KEGG   ENZYME: 1.14.11.29
Entry
EC 1.14.11.29               Enzyme                                 
Name
hypoxia-inducible factor-proline dioxygenase;
HIF hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
hypoxia-inducible factor-L-proline, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating)
Reaction(IUBMB)
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 = hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2
Substrate
hypoxia-inducible factor-L-proline;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
hypoxia-inducible factor-trans-4-hydroxy-L-proline;
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Contains iron, and requires ascorbate. Specifically hydroxylates a proline residue in HIF-alpha, the alpha subunit of the transcriptional regulator HIF (hypoxia-inducible factor), which targets HIF for proteasomal destruction. The requirement of oxygen for the hydroxylation reaction enables animals to respond to hypoxia.
History
EC 1.14.11.29 created 2010
Orthology
K09592  hypoxia-inducible factor prolyl hydroxylase
Genes
HSA112398(EGLN2) 112399(EGLN3) 54583(EGLN1)
PTR452850(EGLN3) 456049(EGLN2) 469708(EGLN1)
PPS100971263(EGLN1) 100984867(EGLN2) 100990967(EGLN3)
GGO101145572(EGLN2) 101147171(EGLN1) 101150306(EGLN3)
PON100172704(EGLN2) 100451138(EGLN3) 100454843(EGLN1)
NLE100584172(EGLN2) 100591967(EGLN3) 100594374(EGLN1)
MCC114674212(EGLN2) 703083(EGLN2) 713410(EGLN1) 717342(EGLN3)
MCF101865926(EGLN3) 102119819(EGLN2) 102128342(EGLN1)
MTHB126942051 126942488 126959176
CSAB103228800(EGLN3) 103230756(EGLN1) 103234719(EGLN2)
CATY105574854(EGLN1) 105592243(EGLN3) 105598009(EGLN2)
PANU100998148(EGLN2) 101006704(EGLN1) 101018094(EGLN3)
TGE112612417(EGLN2) 112623067(EGLN1) 112629359(EGLN3)
RRO104670730(EGLN1) 104676100(EGLN2) 104676305(EGLN3)
RBB108537828(EGLN1) 108539035(EGLN2) 108544680(EGLN3)
TFN117069837(EGLN3) 117075653(EGLN1) 117091935(EGLN2)
PTEH111526217(EGLN1) 111552848(EGLN3) 111553970(EGLN2)
CJC100389821(EGLN3) 100397980(EGLN2) 100413526(EGLN1)
SBQ101029000(EGLN3) 101045149(EGLN2) 101051675(EGLN1)
CSYR103250793 103259521(EGLN2)
MMUR105856453(EGLN1) 105875955(EGLN3) 105876751(EGLN2)
LCAT123624299(EGLN2) 123627448(EGLN1) 123650266(EGLN3)
OGA100952096(EGLN3) 100953629(EGLN2) 100961137(EGLN1)
MMU112405(Egln1) 112406(Egln2) 112407(Egln3)
MCAL110299462(Egln2) 110300648(Egln1) 110307114(Egln3)
MPAH110321385(Egln2) 110324486(Egln3) 110337366(Egln1)
RNO308457(Egln2) 308913(Egln1) 54702(Egln3)
MCOC116070408(Egln1) 116080173(Egln3) 116101867(Egln2)
MUN110552742(Egln3) 110555297(Egln1) 110556732(Egln2)
CGE100754377(Egln3) 100771495(Egln2) 100772704(Egln1)
MAUA101825375(Egln2) 101827803(Egln1) 101832817(Egln3)
PLEU114681532(Egln2) 114689778 114693363(Egln3) 114704866 114707163(Egln1)
MORG121446970(Egln1) 121449369(Egln2) 121452582(Egln3)
MFOT126492564 126499574 126504523
