819 106662860
HHAL106677496 106689248
NLU111046140 111047214 111061999 120353620
PHUPhum_PHUM117430 Phum_PHUM316810
FOC113206778 113210838
ZNE110828085 110829331
CSEC111871260 111873254
FCD110846387 110850612
DPXDAPPUDRAFT_308697
DMK116922797
PVM113812052 113816225 113828611
PJA122243313 122261948
HAME121865035 121876486
PCLA123770279
PTRU123515565 123517900
HAZT108665309 108673958
EAF111697580 111703939 111705001 111707473
ISCIscW_ISCW006941 IscW_ISCW018631
DSV119446592 119457670
RSAN119374841 119389762
RMP119161974 119167101
VDE111251512 111252269
VJA111271887 111273000
TUT107364769 107364877 107364953
DPTE113798945 113798953
DFR124497204 124497205
CSCU111622110 111628258 111640562
PTEP107438310 107451805
SDM118182827 118197598
CELCELE_T26A5.5(jhdm-1) CELE_T28F2.4(jmjc-1)
CBRCBG_01999 CBG_11988(Cbr-jmjc-1) CBG_17150 CBG_19679
LOALOAG_00418 LOAG_01801
NAINECAME_11131 NECAME_11545
HROHELRODRAFT_104360 HELRODRAFT_116230
LGILOTGIDRAFT_194127 LOTGIDRAFT_52553
PCAN112563134 112569766
BGT106056201 106070561
GAE121367980 121370586
HRF124123858 124132061
HRJ124254173 124285197
CRG105328660 105337855
MYI110459592 110463070
PMAX117324179 117332570
MMER123533161 123534922
OBI106871161 106882535
OSN115217342 115222653
LAK106150818 106162160
SMMSmp_127230
OVIT265_03702 T265_13524
EGLEGR_06616
NVE5510735 5512876
EPA110233938 110241366
ATEN116296360 116307035
ADF107332536 107337535
AMIL114952688 114975668
PDAM113673467 113676131
SPIS111322098 111340509
DGT114520394 114522136
XEN124435302 124442673
HMG100198785 100209380 100212991
TADTRIADDRAFT_49824 TRIADDRAFT_50673
AQU100632164 100636565
ATHAT3G20810(JMJD5)
ALY9321472
CRB17891861
CSAT104746496 104765969 104785791
EUSEUTSA_v10021129mg
BRP103869271(JMJ30)
BNA106401865 106451862
BOE106344094
RSZ108856700
THJ104816908
CPAP110811807
CIT102619679
CICCICLE_v10015488mg
PVY116141157
MINC123199410 123205616 123225021
TCC18589751
GRA105772548
GHI107889882 107962150
GAB108486474
DZI111286567 111302754
EGR104421557 104429511
GMX100779376 100813075
GSJ114374564 114379434
PVUPHAVU_011G056900g
VRA106755596
VAR108338976
VUN114169300
CCAJ109798941
APRC113864360 113864393
MTRMTR_4g066020
CAM101494684 101499299
LJALj3g3v3271520.2(Lj3g3v3271520.2)
ADU107476784
AIP107629002
AHF112736762 112788856
LANG109325410 109353441
FVE101301573
RCN112165779
PPER18774862
PMUM103341839
PAVI110770961
PDUL117631324
MDM103447103
PXB103963740
ZJU107412622
CSV101210592
CMO103492075
BHJ120070650
MCHA111021407
CMAX111467010
CMOS111434618
CPEP111792583
RCU8274402
HBR110639322 110648608
MESC110618015
POP7496047
PEU105134948
PALZ118061482
JRE108998746
QSU112002893 112009457 112037524
QLO115976155 115980935
TWL120017196
VVI100267241
VRI117916444
SLY101251119(JMJ524)
SPEN107003102
SOT102591001
CANN107874851
NTA107763337 107809124
NSY104226658
NTO104094942
