KEGG ENZYME: 1.14.11.29

ENZYME: 1.14.11.29

Entry

EC 1.14.11.29               Enzyme

Name

hypoxia-inducible factor-proline dioxygenase;
HIF hydroxylase

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

Sysname

hypoxia-inducible factor-L-proline, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating)

Reaction(IUBMB)

hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 = hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2

Substrate

hypoxia-inducible factor-L-proline;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]

Product

hypoxia-inducible factor-trans-4-hydroxy-L-proline;
succinate [CPD:C00042];
CO2 [CPD:C00011]

Comment

Contains iron, and requires ascorbate. Specifically hydroxylates a proline residue in HIF-alpha, the alpha subunit of the transcriptional regulator HIF (hypoxia-inducible factor), which targets HIF for proteasomal destruction. The requirement of oxygen for the hydroxylation reaction enables animals to respond to hypoxia.

History

EC 1.14.11.29 created 2010

Orthology

K09592

hypoxia-inducible factor prolyl hydroxylase

Genes

HSA:	112398(EGLN2) 112399(EGLN3) 54583(EGLN1)

PTR:	452850(EGLN3) 456049(EGLN2) 469708(EGLN1)

PPS:	100971263(EGLN1) 100984867(EGLN2) 100990967(EGLN3)

GGO:	101145572(EGLN2) 101147171(EGLN1) 101150306(EGLN3)

PON:	100172704(EGLN2) 100451138(EGLN3) 100454843(EGLN1)

NLE:	100584172(EGLN2) 100591967(EGLN3) 100594374(EGLN1)

MCC:	114674212(EGLN2) 703083(EGLN2) 713410(EGLN1) 717342(EGLN3)

MCF:	101865926(EGLN3) 102119819(EGLN2) 102128342(EGLN1)

MTHB:

126942051 126942488 126959176

CSAB:

103228800(EGLN3) 103230756(EGLN1) 103234719(EGLN2)

CATY:

105574854(EGLN1) 105592243(EGLN3) 105598009(EGLN2)

PANU:

100998148(EGLN2) 101006704(EGLN1) 101018094(EGLN3)

TGE:	112612417(EGLN2) 112623067(EGLN1) 112629359(EGLN3)

RRO:	104670730(EGLN1) 104676100(EGLN2) 104676305(EGLN3)

RBB:	108537828(EGLN1) 108539035(EGLN2) 108544680(EGLN3)

TFN:	117069837(EGLN3) 117075653(EGLN1) 117091935(EGLN2)

PTEH:

111526217(EGLN1) 111552848(EGLN3) 111553970(EGLN2)

CJC:	100389821(EGLN3) 100397980(EGLN2) 100413526(EGLN1)

SBQ:	101029000(EGLN3) 101045149(EGLN2) 101051675(EGLN1)

CSYR:

103250793 103259521(EGLN2)

MMUR:

105856453(EGLN1) 105875955(EGLN3) 105876751(EGLN2)

LCAT:

123624299(EGLN2) 123627448(EGLN1) 123650266(EGLN3)

OGA:	100952096(EGLN3) 100953629(EGLN2) 100961137(EGLN1)

MMU:	112405(Egln1) 112406(Egln2) 112407(Egln3)

MCAL:

110299462(Egln2) 110300648(Egln1) 110307114(Egln3)

MPAH:

110321385(Egln2) 110324486(Egln3) 110337366(Egln1)

RNO:	308457(Egln2) 308913(Egln1) 54702(Egln3)

MCOC:

116070408(Egln1) 116080173(Egln3) 116101867(Egln2)

MUN:	110552742(Egln3) 110555297(Egln1) 110556732(Egln2)

CGE:	100754377(Egln3) 100771495(Egln2) 100772704(Egln1)

MAUA:

101825375(Egln2) 101827803(Egln1) 101832817(Egln3)

PLEU:

114681532(Egln2) 114689778 114693363(Egln3) 114704866 114707163(Egln1)

MORG:

121446970(Egln1) 121449369(Egln2) 121452582(Egln3)

MFOT:

126492564 126499574 126504523

AAMP:

119802268(Egln1) 119819202(Egln3) 119821174(Egln2)

NGI:	103738632(Egln3) 103744145(Egln1) 103750775(Egln2)

HGL:	101704717(Egln2) 101707155 101709882(Egln1) 101718787(Egln3)