AAMP119802268(Egln1) 119819202(Egln3) 119821174(Egln2)
NGI103738632(Egln3) 103744145(Egln1) 103750775(Egln2)
HGL101704717(Egln2) 101707155 101709882(Egln1) 101718787(Egln3)
CPOC100717566(Egln3) 100726309(Egln1) 100726886(Egln2)
CCAN109694610(Egln1) 109697177(Egln3) 109697661(Egln2)
DORD105982599(Egln3) 105984393(Egln1) 105998098(Egln2)
DSP122097367(Egln2) 122106547(Egln3) 122113219(Egln1)
NCAR124961783 124966483 124978276
OCU100337938(EGLN2) 100354210(EGLN3) 100357337(EGLN1)
OPI101520745(EGLN3) 101531628(EGLN2) 101535337(EGLN1)
TUP102482051(EGLN1) 102483132(EGLN2) 102502105(EGLN3)
CFA480286(EGLN3) 484495(EGLN2) 488971(EGLN1)
CLUD112645441(EGLN2) 112657132(EGLN3) 112660780(EGLN1)
VVP112926605(EGLN3) 112927397(EGLN1) 112928357(EGLN2)
VLG121484683(EGLN2) 121486802(EGLN1) 121493371(EGLN3)
AML100465601(EGLN2) 100470632(EGLN3) 100474374(EGLN1)
UMR103661051(EGLN2) 103661877(EGLN1) 103680905(EGLN3)
UAH113243552(EGLN2) 113259033(EGLN1) 113266114(EGLN3)
UAR123782957(EGLN1) 123783105(EGLN2) 123795699(EGLN3)
ELK111160510 111160932 111161431
LLV125084509 125088695 125104856
MPUF101675598(EGLN3) 101676101(EGLN2) 101684127(EGLN1)
ORO101367839(EGLN3) 101368021(EGLN2) 101377787(EGLN1)
EJU114202458(EGLN2) 114210271(EGLN1) 114217792(EGLN3)
ZCA113909953(EGLN3) 113919390(EGLN1) 113935977(EGLN2)
MLX118002820 118002865 118012905(EGLN1) 118022639(EGLN2)
NSU110585605(EGLN3) 110586002(EGLN1) 110590276(EGLN2)
LWW102748129(EGLN3) 102748492(EGLN2)
FCA101082320(EGLN3) 101089964(EGLN1) 101090063(EGLN2)
PYU121011422(EGLN2) 121023169(EGLN1) 121031633(EGLN3)
PBG122468983(EGLN3) 122492747(EGLN1) 122494020(EGLN2)
LRUF124508892 124511105 124518601
PTG102951182(EGLN3) 102957902(EGLN1) 102958475(EGLN2)
PPAD109248931(EGLN1) 109254307(EGLN3) 109256611(EGLN2)
AJU106976258(EGLN3) 106979627(EGLN2) 106981639(EGLN1)
HHV120219702(EGLN3) 120237815(EGLN1) 120241257(EGLN2)
BTA534075(EGLN1) 535578(EGLN3) 536763(EGLN2)
BOM102280498(EGLN3) 102280646(EGLN2) 102287116(EGLN1)
BIU109572227(EGLN2) 109575537(EGLN3)
BBUB102400098(EGLN1) 102402360(EGLN3) 102409464(EGLN2)
CHX102179524(EGLN3) 102189459(EGLN1) 102191264(EGLN2)
OAS101114163(EGLN1) 101117367(EGLN3) 101120517(EGLN2)
ODA120865448(EGLN1) 120872418(EGLN2) 120875104(EGLN3)
CCAD122420569(EGLN2) 122446667(EGLN1) 122455242(EGLN3)
SSC100152368(EGLN3) 100153461(EGLN1) 100523673(EGLN2)
CFR102505367(EGLN1) 102507989(EGLN2) 102513612 102516321(EGLN3)
CBAI105062870(EGLN2) 105075082(EGLN1) 105075242(EGLN3)
CDK105093358(EGLN2) 105094177(EGLN3) 105102153(EGLN1)
VPC102537733(EGLN3) 102541517(EGLN2) 102542335(EGLN1)
BACU102997608(EGLN3) 103012144(EGLN2) 103012953(EGLN1)
LVE103078947(EGLN2) 103086133(EGLN1) 103088451(EGLN3)
OOR101284894(EGLN3) 101288091(EGLN1) 101288571(EGLN2)
DLE111163986(EGLN1) 111173240(EGLN3) 111180833(EGLN2)
PCAD102973467(EGLN2) 102988280(EGLN3) 102990364(EGLN1)
