KEGG   ENZYME: 1.14.11.48Help
Entry
EC 1.14.11.48               Enzyme                                 

Name
xanthine dioxygenase;
XanA;
alpha-ketoglutarate-dependent xanthine hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
xanthine,2-oxoglutarate:oxygen oxidoreductase
Reaction(IUBMB)
xanthine + 2-oxoglutarate + O2 = urate + succinate + CO2 [RN:R10920]
Reaction(KEGG)
Substrate
xanthine [CPD:C00385];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
urate [CPD:C00366];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+ and L-ascorbate. The enzyme, which was characterized from fungi, is specific for xanthine.
History
EC 1.14.11.48 created 2015
Orthology
K23516  xanthine dioxygenase
Genes
QSU: 111990112
APRO: F751_4638
KLA: KLLA0_E04357g
KMX: KLMA_20520
LTH: KLTH0A03674g
ZRO: ZYRO0D16324g
TDL: TDEL_0H02320(TDEL0H02320)
PPA: PAS_chr3_0332
DHA: DEHA2A01518g
PIC: PICST_34838
CAL: CAALFM_C201540WA(CaO19.1461)
NCR: NCU09738
NTE: NEUTE1DRAFT78605(NEUTE1DRAFT_78605)
MBE: MBM_00895
ANI: AN0488.2
ANG: ANI_1_3374014(An01g14680)
CNE: CNC06420
CNB: CNBC0790
ABP: AGABI1DRAFT67631(AGABI1DRAFT_67631)
ABV: AGABI2DRAFT196515(AGABI2DRAFT_196515)
 » show all
Taxonomy
Reference
1  [PMID:15948966]
  Authors
Cultrone A, Scazzocchio C, Rochet M, Montero-Moran G, Drevet C, Fernandez-Martin R
  Title
Convergent evolution of hydroxylation mechanisms in the fungal kingdom: molybdenum cofactor-independent hydroxylation of xanthine via alpha-ketoglutarate-dependent dioxygenases.
  Journal
Mol Microbiol 57:276-90 (2005)
DOI:10.1111/j.1365-2958.2005.04686.x
  Sequence
[ani:AN0488.2] [ncr:NCU09738] [spo:SPCC576.01c]
Reference
2  [PMID:17429948]
  Authors
Montero-Moran GM, Li M, Rendon-Huerta E, Jourdan F, Lowe DJ, Stumpff-Kane AW, Feig M, Scazzocchio C, Hausinger RP
  Title
Purification and characterization of the FeII- and alpha-ketoglutarate-dependent  xanthine hydroxylase from Aspergillus nidulans.
  Journal
Biochemistry 46:5293-304 (2007)
DOI:10.1021/bi700065h
  Sequence
[ani:AN0488.2]
Reference
3  [PMID:18036331]
  Authors
Li M, Muller TA, Fraser BA, Hausinger RP
  Title
Characterization of active site variants of xanthine hydroxylase from Aspergillus nidulans.
  Journal
Arch Biochem Biophys 470:44-53 (2008)
DOI:10.1016/j.abb.2007.11.002
  Sequence
[ani:AN0488.2]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.48
IUBMB Enzyme Nomenclature: 1.14.11.48
ExPASy - ENZYME nomenclature database: 1.14.11.48
BRENDA, the Enzyme Database: 1.14.11.48

DBGET integrated database retrieval system