NAU109220083
INI109152231
ITR116004326 116024574
SIND105163547
OEU111380176
EGT105951082
SSPL121792093 121792679
HAN110927139
ECAD122596654
LSV111890249
CCAV112522168
DCR108227309
CSIN114265496
BVG104889940
SOE110801981
CQI110686607 110695983 110736170
NNU104597503
MING122061548
TSS122642450
PSOM113320488
NCOL116256217
OSA4347435 9269734
DOSAOs08t0508500-00(Os08g0508500) Os09t0489200-00(Os09g0489200)
OBR102705376
BDI100831374 100835429
ATS109731690 109755349
TDC119302039 119310833 119331051 119341255
TAES123104170 123112409 123120670 123151191 123157476 123165350
SBI8064848
ZMA100272621 118477004
SITA101763987
SVS117845570 117861409
PVIR120661075 120678675 120712796
PHAI112880435 112897485
PDA103711389
EGU105050222
MUS103996261 103998486
DCT110098668
PEQ110029507
ATR18439881
SMOSELMODRAFT_147465 SELMODRAFT_75959
PPP112277103 112287109 112294064
MNGMNEG_6536
CSLCOCSUDRAFT_37936 COCSUDRAFT_58358 COCSUDRAFT_64552
CVRCHLNCDRAFT_140729 CHLNCDRAFT_142546 CHLNCDRAFT_36633
APROF751_1723 F751_3734
OLUOSTLU_15879 OSTLU_39523
OTAOT_ostta01g04890 OT_ostta06g03570
BPGBathy10g01340
MISMICPUN_68455
MPPMICPUCDRAFT_55966
CMECYME_CMB046C
GSLGasu_02670
CCPCHC_T00004130001
SCEYER051W(JHD1)
AGOAGOS_ADL088W
ERCEcym_4349
KLAKLLA0_F27643g
KMXKLMA_40344(JHD1)
LTHKLTH0A03960g
VPOKpol_1070p18
ZROZYRO0D16588g
CGRCAGL0J02860g
TPFTPHA_0C01220(TPHA0C01220)
TDLTDEL_0H02210(TDEL0H02210)
ZMKHG535_0F03570
PPAPAS_chr1-1_0295
DHADEHA2B02464g
PICPICST_53771
PGUPGUG_00053
SPAASPAPADRAFT_49589
LELLELG_00524
CALCAALFM_CR00750CA(CaO19.3281)
CTPCTRG_01004
COTCORT_0A04120
CDUCD36_25830
YLIYALI0E30393g
CLUCLUG_04360
CLUSA9F13_04g01496
CAURCJI97_000689
SLBAWJ20_3653(JHD1)
PKZC5L36_0A03250
BNNFOA43_004312
BBRXBRETT_002110
ANIAN7455.2
AFMAFUA_2G05970
ACTACLA_068360
NFINFIA_082690
AORAO090001000714
ANGANI_1_3330024(An02g14310)
AFVAFLA_012848
ALUCAKAW2_11201A(JHD1)
ACHEACHE_80271A(JHD1)
APUUAPUU_80592S(JHD1)
PCSPc22g08370
PDPPDIP_32210
TMFPMAA_028800
TRGTRUGW13939_06056
CIMCIMG_00992
CPWCPC735_053600
UREUREG_00939
PBLPAAG_01011
PBNPADG_03818
ABEARB_05068
TVETRV_06674
AJEHCAG_03655
BGHBDBG_05420
PNOSNOG_15868
PTEPTT_16007
BZECOCCADRAFT_23035
BSCCOCSADRAFT_84394
BORCOCMIDRAFT_1476
AALTCC77DRAFT_1025433
ZTRMYCGRDRAFT_43039
PFJMYCFIDRAFT_104451
BCOMBAUCODRAFT_71174
NPAUCRNP2_7305
TMLGSTUM_00006749001
SPOSPCC622.16c(epe1)
CNECNG00620
CNBCNBG4160
CGICGB_G6080W
TASAA1Q1_07436
HIRHETIRDRAFT_407575
LBCLACBIDRAFT_316140(JMJ16203)
CCICC1G_05206
CPUTCONPUDRAFT_118075
WSEWALSEDRAFT_37169
UMAUMAG_04522
PFPPFL1_01420
MGLMGL_3466
MSYMMSY001_1659
PGRPGTG_15521
MLRMELLADRAFT_37912
MBRMONBRDRAFT_25364 MONBRDRAFT_25525
SREPTSG_08718 PTSG_10023
DDIDDB_G0287513(jcdG)
DPPDICPUDRAFT_32138
DFADFA_11703(jcdG)
ACANACA1_116850 ACA1_163410
TGOTGME49_240840
SMINv1.2.004901.t1(symbB.v1.2.004901.t1)
PTIPHATRDRAFT_14981 PHATRDRAFT_42595
FCYFRACYDRAFT_140013 FRACYDRAFT_184520
TPSTHAPSDRAFT_21082
AAFAURANDRAFT_27938 AURANDRAFT_5428 AURANDRAFT_67230
PIFPITG_15871
PSOJPHYSODRAFT_330429
SPARSPRG_19899
EHXEMIHUDRAFT_204434 EMIHUDRAFT_251857 EMIHUDRAFT_468207
GTTGUITHDRAFT_137055 GUITHDRAFT_99731
TCR508141.30
LMALMJF_31_0240
LIFLINJ_31_0250
LDOLDBPK_310250
LMILMXM_30_0240
LBZLBRM_31_0350
LPANLPMP_310240
NGRNAEGRDRAFT_50047
GAIIMCC3135_29925
GSNYC6258_01730
BUUWS70_28025
PMEGFNZ07_13045
MYMA176_001354 A176_001355
SURSTAUR_4147 STAUR_4148
BNEDA69_09585
TSVDSM104635_03271
BOOE2K80_14680
HYTHXX25_00305
CBOTATE48_13775
SKRBRX40_14885
PALGHFP57_13505
EGNBMF35_a0161
GOHB932_3351
MITOCO_32100
MIAOCU_31990
MIDMIP_04812
MYOOEM_31660
MCHIAN480_16830
MIROCQ_33210
MMALCKJ54_14920
MMCMmcs_5250
MKMMkms_5339
MJLMjls_5630
MMMW7S_16070
MNVMNVI_12480
MPAGC0J29_03825
MNMMNVM_13050
MGORH0P51_21535
MCOOMCOO_04950
MRHMycrhN_0917
MDUMDUV_43950
MDRMDOR_37000
MAUUNCTC10437_00364(yxbC)
MMAGMMAD_19710
MARZMARA_23240
MGADMGAD_51900
MJDJDM601_0518
MTER4434518_00510(yxbC)
RPYY013_03855
RBYCEJ39_14485
RHBNY08_907
RHQIM25_17690
RRT4535765_02566
RTMG4H71_01355
GBRGbro_2909
GPOGPOL_c26810
DITC3V38_08235
DIZCT688_02065
DPCA6048_02080
DLUA6035_02390
SALBXNR_5758
SGBWQO_03070
SFASfla_5934
SALSSLNWT_3295
STRPF750_0636
SKYD0C37_31070
SCADDN051_43980 DN051_44435
STRDNI25_36560
SSIAA7J05_04445
SVUB1H20_02705
SSEOD0Z67_25950
SCINCP977_01955
SCALI6J39_02830
AGYATC03_04275
HUMDVJ78_15175
ARRARUE_c03510
ARNCGK93_02080
AAUAAur_0378
KFVAS188_02125
KRSEQG70_00845
SERJSGUI_1093
BCAUI6G59_05370
AUSIPK37_15610
NDKI601_2829
NANOG5V58_24400
NMESH9L09_18325
AERAERYTH_14845
AEZC3E78_09790
AEFGEV26_09165
KQIF1D05_21695
NMLNamu_3066
GOBGobs_3279
BSDBLASA_2203
AOIAORI_4660
PSEAWY02_10010
PBROHOP40_00645
STPStrop_2151
SAQSare_2302
MAUMicau_2895
MILML5_5502
MICBMicB006_6010
MTUACSH63_10600
MICHFJK98_19625
MTEMGCE86_06755
MCABHXZ27_17560
MSAGGCM10017556_48830
VMAVAB18032_23085
MCRAID554_00975
ASEACPL_3966
AMSAMIS_54080
ACTNL083_5136
AFSAFR_26720
ACTSACWT_3837
PLKCIK06_13790
PLABC6361_02940
PLATC6W10_18690
PFLAPflav_019010
VERHUT12_19890
ATLAthai_39110
PRYPrubr_68690
CATICS0771_60650
ATQGH723_03940
MPROBJP34_24110
DOUBMF77_04949(roxA) BMF77_pa00032
FTJFTUN_1194
MGINFRZ54_05290
CIVIMZ16_08555
 » show all
Reference
1  [PMID:16362057]
  Authors
Tsukada Y, Fang J, Erdjument-Bromage H, Warren ME, Borchers CH, Tempst P, Zhang Y
  Title
Histone demethylation by a family of JmjC domain-containing proteins.
  Journal
Nature 439:811-6 (2006)
DOI:10.1038/nature04433
  Sequence
[hsa:22992 84678] [sce:YER051W]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.27
IUBMB Enzyme Nomenclature: 1.14.11.27
ExPASy - ENZYME nomenclature database: 1.14.11.27
BRENDA, the Enzyme Database: 1.14.11.27

DBGET integrated database retrieval system