CPOC:

100717566(Egln3) 100726309(Egln1) 100726886(Egln2)

CCAN:

109694610(Egln1) 109697177(Egln3) 109697661(Egln2)

DORD:

105982599(Egln3) 105984393(Egln1) 105998098(Egln2)

DSP:	122097367(Egln2) 122106547(Egln3) 122113219(Egln1)

NCAR:

124961783 124966483 124978276

OCU:	100337938(EGLN2) 100354210(EGLN3) 100357337(EGLN1)

OPI:	101520745(EGLN3) 101531628(EGLN2) 101535337(EGLN1)

TUP:	102482051(EGLN1) 102483132(EGLN2) 102502105(EGLN3)

CFA:	480286(EGLN3) 484495(EGLN2) 488971(EGLN1)

CLUD:

112645441(EGLN2) 112657132(EGLN3) 112660780(EGLN1)

VVP:	112926605(EGLN3) 112927397(EGLN1) 112928357(EGLN2)

VLG:	121484683(EGLN2) 121486802(EGLN1) 121493371(EGLN3)

AML:	100465601(EGLN2) 100470632(EGLN3) 100474374(EGLN1)

UMR:	103661051(EGLN2) 103661877(EGLN1) 103680905(EGLN3)

UAH:	113243552(EGLN2) 113259033(EGLN1) 113266114(EGLN3)

UAR:	123782957(EGLN1) 123783105(EGLN2) 123795699(EGLN3)

ELK:	111160510 111160932 111161431

LLV:	125084509 125088695 125104856

MPUF:

101675598(EGLN3) 101676101(EGLN2) 101684127(EGLN1)

ORO:	101367839(EGLN3) 101368021(EGLN2) 101377787(EGLN1)

EJU:	114202458(EGLN2) 114210271(EGLN1) 114217792(EGLN3)

ZCA:	113909953(EGLN3) 113919390(EGLN1) 113935977(EGLN2)

MLX:	118002820 118002865 118012905(EGLN1) 118022639(EGLN2)

NSU:	110585605(EGLN3) 110586002(EGLN1) 110590276(EGLN2)

LWW:	102748129(EGLN3) 102748492(EGLN2)

FCA:	101082320(EGLN3) 101089964(EGLN1) 101090063(EGLN2)

PYU:	121011422(EGLN2) 121023169(EGLN1) 121031633(EGLN3)

PBG:	122468983(EGLN3) 122492747(EGLN1) 122494020(EGLN2)

LRUF:

124508892 124511105 124518601

PTG:	102951182(EGLN3) 102957902(EGLN1) 102958475(EGLN2)

PPAD:

109248931(EGLN1) 109254307(EGLN3) 109256611(EGLN2)

AJU:	106976258(EGLN3) 106979627(EGLN2) 106981639(EGLN1)

HHV:	120219702(EGLN3) 120237815(EGLN1) 120241257(EGLN2)

BTA:	534075(EGLN1) 535578(EGLN3) 536763(EGLN2)

BOM:	102280498(EGLN3) 102280646(EGLN2) 102287116(EGLN1)

BIU:	109572227(EGLN2) 109575537(EGLN3)

BBUB:

102400098(EGLN1) 102402360(EGLN3) 102409464(EGLN2)

CHX:	102179524(EGLN3) 102189459(EGLN1) 102191264(EGLN2)

OAS:	101114163(EGLN1) 101117367(EGLN3) 101120517(EGLN2)

ODA:	120865448(EGLN1) 120872418(EGLN2) 120875104(EGLN3)

CCAD:

122420569(EGLN2) 122446667(EGLN1) 122455242(EGLN3)

SSC:	100152368(EGLN3) 100153461(EGLN1) 100523673(EGLN2)

CFR:	102505367(EGLN1) 102507989(EGLN2) 102513612 102516321(EGLN3)

CBAI:

105062870(EGLN2) 105075082(EGLN1) 105075242(EGLN3)

CDK:	105093358(EGLN2) 105094177(EGLN3) 105102153(EGLN1)

VPC:	102537733(EGLN3) 102541517(EGLN2) 102542335(EGLN1)

BACU:

102997608(EGLN3) 103012144(EGLN2) 103012953(EGLN1)

LVE:	103078947(EGLN2) 103086133(EGLN1) 103088451(EGLN3)

