Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

mRNA-N1-methyladenine,2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming)

N1-methyladenine in mRNA + 2-oxoglutarate + O2 = adenine in mRNA + formaldehyde + succinate + CO2

N1-methyladenine in mRNA;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]

Contains iron(II). Catalyses oxidative demethylation of mRNA N1-methyladenine. The enzyme is also involved in alkylation repair in DNA [2].

EC 1.14.11.54 created 2016

1  [PMID:16858410]

Sundheim O, Vagbo CB, Bjoras M, Sousa MM, Talstad V, Aas PA, Drablos F, Krokan HE, Tainer JA, Slupphaug G

Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.

EMBO J 25:3389-97 (2006)
DOI:10.1038/sj.emboj.7601219

[hsa:221120]

2  [PMID:22055184]

Dango S, Mosammaparast N, Sowa ME, Xiong LJ, Wu F, Park K, Rubin M, Gygi S, Harper JW, Shi Y

DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation.

Mol Cell 44:373-84 (2011)
DOI:10.1016/j.molcel.2011.08.039

[hsa:221120]

3  [PMID:26863410]

Li X, Xiong X, Wang K, Wang L, Shu X, Ma S, Yi C

Transcriptome-wide mapping reveals reversible and dynamic N(1)-methyladenosine methylome.

Nat Chem Biol 12:311-6 (2016)
DOI:10.1038/nchembio.2040

[hsa:221120]