Entry |
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Name |
mRNA N1-methyladenine demethylase;
ALKBH3
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Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
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Sysname |
mRNA-N1-methyladenine,2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming)
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Reaction(IUBMB) |
N1-methyladenine in mRNA + 2-oxoglutarate + O2 = adenine in mRNA + formaldehyde + succinate + CO2
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Substrate |
N1-methyladenine in mRNA;
2-oxoglutarate [CPD: C00026];
O2 [CPD: C00007]
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Product |
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Comment |
Contains iron(II). Catalyses oxidative demethylation of mRNA N1-methyladenine. The enzyme is also involved in alkylation repair in DNA [2].
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History |
EC 1.14.11.54 created 2016
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Orthology |
K10860 | mRNA N1-methyladenine demethylase |
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Genes |
» show all
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Reference |
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Authors |
Sundheim O, Vagbo CB, Bjoras M, Sousa MM, Talstad V, Aas PA, Drablos F, Krokan HE, Tainer JA, Slupphaug G |
Title |
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. |
Journal |
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Sequence |
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Reference |
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Authors |
Dango S, Mosammaparast N, Sowa ME, Xiong LJ, Wu F, Park K, Rubin M, Gygi S, Harper JW, Shi Y |
Title |
DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation. |
Journal |
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Sequence |
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Reference |
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Authors |
Li X, Xiong X, Wang K, Wang L, Shu X, Ma S, Yi C |
Title |
Transcriptome-wide mapping reveals reversible and dynamic N(1)-methyladenosine methylome. |
Journal |
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Sequence |
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Other DBs |
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