KEGG   ENZYME: 1.14.11.42
Entry
EC 1.14.11.42               Enzyme                                 
Name
tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase;
TYW5;
tRNA yW-synthesizing enzyme 5
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
tRNAPhe 7-(3-amino-3-carboxypropyl)wyosine37,2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating)
Reaction(IUBMB)
7-(3-amino-3-carboxypropyl)wyosine37 in tRNAPhe + 2-oxoglutarate + O2 = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine37 in tRNAPhe + succinate + CO2 [RN:R10522]
Reaction(KEGG)
R10522
Substrate
7-(3-amino-3-carboxypropyl)wyosine37 in tRNAPhe;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine37 in tRNAPhe;
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+. The enzyme is not active with wybutosine.
History
EC 1.14.11.42 created 2013
Orthology
K18066  tRNA wybutosine-synthesizing protein 5
Genes
HSA129450(TYW5)
PTR745971(TYW5)
PPS100967799(TYW5)
GGO101135719(TYW5)
PON100450056(TYW5)
NLE100583090(TYW5)
MCC699197(TYW5)
MCF102125368(TYW5)
CSAB103217605(TYW5)
CATY105580012(TYW5)
PANU100997617(TYW5)
TGE112636200(TYW5)
RRO104670397(TYW5)
RBB108519762(TYW5)
TFN117094664(TYW5)
PTEH111546801(TYW5)
CJC100388926(TYW5)
SBQ101035244(TYW5)
CSYR103272307(TYW5)
MMUR105856989(TYW5)
LCAT123643964(TYW5)
OGA100942362(TYW5)
MMU68736(Tyw5)
MCAL110300340(Tyw5)
MPAH110321628(Tyw5)
RNO301419(Tyw5)
MCOC116088447(Tyw5)
MUN110565047(Tyw5)
CGE100773600(Tyw5)
MAUA101837004(Tyw5)
PLEU114688994 114704683(Tyw5)
MORG121444845 121458923(Tyw5)
AAMP119804086(Tyw5)
NGI103734457(Tyw5)
HGL101696883(Tyw5)
CPOC100714448(Tyw5)
CCAN109700340(Tyw5)
DORD105981193(Tyw5)
DSP122096416(Tyw5)
NCAR124981291
OCU100351909(TYW5)
OPI101523890(TYW5)
TUP102478614(TYW5)
CFA478861(TYW5)
CLUD112656587(TYW5)
VVP112922892(TYW5)
VLG121480552(TYW5)
AML100473611(TYW5)
UMR103659724(TYW5)
UAH113250615(TYW5)
UAR123798178(TYW5)
ELK111143829
LLV125094984
MPUF101689380(TYW5)
ORO101371629(TYW5)
EJU114224664(TYW5)
ZCA113919774(TYW5)
MLX118012168(TYW5)
PYU121030885(TYW5)
PBG122481621(TYW5)
PTG102964671(TYW5)
PPAD109254446(TYW5)
AJU106980005(TYW5)
HHV120223578(TYW5)
BTA539498(TYW5)
BOM102274184(TYW5)
BIU109569219(TYW5)
BBUB102393392(TYW5)
CHX102185514(TYW5)
OAS101103128(TYW5)
ODA120854110(TYW5)
CCAD122426849(TYW5)
SSC100522402(TYW5)
CFR102512398(TYW5)
CBAI105082317(TYW5)
CDK105099163(TYW5)
VPC102538076(TYW5)
BACU103019997(TYW5)
LVE103072185(TYW5)
OOR101286497(TYW5)
DLE111171708(TYW5)
PCAD102986926(TYW5)
PSIU116756786(TYW5)
ECB100055324(TYW5)
EPZ103560766(TYW5)
EAI106834377(TYW5)
MYB102256011(TYW5)
MYD102758208(TYW5)
MMYO118661047(TYW5)
MLF102431723(TYW5)
MNA107543446(TYW5)
PKL118709081(TYW5)
HAI109379226(TYW5)
