KEGG   ENZYME: 1.14.11.54Help
Entry
EC 1.14.11.54               Enzyme                                 

Name
mRNA N1-methyladenine demethylase;
ALKBH3
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
mRNA-N1-methyladenine,2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming)
Reaction(IUBMB)
N1-methyladenine in mRNA + 2-oxoglutarate + O2 = adenine in mRNA + formaldehyde + succinate + CO2
Substrate
N1-methyladenine in mRNA;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
adenine in mRNA [CPD:C21844];
formaldehyde [CPD:C00067];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Contains iron(II). Catalyses oxidative demethylation of mRNA N1-methyladenine. The enzyme is also involved in alkylation repair in DNA [2].
History
EC 1.14.11.54 created 2016
Orthology
K10860  mRNA N1-methyladenine demethylase
Genes
HSA: 221120(ALKBH3)
PTR: 741336(ALKBH3)
PPS: 100973808(ALKBH3)
GGO: 101128171(ALKBH3)
PON: 100171823(ALKBH3)
NLE: 100602324(ALKBH3)
MCC: 715921(ALKBH3)
MCF: 101925097(ALKBH3)
CSAB: 103237116(ALKBH3)
RRO: 104673889(ALKBH3)
RBB: 108519277(ALKBH3)
CJC: 100399955(ALKBH3)
SBQ: 101038261(ALKBH3)
MMU: 69113(Alkbh3)
MCAL: 110284895(Alkbh3)
MPAH: 110318986(Alkbh3)
RNO: 362169(Alkbh3)
MUN: 110540590(Alkbh3)
CGE: 100774403(Alkbh3)
NGI: 103746670(Alkbh3)
HGL: 101716978(Alkbh3)
CCAN: 109697777(Alkbh3)
OCU: 100342939(ALKBH3)
TUP: 102495653(ALKBH3)
CFA: 475938(ALKBH3)
VVP: 112914443(ALKBH3)
AML: 100483392(ALKBH3)
UMR: 103672347(ALKBH3)
UAH: 113265015(ALKBH3)
ORO: 101367649(ALKBH3)
FCA: 101082850(ALKBH3)
PTG: 102963280(ALKBH3)
PPAD: 109279205(ALKBH3)
AJU: 106978053(ALKBH3)
BTA: 514579(ALKBH3)
BOM: 102274694(ALKBH3)
BIU: 109569676(ALKBH3)
BBUB: 102390815(ALKBH3)
CHX: 102187149(ALKBH3)
OAS: 101110359(ALKBH3)
SSC: 100624169(ALKBH3)
CFR: 102515170(ALKBH3)
CDK: 105106833(ALKBH3)
BACU: 102998891(ALKBH3)
LVE: 103091564(ALKBH3)
OOR: 101280185(ALKBH3)
DLE: 111184013(ALKBH3)
PCAD: 102977330(ALKBH3)
ECB: 100055568(ALKBH3)
EPZ: 103556453(ALKBH3)
EAI: 106843966(ALKBH3)
MYB: 102263934(ALKBH3)
MYD: 107184435(ALKBH3)
MNA: 107525489(ALKBH3)
HAI: 109391971(ALKBH3)
DRO: 112303284(ALKBH3)
PALE: 102889640(ALKBH3)
RAY: 107511889(ALKBH3)
MJV: 108402894(ALKBH3)
LAV: 100670341(ALKBH3)
TMU: 101348315
MDO: 100013323(ALKBH3)
SHR: 100926516(ALKBH3)
PCW: 110223980(ALKBH3)
OAA: 100079123(ALKBH3)
GGA: 423169(ALKBH3)
MGP: 100545576(ALKBH3)
CJO: 107314811(ALKBH3)
NMEL: 110402081(ALKBH3)
APLA: 101803990(ALKBH3)
ACYG: 106044148(ALKBH3)
TGU: 100220917(ALKBH3)
LSR: 110472035(ALKBH3)
SCAN: 103827001(ALKBH3)
GFR: 102039523(ALKBH3)
FAB: 101807443(ALKBH3)
PHI: 102106986(ALKBH3)
PMAJ: 107206104(ALKBH3)
CCAE: 111930139(ALKBH3)
CCW: 104688097(ALKBH3)
ETL: 114064859(ALKBH3)