OOR:	101284894(EGLN3) 101288091(EGLN1) 101288571(EGLN2)

DLE:	111163986(EGLN1) 111173240(EGLN3) 111180833(EGLN2)

PCAD:

102973467(EGLN2) 102988280(EGLN3) 102990364(EGLN1)

PSIU:

116741497(EGLN1) 116743605(EGLN2) 116749704(EGLN3)

ECB:	100056635(EGLN3) 100060551(EGLN1) 100064859(EGLN2)

EPZ:	103553997(EGLN1) 103554984(EGLN3) 103565423(EGLN2)

EAI:	106841256(EGLN3) 106843305(EGLN2) 106846732(EGLN1)

MYB:	102248142(EGLN2) 102261310(EGLN3) 102261609(EGLN1)

MYD:	102752541(EGLN2) 102755440(EGLN1) 102764073(EGLN3)

MMYO:

118674318(EGLN2) 118678172(EGLN3) 118678818(EGLN1)

MLF:	102423938(EGLN2) 102431340(EGLN3)

MNA:	107524237(EGLN1) 107534212(EGLN2) 107534404(EGLN3)

PKL:	118702276(EGLN2) 118718018(EGLN1) 118726548(EGLN3)

HAI:	109374857(EGLN2) 109390367(EGLN3)

DRO:	112296534(EGLN3) 112306105(EGLN1) 112320084(EGLN2)

SHON:

118984215(EGLN2) 118989914(EGLN3) 118996702(EGLN1)

AJM:	119040737(EGLN2) 119042924(EGLN1) 119061156(EGLN3)

PDIC:

114492445(EGLN3) 114510904(EGLN2) 114512310(EGLN1)

PHAS:

123820500(EGLN3) 123823846(EGLN2) 123833021(EGLN1)

MMF:	118638216(EGLN3) 118639025(EGLN2) 118640516(EGLN1)

RFQ:	117018559(EGLN1) 117024016(EGLN3) 117035084(EGLN2)

PALE:

102881942(EGLN2) 102886969(EGLN3) 102894690(EGLN1)

PGIG:

120592591(EGLN1) 120595483(EGLN2) 120608582(EGLN3)

PVP:	105300146(EGLN2) 105305418(EGLN3) 105306014(EGLN1)

RAY:	107499468(EGLN3) 107520040(EGLN1) 107521816(EGLN2)

MJV:	108397735(EGLN2)

TOD:	119239002(EGLN3) 119244603(EGLN1) 119249339(EGLN2)

SARA:

101554353(EGLN1) 101554704(EGLN2) 101555023(EGLN3)

LAV:	100672145(EGLN1) 100674039(EGLN3) 100675805(EGLN2)

TMU:	101351991 101359457 101361248

ETF:	101648186(EGLN2) 101652145(EGLN3) 101658280(EGLN1)

DNM:	101417560(EGLN2) 101438279 101447775(EGLN3)

MDO:	100013679(EGLN3) 100018431(EGLN2) 100029166(EGLN1)

GAS:	123235924(EGLN3) 123240013(EGLN2) 123245463(EGLN1)

SHR:	100913457(EGLN3) 100929665(EGLN1) 116422889(EGLN2)

PCW:	110202901(EGLN2) 110217829(EGLN1) 110223697(EGLN3)

OAA:	100081498(EGLN3) 100090709(EGLN2) 100092885(EGLN1)

GGA:	423316(EGLN3) 768374(EGLN1)

PCOC:

116229351(EGLN3) 116242855(EGLN1)

MGP:	100540578(EGLN1) 100550799(EGLN3)

CJO:	107311390(EGLN1) 107315049(EGLN3)

NMEL:

110395721(EGLN1) 110401145(EGLN3)

APLA:

101794957(EGLN1) 101803442(EGLN3)

ACYG:

106031746(EGLN3) 106048487(EGLN1)

AFUL:

116487639(EGLN1) 116489898(EGLN3)

TGU:	100219039(EGLN3) 100227092(EGLN1)

LSR:	110468883(EGLN1) 110477184(EGLN3)

SCAN:

103818509(EGLN1) 103826557(EGLN3)

PMOA:

120500406(EGLN3) 120501296(EGLN1)

OTC:	121333741(EGLN3) 121334726(EGLN1)