DRO112307714(TYW5)
SHON118985265(TYW5)
AJM119065481(TYW5)
PDIC114495542(TYW5)
PHAS123824440(TYW5)
MMF118625627(TYW5)
RFQ117025682(TYW5)
PALE102893933(TYW5)
PGIG120587508(TYW5)
PVP105298144(TYW5)
RAY107503169(TYW5)
MJV108398249(TYW5)
TOD119256080(TYW5)
SARA101540174(TYW5)
LAV100663295(TYW5)
TMU101361692
DNM101430963 101446969(TYW5)
MDO100022563(TYW5)
GAS123242138(TYW5)
SHR100921241(TYW5)
PCW110207275(TYW5)
OAA100077105(TYW5)
GGA424065(TYW5)
PCOC116233961(TYW5)
MGP100548493(TYW5)
CJO107316539(TYW5)
NMEL110399745(TYW5)
APLA101794829(TYW5)
ACYG106040022(TYW5)
AFUL116490662(TYW5)
TGU100223277(TYW5)
LSR110484575(TYW5)
SCAN103814732(TYW5)
PMOA120506895(TYW5)
OTC121335406(TYW5)
PRUF121356497(TYW5)
GFR102034711(TYW5)
FAB101820286(TYW5)
PHI102106103(TYW5)
PMAJ107207390(TYW5)
CCAE111931974(TYW5)
CCW104694138(TYW5)
CBRC103612677(TYW5)
ETL114061171(TYW5)
ZAB102061090(TYW5)
ACHL103810193(TYW5)
FPG101917669(TYW5)
FCH102047118(TYW5)
CLV102091987(TYW5)
EGZ104130526(TYW5)
NNI104010182(TYW5)
PLET104614347(TYW5)
PCRI104033126(TYW5)
ACUN113477530(TYW5)
TALA104362284(TYW5)
PADL103923292(TYW5)
ACHC115342605(TYW5)
HALD104311374(TYW5)
CCRI104166323(TYW5)
CSTI104558582(TYW5)
EHS104503544(TYW5)
CMAC104478830(TYW5)
MUI104546252(TYW5)
FGA104076444(TYW5)
GSTE104260529(TYW5)
LDI104346849(TYW5)
MNB103777842(TYW5)
OHA104332329(TYW5)
AAM106492374(TYW5)
AROW112969289(TYW5)
NPD112954966(TYW5)
DNE112985851(TYW5)
ASN102375153(TYW5)
AMJ102574664(TYW5)
CPOO109323032(TYW5)
GGN109301884(TYW5)
PSS102458436(TYW5)
CMY102932925(TYW5)
CPIC101951934(TYW5)
TST117884718(TYW5)
CABI116832694(TYW5)
MRV120374282(TYW5)
ACS100559573(tyw5)
PVT110079900(TYW5)
SUND121919809(TYW5)
PBI103063736(TYW5)
PMUR107284903(TYW5)
TSR106538059(TYW5)
PGUT117673065(TYW5)
VKO123024428(TYW5)
PMUA114607883(TYW5)
ZVI118095573(TYW5)
GJA107113374(TYW5)
STOW125425922(TYW5)
XLA108701445(tyw5.L)
XTR100493826(tyw5)
NPR108797594(TYW5)
RTEM120943715(TYW5)
BBUF121008419(TYW5)
BGAR122944582(TYW5)
DRE557725(tyw5)
SRX107725219 107728297
SANH107670714(tyw5)
SGH107571732(tyw5)
CCAR109050426 109095722 109095952
CAUA113053273 113098509 113108616
PPRM120461086(tyw5)
MAMB125270426(tyw5)
IPU108266697(tyw5)
PHYP113544072(tyw5)
SMEO124380600(tyw5)
TFD113646277(tyw5)
AMEX103030415(tyw5)
EEE113575352(tyw5)
TRU101076708(tyw5)
TNGGSTEN00033130G001
LCO109140577(tyw5)
CGOB115026104(tyw5)
ELY117251102(tyw5)
EFO125899291(tyw5)
PLEP121949063(tyw5)
SLUC116043217(tyw5)
ECRA117953170(tyw5)
ESP116697902(tyw5)
PFLV114564509(tyw5)
GAT120833639(tyw5)
PPUG119229091(tyw5)
MSAM119903443(tyw5)
CUD121522158(tyw5)
ALAT119026249(tyw5)
MZE101474877
ONL100691850(tyw5)
OAU116309480(tyw5)
OLA101166925(tyw5)
OML112155485(tyw5)
XMA102223946(tyw5)
XCO114147666(tyw5)
XHE116723121(tyw5)
PRET103461936(tyw5)
PFOR103131665(tyw5)
PLAI106941059(tyw5)
PMEI106907368(tyw5)
GAF122840480(tyw5)
CVG107099058(tyw5)
CTUL119773000(tyw5)
GMU124870835(tyw5)
NFU107396302(tyw5)
KMR108249327(tyw5)
ALIM106524132(tyw5)
NWH119418969(tyw5)
AOCE111580617(tyw5)
MCEP125017921(tyw5)
CSEM103392340(tyw5)
POV109637425(tyw5)
SSEN122763733(tyw5)
HHIP117755387(tyw5)
HSP118119960(tyw5)
LCF108884629(tyw5)
SDU111218767(tyw5)
SLAL111657168(tyw5)
XGL120801043(tyw5)
HCQ109517581(tyw5)
BPEC110160772(tyw5)
MALB109963791(tyw5)
BSPL114846824(tyw5)
SASA106586072(tyw5)
SALP111972622(tyw5)
CCLU121536097(tyw5)
ELS105016088(tyw5)
SFM108936497(tyw5)
PKI111850196(tyw5)
AANG118214222(tyw5)
LOC102695675(tyw5)
PSPA121322567(tyw5)
ARUT117405758(tyw5)
LCM102348802(TYW5)
CMK103182897(tyw5)
RTP109937354(tyw5)
BFO118405645
BBEL109465275
CIN100178290
SCLV120326454
SPU582742
APLC110991081
SKO102804006
CLEC106660845
HHAL106681252
NLU111046738
PHUPhum_PHUM372140
ZNE110832463
CSEC111863620
FCD110858846
DPXDAPPUDRAFT_310540
DMK123473829
EAF111704969
LSM121131919
ISCIscW_ISCW003613
DSV119446849
RSAN119389308
RMP119182785
VDE111246538
VJA111272057
DPTE113794197
DFR124490830
CSCU111619219
PTEP107437954
SDM118184068
HROHELRODRAFT_194025
LGILOTGIDRAFT_172630
PCAN112570657
BGT106073027
GAE121387697
HRF124151663
HRJ124291229
CRG105327034
MYI110449258
PMAX117317362
MMER123538442
OBI106873695
OSN115227532
LAK106157744 106178216
NVE5514866
EPA110232099
ATEN116297967
ADF107339068
AMIL114947417 114949337
PDAM113665801
SPIS111327612
HMG100214061
TADTRIADDRAFT_30960
AQU100639988
OLUOSTLU_34749 OSTLU_42544
OTAOT_ostta08g03390
BPGBathy01g06550
MISMICPUN_70819
MPPMICPUCDRAFT_58151
ELAUCREL1_926
TMLGSTUM_00001407001
MLRMELLADRAFT_46862
TANTA13355
TPVTP02_0471
TOTTOT_020001060
BEQBEWA_022090
BMICBmR1_04g07495
GTTGUITHDRAFT_143741 GUITHDRAFT_158760
NGRNAEGRDRAFT_70499
 » show all
Reference
1  [PMID:20739293]
  Authors
Noma A, Ishitani R, Kato M, Nagao A, Nureki O, Suzuki T
  Title
Expanding role of the jumonji C domain as an RNA hydroxylase.
  Journal
J Biol Chem 285:34503-7 (2010)
DOI:10.1074/jbc.M110.156398
  Sequence
[hsa:129450]
Reference
2  [PMID:20972222]
  Authors
Kato M, Araiso Y, Noma A, Nagao A, Suzuki T, Ishitani R, Nureki O
  Title
Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification.
  Journal
Nucleic Acids Res 39:1576-85 (2011)
DOI:10.1093/nar/gkq919
  Sequence
[hsa:129450]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.42
IUBMB Enzyme Nomenclature: 1.14.11.42
ExPASy - ENZYME nomenclature database: 1.14.11.42
BRENDA, the Enzyme Database: 1.14.11.42

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