FPG: 101917358(ALKBH3)
FCH: 102056465(ALKBH3)
CLV: 102087563(ALKBH3)
EGZ: 104134097(ALKBH3)
NNI: 104019570(ALKBH3)
ACUN: 113480635(ALKBH3)
PADL: 103921725(ALKBH3)
AAM: 106498339(ALKBH3)
ASN: 102379536(ALKBH3)
AMJ: 102559132(ALKBH3)
PSS: 102446051(ALKBH3)
CMY: 102946097(ALKBH3)
CPIC: 101950462(ALKBH3)
ACS: 100557858(alkbh3)
PVT: 110081512(ALKBH3)
PBI: 103049891(ALKBH3)
PMUR: 107289669(ALKBH3)
TSR: 106545010(ALKBH3)
PMUA: 114596277(ALKBH3)
GJA: 107119117(ALKBH3)
XLA: 496071(alkbh3.L)
XTR: 100495476(alkbh3)
NPR: 108785848(ALKBH3)
DRE: 792266(alkbh3)
SRX: 107716661
SGH: 107573924(alkbh3) 107598856
IPU: 100528586(alkbh3)
PHYP: 113529737(alkbh3)
AMEX: 103026192(alkbh3)
EEE: 113571858(alkbh3)
TRU: 101068007(alkbh3)
LCO: 104922397(alkbh3)
NCC: 104950558
MZE: 101486257(alkbh3)
ONL: 100698973(alkbh3)
OLA: 101164226(alkbh3)
XMA: 102224505(alkbh3)
XCO: 114134553(alkbh3)
PRET: 103465694(alkbh3)
CVG: 107092180(alkbh3)
NFU: 107374482(alkbh3)
KMR: 108245714(alkbh3)
ALIM: 106529602(alkbh3)
AOCE: 111567883(alkbh3)
CSEM: 103379804(alkbh3)
POV: 109623981(alkbh3)
LCF: 108889309(alkbh3)
SDU: 111229672(alkbh3)
SLAL: 111650456(alkbh3)
HCQ: 109513176(alkbh3)
BPEC: 110160323(alkbh3)
MALB: 109973531(alkbh3)
SASA: 106561092(alkbh3)
OTW: 112218280(alkbh3)
SALP: 111962104(alkbh3)
ELS: 105006119(alkbh3)
SFM: 108942111(alkbh3)
PKI: 111859477(alkbh3)
LCM: 102354734(ALKBH3)
CMK: 103174969(alkbh3)
RTP: 109933432(alkbh3)
CIN: 100187190
SPU: 592282
APLC: 110989950
SKO: 102804926
CSCU: 111626499
CRG: 105340036
MYI: 110457607
OBI: 106871726
EPA: 110247701
 » show all
Taxonomy
Reference
1  [PMID:16858410]
  Authors
Sundheim O, Vagbo CB, Bjoras M, Sousa MM, Talstad V, Aas PA, Drablos F, Krokan HE, Tainer JA, Slupphaug G
  Title
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.
  Journal
EMBO J 25:3389-97 (2006)
DOI:10.1038/sj.emboj.7601219
  Sequence
[hsa:221120]
Reference
2  [PMID:22055184]
  Authors
Dango S, Mosammaparast N, Sowa ME, Xiong LJ, Wu F, Park K, Rubin M, Gygi S, Harper JW, Shi Y
  Title
DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation.
  Journal
Mol Cell 44:373-84 (2011)
DOI:10.1016/j.molcel.2011.08.039
  Sequence
[hsa:221120]
Reference
3  [PMID:26863410]
  Authors
Li X, Xiong X, Wang K, Wang L, Shu X, Ma S, Yi C
  Title
Transcriptome-wide mapping reveals reversible and dynamic N(1)-methyladenosine methylome.
  Journal
Nat Chem Biol 12:311-6 (2016)
DOI:10.1038/nchembio.2040
  Sequence
[hsa:221120]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.54
IUBMB Enzyme Nomenclature: 1.14.11.54
ExPASy - ENZYME nomenclature database: 1.14.11.54
BRENDA, the Enzyme Database: 1.14.11.54

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