PSIU116741497(EGLN1) 116743605(EGLN2) 116749704(EGLN3)
ECB100056635(EGLN3) 100060551(EGLN1) 100064859(EGLN2)
EPZ103553997(EGLN1) 103554984(EGLN3) 103565423(EGLN2)
EAI106841256(EGLN3) 106843305(EGLN2) 106846732(EGLN1)
MYB102248142(EGLN2) 102261310(EGLN3) 102261609(EGLN1)
MYD102752541(EGLN2) 102755440(EGLN1) 102764073(EGLN3)
MMYO118674318(EGLN2) 118678172(EGLN3) 118678818(EGLN1)
MLF102423938(EGLN2) 102431340(EGLN3)
MNA107524237(EGLN1) 107534212(EGLN2) 107534404(EGLN3)
PKL118702276(EGLN2) 118718018(EGLN1) 118726548(EGLN3)
HAI109374857(EGLN2) 109390367(EGLN3)
DRO112296534(EGLN3) 112306105(EGLN1) 112320084(EGLN2)
SHON118984215(EGLN2) 118989914(EGLN3) 118996702(EGLN1)
AJM119040737(EGLN2) 119042924(EGLN1) 119061156(EGLN3)
PDIC114492445(EGLN3) 114510904(EGLN2) 114512310(EGLN1)
PHAS123820500(EGLN3) 123823846(EGLN2) 123833021(EGLN1)
MMF118638216(EGLN3) 118639025(EGLN2) 118640516(EGLN1)
RFQ117018559(EGLN1) 117024016(EGLN3) 117035084(EGLN2)
PALE102881942(EGLN2) 102886969(EGLN3) 102894690(EGLN1)
PGIG120592591(EGLN1) 120595483(EGLN2) 120608582(EGLN3)
PVP105300146(EGLN2) 105305418(EGLN3) 105306014(EGLN1)
RAY107499468(EGLN3) 107520040(EGLN1) 107521816(EGLN2)
MJV108397735(EGLN2)
TOD119239002(EGLN3) 119244603(EGLN1) 119249339(EGLN2)
SARA101554353(EGLN1) 101554704(EGLN2) 101555023(EGLN3)
LAV100672145(EGLN1) 100674039(EGLN3) 100675805(EGLN2)
TMU101351991 101359457 101361248
ETF101648186(EGLN2) 101652145(EGLN3) 101658280(EGLN1)
DNM101417560(EGLN2) 101438279 101447775(EGLN3)
MDO100013679(EGLN3) 100018431(EGLN2) 100029166(EGLN1)
GAS123235924(EGLN3) 123240013(EGLN2) 123245463(EGLN1)
SHR100913457(EGLN3) 100929665(EGLN1) 116422889(EGLN2)
PCW110202901(EGLN2) 110217829(EGLN1) 110223697(EGLN3)
OAA100081498(EGLN3) 100090709(EGLN2) 100092885(EGLN1)
GGA423316(EGLN3) 768374(EGLN1)
PCOC116229351(EGLN3) 116242855(EGLN1)
MGP100540578(EGLN1) 100550799(EGLN3)
CJO107311390(EGLN1) 107315049(EGLN3)
NMEL110395721(EGLN1) 110401145(EGLN3)
APLA101794957(EGLN1) 101803442(EGLN3)
ACYG106031746(EGLN3) 106048487(EGLN1)
AFUL116487639(EGLN1) 116489898(EGLN3)
TGU100219039(EGLN3) 100227092(EGLN1)
LSR110468883(EGLN1) 110477184(EGLN3)
SCAN103818509(EGLN1) 103826557(EGLN3)
PMOA120500406(EGLN3) 120501296(EGLN1)
OTC121333741(EGLN3) 121334726(EGLN1)
PRUF121354244(EGLN1) 121362528(EGLN3)
GFR102036235(EGLN3) 102036815(EGLN1)
FAB101814352(EGLN3) 101820070(EGLN1)
PHI102100051(EGLN1) 102112105(EGLN3)
PMAJ107202314(EGLN1) 107206290(EGLN3)
CCAE111926882(EGLN1) 111930028(EGLN3)
CCW104684300(EGLN1) 104684695(EGLN3)
CBRC103620846(EGLN3)
ETL114060583(EGLN3) 114064546(EGLN1)
ZAB102062214(EGLN3)
FPG101915692(EGLN1) 101923024(EGLN3)
FCH102047874(EGLN3) 102059512(EGLN1)
CLV102092186(EGLN1) 102096357(EGLN3)
EGZ104131025(EGLN1) 104133309(EGLN3)
NNI104011784(EGLN3) 104018158(EGLN1)
ACUN113478081(EGLN1) 113480695(EGLN3)
TALA104368807(EGLN3) 116965447(EGLN1)
PADL103912943(EGLN3)
AFOR103901020(EGLN1)
ACHC115334796(EGLN3) 115349842(EGLN1)
HLE104828749(EGLN1) 104841765(EGLN3)
AGEN126049414 126051754
GCL127014130 127017298
OHA104332613(EGLN1)
DPUB104300858(EGLN1)
CUCA104060359(EGLN1)
AAM106483112(EGLN3) 106487314(EGLN1)
AROW112969778(EGLN1) 112975415(EGLN3)
NPD112958001(EGLN3) 112959348(EGLN1)
DNE112980330(EGLN3) 112993520(EGLN1)
SCAM104148113(EGLN1)
ASN102372013(EGLN1) 102383580(EGLN3)
AMJ102560217(EGLN3) 102566486(EGLN1)
CPOO109319107(EGLN1) 109321466(EGLN3)
GGN109299328(EGLN3) 109304243(EGLN1)
PSS102454124(EGLN3) 102462349(EGLN1)
CMY102932309(EGLN3) 102944392(EGLN1)
CPIC101944959(EGLN3) 101952573(EGLN1)
TST117874714(EGLN1) 117876454(EGLN3)
CABI116826725(EGLN1) 116835542(EGLN3)
MRV120401212(EGLN1) 120402770 120403289
ACS100555054(egln3) 100559436(egln1) 100567728(egln2)
PVT110070219(EGLN3) 110075404(EGLN1) 110075601(EGLN2)
SUND121915362(EGLN2) 121918952(EGLN3) 121934804(EGLN1)
PBI103051641(EGLN1) 103066300(EGLN3)
PMUR107285645(EGLN2) 107290938(EGLN1) 107292951(EGLN3)
CTIG120303399(EGLN1) 120311831(EGLN3) 120316496(EGLN2)
TSR106537993(EGLN3) 106541106(EGLN2) 106547635(EGLN1)
PGUT117665770(EGLN3) 117672000(EGLN1) 117677834(EGLN2)
VKO123018394(EGLN1) 123026210(EGLN2) 123026506(EGLN3)
PMUA114592657(EGLN3) 114594388(EGLN1) 114603171(EGLN2)
ZVI118081886(EGLN1) 118082320(EGLN3) 118086084(EGLN2)
GJA107108842(EGLN3) 107109906(EGLN2) 107123956(EGLN1)
STOW125426948(EGLN3) 125427101(EGLN1) 125430826(EGLN2)
XLA100036879(egln3.S) 100127282(egln3.L) 100158265(egln2.L) 108700271(egln2.S) 446395(egln1.S)
XTR100145602(egln3) 100487735(egln2) 548714(egln1)
NPR108789517(EGLN1) 108791944(EGLN2) 108794163(EGLN3)
RTEM120913315(EGLN2) 120920263(EGLN3) 120937615(EGLN1)
BBUF120977299(EGLN1) 120981917(EGLN3) 121009508(EGLN2)
BGAR122921870(EGLN3) 122946696(EGLN2) 122946811(EGLN1)
DRE100329385(egln1a) 406602(egln3) 436868(egln1b) 559569(egln2)
SRX107724964 107728333 107729299 107730384 107733839 107737236 107745877 107751107
SANH107667047 107687384 107690805 107691277 107693191 107693259 107699221 107699839
SGH107555273 107556149 107557733 107564238 107572057 107586581 107589684 107592652
CCAR109048049 109048372 109063801 109065546 109074353 109082858 109099512
CAUA113055383 113056581 113058594 113060922 113111041 113112350 113115280 113117678
PPRM120461007(egln1a) 120478692(egln2) 120480489(egln1b) 120480708(egln3)
MAMB125249035(egln2) 125256225(egln1b) 125268634(egln3) 125276461(egln1a)
IPU108270013(egln3) 108270809 108278008(egln2)
PHYP113538882(egln3) 113539196 113547059(egln1)
SMEO124389863(egln3) 124391081 124394487(egln2)
TFD113643564(egln2) 113646133 113659827(egln3)
AMEX103030532 103039372(egln3) 103047661
EEE113568218 113568979(egln1) 113579353(egln3) 113589405
TRU101061820(egln1) 101071309(egln3) 101071669
TNGGSTEN00004022G001 GSTEN00010948G001 GSTEN00014832G001 GSTEN00030880G001
LCO104917997 104924457(egln1) 104924821(egln3)
NCC104953366 104956816 104960291(egln1)
CGOB115017728 115020012(egln1) 115027849(egln3)
ELY117248219(egln1a) 117259653(egln2) 117266601(egln3)
EFO125888465(egln2) 125900877(egln3) 125903370(egln1a)
PLEP121942941(egln2) 121954342(egln1a)
SLUC116047738(egln2) 116051091(egln1a) 116063570(egln3)
ECRA117941964(egln2) 117960098(egln1a)
ESP116678496 116704831(egln1)
PFLV114546865(egln3) 114552365 114571682(egln1)
GAT120820907(egln2) 120821121(egln1a)
PPUG119210231(egln2) 119214106(egln1a)
MSAM119882224(egln2) 119910676(egln3) 119917249(egln1a)
CUD121511129(egln1a) 121520834(egln2) 121525885(egln3)
ALAT119004401(egln3) 119004779(egln2) 119033402(egln1a)
MZE101472504 101475861 101476165(egln1)
ONL100691117 100696862(egln1) 100702648(egln3)
OAU116310685(egln3) 116314728(egln2) 116318567(egln1a)
OLA101164580 101170367(egln1) 101175282(egln3)
OML112149481(egln2) 112149485(egln3) 112161713(egln1a)
XMA102221054 102232168(egln1) 102237645(egln3)
XCO114137982(egln1) 114155587(egln3) 114161371
XHE116707775 116709644(egln3) 116713250(egln1)
PRET103458095(egln3) 103474618 103477256(egln1)
PFOR103136266 103137657(egln1) 103147762(egln3)
PLAI106953845 106953955(egln3) 106957736(egln1)
PMEI106923820(egln1) 106924366(egln3) 106934088
GAF122833238(egln2) 122842780(egln1a) 122846016(egln3)
CVG107086869(egln3) 107087820(egln1) 107094171
CTUL119782918(egln1a) 119792118(egln2) 119797786(egln3)
GMU124855976(egln3) 124858848(egln1a) 124883940(egln2)
NFU107374017(egln3) 107375426(egln1) 107380304
KMR108240690(egln1a) 108243533(egln2) 108247517(egln3)
ALIM106515416 106515869(egln1)
NWH119410879(egln2) 119411172(egln1a) 119427850(egln3)
AOCE111578698 111585559(egln1) 111586571
MCEP125013934(egln2) 125018906(egln1a) 125024199(egln3)
CSEM103378094 103382494(egln3) 103387611(egln1)
POV109630335 109634863(egln1)
SSEN122773523(egln2) 122782254(egln1a) 122783094 122783252
HHIP117772686(egln2) 117775201(egln1a)
HSP118106242(egln2) 118118809(egln1a)
LCF108881163 108885792(egln1a) 108900822(egln2)
SDU111220712(egln1) 111236114(egln3) 111238889
SLAL111649729 111655980 111658942(egln1)
XGL120791579(egln2) 120795330(egln3) 120796246(egln1a)
HCQ109516196(egln1) 109526346
BPEC110153075(egln3) 110154109 110157004(egln1)
MALB109960094(egln1) 109966608(egln3) 109973530
BSPL114847957 114848717 114867698(egln2) 114870422(egln1a)
SASA100306807(egln2) 106564814 106585313 106601984(egln3) 106611226
STRU115162085 115162998 115172358(egln3) 115177591 115187292 115205958 115208520
OTW112222094(egln1a) 112235558 112256840 112261606 112265089 112265624 112266681
OMY101268917(egln1) 110486061 110491214(egln1a) 110497687 110503496(egln2) 110505778 110507058
OGO123993055 124002042 124002878 124005619 124016012 124046631 124048029(egln1a)
ONE115103956 115137073 115138694 115141446 115142643 115146009(egln3)
SALP111960611 111960615 111960623 111963455 111968511(egln3) 112068656 112074833
SNH120018398 120023647 120029052 120032374 120035354 120060448(egln3) 120065243
CCLU121539514 121544707 121556145 121562103 121567389 121572380 121580549 123483072
ELS105006344(egln1) 105012182 105012318(egln1) 105023611(egln3)
SFM108923741(egln3) 108927167(egln1) 108932430 108933731 108934337
PKI111835710(egln1) 111844883 111855010(egln3) 111856378
AANG118209826(egln2) 118214615(egln3) 118217600(egln1a) 118220609
LOC102683659(egln3) 102690383 102696669(egln1)
PSPA121303843 121304921 121316070 121317195 121323841 121330263(egln3)
ARUT117396979 117402530 117411544 117417730 117422076
PSEX120516272(egln1a) 120518526(egln3) 120538666(egln2)
LCM102349490(EGLN1) 102353261(EGLN3) 102361918(EGLN2)
CMK103178556 103178883(egln1a)
RTP109910430 109911211(egln1) 109927258(egln3)
BFO118410958 118414714
BBEL109468137 109483796
CIN100180463
SCLV120334439 120335491 120346711
SPU578715 587363
APLC110980554 110982901
SKO100369706 100377307
DMEDmel_CG44015(Hph)
DER6552383
DSIDsimw501_GD19772(Dsim_GD19772)
DYADyak_GE25458
DAN6501697
DSR110177139
DPO4802487
DPE6591771
DMN108154932
DWI6650708
DGR6567742
DMODmoj_GI22545
DAZ108608752
DNV108657182
DHE111604796
DVI6632954
CCAT101459382
BOD106618249
RZE108360058
MDE101890432
SCAC106081319 106081335
LCQ111677900
LSQ119607468 119612624
HIS119658841
AGAAgaP_AGAP003523
ACOZ120953794
AARA120902931
ASTE118504296
AAG5576110
AALB109403849 115268552
CQUCpipJ_CPIJ008669
CNS116347553
BCOO119067115
AME413929
ACER108001374
ALAB122710949
BIM100747684
BBIF117215186
BVK117236697
BVAN117158152
BTER100648132 100649411
BPYO122567982
CCAL108624820
OBB114873008
MGEN117218352
NMEA116427521
CGIG122400612
SOC105192914
MPHA105831283
AEC105151857
ACEP105617596
PBAR105430352
VEM105563531
HST105185148
DQU106742555
CFO105255753
FEX115233469
LHU105670086
PGC109858347
OBO105275217
PCF106788792
PFUC122523524
VPS122630101
NVI100119129
CSOL105362773
TPRE106655951
MDL103573095
CGLO123275189
FAS105270693
DAM107041605
AGIF122855891
CCIN107274942
TCA656696(Hph)
DPA109544161
SOY115881221
ATD109603171
CSET123308456 123312429
AGB108917529
NVL108557275
APLN108738942
PPYR116177592
OTU111419401
BMOR101739524
BMAN114246443
MSEX115449941
DPLKGM_214589
BANY112057106
PMAC106721680
PPOT106110514
PXU106115810 106120320
PRAP110991997
ZCE119828657
HAW110382172
HZE124640050
TNL113498492
SLIU111350270
OFU114360868
PXY105384261
CFEL113384531
API100169314
DNX107162127
AGS114130704
RMD113555462
BTAB109035468
CLEC106664734
HHAL106681420
NLU111044687
PHUPhum_PHUM515220
FOC113211902
TPAL117643468 117644991
ZNE110840473
CSEC111874689
SGRE126359850
FCD110844239
DPXDAPPUDRAFT_347567 DAPPUDRAFT_347569 DAPPUDRAFT_64722
DMK116922461 116931648
DPZ124313841 124313842 124344550
PVM113824281
PJA122258740
HAME121877703
PCLA123762742
PTRU123501917
ISCIscW_ISCW000901
DSV119458689
RSAN119374103
RMP119167754
VDE111252991
VJA111268555
TUT107367778
DFR124498720
CSCU111623919
PTEP107452195
SDM118204272
CELCELE_F22E12.4(egl-9)
CBRCBG_09602(Cbr-egl-9)
LOALOAG_16560
NAINECAME_16269
TSPTsp_03219
HROHELRODRAFT_72205
LGILOTGIDRAFT_107905
PCAN112569891 112570029
BGT106066196
GAE121370300
HRF124134855
HRJ124261567
CRG105320841 105346171
MYI110449747 110466345
PMAX117323916 117324079
MMER123531899 123545362
OBI106873167
OSN115217520
LAK106161859 106177101
OVIT265_07179
NVE5498635 5510926 5518820 5525260
EPA110234070 110241815 110251771
ATEN116300727 116301813
ADF107336740 107341850
AMIL114968415 114975316
PDAM113673906 113683659
SPIS111345798
DGT114531586
XEN124452646
HMG100209808
TADTRIADDRAFT_50295
VCNVOLCADRAFT_104259
OTAOT_ostta11g00880
BPGBathy04g00800
MISMICPUN_56860
MPPMICPUCDRAFT_38436
SREPTSG_03971
SPARSPRG_13227
GTTGUITHDRAFT_58077
 » show all
Reference
1  [PMID:11292861]
  Authors
Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, Kriegsheim Av, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ
  Title
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
  Journal
Science 292:468-72 (2001)
DOI:10.1126/science.1059796
  Sequence
[hsa:112398]
Reference
2  [PMID:11292862]
  Authors
Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaelin WG Jr
  Title
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.
  Journal
Science 292:464-8 (2001)
DOI:10.1126/science.1059817
Reference
3  [PMID:11598268]
  Authors
Bruick RK, McKnight SL
  Title
A conserved family of prolyl-4-hydroxylases that modify HIF.
  Journal
Science 294:1337-40 (2001)
DOI:10.1126/science.1066373
  Sequence
Reference
4  [PMID:11595184]
  Authors
Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ
  Title
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.
  Journal
Cell 107:43-54 (2001)
DOI:10.1016/S0092-8674(01)00507-4
  Sequence
Reference
5  [PMID:12163023]
  Authors
Oehme F, Ellinghaus P, Kolkhof P, Smith TJ, Ramakrishnan S, Hutter J, Schramm M, Flamme I
  Title
Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors.
  Journal
Biochem Biophys Res Commun 296:343-9 (2002)
DOI:10.1016/s0006-291x(02)00862-8
  Sequence
Reference
6  [PMID:12039559]
  Authors
McNeill LA, Hewitson KS, Gleadle JM, Horsfall LE, Oldham NJ, Maxwell PH, Pugh CW, Ratcliffe PJ, Schofield CJ
  Title
The use of dioxygen by HIF prolyl hydroxylase (PHD1).
  Journal
Bioorg Med Chem Lett 12:1547-50 (2002)
DOI:10.1016/S0960-894X(02)00219-6
  Sequence
[hsa:112398]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.29
IUBMB Enzyme Nomenclature: 1.14.11.29
ExPASy - ENZYME nomenclature database: 1.14.11.29
BRENDA, the Enzyme Database: 1.14.11.29

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