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Entry
EC 1.14.11.46               Enzyme                                 

Name
2-aminoethylphosphonate dioxygenase;
phnY (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
(2-aminoethyl)phosphonate,2-oxoglutarate:oxygen oxidoreductase (1-hydroxylating)
Reaction(IUBMB)
(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 = (2-amino-1-hydroxyethyl)phosphonate + succinate + CO2 [RN:R10724]
Reaction(KEGG)
Substrate
(2-aminoethyl)phosphonate [CPD:C03557];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
(2-amino-1-hydroxyethyl)phosphonate [CPD:C05678];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+ and ascorbate. The enzyme, characterized from an uncultured marine bacterium, is involved in a (2-aminoethyl)phosphonate degradation pathway.
History
EC 1.14.11.46 created 2014
Pathway
ec00440  Phosphonate and phosphinate metabolism
ec01100  Metabolic pathways
Orthology
K21195  2-aminoethylphosphonate dioxygenase
Genes
QSU: 111983342 112009534 112031218
SSCK: SPSK_09539
FVR: FVEG_07745
FOX: FOXG_04606
MAW: MAC_01242
MAJ: MAA_09259
PLJ: VFPFJ_04691 VFPFJ_10443
BFU: BCIN_06g00110
PSCO: LY89DRAFT_740562 LY89DRAFT_780538
ANG: ANI_1_1162024(An02g08170)
LHA: LHA_1528
NOC: Noc_1391
NHL: Nhal_1353
NWA: Nwat_1690
BOK: DM82_2522
BOC: BG90_2211
ARA: Arad_7878
PSWU: SY83_09970
SYND: KR52_11175
 » show all
Taxonomy
Reference
1  [PMID:22564006]
  Authors
McSorley FR, Wyatt PB, Martinez A, DeLong EF, Hove-Jensen B, Zechel DL
  Title
PhnY and PhnZ comprise a new oxidative pathway for enzymatic cleavage of a carbon-phosphorus bond.
  Journal
J Am Chem Soc 134:8364-7 (2012)
DOI:10.1021/ja302072f
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.46
IUBMB Enzyme Nomenclature: 1.14.11.46
ExPASy - ENZYME nomenclature database: 1.14.11.46
BRENDA, the Enzyme Database: 1.14.11.46

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