PRUF:

121354244(EGLN1) 121362528(EGLN3)

GFR:	102036235(EGLN3) 102036815(EGLN1)

FAB:	101814352(EGLN3) 101820070(EGLN1)

PHI:	102100051(EGLN1) 102112105(EGLN3)

PMAJ:

107202314(EGLN1) 107206290(EGLN3)

CCAE:

111926882(EGLN1) 111930028(EGLN3)

CCW:	104684300(EGLN1) 104684695(EGLN3)

CBRC:

103620846(EGLN3)

ETL:	114060583(EGLN3) 114064546(EGLN1)

ZAB:	102062214(EGLN3)

FPG:	101915692(EGLN1) 101923024(EGLN3)

FCH:	102047874(EGLN3) 102059512(EGLN1)

CLV:	102092186(EGLN1) 102096357(EGLN3)

EGZ:	104131025(EGLN1) 104133309(EGLN3)

NNI:	104011784(EGLN3) 104018158(EGLN1)

ACUN:

113478081(EGLN1) 113480695(EGLN3)

TALA:

104368807(EGLN3) 116965447(EGLN1)

PADL:

103912943(EGLN3)

AFOR:

103901020(EGLN1)

ACHC:

115334796(EGLN3) 115349842(EGLN1)

HLE:	104828749(EGLN1) 104841765(EGLN3)

AGEN:

126049414 126051754

GCL:	127014130 127017298

OHA:	104332613(EGLN1)

DPUB:

104300858(EGLN1)

CUCA:

104060359(EGLN1)

AAM:	106483112(EGLN3) 106487314(EGLN1)

AROW:

112969778(EGLN1) 112975415(EGLN3)

NPD:	112958001(EGLN3) 112959348(EGLN1)

DNE:	112980330(EGLN3) 112993520(EGLN1)

SCAM:

104148113(EGLN1)

ASN:	102372013(EGLN1) 102383580(EGLN3)

AMJ:	102560217(EGLN3) 102566486(EGLN1)

CPOO:

109319107(EGLN1) 109321466(EGLN3)

GGN:	109299328(EGLN3) 109304243(EGLN1)

PSS:	102454124(EGLN3) 102462349(EGLN1)

CMY:	102932309(EGLN3) 102944392(EGLN1)

CPIC:

101944959(EGLN3) 101952573(EGLN1)

TST:	117874714(EGLN1) 117876454(EGLN3)

CABI:

116826725(EGLN1) 116835542(EGLN3)

MRV:	120401212(EGLN1) 120402770 120403289

ACS:	100555054(egln3) 100559436(egln1) 100567728(egln2)

PVT:	110070219(EGLN3) 110075404(EGLN1) 110075601(EGLN2)

SUND:

121915362(EGLN2) 121918952(EGLN3) 121934804(EGLN1)

PBI:	103051641(EGLN1) 103066300(EGLN3)

PMUR:

107285645(EGLN2) 107290938(EGLN1) 107292951(EGLN3)

CTIG:

120303399(EGLN1) 120311831(EGLN3) 120316496(EGLN2)

TSR:	106537993(EGLN3) 106541106(EGLN2) 106547635(EGLN1)

PGUT:

117665770(EGLN3) 117672000(EGLN1) 117677834(EGLN2)

VKO:	123018394(EGLN1) 123026210(EGLN2) 123026506(EGLN3)

PMUA:

114592657(EGLN3) 114594388(EGLN1) 114603171(EGLN2)

ZVI:	118081886(EGLN1) 118082320(EGLN3) 118086084(EGLN2)

GJA:	107108842(EGLN3) 107109906(EGLN2) 107123956(EGLN1)

STOW:

125426948(EGLN3) 125427101(EGLN1) 125430826(EGLN2)

XLA:	100036879(egln3.S) 100127282(egln3.L) 100158265(egln2.L) 108700271(egln2.S) 446395(egln1.S)

XTR:	100145602(egln3) 100487735(egln2) 548714(egln1)

NPR:	108789517(EGLN1) 108791944(EGLN2) 108794163(EGLN3)

RTEM:

120913315(EGLN2) 120920263(EGLN3) 120937615(EGLN1)

BBUF:

120977299(EGLN1) 120981917(EGLN3) 121009508(EGLN2)

BGAR:

122921870(EGLN3) 122946696(EGLN2) 122946811(EGLN1)

DRE:	100329385(egln1a) 406602(egln3) 436868(egln1b) 559569(egln2)

SRX:	107724964 107728333 107729299 107730384 107733839 107737236 107745877 107751107

SANH:

107667047 107687384 107690805 107691277 107693191 107693259 107699221 107699839

SGH:	107555273 107556149 107557733 107564238 107572057 107586581 107589684 107592652

CCAR:

109048049 109048372 109063801 109065546 109074353 109082858 109099512

CAUA:

113055383 113056581 113058594 113060922 113111041 113112350 113115280 113117678

PPRM:

120461007(egln1a) 120478692(egln2) 120480489(egln1b) 120480708(egln3)

MAMB:

125249035(egln2) 125256225(egln1b) 125268634(egln3) 125276461(egln1a)

IPU:	108270013(egln3) 108270809 108278008(egln2)

PHYP:

113538882(egln3) 113539196 113547059(egln1)

SMEO:

124389863(egln3) 124391081 124394487(egln2)

TFD:	113643564(egln2) 113646133 113659827(egln3)

AMEX:

103030532 103039372(egln3) 103047661

EEE:	113568218 113568979(egln1) 113579353(egln3) 113589405

TRU:	101061820(egln1) 101071309(egln3) 101071669

TNG:	GSTEN00004022G001 GSTEN00010948G001 GSTEN00014832G001 GSTEN00030880G001

LCO:	104917997 104924457(egln1) 104924821(egln3)

NCC:	104953366 104956816 104960291(egln1)

CGOB:

115017728 115020012(egln1) 115027849(egln3)

ELY:	117248219(egln1a) 117259653(egln2) 117266601(egln3)

EFO:	125888465(egln2) 125900877(egln3) 125903370(egln1a)

PLEP:

121942941(egln2) 121954342(egln1a)

SLUC:

116047738(egln2) 116051091(egln1a) 116063570(egln3)

ECRA:

117941964(egln2) 117960098(egln1a)

ESP:	116678496 116704831(egln1)

PFLV:

114546865(egln3) 114552365 114571682(egln1)

GAT:	120820907(egln2) 120821121(egln1a)

PPUG:

119210231(egln2) 119214106(egln1a)

MSAM:

119882224(egln2) 119910676(egln3) 119917249(egln1a)

CUD:	121511129(egln1a) 121520834(egln2) 121525885(egln3)

ALAT:

119004401(egln3) 119004779(egln2) 119033402(egln1a)

MZE:	101472504 101475861 101476165(egln1)

ONL:	100691117 100696862(egln1) 100702648(egln3)

OAU:	116310685(egln3) 116314728(egln2) 116318567(egln1a)

OLA:	101164580 101170367(egln1) 101175282(egln3)

OML:	112149481(egln2) 112149485(egln3) 112161713(egln1a)

XMA:	102221054 102232168(egln1) 102237645(egln3)

XCO:	114137982(egln1) 114155587(egln3) 114161371

XHE:	116707775 116709644(egln3) 116713250(egln1)

PRET:

103458095(egln3) 103474618 103477256(egln1)

PFOR:

103136266 103137657(egln1) 103147762(egln3)

PLAI:

106953845 106953955(egln3) 106957736(egln1)

PMEI:

106923820(egln1) 106924366(egln3) 106934088

GAF:	122833238(egln2) 122842780(egln1a) 122846016(egln3)

CVG:	107086869(egln3) 107087820(egln1) 107094171

CTUL:

119782918(egln1a) 119792118(egln2) 119797786(egln3)

GMU:	124855976(egln3) 124858848(egln1a) 124883940(egln2)

NFU:	107374017(egln3) 107375426(egln1) 107380304

KMR:	108240690(egln1a) 108243533(egln2) 108247517(egln3)

ALIM:

106515416 106515869(egln1)

NWH:	119410879(egln2) 119411172(egln1a) 119427850(egln3)

AOCE:

111578698 111585559(egln1) 111586571

MCEP:

125013934(egln2) 125018906(egln1a) 125024199(egln3)

CSEM:

103378094 103382494(egln3) 103387611(egln1)

POV:	109630335 109634863(egln1)

SSEN:

122773523(egln2) 122782254(egln1a) 122783094 122783252

HHIP:

117772686(egln2) 117775201(egln1a)

HSP:	118106242(egln2) 118118809(egln1a)

LCF:	108881163 108885792(egln1a) 108900822(egln2)

SDU:	111220712(egln1) 111236114(egln3) 111238889

SLAL:

111649729 111655980 111658942(egln1)

XGL:	120791579(egln2) 120795330(egln3) 120796246(egln1a)

HCQ:	109516196(egln1) 109526346

BPEC:

110153075(egln3) 110154109 110157004(egln1)

MALB:

109960094(egln1) 109966608(egln3) 109973530

BSPL:

114847957 114848717 114867698(egln2) 114870422(egln1a)

SASA:

100306807(egln2) 106564814 106585313 106601984(egln3) 106611226

STRU:

115162085 115162998 115172358(egln3) 115177591 115187292 115205958 115208520

OTW:	112222094(egln1a) 112235558 112256840 112261606 112265089 112265624 112266681

OMY:	101268917(egln1) 110486061 110491214(egln1a) 110497687 110503496(egln2) 110505778 110507058

OGO:	123993055 124002042 124002878 124005619 124016012 124046631 124048029(egln1a)

ONE:	115103956 115137073 115138694 115141446 115142643 115146009(egln3)

SALP:

111960611 111960615 111960623 111963455 111968511(egln3) 112068656 112074833

SNH:	120018398 120023647 120029052 120032374 120035354 120060448(egln3) 120065243

CCLU:

121539514 121544707 121556145 121562103 121567389 121572380 121580549 123483072

ELS:	105006344(egln1) 105012182 105012318(egln1) 105023611(egln3)

SFM:	108923741(egln3) 108927167(egln1) 108932430 108933731 108934337

PKI:	111835710(egln1) 111844883 111855010(egln3) 111856378

AANG:

118209826(egln2) 118214615(egln3) 118217600(egln1a) 118220609

LOC:	102683659(egln3) 102690383 102696669(egln1)

PSPA:

121303843 121304921 121316070 121317195 121323841 121330263(egln3)

ARUT:

117396979 117402530 117411544 117417730 117422076

PSEX:

120516272(egln1a) 120518526(egln3) 120538666(egln2)

LCM:	102349490(EGLN1) 102353261(EGLN3) 102361918(EGLN2)

CMK:	103178556 103178883(egln1a)

RTP:	109910430 109911211(egln1) 109927258(egln3)

BFO:	118410958 118414714

BBEL:

109468137 109483796

CIN:

100180463

SCLV:

120334439 120335491 120346711

SPU:	578715 587363

APLC:

110980554 110982901

SKO:	100369706 100377307

DME:	Dmel_CG44015(Hph)

DER:

6552383

DSI:	Dsimw501_GD19772(Dsim_GD19772)

DYA:	Dyak_GE25458

DAN:

6501697

DSR:

110177139

DPO:

4802487

DPE:

6591771

DMN:

108154932

DWI:

6650708

DGR:

6567742

DMO:	Dmoj_GI22545

DAZ:

108608752

DNV:

108657182

DHE:

111604796

DVI:

6632954

CCAT:

101459382

BOD:

106618249

RZE:

108360058

MDE:

101890432

SCAC:

106081319 106081335

LCQ:

111677900

LSQ:	119607468 119612624

HIS:

119658841

AGA:	AgaP_AGAP003523

ACOZ:

120953794

AARA:

120902931

ASTE:

118504296

AAG:

5576110

AALB:

109403849 115268552

CQU:	CpipJ_CPIJ008669

CNS:

116347553

BCOO:

119067115

AME:

413929

ACER:

108001374

ALAB:

122710949

BIM:

100747684

BBIF:

117215186

BVK:

117236697

BVAN:

117158152

BTER:

100648132 100649411

BPYO:

122567982

CCAL:

108624820

OBB:

114873008

MGEN:

117218352

NMEA:

116427521

CGIG:

122400612

SOC:

105192914

MPHA:

105831283

AEC:

105151857

ACEP:

105617596

PBAR:

105430352

VEM:

105563531

HST:

105185148

DQU:

106742555

CFO:

105255753

FEX:

115233469

LHU:

105670086

PGC:

109858347

OBO:

105275217

PCF:

106788792

PFUC:

122523524

VPS:

122630101

NVI:

100119129

CSOL:

105362773

TPRE:

106655951

MDL:

103573095

CGLO:

123275189

FAS:

105270693

DAM:

107041605

AGIF:

122855891

CCIN:

107274942

TCA:	656696(Hph)

DPA:

109544161

SOY:

115881221

ATD:

109603171

CSET:

123308456 123312429

AGB:

108917529

NVL:

108557275

APLN:

108738942

PPYR:

116177592

OTU:

111419401

BMOR:

101739524

BMAN:

114246443

MSEX:

115449941

DPL:	KGM_214589

BANY:

112057106

PMAC:

106721680

PPOT:

106110514

PXU:	106115810 106120320

PRAP:

110991997

ZCE:

119828657

HAW:

110382172

HZE:

124640050

TNL:

113498492

SLIU:

111350270

OFU:

114360868

PXY:

105384261

CFEL:

113384531

API:

100169314

DNX:

107162127

AGS:

114130704

RMD:

113555462

BTAB:

109035468

CLEC:

106664734

HHAL:

106681420

NLU:

111044687

PHU:	Phum_PHUM515220

FOC:

113211902

TPAL:

117643468 117644991

ZNE:

110840473

CSEC:

111874689

SGRE:

126359850

FCD:

110844239

DPX:	DAPPUDRAFT_347567 DAPPUDRAFT_347569 DAPPUDRAFT_64722

DMK:	116922461 116931648

DPZ:	124313841 124313842 124344550

PVM:

113824281

PJA:

122258740

HAME:

121877703

PCLA:

123762742

PTRU:

123501917

ISC:	IscW_ISCW000901

DSV:

119458689

RSAN:

119374103

RMP:

119167754

VDE:

111252991

VJA:

111268555

TUT:

107367778

DFR:

124498720

CSCU:

111623919

PTEP:

107452195

SDM:

118204272

CEL:	CELE_F22E12.4(egl-9)

CBR:	CBG_09602(Cbr-egl-9)

LOA:	LOAG_16560

NAI:	NECAME_16269

TSP:

Tsp_03219

HRO:	HELRODRAFT_72205

LGI:	LOTGIDRAFT_107905

PCAN:

112569891 112570029

BGT:

106066196

GAE:

121370300

HRF:

124134855

HRJ:

124261567

CRG:	105320841 105346171

MYI:	110449747 110466345

PMAX:

117323916 117324079

MMER:

123531899 123545362

OBI:

106873167

OSN:

115217520

LAK:	106161859 106177101

OVI:	T265_07179

NVE:	5498635 5510926 5518820 5525260

EPA:	110234070 110241815 110251771

ATEN:

116300727 116301813

ADF:	107336740 107341850

AMIL:

114968415 114975316

PDAM:

113673906 113683659

SPIS:

111345798

DGT:

114531586

XEN:

124452646

HMG:

100209808

TAD:	TRIADDRAFT_50295

VCN:	VOLCADRAFT_104259

OTA:	OT_ostta11g00880

BPG:	Bathy04g00800

MIS:	MICPUN_56860

MPP:	MICPUCDRAFT_38436

SRE:	PTSG_03971

SPAR:

SPRG_13227

GTT:	GUITHDRAFT_58077

» show all

Reference

1 [PMID:11292861]

Authors

Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, Kriegsheim Av, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ

Title

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.

Journal

Science 292:468-72 (2001)
DOI:10.1126/science.1059796

Sequence

[hsa:112398]

Reference

2 [PMID:11292862]

Authors

Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaelin WG Jr

Title

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.

Journal

Science 292:464-8 (2001)
DOI:10.1126/science.1059817

Reference

3 [PMID:11598268]

Authors

Bruick RK, McKnight SL

Title

A conserved family of prolyl-4-hydroxylases that modify HIF.

Journal

Science 294:1337-40 (2001)
DOI:10.1126/science.1066373

Sequence

[hsa:54583 112398 112399]

Reference

4 [PMID:11595184]

Authors

Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ

Title

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

Journal

Cell 107:43-54 (2001)
DOI:10.1016/S0092-8674(01)00507-4

Sequence

[hsa:54583 112398 112399]

Reference

5 [PMID:12163023]

Authors

Oehme F, Ellinghaus P, Kolkhof P, Smith TJ, Ramakrishnan S, Hutter J, Schramm M, Flamme I

Title

Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors.