Entry
Name
DNA oxidative demethylase;
alkylated DNA repair protein;
alpha-ketoglutarate-dependent dioxygenase ABH1;
alkB (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
methyl DNA-base, 2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming)
Reaction(IUBMB)
DNA-base-CH3 + 2-oxoglutarate + O2 = DNA-base + formaldehyde + succinate + CO2
Substrate
Product
Comment
Contains iron; activity is slightly stimulated by ascorbate. Catalyses oxidative demethylation of the DNA base lesions N1-methyladenine, N3-methylcytosine, N1-methylguanine, and N3-methylthymine. It works better on single-stranded DNA (ssDNA) and is capable of repairing damaged bases in RNA.
History
EC 1.14.11.33 created 2011
Orthology
K03919 DNA oxidative demethylase
K10859 DNA oxidative demethylase
Genes
VLG : 121475675(ALKBH2) 121476118
NVS : 122890377 122903329(ALKBH2)
MNA : 107533877 107533878(ALKBH2)
ARUT : 117426315 117427819
BBEL : 109474732 109474733 109481451 109485891
SDM : 118184484 118185316 118188581 118200752 118201220 118201427 118203052 118203235
DPOL : 127847997 127850163
CSAT : 104702766 104713667
EGR : 104428140 104445577 104445579
PSAT : 127076097 127076346 127101210 127106829 127107409 127114583 127126874 127136114
LJA : Lj6g3v1709510.1(Lj6g3v1709510.1)
PSOM : 113348306 113349055
TAES : 123150215 123157784 123164576
PDA : 103720690 103720695 120107605
ECOO : ECRM13514_2974(alkB)
ECOH : ECRM13516_2917(alkB)
ECW : EcE24377A_2511(alkB)
EDJ : ECDH1ME8569_2148(alkB)
ECOI : ECOPMV1_02373(alkB)
SEM : STMDT12_C22860(alkB)
RTG : NCTC13098_02061(alkB)
REE : electrica_01510(alkB)
CLAP : NCTC11466_01359(alkB)
KIE : NCTC12125_00444(alkB)
AHN : NCTC12129_01598(alkB)
SMW : SMWW4_v1c32050(alkB)
SFJ : SAMEA4384070_3251(alkB)
SOF : NCTC11214_03617(alkB)
DIC : Dpoa569_003134(alkB)
TPTY : NCTC11468_02476(alkB)
PVD : CFBP1590__3020(alkB)
PPRC : PFLCHA0_c34390(alkB2)
PMUD : NCTC8068_02267(alkB_1)
PFW : PF1751_v1c27500(alkB)
PPUU : PputUW4_02403(alkB)
PTRT : HU722_0015550(alkB)
PTAE : NCTC10697_02372(alkB)
GAI : IMCC3135_26810(alkB)
RME : Rmet_3769(alkB1) Rmet_5268(alkB2)
BUR : Bcep18194_A4921 Bcep18194_A4927
PLG : NCTC10937_02559(alkB)
BTRM : SAMEA390648700981(aidD)
AXX : ERS451415_05135(alkB)
RHOA : HZ993_18515(alkB) HZ993_18600
MAM : Mesau_00378 Mesau_00948
RBS : RHODOSMS8_03160(alkB)
SMEL : SM2011_c02566(alkB)
SFD : USDA257_c59110(alkB)
SAME : SAMCFNEI73_Ch0048(alkB)
EAD : OV14_0929 OV14_a1908
ALF : CFBP5473_15780(alkB)
REC : RHECIAT_CH0000041(alkB)
REL : REMIM1_CH00039(alkB)
REP : IE4803_CH00038(alkB)
REI : IE4771_CH00039(alkB)
RGA : RGR602_CH00040(alkB)
RPHA : AMC79_CH00041(alkB)
NGL : RG1141_CH40230(alkB)
NEN : NCHU2750_37600(alkB)
BSW : IY71_00005 IY71_13710
BSG : IY72_00005 IY72_13250
BIO : BR141012304_20464(alkB)
BSEP : HAP48_0030740(alkB)
BCAN : BcanWSM471_14100(alkB)
MAQU : Maq22A_1p33295(alkB)
MTUN : MTUNDRAET4_0348(alkB)
FIL : BN1229_v1_0850(alkB)
FIY : BN1229_v1_0855(alkB)
LAGG : B0E33_09660 B0E33_18755
PSTG : E8M01_13930 E8M01_23050(alkB)
BVY : NCTC9239_03146(alkB)
TSV : DSM104635_03861(alkB)
RLI : RLO149_c042200(alkB)
PHP : PhaeoP97_03497(alkB)
PPIC : PhaeoP14_03259(alkB)
OAT : OAN307_c46560(alkB2)
SINL : DSM14862_00024(alkB)
SPSE : SULPSESMR1_03101(alkB)
RMM : ROSMUCSMR3_01871(alkB)
AHT : ANTHELSMS3_00784(alkB)
NOV : TQ38_020930 TQ38_025965
SPHB : EP837_01138 EP837_01761
SPYG : YGS_C2P0851 YGS_C2P1425
APK : APA386B_1046(alkB) APA386B_1P102(alkB)
CDP : CD241_0130 CD241_0292
CDH : CDB402_0095 CDB402_0265
CDT : CDHC01_0130 CDHC01_0293
CDE : CDHC02_0136 CDHC02_0305
CDR : CDHC03_0102 CDHC03_0278
CDA : CDHC04_0098 CDHC04_0262
CDZ : CD31A_0141 CD31A_0353
CDB : CDBH8_0139 CDBH8_0294
CDS : CDC7B_0095 CDC7B_0297
CDD : CDCE8392_0095 CDCE8392_0302
CDW : CDPW8_0101 CDPW8_0356
CDV : CDVA01_0096 CDVA01_0245
CDIP : ERS451417_00104(alkB_1) ERS451417_00275(alkB_2)
CUN : Cul210932_0134(alkB)
CUQ : Cul210931_0128(alkB)
CUJ : CUL131002_0117(alkB)
CRF : FRC0190_00140 FRC0190_00350
CCYS : SAMEA4530656_2436(alkB)
RRT : 4535765_00733(alkB_1)
RCR : NCTC10994_01998(alkB_1)
TPUL : TPB0596_38660(alkB)
SLE : sle_60640(sle_60640)
SXT : KPP03845_101193(alkB)
AAGI : NCTC2676_1_02811(alkB)
KSE : Ksed_06510 Ksed_21790
ANB : ANA_C13025 ANA_C13441
GMA : AciX8_2356 AciX8_3728
» show all
Taxonomy
Reference
Authors
Falnes PO, Johansen RF, Seeberg E
Title
AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli.
Journal
Sequence
Reference
Authors
Yi C, Yang CG, He C
Title
A non-heme iron-mediated chemical demethylation in DNA and RNA.
Journal
Reference
Authors
Yi C, Jia G, Hou G, Dai Q, Zhang W, Zheng G, Jian X, Yang CG, Cui Q, He C
Title
Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase.
Journal
Sequence
Other DBs