KEGG   ENZYME: 1.14.11.54
Entry
EC 1.14.11.54               Enzyme                                 
Name
mRNA N1-methyladenine demethylase;
ALKBH3
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
mRNA-N1-methyladenine,2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming)
Reaction(IUBMB)
N1-methyladenine in mRNA + 2-oxoglutarate + O2 = adenine in mRNA + formaldehyde + succinate + CO2
Substrate
N1-methyladenine in mRNA;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
adenine in mRNA [CPD:C21844];
formaldehyde [CPD:C00067];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Contains iron(II). Catalyses oxidative demethylation of mRNA N1-methyladenine. The enzyme is also involved in alkylation repair in DNA [2].
History
EC 1.14.11.54 created 2016
Orthology
K10860  mRNA N1-methyladenine demethylase
Genes
HSA221120(ALKBH3)
PTR741336(ALKBH3)
PPS100973808(ALKBH3)
GGO101128171(ALKBH3)
PON100171823(ALKBH3)
NLE100602324(ALKBH3)
HMH116476330(ALKBH3)
MCC715921(ALKBH3)
MCF101925097(ALKBH3)
MTHB126935986
MNI105471609(ALKBH3)
CSAB103237116(ALKBH3)
CATY105586836(ALKBH3)
PANU101021086(ALKBH3)
TGE112607176(ALKBH3)
MLEU105554773(ALKBH3)
RRO104673889(ALKBH3)
RBB108519277(ALKBH3)
TFN117079980(ALKBH3)
PTEH111544937(ALKBH3)
CANG105527083(ALKBH3)
CJC100399955(ALKBH3)
SBQ101038261(ALKBH3)
CIMI108304911(ALKBH3)
CSYR103272130(ALKBH3)
MMUR105885533(ALKBH3)
LCAT123642614(ALKBH3)
PCOQ105819147(ALKBH3)
OGA100948961(ALKBH3)
MMU69113(Alkbh3)
MCAL110284895(Alkbh3)
MPAH110318986(Alkbh3)
RNO362169(Alkbh3)
MCOC116090520(Alkbh3)
ANU117704196(Alkbh3)
MUN110540590(Alkbh3)
CGE100774403(Alkbh3)
MAUA101841578(Alkbh3)
PROB127222210(Alkbh3)
PLEU114699732(Alkbh3)
MORG121440554(Alkbh3)
MFOT126504682
AAMP119814197(Alkbh3)
NGI103746670(Alkbh3)
HGL101716978(Alkbh3)
CPOC100721589(Alkbh3)
CCAN109697777(Alkbh3)
DORD105996071(Alkbh3)
DSP122100744(Alkbh3)
PLOP125361836(Alkbh3)
NCAR124960109
MMMA107135772(Alkbh3)
OCU100342939
OPI101520863 101530194(ALKBH3)
TUP102495653(ALKBH3)
GVR103602945(ALKBH3)
CFA475938(ALKBH3)
CLUD112663517(ALKBH3)
VVP112914443(ALKBH3)
VLG121501576(ALKBH3)
NPO129494106(ALKBH3)
AML100483392(ALKBH3)
UMR103672347(ALKBH3)
UAH113265015(ALKBH3)
UAR123799600(ALKBH3)
ELK111150166
LLV125079412
MPUF101674082(ALKBH3)
MNP132008213 132008402
MLK131811629(ALKBH3)
NVS122912859(ALKBH3)
ORO101367649(ALKBH3)
EJU114215268(ALKBH3)
ZCA113913808(ALKBH3)
MLX118016268(ALKBH3)
NSU110575738(ALKBH3)
LWW102747133(ALKBH3)
FCA101082850(ALKBH3)
PYU121043520(ALKBH3)
PCOO112865460(ALKBH3)
PBG122483722(ALKBH3)
LRUF124505824
PTG102963280(ALKBH3)
PPAD109279205(ALKBH3)
PUC125912836
AJU106978053
HHV120228413(ALKBH3)
BTA514579(ALKBH3)
BOM102274694(ALKBH3)
BIU109569676(ALKBH3)
BBUB102390815(ALKBH3)
BBIS105000307(ALKBH3)
CHX102187149(ALKBH3)
OAS101110359(ALKBH3)
BTAX128060163(ALKBH3)
ODA120876904(ALKBH3)
CCAD122450095(ALKBH3)
MBEZ129554769(ALKBH3)
SSC100624169(ALKBH3)
CFR102515170(ALKBH3)
CBAI105076492(ALKBH3)
CDK105106833(ALKBH3)
VPC102543076(ALKBH3)
BACU102998891(ALKBH3)
LVE103091564(ALKBH3)
OOR101280185(ALKBH3)
DLE111184013(ALKBH3)
PCAD102977330(ALKBH3)
PSIU116757913(ALKBH3)
NASI112402140(ALKBH3)
ECB100055568(ALKBH3)
EPZ103556453(ALKBH3)
EAI106843966(ALKBH3)
MYB102263934(ALKBH3)
MYD107184435(ALKBH3)
MMYO118665114(ALKBH3)
MLF102422610(ALKBH3)
MNA107525489(ALKBH3)
PKL118713577(ALKBH3)
EFUS103290864(ALKBH3)
HAI109391971(ALKBH3)
DRO112303284(ALKBH3)
SHON119002962(ALKBH3)
AJM119064442(ALKBH3)
PDIC114499939(ALKBH3)
PHAS123810082(ALKBH3)
MMF118627768(ALKBH3)
RFQ117031275(ALKBH3)
PPAM129081460(ALKBH3)
PALE102889640(ALKBH3)
PGIG120606250(ALKBH3)
PVP105289992(ALKBH3)
RAY107511889(ALKBH3)
MJV108402894(ALKBH3)
TOD119255345(ALKBH3)
SARA101545936(ALKBH3)
LAV100670341(ALKBH3)
TMU101348315
ETF101653877(ALKBH3)
DNM101439626(ALKBH3)
MDO100013323(ALKBH3)
GAS123251680(ALKBH3)
SHR100926516(ALKBH3)
AFZ127539676
PCW110223980(ALKBH3)
OAA100079123(ALKBH3)
GGA423169(ALKBH3)
PCOC116228989(ALKBH3)
MGP100545576(ALKBH3)
CJO107314811(ALKBH3)
TPAI128086952(ALKBH3)
LMUT125695031(ALKBH3)
NMEL110402081(ALKBH3)
APLA101803990(ALKBH3)
ACYG106044148(ALKBH3)
CATA118250817(ALKBH3)
AFUL116489599(ALKBH3)
TGU100220917(ALKBH3)
LSR110472035(ALKBH3)
SCAN103827001(ALKBH3)
PMOA120512571(ALKBH3)
OTC121334524(ALKBH3)
PRUF121349558(ALKBH3)
GFR102039523(ALKBH3)
FAB101807443(ALKBH3)
OMA130253384(ALKBH3)
PHI102106986(ALKBH3)
PMAJ107206104(ALKBH3)
CCAE111930139(ALKBH3)
CCW104688097(ALKBH3)
CBRC103620913(ALKBH3)
ETL114064859(ALKBH3)
ZAB102064160(ALKBH3)
ACHL103804349(ALKBH3)
SVG106851558(ALKBH3)
MMEA130572487(ALKBH3)
HRT120754644(ALKBH3)
FPG101917358(ALKBH3)
FCH102056465(ALKBH3)
CLV102087563(ALKBH3)
EGZ104134097(ALKBH3)
NNI104019570(ALKBH3)
PCRI104031898(ALKBH3)
PCAO104046663(ALKBH3)
ACUN113480635(ALKBH3)
TALA104367470(ALKBH3)
PADL103921725(ALKBH3)
AFOR103897533(ALKBH3)
ACHC115334572(ALKBH3)
HALD104324275(ALKBH3)
HLE104839722(ALKBH3)
AGEN126049421
GCL127016888
CCRI104155532(ALKBH3)
CSTI104560638(ALKBH3)
CMAC104483325(ALKBH3)
MUI104545681(ALKBH3)
BREG104640696(ALKBH3)
FGA104070497(ALKBH3)
GSTE104257560(ALKBH3)
LDI104349545(ALKBH3)
OHA104330178(ALKBH3)
NNT104410311(ALKBH3)
SHAB115607336(ALKBH3)
DPUB104303048(ALKBH3)
PGUU104463662(ALKBH3)
ACAR104527082(ALKBH3)
CPEA104390445(ALKBH3)
AVIT104274782(ALKBH3)
CVF104295885(ALKBH3)
RTD128908798(ALKBH3)
CUCA104067330(ALKBH3)
TEO104377610(ALKBH3)
BRHI104488160(ALKBH3)
AAM106498339(ALKBH3)
AROW112978305(ALKBH3)
NPD112943532(ALKBH3)
TGT104565057(ALKBH3)
DNE112979237(ALKBH3)
SCAM104149261(ALKBH3)
ASN102379536(ALKBH3)
AMJ102559132(ALKBH3)
CPOO109321369(ALKBH3)
GGN109298938(ALKBH3)
PSS102446051(ALKBH3)
CMY102946097(ALKBH3)
CCAY125638498(ALKBH3)
DCC119857851(ALKBH3)
CPIC101950462(ALKBH3)
TST117876979(ALKBH3)
CABI116830762(ALKBH3)
MRV120404300(ALKBH3)
ACS100557858(alkbh3)
ASAO132768512(ALKBH3)
PVT110081512(ALKBH3)
SUND121936322(ALKBH3)
PBI103049891(ALKBH3)
PMUR107289669(ALKBH3)
CTIG120307966(ALKBH3)
TSR106545010(ALKBH3)
PGUT117665487(ALKBH3)
APRI131187431(ALKBH3)
PTEX113440762(ALKBH3)
NSS113410224(ALKBH3)
VKO123026755(ALKBH3)
PMUA114596277(ALKBH3)
PRAF128413537(ALKBH3)
ZVI118085411(ALKBH3)
HCG128339352(ALKBH3)
GJA107119117(ALKBH3)
STOW125425939(ALKBH3)
EMC129325315(ALKBH3)
XLA496071(alkbh3.L)
XTR100495476(alkbh3)
NPR108785848(ALKBH3)
RTEM120917034(ALKBH3)
BBUF120981146(ALKBH3)
BGAR122920137(ALKBH3)
MUO115468805(ALKBH3)
GSH117352284(ALKBH3)
DRE792266(alkbh3)
SRX107716661
SANH107661502 107696266
SGH107573924(alkbh3) 107598856
CCAR109063459
CAUA113043364 113066937(alkbh3)
CGIB127946686 128013916
PTET122330312(alkbh3)
LROH127156747(alkbh3)
OMC131534815(alkbh3)
PPRM120469201(alkbh3)
RKG130104469(alkbh3)
MAMB125247648(alkbh3)
CIDE127507617
MASI127437772
TROS130552230(alkbh3)
TDW130414571(alkbh3)
MANU129433406(alkbh3)
IPU100528586(alkbh3)
IFU128617854(alkbh3)
PHYP113529737(alkbh3)
SMEO124392890(alkbh3)
TFD113654064(alkbh3)
TVC132856867(alkbh3)
AMEX103026192(alkbh3)
CMAO118811762(alkbh3)
EEE113571858(alkbh3)
CHAR105913394(alkbh3)
TRU101068007(alkbh3)
TFS130535909(alkbh3)
TNGGSTEN00019672G001
LCO104922397(alkbh3)
NCC104950558
TBEN117497258(alkbh3)
CGOB115010259(alkbh3)
PGEO117448142(alkbh3)
GACU117557472(alkbh3)
ELY117262634(alkbh3)
EFO125887888(alkbh3)
PLEP121938181 121950266(alkbh3)
SLUC116046802(alkbh3)
ECRA117948979(alkbh3)
ESP116693583(alkbh3)
PFLV114560330(alkbh3)
GAT120809369(alkbh3)
PPUG119196541(alkbh3)
AFB129108403(alkbh3)
CLUM117731839(alkbh3)
MSAM119893647(alkbh3)
SCHU122874606(alkbh3)
CUD121514579(alkbh3)
ALAT119024425(alkbh3)
MZE101486257(alkbh3)
ONL100698973(alkbh3)
OAU116313952(alkbh3)
OLA101164226(alkbh3)
OML112151953(alkbh3)
XMA102224505(alkbh3)
XCO114134553(alkbh3)
XHE116710020(alkbh3)
PRET103465694(alkbh3)
PFOR103152824(alkbh3)
PLAI106964818(alkbh3)
PMEI106904444(alkbh3)
GAF122835862(alkbh3)
CVG107092180(alkbh3)
CTUL119798181(alkbh3)
GMU124861177(alkbh3)
NFU107374482(alkbh3)
KMR108245714(alkbh3)
ALIM106529602(alkbh3)
NWH119415412(alkbh3)
AOCE111567883(alkbh3)
MCEP125014327(alkbh3)
CSEM103379804(alkbh3)
POV109623981(alkbh3)
SSEN122775381(alkbh3)
HHIP117763684(alkbh3)
HSP118110022(alkbh3)
LCF108889309
SDU111229672(alkbh3)
SLAL111650456(alkbh3)
XGL120793747(alkbh3)
HCQ109513176(alkbh3)
SSCV125970945
SBIA133502085(alkbh3)
PEE133403357(alkbh3)
PTAO133478263(alkbh3)
BPEC110160323(alkbh3)
MALB109973531(alkbh3)
BSPL114857821(alkbh3)
SJO128358313(alkbh3)
SASA106561092(alkbh3)
STRU115197101(alkbh3)
OTW112218280
OMY110492083(alkbh3)
OGO124039647(alkbh3)
ONE115121940 115134525(alkbh3)
OKI109867581(alkbh3)
OKE118396401(alkbh3)
SALP111962104(alkbh3)
SNH120066092(alkbh3)
CCLU121532127 121540108
ELS105006119(alkbh3)
SFM108942111(alkbh3)
PKI111859477(alkbh3)
AANG118215767(alkbh3)
LOC102684577(alkbh3)
PSPA121330137(alkbh3)
ARUT117432411 117434590
PSEX120523169(alkbh3)
LCM102354734(ALKBH3)
CMK103174969(alkbh3)
RTP109933432(alkbh3)
CPLA122557662(alkbh3)
HOC132824262(alkbh3)
LERI129705678(alkbh3)
PMRN116949621(ALKBH3)
LRJ133346906(ALKBH3)
BFO118408270
BBEL109480313
CIN100187190
SPU592282
LPIC129283390
APLC110989950
AJC117105046
SKO102804926
CSCU111626499
PTEP107437569 122268709
LPOL106465920
HROHELRODRAFT_185055
LGILOTGIDRAFT_133518
PVUL126829374
BGT106056468
GAE121370573
HRF124123766
HRJ124256624
CRG105340036
CVN111101457 111101679 111101938
CANU128184610
OED125672974
MYI110457607
PMAX117326994
MCAF127724249
MMER123552565
RPHI132743640
DPOL127852137
OBI106871726
OSN115232595
LAK106150965 106173692
NVE5510799
EPA110247701
ATEN116301025
XEN124446187
HSY130655960
 » show all
Reference
1  [PMID:16858410]
  Authors
Sundheim O, Vagbo CB, Bjoras M, Sousa MM, Talstad V, Aas PA, Drablos F, Krokan HE, Tainer JA, Slupphaug G
  Title
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.
  Journal
EMBO J 25:3389-97 (2006)
DOI:10.1038/sj.emboj.7601219
  Sequence
[hsa:221120]
Reference
2  [PMID:22055184]
  Authors
Dango S, Mosammaparast N, Sowa ME, Xiong LJ, Wu F, Park K, Rubin M, Gygi S, Harper JW, Shi Y
  Title
DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation.
  Journal
Mol Cell 44:373-84 (2011)
DOI:10.1016/j.molcel.2011.08.039
  Sequence
[hsa:221120]
Reference
3  [PMID:26863410]
  Authors
Li X, Xiong X, Wang K, Wang L, Shu X, Ma S, Yi C
  Title
Transcriptome-wide mapping reveals reversible and dynamic N(1)-methyladenosine methylome.
  Journal
Nat Chem Biol 12:311-6 (2016)
DOI:10.1038/nchembio.2040
  Sequence
[hsa:221120]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.54
IUBMB Enzyme Nomenclature: 1.14.11.54
ExPASy - ENZYME nomenclature database: 1.14.11.54
BRENDA, the Enzyme Database: 1.14.11.54

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